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Fusion gene ID: 37855 |
FusionGeneSummary for TFG_TRPC5 |
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Fusion gene information | Fusion gene name: TFG_TRPC5 | Fusion gene ID: 37855 | Hgene | Tgene | Gene symbol | TFG | TRPC5 | Gene ID | 10342 | 7224 |
Gene name | TRK-fused gene | transient receptor potential cation channel subfamily C member 5 | |
Synonyms | HMSNP|SPG57|TF6|TRKT3 | PPP1R159|TRP5 | |
Cytomap | 3q12.2 | Xq23 | |
Type of gene | protein-coding | protein-coding | |
Description | protein TFGTRK-fused gene proteinTRKT3 oncogene | short transient receptor potential channel 5TRP-5hTRP5protein phosphatase 1, regulatory subunit 159transient receptor potential channel 5transient receptor protein 5 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q92734 | Q9UL62 | |
Ensembl transtripts involved in fusion gene | ENST00000418917, ENST00000490574, ENST00000240851, ENST00000476228, ENST00000481203, | ENST00000262839, | |
Fusion gene scores | * DoF score | 8 X 7 X 3=168 | 2 X 2 X 2=8 |
# samples | 12 | 2 | |
** MAII score | log2(12/168*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TFG [Title/Abstract] AND TRPC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T05994 | TFG | chr3 | 100467300 | + | TRPC5 | chrX | 111289237 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000418917 | ENST00000262839 | TFG | chr3 | 100467300 | + | TRPC5 | chrX | 111289237 | - |
5CDS-intron | ENST00000490574 | ENST00000262839 | TFG | chr3 | 100467300 | + | TRPC5 | chrX | 111289237 | - |
5CDS-intron | ENST00000240851 | ENST00000262839 | TFG | chr3 | 100467300 | + | TRPC5 | chrX | 111289237 | - |
5CDS-intron | ENST00000476228 | ENST00000262839 | TFG | chr3 | 100467300 | + | TRPC5 | chrX | 111289237 | - |
3UTR-intron | ENST00000481203 | ENST00000262839 | TFG | chr3 | 100467300 | + | TRPC5 | chrX | 111289237 | - |
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FusionProtFeatures for TFG_TRPC5 |
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Hgene | Tgene |
TFG | TRPC5 |
Plays a role in the normal dynamic function of theendoplasmic reticulum (ER) and its associated microtubules(PubMed:23479643, PubMed:27813252). {ECO:0000269|PubMed:23479643,ECO:0000269|PubMed:27813252}. | Thought to form a receptor-activated non-selectivecalcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptortyrosine kinases or G-protein coupled receptors. Has also beenshown to be calcium-selective (By similarity). May also beactivated by intracellular calcium store depletion. {ECO:0000250,ECO:0000269|PubMed:16284075}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TFG_TRPC5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TFG_TRPC5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TFG_TRPC5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TFG_TRPC5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TFG | C1858338 | Neuropathy, hereditary motor and sensory, Okinawa type | 1 | ORPHANET;UNIPROT |
Hgene | TFG | C3714897 | SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE | 1 | ORPHANET;UNIPROT |
Tgene | TRPC5 | C0020538 | Hypertensive disease | 1 | CTD_human |