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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37855

FusionGeneSummary for TFG_TRPC5

check button Fusion gene summary
Fusion gene informationFusion gene name: TFG_TRPC5
Fusion gene ID: 37855
HgeneTgene
Gene symbol

TFG

TRPC5

Gene ID

10342

7224

Gene nameTRK-fused genetransient receptor potential cation channel subfamily C member 5
SynonymsHMSNP|SPG57|TF6|TRKT3PPP1R159|TRP5
Cytomap

3q12.2

Xq23

Type of geneprotein-codingprotein-coding
Descriptionprotein TFGTRK-fused gene proteinTRKT3 oncogeneshort transient receptor potential channel 5TRP-5hTRP5protein phosphatase 1, regulatory subunit 159transient receptor potential channel 5transient receptor protein 5
Modification date2018052220180523
UniProtAcc

Q92734

Q9UL62

Ensembl transtripts involved in fusion geneENST00000418917, ENST00000490574, 
ENST00000240851, ENST00000476228, 
ENST00000481203, 
ENST00000262839, 
Fusion gene scores* DoF score8 X 7 X 3=1682 X 2 X 2=8
# samples 122
** MAII scorelog2(12/168*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TFG [Title/Abstract] AND TRPC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T05994TFGchr3

100467300

+TRPC5chrX

111289237

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000418917ENST00000262839TFGchr3

100467300

+TRPC5chrX

111289237

-
5CDS-intronENST00000490574ENST00000262839TFGchr3

100467300

+TRPC5chrX

111289237

-
5CDS-intronENST00000240851ENST00000262839TFGchr3

100467300

+TRPC5chrX

111289237

-
5CDS-intronENST00000476228ENST00000262839TFGchr3

100467300

+TRPC5chrX

111289237

-
3UTR-intronENST00000481203ENST00000262839TFGchr3

100467300

+TRPC5chrX

111289237

-

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FusionProtFeatures for TFG_TRPC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFG

Q92734

TRPC5

Q9UL62

Plays a role in the normal dynamic function of theendoplasmic reticulum (ER) and its associated microtubules(PubMed:23479643, PubMed:27813252). {ECO:0000269|PubMed:23479643,ECO:0000269|PubMed:27813252}. Thought to form a receptor-activated non-selectivecalcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptortyrosine kinases or G-protein coupled receptors. Has also beenshown to be calcium-selective (By similarity). May also beactivated by intracellular calcium store depletion. {ECO:0000250,ECO:0000269|PubMed:16284075}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TFG_TRPC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TFG_TRPC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TFG_TRPC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TFG_TRPC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFGC1858338Neuropathy, hereditary motor and sensory, Okinawa type1ORPHANET;UNIPROT
HgeneTFGC3714897SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT
TgeneTRPC5C0020538Hypertensive disease1CTD_human