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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37827

FusionGeneSummary for TFDP2_LANCL2

check button Fusion gene summary
Fusion gene informationFusion gene name: TFDP2_LANCL2
Fusion gene ID: 37827
HgeneTgene
Gene symbol

TFDP2

LANCL2

Gene ID

7029

55915

Gene nametranscription factor Dp-2LanC like 2
SynonymsDP2GPR69B|TASP
Cytomap

3q23

7p11.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor Dp-2transcription factor Dp-2 (E2F dimerization partner 2)lanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity protein
Modification date2018052320180523
UniProtAcc

Q14188

Q9NS86

Ensembl transtripts involved in fusion geneENST00000499676, ENST00000489671, 
ENST00000486111, ENST00000477292, 
ENST00000495310, ENST00000467072, 
ENST00000317104, ENST00000310282, 
ENST00000479040, ENST00000397991, 
ENST00000464782, 
ENST00000254770, 
ENST00000486376, 
Fusion gene scores* DoF score5 X 2 X 4=407 X 5 X 5=175
# samples 58
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFDP2 [Title/Abstract] AND LANCL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFDP2

GO:0045892

negative regulation of transcription, DNA-templated

20176812

HgeneTFDP2

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537

TgeneLANCL2

GO:0009789

positive regulation of abscisic acid-activated signaling pathway

19667068

TgeneLANCL2

GO:0045892

negative regulation of transcription, DNA-templated

12566319


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A25F-01ATFDP2chr3

141811903

-LANCL2chr7

55466116

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000499676ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000499676ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
Frame-shitENST00000489671ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
5CDS-3UTRENST00000489671ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000486111ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000486111ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000477292ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000477292ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000495310ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000495310ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
5UTR-3CDSENST00000467072ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
5UTR-3UTRENST00000467072ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
5UTR-3CDSENST00000317104ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
5UTR-3UTRENST00000317104ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000310282ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000310282ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000479040ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000479040ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000397991ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000397991ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3CDSENST00000464782ENST00000254770TFDP2chr3

141811903

-LANCL2chr7

55466116

+
intron-3UTRENST00000464782ENST00000486376TFDP2chr3

141811903

-LANCL2chr7

55466116

+

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FusionProtFeatures for TFDP2_LANCL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFDP2

Q14188

LANCL2

Q9NS86

Necessary for abscisic acid (ABA) binding on the cellmembrane and activation of the ABA signaling pathway ingranulocytes. {ECO:0000269|PubMed:19667068}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TFDP2_LANCL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TFDP2_LANCL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TFDP2E2F6, E2F1, RB1, RBL1, E2F4, RBL2, LIN9, LIN37, LIN54, E2F5, E2F2, E2F3, PCGF6, L3MBTL2, COMMD8, RYBPLANCL2OTUD5, TCF3, TERF2IP, TERF2, APP, MON1B, CDK9, EGFR, APPBP2, MOV10, NXF1, FAM188A, GSTM3, MCM2, NF2, RHOU, AIRE, DOK2, KCNJ5, PVR, GMFG, FEZ1, PCGF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TFDP2_LANCL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TFDP2_LANCL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFDP2C0345967Malignant mesothelioma1CTD_human