![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 37827 |
FusionGeneSummary for TFDP2_LANCL2 |
![]() |
Fusion gene information | Fusion gene name: TFDP2_LANCL2 | Fusion gene ID: 37827 | Hgene | Tgene | Gene symbol | TFDP2 | LANCL2 | Gene ID | 7029 | 55915 |
Gene name | transcription factor Dp-2 | LanC like 2 | |
Synonyms | DP2 | GPR69B|TASP | |
Cytomap | 3q23 | 7p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor Dp-2transcription factor Dp-2 (E2F dimerization partner 2) | lanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14188 | Q9NS86 | |
Ensembl transtripts involved in fusion gene | ENST00000499676, ENST00000489671, ENST00000486111, ENST00000477292, ENST00000495310, ENST00000467072, ENST00000317104, ENST00000310282, ENST00000479040, ENST00000397991, ENST00000464782, | ENST00000254770, ENST00000486376, | |
Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 7 X 5 X 5=175 |
# samples | 5 | 8 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TFDP2 [Title/Abstract] AND LANCL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TFDP2 | GO:0045892 | negative regulation of transcription, DNA-templated | 20176812 |
Hgene | TFDP2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
Tgene | LANCL2 | GO:0009789 | positive regulation of abscisic acid-activated signaling pathway | 19667068 |
Tgene | LANCL2 | GO:0045892 | negative regulation of transcription, DNA-templated | 12566319 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A2-A25F-01A | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000499676 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000499676 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
Frame-shift | ENST00000489671 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
5CDS-3UTR | ENST00000489671 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000486111 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000486111 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000477292 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000477292 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000495310 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000495310 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
5UTR-3CDS | ENST00000467072 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
5UTR-3UTR | ENST00000467072 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
5UTR-3CDS | ENST00000317104 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
5UTR-3UTR | ENST00000317104 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000310282 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000310282 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000479040 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000479040 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000397991 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000397991 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3CDS | ENST00000464782 | ENST00000254770 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
intron-3UTR | ENST00000464782 | ENST00000486376 | TFDP2 | chr3 | 141811903 | - | LANCL2 | chr7 | 55466116 | + |
Top |
FusionProtFeatures for TFDP2_LANCL2 |
![]() |
Hgene | Tgene |
TFDP2 | LANCL2 |
Necessary for abscisic acid (ABA) binding on the cellmembrane and activation of the ABA signaling pathway ingranulocytes. {ECO:0000269|PubMed:19667068}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TFDP2_LANCL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TFDP2_LANCL2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TFDP2 | E2F6, E2F1, RB1, RBL1, E2F4, RBL2, LIN9, LIN37, LIN54, E2F5, E2F2, E2F3, PCGF6, L3MBTL2, COMMD8, RYBP | LANCL2 | OTUD5, TCF3, TERF2IP, TERF2, APP, MON1B, CDK9, EGFR, APPBP2, MOV10, NXF1, FAM188A, GSTM3, MCM2, NF2, RHOU, AIRE, DOK2, KCNJ5, PVR, GMFG, FEZ1, PCGF2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TFDP2_LANCL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TFDP2_LANCL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TFDP2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |