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Fusion gene ID: 37824 |
FusionGeneSummary for TFDP1_LAMP1 |
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Fusion gene information | Fusion gene name: TFDP1_LAMP1 | Fusion gene ID: 37824 | Hgene | Tgene | Gene symbol | TFDP1 | LAMP1 | Gene ID | 7027 | 3916 |
Gene name | transcription factor Dp-1 | lysosomal associated membrane protein 1 | |
Synonyms | DILC|DP1|DRTF1|Dp-1 | CD107a|LAMPA|LGP120 | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | lysosome-associated membrane glycoprotein 1CD107 antigen-like family member ALAMP-1lysosome-associated membrane protein 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q14186 | P11279 | |
Ensembl transtripts involved in fusion gene | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | ENST00000332556, ENST00000397181, ENST00000471046, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TFDP1 [Title/Abstract] AND LAMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-56-A4ZK-01A | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000375370 | ENST00000332556 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
Frame-shift | ENST00000375370 | ENST00000397181 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5CDS-intron | ENST00000375370 | ENST00000471046 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5UTR-3CDS | ENST00000538138 | ENST00000332556 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5UTR-3CDS | ENST00000538138 | ENST00000397181 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5UTR-intron | ENST00000538138 | ENST00000471046 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
3UTR-3CDS | ENST00000465174 | ENST00000332556 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
3UTR-3CDS | ENST00000465174 | ENST00000397181 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
3UTR-intron | ENST00000465174 | ENST00000471046 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5UTR-3CDS | ENST00000544902 | ENST00000332556 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5UTR-3CDS | ENST00000544902 | ENST00000397181 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
5UTR-intron | ENST00000544902 | ENST00000471046 | TFDP1 | chr13 | 114240164 | + | LAMP1 | chr13 | 113973784 | + |
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FusionProtFeatures for TFDP1_LAMP1 |
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Hgene | Tgene |
TFDP1 | LAMP1 |
Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. | Presents carbohydrate ligands to selectins. Alsoimplicated in tumor cell metastasis. Acts as a receptor for Lassa virus protein.{ECO:0000269|PubMed:24970085}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TFDP1_LAMP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TFDP1_LAMP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TFDP1 | E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1 | LAMP1 | TNFAIP3, SVIP, ELAVL1, ALG2, LAPTM5, ATP13A2, ATP6V1B1, ILF3, PTP4A1, TM9SF4, SDAD1, ILF2, UBL4A, FBXO6, AIP, HSD17B10, OSGEP, LGALS3, EPAS1, HNRNPA1, ZFPL1, EWSR1, NOTCH1, STK17B, SLC38A7, FZD7, RAB4A, FZD2, PLAA, C4A, LEMD3, LGALS1, ELP6, RARS, ORC4, DNM3, CUX1, FAM3C, ANAPC7, FAM207A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TFDP1_LAMP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TFDP1_LAMP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TFDP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |