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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37824

FusionGeneSummary for TFDP1_LAMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TFDP1_LAMP1
Fusion gene ID: 37824
HgeneTgene
Gene symbol

TFDP1

LAMP1

Gene ID

7027

3916

Gene nametranscription factor Dp-1lysosomal associated membrane protein 1
SynonymsDILC|DP1|DRTF1|Dp-1CD107a|LAMPA|LGP120
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cellslysosome-associated membrane glycoprotein 1CD107 antigen-like family member ALAMP-1lysosome-associated membrane protein 1
Modification date2018052320180519
UniProtAcc

Q14186

P11279

Ensembl transtripts involved in fusion geneENST00000375370, ENST00000538138, 
ENST00000465174, ENST00000544902, 
ENST00000332556, ENST00000397181, 
ENST00000471046, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: TFDP1 [Title/Abstract] AND LAMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFDP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-56-A4ZK-01ATFDP1chr13

114240164

+LAMP1chr13

113973784

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000375370ENST00000332556TFDP1chr13

114240164

+LAMP1chr13

113973784

+
Frame-shitENST00000375370ENST00000397181TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5CDS-intronENST00000375370ENST00000471046TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5UTR-3CDSENST00000538138ENST00000332556TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5UTR-3CDSENST00000538138ENST00000397181TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5UTR-intronENST00000538138ENST00000471046TFDP1chr13

114240164

+LAMP1chr13

113973784

+
3UTR-3CDSENST00000465174ENST00000332556TFDP1chr13

114240164

+LAMP1chr13

113973784

+
3UTR-3CDSENST00000465174ENST00000397181TFDP1chr13

114240164

+LAMP1chr13

113973784

+
3UTR-intronENST00000465174ENST00000471046TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5UTR-3CDSENST00000544902ENST00000332556TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5UTR-3CDSENST00000544902ENST00000397181TFDP1chr13

114240164

+LAMP1chr13

113973784

+
5UTR-intronENST00000544902ENST00000471046TFDP1chr13

114240164

+LAMP1chr13

113973784

+

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FusionProtFeatures for TFDP1_LAMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFDP1

Q14186

LAMP1

P11279

Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. Presents carbohydrate ligands to selectins. Alsoimplicated in tumor cell metastasis. Acts as a receptor for Lassa virus protein.{ECO:0000269|PubMed:24970085}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TFDP1_LAMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TFDP1_LAMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TFDP1E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1LAMP1TNFAIP3, SVIP, ELAVL1, ALG2, LAPTM5, ATP13A2, ATP6V1B1, ILF3, PTP4A1, TM9SF4, SDAD1, ILF2, UBL4A, FBXO6, AIP, HSD17B10, OSGEP, LGALS3, EPAS1, HNRNPA1, ZFPL1, EWSR1, NOTCH1, STK17B, SLC38A7, FZD7, RAB4A, FZD2, PLAA, C4A, LEMD3, LGALS1, ELP6, RARS, ORC4, DNM3, CUX1, FAM3C, ANAPC7, FAM207A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TFDP1_LAMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TFDP1_LAMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFDP1C3495559Juvenile arthritis1CTD_human