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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37823

FusionGeneSummary for TFDP1_CUL4A

check button Fusion gene summary
Fusion gene informationFusion gene name: TFDP1_CUL4A
Fusion gene ID: 37823
HgeneTgene
Gene symbol

TFDP1

CUL4A

Gene ID

7027

8451

Gene nametranscription factor Dp-1cullin 4A
SynonymsDILC|DP1|DRTF1|Dp-1-
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cellscullin-4ACUL-4A
Modification date2018052320180523
UniProtAcc

Q14186

Q13619

Ensembl transtripts involved in fusion geneENST00000375370, ENST00000538138, 
ENST00000465174, ENST00000544902, 
ENST00000375441, ENST00000451881, 
ENST00000326335, ENST00000375440, 
ENST00000463426, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 7 X 5=175
# samples 48
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFDP1 [Title/Abstract] AND CUL4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFDP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A6TD-01ATFDP1chr13

114286059

+CUL4Achr13

113883760

+
TCGARVLUADTCGA-55-8620-01ATFDP1chr13

114265377

+CUL4Achr13

113873259

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000375370ENST00000375441TFDP1chr13

114286059

+CUL4Achr13

113883760

+
Frame-shitENST00000375370ENST00000451881TFDP1chr13

114286059

+CUL4Achr13

113883760

+
Frame-shitENST00000375370ENST00000326335TFDP1chr13

114286059

+CUL4Achr13

113883760

+
Frame-shitENST00000375370ENST00000375440TFDP1chr13

114286059

+CUL4Achr13

113883760

+
5CDS-3UTRENST00000375370ENST00000463426TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000538138ENST00000375441TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000538138ENST00000451881TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000538138ENST00000326335TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000538138ENST00000375440TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3UTRENST00000538138ENST00000463426TFDP1chr13

114286059

+CUL4Achr13

113883760

+
3UTR-3CDSENST00000465174ENST00000375441TFDP1chr13

114286059

+CUL4Achr13

113883760

+
3UTR-3CDSENST00000465174ENST00000451881TFDP1chr13

114286059

+CUL4Achr13

113883760

+
3UTR-3CDSENST00000465174ENST00000326335TFDP1chr13

114286059

+CUL4Achr13

113883760

+
3UTR-3CDSENST00000465174ENST00000375440TFDP1chr13

114286059

+CUL4Achr13

113883760

+
3UTR-3UTRENST00000465174ENST00000463426TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000544902ENST00000375441TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000544902ENST00000451881TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000544902ENST00000326335TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3CDSENST00000544902ENST00000375440TFDP1chr13

114286059

+CUL4Achr13

113883760

+
intron-3UTRENST00000544902ENST00000463426TFDP1chr13

114286059

+CUL4Achr13

113883760

+
5CDS-5UTRENST00000375370ENST00000375441TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5CDS-5UTRENST00000375370ENST00000451881TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5CDS-5UTRENST00000375370ENST00000326335TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5CDS-5UTRENST00000375370ENST00000375440TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5CDS-3UTRENST00000375370ENST00000463426TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000538138ENST00000375441TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000538138ENST00000451881TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000538138ENST00000326335TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000538138ENST00000375440TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-3UTRENST00000538138ENST00000463426TFDP1chr13

114265377

+CUL4Achr13

113873259

+
3UTR-5UTRENST00000465174ENST00000375441TFDP1chr13

114265377

+CUL4Achr13

113873259

+
3UTR-5UTRENST00000465174ENST00000451881TFDP1chr13

114265377

+CUL4Achr13

113873259

+
3UTR-5UTRENST00000465174ENST00000326335TFDP1chr13

114265377

+CUL4Achr13

113873259

+
3UTR-5UTRENST00000465174ENST00000375440TFDP1chr13

114265377

+CUL4Achr13

113873259

+
3UTR-3UTRENST00000465174ENST00000463426TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000544902ENST00000375441TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000544902ENST00000451881TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000544902ENST00000326335TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-5UTRENST00000544902ENST00000375440TFDP1chr13

114265377

+CUL4Achr13

113873259

+
5UTR-3UTRENST00000544902ENST00000463426TFDP1chr13

114265377

+CUL4Achr13

113873259

+

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FusionProtFeatures for TFDP1_CUL4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFDP1

Q14186

CUL4A

Q13619

Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TFDP1_CUL4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TFDP1_CUL4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TFDP1E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1CUL4ARNF7, DET1, RFWD2, CAND1, RBX1, HSPA1A, HSP90AA1, NEDD8, TUBA1B, CDKN1A, DDB1, DDB2, CUL4B, FBXW5, NF2, SAP130, CDKN1B, COPS5, COPS6, PTGS2, UBC, PCNA, TRPC4AP, DDA1, CRBN, COPS3, COPS4, COPS2, COPS8, COPS7B, COPS7A, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, SKP2, TOR1AIP2, BANF1, EMD, DTL, WDR26, GRWD1, RBBP5, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR82, WDR5, TLE2, EED, HIST1H3A, CDT1, CHEK1, COMMD1, DNMT3B, VPRBP, UBXN7, MYC, KAT2A, RASSF1, RAG1, SALL2, RAD21, HOXA9, HOXB4, GPS1, GLMN, MCM10, NACC1, CTNNB1, TP53, MDM2, CUL1, RBBP7, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, ERCC8, CUL4A, DCUN1D1, AK9, DCST1, DCAF8, AMBRA1, DCAF12L2, DCAF16, CUL5, DCAF4L1, IGF2BP1, IGHV3OR15-7, MYEOV2, ANAPC5, CDY2B, CDY2A, OTULIN, LOC285556, NXPH3, RGS12, SCAF11, SH3RF2, SLA, TCHP, USP7, MAP4, ABCA10, XXYLT1, SYNM, ZNF407, ZNF525, CSRP2BP, RPL26, SLC25A22, SFXN1, HSPA8, TFG, CUL3, KRT10, DCAF7, CA2, KLHL9, KRT1, TUBA4B, FUS, HSPA1B, KRT9, TUBB4B, HSP90B1, PSMC6, SKP1, TUBA4A, EWSR1, H2AFV, HAX1, HNRNPA2B1, HNRNPUL1, HSPA1L, IARS, KRT2, KRT24, PCBD1, SNRPD1, TUBA1C, TUBB1, HNRNPH1, HNRNPH3, HSPA5, LGALS3BP, NCL, PABPC1, PPP2R1A, SNRPA, SNRPB, CCT5, DNAJC10, EEF1A1, EEF1A2, ENO1, HNRNPAB, HNRNPF, HNRNPDL, HSPA7, HSPA9, KRT76, PRDX1, QPCT, RPL15, RPL7A, RPLP2, RPS2, SRSF3, SLC25A5, SLC25A6, SSBP1, TAF15, TUBB, BAG4, C1QBP, DDX21, DDX5, DHX15, DHX9, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HNRNPD, HSP90AB1, HSPD1, KRT75, NFKB1, NPM1, PABPC4, RPL10A, RPL11, RPL19, RPL22, RPL23A, RPL38, RPL4, RPL7AP27, RPLP1, RPS14, RPS15A, RPS18, RPS20, RPS3, SDHA, SNRNP70, SNRPD3, SNRPE, TIA1, TIAL1, CSN1S1, MYB, LRWD1, ERCC6, UBE2E3, GRK5, SENP8, DCAF15, SUGT1, CHEK2, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DDIT4, SF3B3, DICER1, DLC1, CAST, PRMT5, ASB4, HIST1H1C, DAB2IP, DCAF17, IP6K1, HIST1H1A, VCP, ARIH1, ABCE1, CLCN1, DCAF4L2, C9orf41, MRPS11, CCNG1, TUBG1, SAMHD1, UNK, MTM1, IFI16, CENPA, HIST1H2BG, PYGO2, GNB2, GNB1, GNB3, GNB4, GNB5, MCM2, DPPA4, NANOG, POU5F1, UVRAG, SLBP, FKBP8, IKZF3, ATP6V0D1, TMCO3, CRYBA4, TRIM16, TRIM25, LATS1, TWIST1, TES, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TFDP1_CUL4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TFDP1_CUL4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFDP1C3495559Juvenile arthritis1CTD_human
TgeneCUL4AC0038325Stevens-Johnson Syndrome1CTD_human