|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37822 |
FusionGeneSummary for TFDP1_ATP4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TFDP1_ATP4B | Fusion gene ID: 37822 | Hgene | Tgene | Gene symbol | TFDP1 | ATP4B | Gene ID | 7027 | 496 |
| Gene name | transcription factor Dp-1 | ATPase H+/K+ transporting subunit beta | |
| Synonyms | DILC|DP1|DRTF1|Dp-1 | ATP6B | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | potassium-transporting ATPase subunit betaATPase H+/K+ transporting beta subunitATPase, H+/K+ exchanging, beta polypeptideATPase, H+/K+ transporting, beta polypeptidegastric H(+)/K(+) ATPase subunit betagastric H+/K+ ATPase beta subunitgastric hydro | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14186 | P51164 | |
| Ensembl transtripts involved in fusion gene | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | ENST00000335288, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 1 X 2=6 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/6*10)=1.73696559416621 | |
| Context | PubMed: TFDP1 [Title/Abstract] AND ATP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-56-A4ZK-01A | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375370 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
| 5UTR-3CDS | ENST00000538138 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
| 3UTR-3CDS | ENST00000465174 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
| 5UTR-3CDS | ENST00000544902 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
Top |
FusionProtFeatures for TFDP1_ATP4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TFDP1 | ATP4B |
| Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. | Required for stabilization and maturation of thecatalytic proton pump alpha subunit and may also involved in celladhesion and establishing epithelial cell polarity.{ECO:0000269|PubMed:19694409}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 194_291 | 37 | 292 | Region | Note=immunoglobulin-like |
| Tgene | >ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 58_291 | 37 | 292 | Topological domain | Extracellular |
| Tgene | >ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 37_57 | 37 | 292 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 250_253 | 26 | 411 | Compositional bias | Note=Poly-Pro |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 394_410 | 26 | 411 | Compositional bias | Note=Asp/Glu-rich (acidic%3B NCB domain) |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 113_195 | 26 | 411 | DNA binding | Ontology_term=ECO:0000255 |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 161_195 | 26 | 411 | Motif | Note=DEF box |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 204_277 | 26 | 411 | Region | Dimerization |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 211_327 | 26 | 411 | Region | Note=Enhances binding of RB protein to E2F |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 214_246 | 26 | 411 | Region | Note=DCB1 |
| Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 259_315 | 26 | 411 | Region | Note=DCB2 |
| Tgene | ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 1_36 | 37 | 292 | Topological domain | Cytoplasmic |
Top |
FusionGeneSequence for TFDP1_ATP4B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TFDP1_ATP4B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TFDP1 | E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1 | ATP4B | ATP4A, AGO3, BPGM, CCNDBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 105_127 | 26 | 411 | CEBPA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TFDP1_ATP4B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ATP4B | P51164 | DB05351 | Dexlansoprazole | Potassium-transporting ATPase subunit beta | small molecule | approved|investigational |
Top |
RelatedDiseases for TFDP1_ATP4B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TFDP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|