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Fusion gene ID: 37822 |
FusionGeneSummary for TFDP1_ATP4B |
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Fusion gene information | Fusion gene name: TFDP1_ATP4B | Fusion gene ID: 37822 | Hgene | Tgene | Gene symbol | TFDP1 | ATP4B | Gene ID | 7027 | 496 |
Gene name | transcription factor Dp-1 | ATPase H+/K+ transporting subunit beta | |
Synonyms | DILC|DP1|DRTF1|Dp-1 | ATP6B | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | potassium-transporting ATPase subunit betaATPase H+/K+ transporting beta subunitATPase, H+/K+ exchanging, beta polypeptideATPase, H+/K+ transporting, beta polypeptidegastric H(+)/K(+) ATPase subunit betagastric H+/K+ ATPase beta subunitgastric hydro | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14186 | P51164 | |
Ensembl transtripts involved in fusion gene | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | ENST00000335288, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 1 X 2=6 |
# samples | 4 | 2 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/6*10)=1.73696559416621 | |
Context | PubMed: TFDP1 [Title/Abstract] AND ATP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-56-A4ZK-01A | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000375370 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
5UTR-3CDS | ENST00000538138 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
3UTR-3CDS | ENST00000465174 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
5UTR-3CDS | ENST00000544902 | ENST00000335288 | TFDP1 | chr13 | 114265377 | + | ATP4B | chr13 | 114309257 | - |
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FusionProtFeatures for TFDP1_ATP4B |
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Hgene | Tgene |
TFDP1 | ATP4B |
Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. | Required for stabilization and maturation of thecatalytic proton pump alpha subunit and may also involved in celladhesion and establishing epithelial cell polarity.{ECO:0000269|PubMed:19694409}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 194_291 | 37 | 292 | Region | Note=immunoglobulin-like |
Tgene | >ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 58_291 | 37 | 292 | Topological domain | Extracellular |
Tgene | >ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 37_57 | 37 | 292 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 250_253 | 26 | 411 | Compositional bias | Note=Poly-Pro |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 394_410 | 26 | 411 | Compositional bias | Note=Asp/Glu-rich (acidic%3B NCB domain) |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 113_195 | 26 | 411 | DNA binding | Ontology_term=ECO:0000255 |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 161_195 | 26 | 411 | Motif | Note=DEF box |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 204_277 | 26 | 411 | Region | Dimerization |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 211_327 | 26 | 411 | Region | Note=Enhances binding of RB protein to E2F |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 214_246 | 26 | 411 | Region | Note=DCB1 |
Hgene | >TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 259_315 | 26 | 411 | Region | Note=DCB2 |
Tgene | ATP4B | chr13:114265377 | chr13:114309257 | ENST00000335288 | - | 0 | 7 | 1_36 | 37 | 292 | Topological domain | Cytoplasmic |
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FusionGeneSequence for TFDP1_ATP4B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TFDP1_ATP4B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TFDP1 | E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1 | ATP4B | ATP4A, AGO3, BPGM, CCNDBP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | TFDP1 | chr13:114265377 | chr13:114309257 | ENST00000375370 | + | 3 | 12 | 105_127 | 26 | 411 | CEBPA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TFDP1_ATP4B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ATP4B | P51164 | DB05351 | Dexlansoprazole | Potassium-transporting ATPase subunit beta | small molecule | approved|investigational |
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RelatedDiseases for TFDP1_ATP4B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TFDP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |