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Fusion gene ID: 37798 |
FusionGeneSummary for TEX2_PDLIM3 |
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Fusion gene information | Fusion gene name: TEX2_PDLIM3 | Fusion gene ID: 37798 | Hgene | Tgene | Gene symbol | TEX2 | PDLIM3 | Gene ID | 55852 | 27295 |
Gene name | testis expressed 2 | PDZ and LIM domain 3 | |
Synonyms | HT008|TMEM96 | ALP | |
Cytomap | 17q23.3 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | testis-expressed protein 2testis expressed sequence 2testis-expressed sequence 2 proteintransmembrane protein 96 | PDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8IWB9 | Q53GG5 | |
Ensembl transtripts involved in fusion gene | ENST00000258991, ENST00000583097, ENST00000584379, ENST00000581812, | ENST00000284770, ENST00000284771, ENST00000284767, | |
Fusion gene scores | * DoF score | 11 X 5 X 6=330 | 4 X 3 X 4=48 |
# samples | 11 | 4 | |
** MAII score | log2(11/330*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TEX2 [Title/Abstract] AND PDLIM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-29-1707-02A | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000258991 | ENST00000284770 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
5UTR-3CDS | ENST00000258991 | ENST00000284771 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
5UTR-3CDS | ENST00000258991 | ENST00000284767 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
intron-3CDS | ENST00000583097 | ENST00000284770 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
intron-3CDS | ENST00000583097 | ENST00000284771 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
intron-3CDS | ENST00000583097 | ENST00000284767 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
5UTR-3CDS | ENST00000584379 | ENST00000284770 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
5UTR-3CDS | ENST00000584379 | ENST00000284771 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
5UTR-3CDS | ENST00000584379 | ENST00000284767 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
intron-3CDS | ENST00000581812 | ENST00000284770 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
intron-3CDS | ENST00000581812 | ENST00000284771 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
intron-3CDS | ENST00000581812 | ENST00000284767 | TEX2 | chr17 | 62340528 | - | PDLIM3 | chr4 | 186446325 | - |
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FusionProtFeatures for TEX2_PDLIM3 |
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Hgene | Tgene |
TEX2 | PDLIM3 |
May play a role in the organization of actin filamentarrays within muscle cells. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TEX2_PDLIM3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TEX2_PDLIM3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TEX2 | APP, DYNLT1, TMEM216, SLC6A15, MRAP2, EFNB2, TRIM25 | PDLIM3 | LMNA, BAG3, ACTN2, ALK, RHOU |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TEX2_PDLIM3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEX2_PDLIM3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |