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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37778

FusionGeneSummary for TET3_GRK4

check button Fusion gene summary
Fusion gene informationFusion gene name: TET3_GRK4
Fusion gene ID: 37778
HgeneTgene
Gene symbol

TET3

GRK4

Gene ID

200424

2868

Gene nametet methylcytosine dioxygenase 3G protein-coupled receptor kinase 4
SynonymshCG_40738GPRK2L|GPRK4|GRK4a|IT11
Cytomap

2p13.1

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionmethylcytosine dioxygenase TET3probable methylcytosine dioxygenase TET3putative methylcytosine dioxygenasetet oncogene family member 3G protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like
Modification date2018052320180519
UniProtAcc

O43151

P32298

Ensembl transtripts involved in fusion geneENST00000409262, ENST00000398051, 
ENST00000398052, ENST00000504933, 
ENST00000345167, ENST00000503518, 
ENST00000442472, ENST00000509545, 
Fusion gene scores* DoF score10 X 6 X 8=4804 X 7 X 6=168
# samples 157
** MAII scorelog2(15/480*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TET3 [Title/Abstract] AND GRK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRK4

GO:0031623

receptor internalization

20074556


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF355916TET3chr2

74308279

-GRK4chr4

3039863

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409262ENST00000398051TET3chr2

74308279

-GRK4chr4

3039863

+
intron-intronENST00000409262ENST00000398052TET3chr2

74308279

-GRK4chr4

3039863

+
intron-intronENST00000409262ENST00000504933TET3chr2

74308279

-GRK4chr4

3039863

+
intron-intronENST00000409262ENST00000345167TET3chr2

74308279

-GRK4chr4

3039863

+
intron-intronENST00000409262ENST00000503518TET3chr2

74308279

-GRK4chr4

3039863

+
intron-intronENST00000409262ENST00000442472TET3chr2

74308279

-GRK4chr4

3039863

+
intron-intronENST00000409262ENST00000509545TET3chr2

74308279

-GRK4chr4

3039863

+

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FusionProtFeatures for TET3_GRK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TET3

O43151

GRK4

P32298

Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigeneticchromatin reprogramming in the zygote following fertilization.Also mediates subsequent conversion of 5hmC into 5-formylcytosine(5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes thefirst step in cytosine demethylation (By similarity). Selectivelybinds to the promoter region of target genes and contributes toregulate the expression of numerous developmental genes(PubMed:23217707). In zygotes, DNA demethylation occursselectively in the paternal pronucleus before the first celldivision, while the adjacent maternal pronucleus and certainpaternally-imprinted loci are protected from this process.Participates in DNA demethylation in the paternal pronucleus bymediating conversion of 5mC into 5hmC, 5fC and 5caC. Does notmediate DNA demethylation of maternal pronucleus because of thepresence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role inDNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites ofactive genes, thereby promoting histone H2B GlcNAcylation by OGT(PubMed:23353889). {ECO:0000250|UniProtKB:Q8BG87,ECO:0000269|PubMed:23217707, ECO:0000269|PubMed:23353889}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TET3_GRK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TET3_GRK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TET3_GRK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TET3_GRK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTET3C1510586Autism Spectrum Disorders1CTD_human