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Fusion gene ID: 37775 |
FusionGeneSummary for TET3_ANXA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TET3_ANXA4 | Fusion gene ID: 37775 | Hgene | Tgene | Gene symbol | TET3 | ANXA4 | Gene ID | 200424 | 307 |
| Gene name | tet methylcytosine dioxygenase 3 | annexin A4 | |
| Synonyms | hCG_40738 | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | |
| Cytomap | 2p13.1 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methylcytosine dioxygenase TET3probable methylcytosine dioxygenase TET3putative methylcytosine dioxygenasetet oncogene family member 3 | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43151 | P09525 | |
| Ensembl transtripts involved in fusion gene | ENST00000409262, | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 8 X 3 X 7=168 |
| # samples | 15 | 10 | |
| ** MAII score | log2(15/480*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TET3 [Title/Abstract] AND ANXA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
| Tgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-FP-7829-01A | TET3 | chr2 | 74230293 | + | ANXA4 | chr2 | 70008652 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000409262 | ENST00000418066 | TET3 | chr2 | 74230293 | + | ANXA4 | chr2 | 70008652 | + |
| intron-5UTR | ENST00000409262 | ENST00000409920 | TET3 | chr2 | 74230293 | + | ANXA4 | chr2 | 70008652 | + |
| intron-5UTR | ENST00000409262 | ENST00000394295 | TET3 | chr2 | 74230293 | + | ANXA4 | chr2 | 70008652 | + |
| intron-5UTR | ENST00000409262 | ENST00000536030 | TET3 | chr2 | 74230293 | + | ANXA4 | chr2 | 70008652 | + |
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FusionProtFeatures for TET3_ANXA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TET3 | ANXA4 |
| Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigeneticchromatin reprogramming in the zygote following fertilization.Also mediates subsequent conversion of 5hmC into 5-formylcytosine(5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes thefirst step in cytosine demethylation (By similarity). Selectivelybinds to the promoter region of target genes and contributes toregulate the expression of numerous developmental genes(PubMed:23217707). In zygotes, DNA demethylation occursselectively in the paternal pronucleus before the first celldivision, while the adjacent maternal pronucleus and certainpaternally-imprinted loci are protected from this process.Participates in DNA demethylation in the paternal pronucleus bymediating conversion of 5mC into 5hmC, 5fC and 5caC. Does notmediate DNA demethylation of maternal pronucleus because of thepresence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role inDNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites ofactive genes, thereby promoting histone H2B GlcNAcylation by OGT(PubMed:23353889). {ECO:0000250|UniProtKB:Q8BG87,ECO:0000269|PubMed:23217707, ECO:0000269|PubMed:23353889}. | Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TET3_ANXA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TET3_ANXA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TET3 | APP, VPRBP, DDB1, BAG3, LTN1 | ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TET3_ANXA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TET3_ANXA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TET3 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Tgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |
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