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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37770

FusionGeneSummary for TET2_KLK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TET2_KLK3
Fusion gene ID: 37770
HgeneTgene
Gene symbol

TET2

KLK3

Gene ID

54790

354

Gene nametet methylcytosine dioxygenase 2kallikrein related peptidase 3
SynonymsKIAA1546|MDSAPS|KLK2A1|PSA|hK3
Cytomap

4q24

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionmethylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2prostate-specific antigenP-30 antigengamma-seminoproteinkallikrein-3semenogelaseseminin
Modification date2018052320180523
UniProtAcc

Q6N021

P07288

Ensembl transtripts involved in fusion geneENST00000545826, ENST00000513237, 
ENST00000540549, ENST00000380013, 
ENST00000305737, ENST00000394764, 
ENST00000504042, ENST00000413648, 
ENST00000326003, ENST00000597483, 
ENST00000593997, ENST00000595952, 
ENST00000360617, 
Fusion gene scores* DoF score6 X 4 X 6=14411 X 8 X 2=176
# samples 713
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/176*10)=-0.437063805608843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TET2 [Title/Abstract] AND KLK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTET2

GO:0006211

5-methylcytosine catabolic process

24315485

HgeneTET2

GO:0006493

protein O-linked glycosylation

23222540

HgeneTET2

GO:0080111

DNA demethylation

24315485

TgeneKLK3

GO:0002778

antibacterial peptide production

18714013


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7794-01ATET2chr4

106200973

+KLK3chr19

51358191

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000545826ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000545826ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000545826ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-intronENST00000545826ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-intronENST00000545826ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000513237ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000513237ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000513237ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-intronENST00000513237ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-intronENST00000513237ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000540549ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000540549ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-5UTRENST00000540549ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-intronENST00000540549ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
5CDS-intronENST00000540549ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000380013ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000380013ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000380013ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000380013ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000380013ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000305737ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000305737ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000305737ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000305737ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000305737ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000394764ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000394764ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000394764ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000394764ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000394764ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000504042ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000504042ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000504042ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000504042ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000504042ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000413648ENST00000326003TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000413648ENST00000597483TET2chr4

106200973

+KLK3chr19

51358191

+
intron-5UTRENST00000413648ENST00000593997TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000413648ENST00000595952TET2chr4

106200973

+KLK3chr19

51358191

+
intron-intronENST00000413648ENST00000360617TET2chr4

106200973

+KLK3chr19

51358191

+

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FusionProtFeatures for TET2_KLK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TET2

Q6N021

KLK3

P07288

Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Has a preference for 5-hydroxymethylcytosine in CpGmotifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, also involved in the recruitment of the O-GlcNActransferase OGT to CpG-rich transcription start sites of activegenes, thereby promoting histone H2B GlcNAcylation by OGT.{ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493,ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540,ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485}. Hydrolyzes semenogelin-1 thus leading to theliquefaction of the seminal coagulum.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TET2_KLK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TET2_KLK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TET2TBC1D4, TCF3, PAN2, OGT, VPRBP, DDB1, EBF1, NONO, SEMG1KLK3SERPINA1, A2M, SERPINA5, ALB, UBA52, HSPA5, MIF4GD, AR, FN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TET2_KLK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKLK3P07288DB00834MifepristoneProstate-specific antigensmall moleculeapproved|investigational
TgeneKLK3P07288DB04839Cyproterone acetateProstate-specific antigensmall moleculeapproved|investigational

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RelatedDiseases for TET2_KLK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTET2C0079774Peripheral T-Cell Lymphoma2CTD_human
HgeneTET2C0007134Renal Cell Carcinoma1CTD_human
HgeneTET2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
HgeneTET2C0023487Acute Promyelocytic Leukemia1CTD_human
HgeneTET2C0027643Neoplasm Recurrence, Local1CTD_human
HgeneTET2C0033578Prostatic Neoplasms1CTD_human
HgeneTET2C0036920Sezary Syndrome1CTD_human
HgeneTET2C3463824MYELODYSPLASTIC SYNDROME1CTD_human;HPO
TgeneKLK3C0033578Prostatic Neoplasms10CTD_human
TgeneKLK3C0027643Neoplasm Recurrence, Local1CTD_human
TgeneKLK3C1334615Malignant Phyllodes Tumor of Prostate1CTD_human
TgeneKLK3C2937421Prostatic Hyperplasia1CTD_human