|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37767 |
FusionGeneSummary for TET1_TMEM222 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TET1_TMEM222 | Fusion gene ID: 37767 | Hgene | Tgene | Gene symbol | TET1 | TMEM222 | Gene ID | 80312 | 84065 |
| Gene name | tet methylcytosine dioxygenase 1 | transmembrane protein 222 | |
| Synonyms | CXXC6|LCX|bA119F7.1 | C1orf160 | |
| Cytomap | 10q21.3 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methylcytosine dioxygenase TET1CXXC finger 6CXXC zinc finger 6CXXC-type zinc finger protein 6TET1 splice variant VP_DE4TET1 splice variant VP_DE456leukemia-associated protein with a CXXC domainten-eleven translocation 1 gene proteinten-eleven tran | transmembrane protein 222 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NFU7 | Q9H0R3 | |
| Ensembl transtripts involved in fusion gene | ENST00000373644, | ENST00000374076, ENST00000608611, | |
| Fusion gene scores | * DoF score | 6 X 9 X 5=270 | 5 X 2 X 5=50 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: TET1 [Title/Abstract] AND TMEM222 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-IF-A4AK-01A | TET1 | chr10 | 70411693 | + | TMEM222 | chr1 | 27660449 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000373644 | ENST00000374076 | TET1 | chr10 | 70411693 | + | TMEM222 | chr1 | 27660449 | + |
| In-frame | ENST00000373644 | ENST00000608611 | TET1 | chr10 | 70411693 | + | TMEM222 | chr1 | 27660449 | + |
Top |
FusionProtFeatures for TET1_TMEM222 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TET1 | TMEM222 |
| Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, plays a more general role in chromatin regulation.Preferentially binds to CpG-rich sequences at promoters of bothtranscriptionally active and Polycomb-repressed genes. Involved inthe recruitment of the O-GlcNAc transferase OGT to CpG-richtranscription start sites of active genes, thereby promotinghistone H2B GlcNAcylation by OGT. Also involved in transcriptionrepression of a subset of genes through recruitment oftranscriptional repressors to promoters. Involved in the balancebetween pluripotency and lineage commitment of cells it plays arole in embryonic stem cells maintenance and inner cell mass cellspecification. Plays an important role in the tumorigenicity ofglioblastoma cells. TET1-mediated production of 5hmC acts as arecruitment signal for the CHTOP-methylosome complex to selectivesites on the chromosome, where it methylates H4R3 and activatesthe transcription of genes involved in glioblastomagenesis(PubMed:25284789). {ECO:0000269|PubMed:12124344,ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393,ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364,ECO:0000269|PubMed:25284789}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TET1 | chr10:70411693 | chr1:27660449 | ENST00000373644 | + | 5 | 12 | 528_674 | 1455 | 2137 | Region | Note=Sufficient for binding to genomic CpG islands |
| Hgene | TET1 | chr10:70411693 | chr1:27660449 | ENST00000373644 | + | 5 | 12 | 584_625 | 1455 | 2137 | Zinc finger | CXXC-type |
| Tgene | >TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 186_186 | 103 | 209 | Topological domain | Extracellular |
| Tgene | >TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 208_208 | 103 | 209 | Topological domain | Cytoplasmic |
| Tgene | >TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 165_185 | 103 | 209 | Transmembrane | Helical |
| Tgene | >TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 187_207 | 103 | 209 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TET1 | chr10:70411693 | chr1:27660449 | ENST00000373644 | + | 5 | 12 | 2043_2045 | 1455 | 2137 | Region | 2-oxoglutarate binding |
| Hgene | >TET1 | chr10:70411693 | chr1:27660449 | ENST00000373644 | + | 5 | 12 | 2049_2051 | 1455 | 2137 | Region | Substrate binding |
| Tgene | TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 1_55 | 103 | 209 | Topological domain | Extracellular |
| Tgene | TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 77_164 | 103 | 209 | Topological domain | Cytoplasmic |
| Tgene | TMEM222 | chr10:70411693 | chr1:27660449 | ENST00000374076 | + | 2 | 6 | 56_76 | 103 | 209 | Transmembrane | Helical |
Top |
FusionGeneSequence for TET1_TMEM222 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TET1_ENST00000373644_chr10_70411693_+_TMEM222_ENST00000374076_chr1_27660449_+_1561aa MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK PSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTD HVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTANHKNAMSSVATD MSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQL SEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSNSHINSATNQAS TKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQ LTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRRKKKPTVVSYQE NDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPL DSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPGISHETPLPESA LTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPYYTHL GAGPSVAAVREIMENRYWKLDPAQVYASGPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKY >In-frame_TET1_ENST00000373644_chr10_70411693_+_TMEM222_ENST00000608611_chr1_27660449_+_1561aa MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK PSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTD HVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTANHKNAMSSVATD MSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQL SEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSNSHINSATNQAS TKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQ LTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRRKKKPTVVSYQE NDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPL DSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPGISHETPLPESA LTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPYYTHL GAGPSVAAVREIMENRYWKLDPAQVYASGPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TET1_ENST00000373644_chr10_70411693_+_TMEM222_ENST00000374076_chr1_27660449_+_4683nt ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGCAGATTTTGAC AACAAACCAGTAAATGGCCCCAAGTCAGAATCCATGGACTACAGTAGATGTGGTCATGGGGAAGAACAAAAATTGGAATTGAACCCACAT ACTGTTGAAAATGTAACTAAAAATGAAGACAGCATGACAGGCATCGAGGTGGAGAAGTGGACACAAAACAAGAAATCACAGTTAACTGAT CACGTGAAAGGAGATTTTAGTGCTAATGTCCCAGAAGCTGAAAAATCGAAAAACTCTGAAGTTGACAAGAAACGAACCAAATCTCCAAAA TTGTTTGTACAAACCGTAAGAAATGGCATTAAACATGTACACTGTTTACCAGCTGAAACAAATGTTTCATTTAAAAAATTCAATATTGAA GAATTCGGCAAGACATTGGAAAACAATTCTTATAAATTCCTAAAAGACACTGCAAACCATAAAAACGCTATGAGCTCTGTTGCTACTGAT ATGAGTTGTGATCATCTCAAGGGGAGAAGTAACGTTTTAGTATTCCAGCAGCCTGGCTTTAACTGCAGTTCCATTCCACATTCTTCACAC TCCATCATAAATCATCATGCTAGTATACACAATGAAGGTGATCAACCAAAAACTCCTGAGAATATACCAAGTAAAGAACCAAAAGATGGA TCTCCCGTTCAACCAAGTCTCTTATCGTTAATGAAAGATAGGAGATTAACATTGGAGCAAGTGGTAGCCATAGAGGCCCTGACTCAACTC TCAGAAGCCCCATCAGAGAATTCCTCCCCATCAAAGTCAGAGAAGGATGAGGAATCAGAGCAGAGAACAGCCAGTTTGCTTAATAGCTGC AAAGCTATCCTCTACACTGTAAGAAAAGACCTCCAAGACCCAAACTTACAGGGAGAGCCACCAAAACTTAATCACTGTCCATCTTTGGAA AAACAAAGTTCATGCAACACGGTGGTTTTCAATGGGCAAACTACTACCCTTTCCAACTCACATATCAACTCAGCTACTAACCAAGCATCC ACAAAGTCACATGAATATTCAAAAGTCACAAATTCATTATCTCTTTTTATACCAAAATCAAATTCATCCAAGATTGACACCAATAAAAGT ATTGCTCAAGGGATAATTACTCTTGACAATTGTTCCAATGATTTGCATCAGTTGCCACCAAGAAATAATGAAGTGGAGTATTGCAACCAG TTACTGGACAGCAGCAAAAAATTGGACTCAGATGATCTATCATGTCAGGATGCAACCCATACCCAAATTGAGGAAGATGTTGCAACACAG TTGACACAACTTGCTTCGATAATTAAGATCAATTATATAAAACCAGAGGACAAAAAAGTTGAAAGTACACCAACAAGCCTTGTCACATGT AATGTACAGCAAAAATACAATCAGGAGAAGGGCACAATACAACAGAAACCACCTTCAAGTGTACACAATAATCATGGTTCATCATTAACA AAACAAAAGAACCCAACCCAGAAAAAGACAAAATCCACCCCATCAAGAGATCGGCGGAAAAAGAAGCCCACAGTTGTAAGTTATCAAGAA AATGATCGGCAGAAGTGGGAAAAGTTGTCCTATATGTATGGCACAATATGCGACATTTGGATAGCATCGAAATTTCAAAATTTTGGGCAA TTTTGTCCACATGATTTTCCTACTGTATTTGGGAAAATTTCTTCCTCGACCAAAATATGGAAACCACTGGCTCAAACGAGGTCCATTATG CAACCCAAAACAGTATTTCCACCACTCACTCAGATAAAATTACAGAGATATCCTGAATCAGCAGAGGAAAAGGTGAAGGTTGAACCATTG GATTCACTCAGCTTATTTCATCTTAAAACGGAATCCAACGGGAAGGCATTCACTGATAAAGCTTATAATTCTCAGGTACAGTTAACGGTG AATGCCAATCAGAAAGCCCATCCTTTGACCCAGCCCTCCTCTCCACCTAACCAGTGTGCTAACGTGATGGCAGGCGATGACCAAATACGG TTTCAGCAGGTTGTTAAGGAGCAACTCATGCATCAGAGACTGCCAACATTGCCTGGTATCTCTCATGAAACACCCTTACCGGAGTCAGCA CTAACTCTCAGGAATGTAAATGTAGTGTGTTCAGGTGGAATTACAGTGGTTTCTACCAAAAGTGAAGAGGAAGTCTGTTCATCCAGTTTT GGAACATCAGAATTTTCCACAGTGGACAGTGCACAGAAAAATTTTAATGATTATGCCATGAACTTCTTTACTAACCCTACAAAAAACCTA GTGTCTATAACTAAAGATTCTGAACTGCCCACCTGCAGCTGTCTTGATCGAGTTATACAAAAAGACAAAGGCCCATATTATACACACCTT GGGGCAGGACCAAGTGTTGCTGCTGTCAGGGAAATCATGGAGAATAGGTACTGGAAGTTGGACCCTGCTCAGGTCTATGCTAGCGGGCCC AACGCATGGGACACGGCTGTGCACGACGCCTCTGAGGAGTACAAGCACCGCATGCACAATCTCTGCTGTGACAACTGCCACTCGCACGTG GCATTGGCCCTGAATCTGATGCGCTACAACAACAGCACCAACTGGAATATGGTGACGCTCTGCTTCTTCTGCCTGCTCTACGGGAAGTAC GTCAGCGTTGGGGCCTTCGTGAAGACCTGGCTGCCCTTCATCCTTCTCCTGGGCATCATCCTCACCGTCAGCCTGGTCTTTAACCTCCGG >In-frame_TET1_ENST00000373644_chr10_70411693_+_TMEM222_ENST00000608611_chr1_27660449_+_4683nt ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGCAGATTTTGAC AACAAACCAGTAAATGGCCCCAAGTCAGAATCCATGGACTACAGTAGATGTGGTCATGGGGAAGAACAAAAATTGGAATTGAACCCACAT ACTGTTGAAAATGTAACTAAAAATGAAGACAGCATGACAGGCATCGAGGTGGAGAAGTGGACACAAAACAAGAAATCACAGTTAACTGAT CACGTGAAAGGAGATTTTAGTGCTAATGTCCCAGAAGCTGAAAAATCGAAAAACTCTGAAGTTGACAAGAAACGAACCAAATCTCCAAAA TTGTTTGTACAAACCGTAAGAAATGGCATTAAACATGTACACTGTTTACCAGCTGAAACAAATGTTTCATTTAAAAAATTCAATATTGAA GAATTCGGCAAGACATTGGAAAACAATTCTTATAAATTCCTAAAAGACACTGCAAACCATAAAAACGCTATGAGCTCTGTTGCTACTGAT ATGAGTTGTGATCATCTCAAGGGGAGAAGTAACGTTTTAGTATTCCAGCAGCCTGGCTTTAACTGCAGTTCCATTCCACATTCTTCACAC TCCATCATAAATCATCATGCTAGTATACACAATGAAGGTGATCAACCAAAAACTCCTGAGAATATACCAAGTAAAGAACCAAAAGATGGA TCTCCCGTTCAACCAAGTCTCTTATCGTTAATGAAAGATAGGAGATTAACATTGGAGCAAGTGGTAGCCATAGAGGCCCTGACTCAACTC TCAGAAGCCCCATCAGAGAATTCCTCCCCATCAAAGTCAGAGAAGGATGAGGAATCAGAGCAGAGAACAGCCAGTTTGCTTAATAGCTGC AAAGCTATCCTCTACACTGTAAGAAAAGACCTCCAAGACCCAAACTTACAGGGAGAGCCACCAAAACTTAATCACTGTCCATCTTTGGAA AAACAAAGTTCATGCAACACGGTGGTTTTCAATGGGCAAACTACTACCCTTTCCAACTCACATATCAACTCAGCTACTAACCAAGCATCC ACAAAGTCACATGAATATTCAAAAGTCACAAATTCATTATCTCTTTTTATACCAAAATCAAATTCATCCAAGATTGACACCAATAAAAGT ATTGCTCAAGGGATAATTACTCTTGACAATTGTTCCAATGATTTGCATCAGTTGCCACCAAGAAATAATGAAGTGGAGTATTGCAACCAG TTACTGGACAGCAGCAAAAAATTGGACTCAGATGATCTATCATGTCAGGATGCAACCCATACCCAAATTGAGGAAGATGTTGCAACACAG TTGACACAACTTGCTTCGATAATTAAGATCAATTATATAAAACCAGAGGACAAAAAAGTTGAAAGTACACCAACAAGCCTTGTCACATGT AATGTACAGCAAAAATACAATCAGGAGAAGGGCACAATACAACAGAAACCACCTTCAAGTGTACACAATAATCATGGTTCATCATTAACA AAACAAAAGAACCCAACCCAGAAAAAGACAAAATCCACCCCATCAAGAGATCGGCGGAAAAAGAAGCCCACAGTTGTAAGTTATCAAGAA AATGATCGGCAGAAGTGGGAAAAGTTGTCCTATATGTATGGCACAATATGCGACATTTGGATAGCATCGAAATTTCAAAATTTTGGGCAA TTTTGTCCACATGATTTTCCTACTGTATTTGGGAAAATTTCTTCCTCGACCAAAATATGGAAACCACTGGCTCAAACGAGGTCCATTATG CAACCCAAAACAGTATTTCCACCACTCACTCAGATAAAATTACAGAGATATCCTGAATCAGCAGAGGAAAAGGTGAAGGTTGAACCATTG GATTCACTCAGCTTATTTCATCTTAAAACGGAATCCAACGGGAAGGCATTCACTGATAAAGCTTATAATTCTCAGGTACAGTTAACGGTG AATGCCAATCAGAAAGCCCATCCTTTGACCCAGCCCTCCTCTCCACCTAACCAGTGTGCTAACGTGATGGCAGGCGATGACCAAATACGG TTTCAGCAGGTTGTTAAGGAGCAACTCATGCATCAGAGACTGCCAACATTGCCTGGTATCTCTCATGAAACACCCTTACCGGAGTCAGCA CTAACTCTCAGGAATGTAAATGTAGTGTGTTCAGGTGGAATTACAGTGGTTTCTACCAAAAGTGAAGAGGAAGTCTGTTCATCCAGTTTT GGAACATCAGAATTTTCCACAGTGGACAGTGCACAGAAAAATTTTAATGATTATGCCATGAACTTCTTTACTAACCCTACAAAAAACCTA GTGTCTATAACTAAAGATTCTGAACTGCCCACCTGCAGCTGTCTTGATCGAGTTATACAAAAAGACAAAGGCCCATATTATACACACCTT GGGGCAGGACCAAGTGTTGCTGCTGTCAGGGAAATCATGGAGAATAGGTACTGGAAGTTGGACCCTGCTCAGGTCTATGCTAGCGGGCCC AACGCATGGGACACGGCTGTGCACGACGCCTCTGAGGAGTACAAGCACCGCATGCACAATCTCTGCTGTGACAACTGCCACTCGCACGTG GCATTGGCCCTGAATCTGATGCGCTACAACAACAGCACCAACTGGAATATGGTGACGCTCTGCTTCTTCTGCCTGCTCTACGGGAAGTAC GTCAGCGTTGGGGCCTTCGTGAAGACCTGGCTGCCCTTCATCCTTCTCCTGGGCATCATCCTCACCGTCAGCCTGGTCTTTAACCTCCGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TET1_ENST00000373644_chr10_70411693_+_TMEM222_ENST00000374076_chr1_27660449_+_5826nt GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA AGCCCAAAGTTTTAAAGGCAGATTTTGACAACAAACCAGTAAATGGCCCCAAGTCAGAATCCATGGACTACAGTAGATGTGGTCATGGGG AAGAACAAAAATTGGAATTGAACCCACATACTGTTGAAAATGTAACTAAAAATGAAGACAGCATGACAGGCATCGAGGTGGAGAAGTGGA CACAAAACAAGAAATCACAGTTAACTGATCACGTGAAAGGAGATTTTAGTGCTAATGTCCCAGAAGCTGAAAAATCGAAAAACTCTGAAG TTGACAAGAAACGAACCAAATCTCCAAAATTGTTTGTACAAACCGTAAGAAATGGCATTAAACATGTACACTGTTTACCAGCTGAAACAA ATGTTTCATTTAAAAAATTCAATATTGAAGAATTCGGCAAGACATTGGAAAACAATTCTTATAAATTCCTAAAAGACACTGCAAACCATA AAAACGCTATGAGCTCTGTTGCTACTGATATGAGTTGTGATCATCTCAAGGGGAGAAGTAACGTTTTAGTATTCCAGCAGCCTGGCTTTA ACTGCAGTTCCATTCCACATTCTTCACACTCCATCATAAATCATCATGCTAGTATACACAATGAAGGTGATCAACCAAAAACTCCTGAGA ATATACCAAGTAAAGAACCAAAAGATGGATCTCCCGTTCAACCAAGTCTCTTATCGTTAATGAAAGATAGGAGATTAACATTGGAGCAAG TGGTAGCCATAGAGGCCCTGACTCAACTCTCAGAAGCCCCATCAGAGAATTCCTCCCCATCAAAGTCAGAGAAGGATGAGGAATCAGAGC AGAGAACAGCCAGTTTGCTTAATAGCTGCAAAGCTATCCTCTACACTGTAAGAAAAGACCTCCAAGACCCAAACTTACAGGGAGAGCCAC CAAAACTTAATCACTGTCCATCTTTGGAAAAACAAAGTTCATGCAACACGGTGGTTTTCAATGGGCAAACTACTACCCTTTCCAACTCAC ATATCAACTCAGCTACTAACCAAGCATCCACAAAGTCACATGAATATTCAAAAGTCACAAATTCATTATCTCTTTTTATACCAAAATCAA ATTCATCCAAGATTGACACCAATAAAAGTATTGCTCAAGGGATAATTACTCTTGACAATTGTTCCAATGATTTGCATCAGTTGCCACCAA GAAATAATGAAGTGGAGTATTGCAACCAGTTACTGGACAGCAGCAAAAAATTGGACTCAGATGATCTATCATGTCAGGATGCAACCCATA CCCAAATTGAGGAAGATGTTGCAACACAGTTGACACAACTTGCTTCGATAATTAAGATCAATTATATAAAACCAGAGGACAAAAAAGTTG AAAGTACACCAACAAGCCTTGTCACATGTAATGTACAGCAAAAATACAATCAGGAGAAGGGCACAATACAACAGAAACCACCTTCAAGTG TACACAATAATCATGGTTCATCATTAACAAAACAAAAGAACCCAACCCAGAAAAAGACAAAATCCACCCCATCAAGAGATCGGCGGAAAA AGAAGCCCACAGTTGTAAGTTATCAAGAAAATGATCGGCAGAAGTGGGAAAAGTTGTCCTATATGTATGGCACAATATGCGACATTTGGA TAGCATCGAAATTTCAAAATTTTGGGCAATTTTGTCCACATGATTTTCCTACTGTATTTGGGAAAATTTCTTCCTCGACCAAAATATGGA AACCACTGGCTCAAACGAGGTCCATTATGCAACCCAAAACAGTATTTCCACCACTCACTCAGATAAAATTACAGAGATATCCTGAATCAG CAGAGGAAAAGGTGAAGGTTGAACCATTGGATTCACTCAGCTTATTTCATCTTAAAACGGAATCCAACGGGAAGGCATTCACTGATAAAG CTTATAATTCTCAGGTACAGTTAACGGTGAATGCCAATCAGAAAGCCCATCCTTTGACCCAGCCCTCCTCTCCACCTAACCAGTGTGCTA ACGTGATGGCAGGCGATGACCAAATACGGTTTCAGCAGGTTGTTAAGGAGCAACTCATGCATCAGAGACTGCCAACATTGCCTGGTATCT CTCATGAAACACCCTTACCGGAGTCAGCACTAACTCTCAGGAATGTAAATGTAGTGTGTTCAGGTGGAATTACAGTGGTTTCTACCAAAA GTGAAGAGGAAGTCTGTTCATCCAGTTTTGGAACATCAGAATTTTCCACAGTGGACAGTGCACAGAAAAATTTTAATGATTATGCCATGA ACTTCTTTACTAACCCTACAAAAAACCTAGTGTCTATAACTAAAGATTCTGAACTGCCCACCTGCAGCTGTCTTGATCGAGTTATACAAA AAGACAAAGGCCCATATTATACACACCTTGGGGCAGGACCAAGTGTTGCTGCTGTCAGGGAAATCATGGAGAATAGGTACTGGAAGTTGG ACCCTGCTCAGGTCTATGCTAGCGGGCCCAACGCATGGGACACGGCTGTGCACGACGCCTCTGAGGAGTACAAGCACCGCATGCACAATC TCTGCTGTGACAACTGCCACTCGCACGTGGCATTGGCCCTGAATCTGATGCGCTACAACAACAGCACCAACTGGAATATGGTGACGCTCT GCTTCTTCTGCCTGCTCTACGGGAAGTACGTCAGCGTTGGGGCCTTCGTGAAGACCTGGCTGCCCTTCATCCTTCTCCTGGGCATCATCC TCACCGTCAGCCTGGTCTTTAACCTCCGGTGATGGCTGCTCGGTGGCCCCACACCCACCAGGGTCCCGAGGAAACAGCCGCCATCCCTTT TGGTTCCAGATTTTTTTCTCCTCACCCCAAAAGGCAGGGTTGGGCCTGCTGTTGTGGACCGGGGGTCGGGGCTGGCAGGATGGAAGGACT GAGGACCAGCATGAAGTGGGGGTTTGTTGTCTCCCTGCCTCTCAGAAGCACCCTGTCCCCTCCTCCCCAGGCCTGTGACTCCGGCCCTGG AAGCCCCTTTGTTCTTCTGTTGAAAGGCTTTGGCTTCCCGCTGTAGAGCTGCTCCCGCCACCACCTGCTGGGGTCCTGCCTCAGCCCAGT GCCCAGTATGGGGAGAGGAGGACATTTGGGCTCACCTGTCAAGGTGGCCCTGGGACCAGAGCTGGTCCCAGCATGGGGTGCACCGGGTAC ACTTAACGTGTCTCTATAAGCCAAGTTGCTTCAGGACCTTCACCACTGGCCTCTAGAATGGTCCAGAGGGGCTGGCTGGGTCCCTTTGTC AGACTCCTGCCGGCAGCTGCCCTGGGGGACATGTGTGCCCATCTGGCATCCTCCAGCCCGTGCAGTCCGCTCTTCACTGTTCCACGGCCT CCCAGTGCCTCCCAGCATTGGACCCATCTCCCCCTGCAGTTTGAGGCCAGAGAGGTGAGTGGACCTGACAAGTGCCAGAGTAACCGTGTA GACAGAGCAGTGTAGACAGCACTCAGCCCCAGCCCCAGGTGTGGACCTCATGCTGGTGATGGCTCCCCTGGGTGGCCTGCCAGCACAGCC AGTGCCATCAGGGAGCTGAAGGGGCTGTCCCCCACCTAACTCCAGCTCCCCCTTCACGTTGTCACCAAGGCCCTGTGCCGCCCGCCTCGC >In-frame_TET1_ENST00000373644_chr10_70411693_+_TMEM222_ENST00000608611_chr1_27660449_+_5826nt GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA AGCCCAAAGTTTTAAAGGCAGATTTTGACAACAAACCAGTAAATGGCCCCAAGTCAGAATCCATGGACTACAGTAGATGTGGTCATGGGG AAGAACAAAAATTGGAATTGAACCCACATACTGTTGAAAATGTAACTAAAAATGAAGACAGCATGACAGGCATCGAGGTGGAGAAGTGGA CACAAAACAAGAAATCACAGTTAACTGATCACGTGAAAGGAGATTTTAGTGCTAATGTCCCAGAAGCTGAAAAATCGAAAAACTCTGAAG TTGACAAGAAACGAACCAAATCTCCAAAATTGTTTGTACAAACCGTAAGAAATGGCATTAAACATGTACACTGTTTACCAGCTGAAACAA ATGTTTCATTTAAAAAATTCAATATTGAAGAATTCGGCAAGACATTGGAAAACAATTCTTATAAATTCCTAAAAGACACTGCAAACCATA AAAACGCTATGAGCTCTGTTGCTACTGATATGAGTTGTGATCATCTCAAGGGGAGAAGTAACGTTTTAGTATTCCAGCAGCCTGGCTTTA ACTGCAGTTCCATTCCACATTCTTCACACTCCATCATAAATCATCATGCTAGTATACACAATGAAGGTGATCAACCAAAAACTCCTGAGA ATATACCAAGTAAAGAACCAAAAGATGGATCTCCCGTTCAACCAAGTCTCTTATCGTTAATGAAAGATAGGAGATTAACATTGGAGCAAG TGGTAGCCATAGAGGCCCTGACTCAACTCTCAGAAGCCCCATCAGAGAATTCCTCCCCATCAAAGTCAGAGAAGGATGAGGAATCAGAGC AGAGAACAGCCAGTTTGCTTAATAGCTGCAAAGCTATCCTCTACACTGTAAGAAAAGACCTCCAAGACCCAAACTTACAGGGAGAGCCAC CAAAACTTAATCACTGTCCATCTTTGGAAAAACAAAGTTCATGCAACACGGTGGTTTTCAATGGGCAAACTACTACCCTTTCCAACTCAC ATATCAACTCAGCTACTAACCAAGCATCCACAAAGTCACATGAATATTCAAAAGTCACAAATTCATTATCTCTTTTTATACCAAAATCAA ATTCATCCAAGATTGACACCAATAAAAGTATTGCTCAAGGGATAATTACTCTTGACAATTGTTCCAATGATTTGCATCAGTTGCCACCAA GAAATAATGAAGTGGAGTATTGCAACCAGTTACTGGACAGCAGCAAAAAATTGGACTCAGATGATCTATCATGTCAGGATGCAACCCATA CCCAAATTGAGGAAGATGTTGCAACACAGTTGACACAACTTGCTTCGATAATTAAGATCAATTATATAAAACCAGAGGACAAAAAAGTTG AAAGTACACCAACAAGCCTTGTCACATGTAATGTACAGCAAAAATACAATCAGGAGAAGGGCACAATACAACAGAAACCACCTTCAAGTG TACACAATAATCATGGTTCATCATTAACAAAACAAAAGAACCCAACCCAGAAAAAGACAAAATCCACCCCATCAAGAGATCGGCGGAAAA AGAAGCCCACAGTTGTAAGTTATCAAGAAAATGATCGGCAGAAGTGGGAAAAGTTGTCCTATATGTATGGCACAATATGCGACATTTGGA TAGCATCGAAATTTCAAAATTTTGGGCAATTTTGTCCACATGATTTTCCTACTGTATTTGGGAAAATTTCTTCCTCGACCAAAATATGGA AACCACTGGCTCAAACGAGGTCCATTATGCAACCCAAAACAGTATTTCCACCACTCACTCAGATAAAATTACAGAGATATCCTGAATCAG CAGAGGAAAAGGTGAAGGTTGAACCATTGGATTCACTCAGCTTATTTCATCTTAAAACGGAATCCAACGGGAAGGCATTCACTGATAAAG CTTATAATTCTCAGGTACAGTTAACGGTGAATGCCAATCAGAAAGCCCATCCTTTGACCCAGCCCTCCTCTCCACCTAACCAGTGTGCTA ACGTGATGGCAGGCGATGACCAAATACGGTTTCAGCAGGTTGTTAAGGAGCAACTCATGCATCAGAGACTGCCAACATTGCCTGGTATCT CTCATGAAACACCCTTACCGGAGTCAGCACTAACTCTCAGGAATGTAAATGTAGTGTGTTCAGGTGGAATTACAGTGGTTTCTACCAAAA GTGAAGAGGAAGTCTGTTCATCCAGTTTTGGAACATCAGAATTTTCCACAGTGGACAGTGCACAGAAAAATTTTAATGATTATGCCATGA ACTTCTTTACTAACCCTACAAAAAACCTAGTGTCTATAACTAAAGATTCTGAACTGCCCACCTGCAGCTGTCTTGATCGAGTTATACAAA AAGACAAAGGCCCATATTATACACACCTTGGGGCAGGACCAAGTGTTGCTGCTGTCAGGGAAATCATGGAGAATAGGTACTGGAAGTTGG ACCCTGCTCAGGTCTATGCTAGCGGGCCCAACGCATGGGACACGGCTGTGCACGACGCCTCTGAGGAGTACAAGCACCGCATGCACAATC TCTGCTGTGACAACTGCCACTCGCACGTGGCATTGGCCCTGAATCTGATGCGCTACAACAACAGCACCAACTGGAATATGGTGACGCTCT GCTTCTTCTGCCTGCTCTACGGGAAGTACGTCAGCGTTGGGGCCTTCGTGAAGACCTGGCTGCCCTTCATCCTTCTCCTGGGCATCATCC TCACCGTCAGCCTGGTCTTTAACCTCCGGTGATGGCTGCTCGGTGGCCCCACACCCACCAGGGTCCCGAGGAAACAGCCGCCATCCCTTT TGGTTCCAGATTTTTTTCTCCTCACCCCAAAAGGCAGGGTTGGGCCTGCTGTTGTGGACCGGGGGTCGGGGCTGGCAGGATGGAAGGACT GAGGACCAGCATGAAGTGGGGGTTTGTTGTCTCCCTGCCTCTCAGAAGCACCCTGTCCCCTCCTCCCCAGGCCTGTGACTCCGGCCCTGG AAGCCCCTTTGTTCTTCTGTTGAAAGGCTTTGGCTTCCCGCTGTAGAGCTGCTCCCGCCACCACCTGCTGGGGTCCTGCCTCAGCCCAGT GCCCAGTATGGGGAGAGGAGGACATTTGGGCTCACCTGTCAAGGTGGCCCTGGGACCAGAGCTGGTCCCAGCATGGGGTGCACCGGGTAC ACTTAACGTGTCTCTATAAGCCAAGTTGCTTCAGGACCTTCACCACTGGCCTCTAGAATGGTCCAGAGGGGCTGGCTGGGTCCCTTTGTC AGACTCCTGCCGGCAGCTGCCCTGGGGGACATGTGTGCCCATCTGGCATCCTCCAGCCCGTGCAGTCCGCTCTTCACTGTTCCACGGCCT CCCAGTGCCTCCCAGCATTGGACCCATCTCCCCCTGCAGTTTGAGGCCAGAGAGGTGAGTGGACCTGACAAGTGCCAGAGTAACCGTGTA GACAGAGCAGTGTAGACAGCACTCAGCCCCAGCCCCAGGTGTGGACCTCATGCTGGTGATGGCTCCCCTGGGTGGCCTGCCAGCACAGCC AGTGCCATCAGGGAGCTGAAGGGGCTGTCCCCCACCTAACTCCAGCTCCCCCTTCACGTTGTCACCAAGGCCCTGTGCCGCCCGCCTCGC |
Top |
FusionGenePPI for TET1_TMEM222 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TET1 | MBD3, VPRBP, DDB1 | TMEM222 | ABHD16A, PRSS23, MOV10, NXF1, GNAI3, TCTN2, CREB3, UPK1A, TMEM206, RTN4, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TET1 | chr10:70411693 | chr1:27660449 | ENST00000373644 | + | 5 | 12 | 1580_1593 | 1455 | 2137 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TET1_TMEM222 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TET1_TMEM222 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TET1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | TET1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | TET1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Hgene | TET1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|