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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37759

FusionGeneSummary for TES_SLC12A6

check button Fusion gene summary
Fusion gene informationFusion gene name: TES_SLC12A6
Fusion gene ID: 37759
HgeneTgene
Gene symbol

TES

SLC12A6

Gene ID

26136

9990

Gene nametestin LIM domain proteinsolute carrier family 12 member 6
SynonymsTESS|TESS-2ACCPN|KCC3|KCC3A|KCC3B
Cytomap

7q31.2

15q14

Type of geneprotein-codingprotein-coding
Descriptiontestintestis derived transcript (3 LIM domains)solute carrier family 12 member 6K-Cl cotransporter 3electroneutral potassium-chloride cotransporter 3potassium chloride cotransporter 3potassium chloride cotransporter KCC3a-S3potassium-chloride transporter-3apotassium-chloride transporter-3bsolut
Modification date2018052220180523
UniProtAcc

Q9UGI8

Q9UHW9

Ensembl transtripts involved in fusion geneENST00000358204, ENST00000537767, 
ENST00000393481, ENST00000485009, 
ENST00000397707, ENST00000560611, 
ENST00000354181, ENST00000458406, 
ENST00000397702, ENST00000290209, 
ENST00000558667, ENST00000558589, 
ENST00000451844, ENST00000560164, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 1=4
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: TES [Title/Abstract] AND SLC12A6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC12A6

GO:0006811

ion transport

10187864

TgeneSLC12A6

GO:0071477

cellular hypotonic salinity response

16048901


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA142838TESchr7

115898429

-SLC12A6chr15

34524726

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000358204ENST00000397707TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000560611TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000354181TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000458406TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000397702TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000290209TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000558667TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000558589TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000451844TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000358204ENST00000560164TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000397707TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000560611TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000354181TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000458406TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000397702TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000290209TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000558667TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000558589TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000451844TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000537767ENST00000560164TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000397707TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000560611TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000354181TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000458406TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000397702TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000290209TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000558667TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000558589TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000451844TESchr7

115898429

-SLC12A6chr15

34524726

+
3UTR-intronENST00000393481ENST00000560164TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000397707TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000560611TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000354181TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000458406TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000397702TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000290209TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000558667TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000558589TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000451844TESchr7

115898429

-SLC12A6chr15

34524726

+
intron-intronENST00000485009ENST00000560164TESchr7

115898429

-SLC12A6chr15

34524726

+

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FusionProtFeatures for TES_SLC12A6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TES

Q9UGI8

SLC12A6

Q9UHW9

Scaffold protein that may play a role in cell adhesion,cell spreading and in the reorganization of the actincytoskeleton. Plays a role in the regulation of cellproliferation. May act as a tumor suppressor. Inhibits tumor cellgrowth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287,ECO:0000269|PubMed:12695497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TES_SLC12A6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TES_SLC12A6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TES_SLC12A6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC12A6Q9UHW9DB00761Potassium ChlorideSolute carrier family 12 member 6small moleculeapproved|withdrawn

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RelatedDiseases for TES_SLC12A6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTESC0017636Glioblastoma1CTD_human
HgeneTESC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC12A6C0005586Bipolar Disorder3PSYGENET
TgeneSLC12A6C0031117Peripheral Neuropathy1CTD_human;HPO