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Fusion gene ID: 37755 |
FusionGeneSummary for TESK2_KNCN |
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Fusion gene information | Fusion gene name: TESK2_KNCN | Fusion gene ID: 37755 | Hgene | Tgene | Gene symbol | TESK2 | KNCN | Gene ID | 10420 | 148930 |
Gene name | testis associated actin remodelling kinase 2 | kinocilin | |
Synonyms | - | Kino|L5 | |
Cytomap | 1p34.1 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | dual specificity testis-specific protein kinase 2testicular protein kinase 2testis-specific kinase 2 | kinocilin | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96S53 | A6PVL3 | |
Ensembl transtripts involved in fusion gene | ENST00000372084, ENST00000372086, ENST00000341771, ENST00000486676, ENST00000538496, ENST00000451835, | ENST00000524908, ENST00000481882, ENST00000396314, | |
Fusion gene scores | * DoF score | 6 X 4 X 7=168 | 2 X 1 X 2=4 |
# samples | 8 | 2 | |
** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TESK2 [Title/Abstract] AND KNCN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-GN-A26D-06A | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000372084 | ENST00000524908 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000372084 | ENST00000481882 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000372084 | ENST00000396314 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000372086 | ENST00000524908 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000372086 | ENST00000481882 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000372086 | ENST00000396314 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000341771 | ENST00000524908 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000341771 | ENST00000481882 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000341771 | ENST00000396314 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5UTR-intron | ENST00000486676 | ENST00000524908 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5UTR-intron | ENST00000486676 | ENST00000481882 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5UTR-intron | ENST00000486676 | ENST00000396314 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
intron-intron | ENST00000538496 | ENST00000524908 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
intron-intron | ENST00000538496 | ENST00000481882 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
intron-intron | ENST00000538496 | ENST00000396314 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000451835 | ENST00000524908 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000451835 | ENST00000481882 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
5CDS-intron | ENST00000451835 | ENST00000396314 | TESK2 | chr1 | 45923236 | - | KNCN | chr1 | 47015674 | - |
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FusionProtFeatures for TESK2_KNCN |
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Hgene | Tgene |
TESK2 | KNCN |
Dual specificity protein kinase activity catalyzingautophosphorylation and phosphorylation of exogenous substrates onboth serine/threonine and tyrosine residues. Phosphorylatescofilin at 'Ser-3'. May play an important role in spermatogenesis. | May play a role in stabilizing dense microtubularnetworks or in vesicular trafficking. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TESK2_KNCN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TESK2_KNCN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TESK2 | YWHAB, HSP90AA1, ZBTB1, EID1, HSP90AA5P, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, DCLK1, ZNF638, SRSF12, RTKN, MAST3, SYDE1, PPM1H, AGAP1, DENND4C, CDC25B, CDK16, FAM110B, USP21, MAPKAP1, FAM53C, ANKRD34A, CGN, FAM110A, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, LPIN3, CDC25C, KIF1C, GIGYF2, DEPDC1B, NAV1, DENND4A, MLLT4, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, SH3RF3, HDAC7, EDC3, LARP1, RAB3IP, INPP5E | KNCN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TESK2_KNCN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TESK2_KNCN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TESK2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |