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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 37731

FusionGeneSummary for TENM4_INTS4

check button Fusion gene summary
Fusion gene informationFusion gene name: TENM4_INTS4
Fusion gene ID: 37731
HgeneTgene
Gene symbol

TENM4

INTS4

Gene ID

26011

92105

Gene nameteneurin transmembrane protein 4integrator complex subunit 4
SynonymsDoc4|ETM5|ODZ4|TNM4|Ten-M4|ten-4INT4|MST093
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionteneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4integrator complex subunit 4MSTP093
Modification date2018052320180523
UniProtAcc

Q6N022

Q96HW7

Ensembl transtripts involved in fusion geneENST00000278550, ENST00000533038, 
ENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 
Fusion gene scores* DoF score8 X 7 X 5=2806 X 4 X 5=120
# samples 87
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TENM4 [Title/Abstract] AND INTS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINTS4

GO:0016180

snRNA processing

16239144


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0HY-01ATENM4chr11

78600830

-INTS4chr11

77594998

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000278550ENST00000534064TENM4chr11

78600830

-INTS4chr11

77594998

-
In-frameENST00000278550ENST00000535943TENM4chr11

78600830

-INTS4chr11

77594998

-
5CDS-intronENST00000278550ENST00000525931TENM4chr11

78600830

-INTS4chr11

77594998

-
5CDS-intronENST00000278550ENST00000529807TENM4chr11

78600830

-INTS4chr11

77594998

-
5CDS-intronENST00000278550ENST00000527522TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-3CDSENST00000533038ENST00000534064TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-3CDSENST00000533038ENST00000535943TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-intronENST00000533038ENST00000525931TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-intronENST00000533038ENST00000529807TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-intronENST00000533038ENST00000527522TENM4chr11

78600830

-INTS4chr11

77594998

-

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FusionProtFeatures for TENM4_INTS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TENM4

Q6N022

INTS4

Q96HW7

Involved in neural development, regulating theestablishment of proper connectivity within the nervous system.Plays a role in the establishment of the anterior-posterior axisduring gastrulation. Regulates the differentiation and cellularprocess formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS)(PubMed:26188006). Promotes activation of focal adhesion kinase.May function as a cellular signal transducer (By similarity).{ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. Component of the Integrator (INT) complex, a complexinvolved in the small nuclear RNAs (snRNA) U1 and U2 transcriptionand in their 3'-box-dependent processing. The Integrator complexis associated with the C-terminal domain (CTD) of RNA polymeraseII largest subunit (POLR2A) and is recruited to the U1 and U2snRNAs genes (Probable). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:23904267,ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934179_1823612770Compositional biasNote=Poly-Pro
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341_3413612770DomainTeneurin N-terminal
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341_3453612770Topological domainCytoplasmic
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012145_183-8506RepeatNote=HEAT 2
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012190_228-8506RepeatNote=HEAT 3
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012229_263-8506RepeatNote=HEAT 4
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012277_313-8506RepeatNote=HEAT 5
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012369_405-8506RepeatNote=HEAT 6
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012406_444-8506RepeatNote=HEAT 7
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-012446_484-8506RepeatNote=HEAT 8
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807-01266_105-8506RepeatNote=HEAT 1
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69277_313239339RepeatNote=HEAT 5
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69369_405239339RepeatNote=HEAT 6
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69406_444239339RepeatNote=HEAT 7
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69446_484239339RepeatNote=HEAT 8

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934562_5933612770DomainEGF-like 1
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934594_6243612770DomainEGF-like 2
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934626_6583612770DomainEGF-like 3
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934659_6903612770DomainEGF-like 4
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934692_7253612770DomainEGF-like 5
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934726_7573612770DomainEGF-like 6
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934758_7873612770DomainEGF-like 7
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934788_8313612770DomainEGF-like 8
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341216_12593612770RepeatNote=NHL 1
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341264_13083612770RepeatNote=NHL 2
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341334_13783612770RepeatNote=NHL 3
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341393_14443612770RepeatNote=NHL 4
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341523_15663612770RepeatNote=NHL 5
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341576_15953612770RepeatNote=YD 1
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341612_16323612770RepeatNote=YD 2
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341675_16943612770RepeatNote=YD 3
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341695_17173612770RepeatNote=YD 4
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341887_19063612770RepeatNote=YD 5
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341928_19463612770RepeatNote=YD 6
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341947_19673612770RepeatNote=YD 7
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341974_19913612770RepeatNote=YD 8
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341992_20133612770RepeatNote=YD 9
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342014_20313612770RepeatNote=YD 10
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342034_20543612770RepeatNote=YD 11
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342057_20773612770RepeatNote=YD 12
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342085_21043612770RepeatNote=YD 13
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342110_21273612770RepeatNote=YD 14
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342128_21543612770RepeatNote=YD 15
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342156_21693612770RepeatNote=YD 16
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342170_21933612770RepeatNote=YD 17
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342196_22163612770RepeatNote=YD 18
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342217_22373612770RepeatNote=YD 19
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342239_22593612770RepeatNote=YD 20
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342271_22913612770RepeatNote=YD 21
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342293_23133612770RepeatNote=YD 22
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342339_23803612770RepeatNote=YD 23
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934367_27693612770Topological domainExtracellular
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934346_3663612770TransmembraneHelical
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023145_183864964RepeatNote=HEAT 2
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023190_228864964RepeatNote=HEAT 3
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023229_263864964RepeatNote=HEAT 4
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023277_313864964RepeatNote=HEAT 5
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023369_405864964RepeatNote=HEAT 6
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023406_444864964RepeatNote=HEAT 7
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-2023446_484864964RepeatNote=HEAT 8
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064-202366_105864964RepeatNote=HEAT 1
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69145_183239339RepeatNote=HEAT 2
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69190_228239339RepeatNote=HEAT 3
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-69229_263239339RepeatNote=HEAT 4
TgeneINTS4chr11:78600830chr11:77594998ENST00000535943-6966_105239339RepeatNote=HEAT 1


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FusionGeneSequence for TENM4_INTS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TENM4_ENST00000278550_chr11_78600830_-_INTS4_ENST00000534064_chr11_77594998_-_461aa
MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEVTP
PHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPP
PPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNLGKQPFLGTLQDNLIEMDI
LGASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYF
VGLISRWPGSDDSPQACRLPESWPRAAPAHHSGLSLPHRLDRGMPGGSEAAAGLQLQCSHSKMPLDGGWXDVTTGGNQHRGHHSLQQACK

>In-frame_TENM4_ENST00000278550_chr11_78600830_-_INTS4_ENST00000535943_chr11_77594998_-_461aa
MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEVTP
PHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPP
PPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNLGKQPFLGTLQDNLIEMDI
LGASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYF
VGLISRWPGSDDSPQACRLPESWPRAAPAHHSGLSLPHRLDRGMPGGSEAAAGLQLQCSHSKMPLDGGWXDVTTGGNQHRGHHSLQQACK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TENM4_ENST00000278550_chr11_78600830_-_INTS4_ENST00000534064_chr11_77594998_-_1384nt
ATGGACGTGAAGGAGAGGAAGCCTTACCGCTCGCTGACCCGGCGCCGCGACGCCGAGCGCCGCTACACCAGCTCGTCCGCGGACAGCGAG
GAGGGCAAAGCCCCGCAGAAATCGTACAGCTCCAGCGAGACCCTGAAGGCCTACGACCAGGACGCCCGCCTAGCCTATGGCAGCCGCGTC
AAGGACATTGTGCCGCAGGAGGCCGAGGAATTCTGCCGCACAGGTGCCAACTTCACCCTGCGGGAGCTGGGGCTGGAAGAAGTAACGCCC
CCTCACGGGACCCTGTACCGGACAGACATTGGCCTCCCCCACTGCGGCTACTCCATGGGGGCTGGCTCTGATGCCGACATGGAGGCTGAC
ACGGTGCTGTCCCCTGAGCACCCCGTGCGTCTGTGGGGCCGGAGCACACGGTCAGGGCGCAGCTCCTGCCTGTCCAGCCGGGCCAATTCC
AATCTCACACTCACCGACACCGAGCATGAAAACACTGAGACTGATCATCCGGGCGGCCTGCAGAACCACGCGCGGCTCCGGACGCCGCCG
CCGCCGCTCTCGCACGCCCACACCCCCAACCAGCACCACGCGGCCTCCATTAACTCCCTGAACCGGGGCAACTTCACGCCGAGGAGCAAC
CCCAGCCCGGCCCCCACGGACCACTCGCTCTCCGGAGAGCCCCCTGCCGGCGGCGCCCAGGAGCCTGCCCACGCCCAGGAGAACTGGCTG
CTCAACAGCAACATCCCCCTGGAGACCAGAAACCTAGGCAAGCAGCCATTCCTAGGGACATTGCAGGACAACCTCATTGAGATGGACATT
CTCGGCGCCTCCCGCCATGATGGGGCTTACAGTGACGGGCACTTCCTCTTCAAGCCTGGAGGCACCTCCCCGCTCTTCTGCACCACATCA
CCAGGGTACCCACTGACGTCCAGCACAGTGTACTCTCCTCCGCCCCGACCCCTGCCCCGCAGCACCTTCGCCCGGCCGGCCTTTAACCTC
AAGAAGCCCTCCAAGTACTGTAACTGGAAGTGCGCAGCCCTGAGCGCCATCGTCATCTCAGCCACTCTGGTCATCCTGCTGGCATACTTT
GTGGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCAT
CACTCAGGTTTATCTCTCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCAT
TCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAA

>In-frame_TENM4_ENST00000278550_chr11_78600830_-_INTS4_ENST00000535943_chr11_77594998_-_1384nt
ATGGACGTGAAGGAGAGGAAGCCTTACCGCTCGCTGACCCGGCGCCGCGACGCCGAGCGCCGCTACACCAGCTCGTCCGCGGACAGCGAG
GAGGGCAAAGCCCCGCAGAAATCGTACAGCTCCAGCGAGACCCTGAAGGCCTACGACCAGGACGCCCGCCTAGCCTATGGCAGCCGCGTC
AAGGACATTGTGCCGCAGGAGGCCGAGGAATTCTGCCGCACAGGTGCCAACTTCACCCTGCGGGAGCTGGGGCTGGAAGAAGTAACGCCC
CCTCACGGGACCCTGTACCGGACAGACATTGGCCTCCCCCACTGCGGCTACTCCATGGGGGCTGGCTCTGATGCCGACATGGAGGCTGAC
ACGGTGCTGTCCCCTGAGCACCCCGTGCGTCTGTGGGGCCGGAGCACACGGTCAGGGCGCAGCTCCTGCCTGTCCAGCCGGGCCAATTCC
AATCTCACACTCACCGACACCGAGCATGAAAACACTGAGACTGATCATCCGGGCGGCCTGCAGAACCACGCGCGGCTCCGGACGCCGCCG
CCGCCGCTCTCGCACGCCCACACCCCCAACCAGCACCACGCGGCCTCCATTAACTCCCTGAACCGGGGCAACTTCACGCCGAGGAGCAAC
CCCAGCCCGGCCCCCACGGACCACTCGCTCTCCGGAGAGCCCCCTGCCGGCGGCGCCCAGGAGCCTGCCCACGCCCAGGAGAACTGGCTG
CTCAACAGCAACATCCCCCTGGAGACCAGAAACCTAGGCAAGCAGCCATTCCTAGGGACATTGCAGGACAACCTCATTGAGATGGACATT
CTCGGCGCCTCCCGCCATGATGGGGCTTACAGTGACGGGCACTTCCTCTTCAAGCCTGGAGGCACCTCCCCGCTCTTCTGCACCACATCA
CCAGGGTACCCACTGACGTCCAGCACAGTGTACTCTCCTCCGCCCCGACCCCTGCCCCGCAGCACCTTCGCCCGGCCGGCCTTTAACCTC
AAGAAGCCCTCCAAGTACTGTAACTGGAAGTGCGCAGCCCTGAGCGCCATCGTCATCTCAGCCACTCTGGTCATCCTGCTGGCATACTTT
GTGGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCAT
CACTCAGGTTTATCTCTCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCAT
TCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TENM4_ENST00000278550_chr11_78600830_-_INTS4_ENST00000534064_chr11_77594998_-_2076nt
ACCTGCTCCTTCCTGGGCGCCCCGCTACGGCTCGCGGAGCAGAGGAGCCGCGCCGCCGAGAGAGAGAGGAGCCACCGGCGCGGCGCCTTG
CCTCCCTGCCGCCGTCCTCGCCGCTTCCCCGGCGGTAGCAGCCTGCAGCCACGATGGAAAAACTGAGAATCAGAGAGGGCTAGTGATCTC
TCAGACACTTGGTCGGTAGAAAAGATCCCGCACCATCCTCCAGGATCCAATGGCCTTGGAGAGAGGGCTGCAGGGCCCACGGACATTGCT
GACTCTTCAGAACGTGCTGACATGGAGCCAGGTAGACTGAAATTACCATGTGTCCAAATTAAAATTGCATACTTCAAGGATTATTTGAAG
GACTATTCTTAGACCCTTTTAAGAAGATTTAAAGAAAAACCACTCGGCCCTGAGTGCGGCGAGGACCCTGTTTGTGGATGTGGAGGAGCG
CGGGCCGGAGGCCATGGACGTGAAGGAGAGGAAGCCTTACCGCTCGCTGACCCGGCGCCGCGACGCCGAGCGCCGCTACACCAGCTCGTC
CGCGGACAGCGAGGAGGGCAAAGCCCCGCAGAAATCGTACAGCTCCAGCGAGACCCTGAAGGCCTACGACCAGGACGCCCGCCTAGCCTA
TGGCAGCCGCGTCAAGGACATTGTGCCGCAGGAGGCCGAGGAATTCTGCCGCACAGGTGCCAACTTCACCCTGCGGGAGCTGGGGCTGGA
AGAAGTAACGCCCCCTCACGGGACCCTGTACCGGACAGACATTGGCCTCCCCCACTGCGGCTACTCCATGGGGGCTGGCTCTGATGCCGA
CATGGAGGCTGACACGGTGCTGTCCCCTGAGCACCCCGTGCGTCTGTGGGGCCGGAGCACACGGTCAGGGCGCAGCTCCTGCCTGTCCAG
CCGGGCCAATTCCAATCTCACACTCACCGACACCGAGCATGAAAACACTGAGACTGATCATCCGGGCGGCCTGCAGAACCACGCGCGGCT
CCGGACGCCGCCGCCGCCGCTCTCGCACGCCCACACCCCCAACCAGCACCACGCGGCCTCCATTAACTCCCTGAACCGGGGCAACTTCAC
GCCGAGGAGCAACCCCAGCCCGGCCCCCACGGACCACTCGCTCTCCGGAGAGCCCCCTGCCGGCGGCGCCCAGGAGCCTGCCCACGCCCA
GGAGAACTGGCTGCTCAACAGCAACATCCCCCTGGAGACCAGAAACCTAGGCAAGCAGCCATTCCTAGGGACATTGCAGGACAACCTCAT
TGAGATGGACATTCTCGGCGCCTCCCGCCATGATGGGGCTTACAGTGACGGGCACTTCCTCTTCAAGCCTGGAGGCACCTCCCCGCTCTT
CTGCACCACATCACCAGGGTACCCACTGACGTCCAGCACAGTGTACTCTCCTCCGCCCCGACCCCTGCCCCGCAGCACCTTCGCCCGGCC
GGCCTTTAACCTCAAGAAGCCCTCCAAGTACTGTAACTGGAAGTGCGCAGCCCTGAGCGCCATCGTCATCTCAGCCACTCTGGTCATCCT
GCTGGCATACTTTGTGGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGC
GGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACT
CCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCA
GCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTT
AGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTA
TCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAACCTTCAAGTCTACTTACCCTTCTCCTGTCCACAATAAAGTTGAGAAAA

>In-frame_TENM4_ENST00000278550_chr11_78600830_-_INTS4_ENST00000535943_chr11_77594998_-_2074nt
ACCTGCTCCTTCCTGGGCGCCCCGCTACGGCTCGCGGAGCAGAGGAGCCGCGCCGCCGAGAGAGAGAGGAGCCACCGGCGCGGCGCCTTG
CCTCCCTGCCGCCGTCCTCGCCGCTTCCCCGGCGGTAGCAGCCTGCAGCCACGATGGAAAAACTGAGAATCAGAGAGGGCTAGTGATCTC
TCAGACACTTGGTCGGTAGAAAAGATCCCGCACCATCCTCCAGGATCCAATGGCCTTGGAGAGAGGGCTGCAGGGCCCACGGACATTGCT
GACTCTTCAGAACGTGCTGACATGGAGCCAGGTAGACTGAAATTACCATGTGTCCAAATTAAAATTGCATACTTCAAGGATTATTTGAAG
GACTATTCTTAGACCCTTTTAAGAAGATTTAAAGAAAAACCACTCGGCCCTGAGTGCGGCGAGGACCCTGTTTGTGGATGTGGAGGAGCG
CGGGCCGGAGGCCATGGACGTGAAGGAGAGGAAGCCTTACCGCTCGCTGACCCGGCGCCGCGACGCCGAGCGCCGCTACACCAGCTCGTC
CGCGGACAGCGAGGAGGGCAAAGCCCCGCAGAAATCGTACAGCTCCAGCGAGACCCTGAAGGCCTACGACCAGGACGCCCGCCTAGCCTA
TGGCAGCCGCGTCAAGGACATTGTGCCGCAGGAGGCCGAGGAATTCTGCCGCACAGGTGCCAACTTCACCCTGCGGGAGCTGGGGCTGGA
AGAAGTAACGCCCCCTCACGGGACCCTGTACCGGACAGACATTGGCCTCCCCCACTGCGGCTACTCCATGGGGGCTGGCTCTGATGCCGA
CATGGAGGCTGACACGGTGCTGTCCCCTGAGCACCCCGTGCGTCTGTGGGGCCGGAGCACACGGTCAGGGCGCAGCTCCTGCCTGTCCAG
CCGGGCCAATTCCAATCTCACACTCACCGACACCGAGCATGAAAACACTGAGACTGATCATCCGGGCGGCCTGCAGAACCACGCGCGGCT
CCGGACGCCGCCGCCGCCGCTCTCGCACGCCCACACCCCCAACCAGCACCACGCGGCCTCCATTAACTCCCTGAACCGGGGCAACTTCAC
GCCGAGGAGCAACCCCAGCCCGGCCCCCACGGACCACTCGCTCTCCGGAGAGCCCCCTGCCGGCGGCGCCCAGGAGCCTGCCCACGCCCA
GGAGAACTGGCTGCTCAACAGCAACATCCCCCTGGAGACCAGAAACCTAGGCAAGCAGCCATTCCTAGGGACATTGCAGGACAACCTCAT
TGAGATGGACATTCTCGGCGCCTCCCGCCATGATGGGGCTTACAGTGACGGGCACTTCCTCTTCAAGCCTGGAGGCACCTCCCCGCTCTT
CTGCACCACATCACCAGGGTACCCACTGACGTCCAGCACAGTGTACTCTCCTCCGCCCCGACCCCTGCCCCGCAGCACCTTCGCCCGGCC
GGCCTTTAACCTCAAGAAGCCCTCCAAGTACTGTAACTGGAAGTGCGCAGCCCTGAGCGCCATCGTCATCTCAGCCACTCTGGTCATCCT
GCTGGCATACTTTGTGGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGC
GGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACT
CCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCA
GCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTT
AGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTA
TCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAACCTTCAAGTCTACTTACCCTTCTCCTGTCCACAATAAAGTTGAGAAAA


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FusionGenePPI for TENM4_INTS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TENM4CAND1INTS4RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, INTS9, HECW2, HGS, ZMIZ2, USHBP1, HLA-B, SLAMF1, VSIG4, LOC554223, ISLR, INTS4P2, TGOLN2, FAF2, C7orf26, CPSF3L, FAM98A, ASUN, NTRK1, PPP2CA, PPP2CB, PPP2R1A, VWA9, SIGLECL1, BMP2K, VSIG1, PMEL, PDCD1, CD70, GORASP1, AP2A1, CD79B, SIGLEC5, ADAM32, PCDHA12, AP2A2, CLEC2D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TENM4_INTS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TENM4_INTS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTENM4C0005586Bipolar Disorder1CTD_human
HgeneTENM4C0033975Psychotic Disorders1PSYGENET
HgeneTENM4C0036341Schizophrenia1PSYGENET
HgeneTENM4C0349204Nonorganic psychosis1PSYGENET
HgeneTENM4C4225223TREMOR, HEREDITARY ESSENTIAL, 51UNIPROT
TgeneINTS4C0033578Prostatic Neoplasms1CTD_human