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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37728

FusionGeneSummary for TENM3_SPAG11B

check button Fusion gene summary
Fusion gene informationFusion gene name: TENM3_SPAG11B
Fusion gene ID: 37728
HgeneTgene
Gene symbol

TENM3

SPAG11B

Gene ID

55714

10407

Gene nameteneurin transmembrane protein 3sperm associated antigen 11B
SynonymsMCOPCB9|ODZ3|TNM3|Ten-m3|ten-3EDDM2B|EP2|EP2C|EP2D|HE2|HE2C|SPAG11
Cytomap

4q34.3-q35.1

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionteneurin-3ODZ3-like proteinodz, odd Oz/ten-m homolog 3protein Odd Oz/ten-m homolog 3tenascin-M3testicular tissue protein Li 195sperm-associated antigen 11Bepididymal protein 2Bhuman epididymis-specific protein 2sperm antigen HE2
Modification date2018052320180519
UniProtAcc

Q9P273

Q08648

Ensembl transtripts involved in fusion geneENST00000511685, ENST00000406950, 
ENST00000502950, 		ENST00000361111, 
ENST00000359758, ENST00000297498, 
ENST00000458665, ENST00000528168, 
ENST00000398462, ENST00000317900, 
Fusion gene scores* DoF score6 X 6 X 2=724 X 4 X 3=48
# samples 64
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TENM3 [Title/Abstract] AND SPAG11B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL133652TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000511685ENST00000361111TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000511685ENST00000359758TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000511685ENST00000297498TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000511685ENST00000458665TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000511685ENST00000528168TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000511685ENST00000398462TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000511685ENST00000317900TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000361111TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000359758TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000297498TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000458665TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000528168TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000398462TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000406950ENST00000317900TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000361111TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000359758TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000297498TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000458665TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000528168TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000398462TENM3chr4

183354105

-SPAG11Bchr8

7705597

+
intron-intronENST00000502950ENST00000317900TENM3chr4

183354105

-SPAG11Bchr8

7705597

+

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FusionProtFeatures for TENM3_SPAG11B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TENM3

Q9P273

SPAG11B

Q08648

Involved in neural development by regulating theestablishment of proper connectivity within the nervous system.Acts in both pre- and postsynaptic neurons in the hippocampus tocontrol the assembly of a precise topographic projection: requiredin both CA1 and subicular neurons for the precise targeting ofproximal CA1 axons to distal subiculum, probably by promotinghomophilic cell adhesion. Required for proper dendritemorphogenesis and axon targeting in the vertebrate visual system,thereby playing a key role in the development of the visualpathway. Regulates the formation in ipsilateral retinal mapping toboth the dorsal lateral geniculate nucleus (dLGN) and the superiorcolliculus (SC). May also be involved in the differentiation ofthe fibroblast-like cells in the superficial layer of mandibularcondylar cartilage into chondrocytes.{ECO:0000250|UniProtKB:Q9WTS6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TENM3_SPAG11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TENM3_SPAG11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TENM3_SPAG11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TENM3_SPAG11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTENM3C0236736Cocaine-Related Disorders1CTD_human
HgeneTENM3C0264423Asthma, Occupational1CTD_human