FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37725

FusionGeneSummary for TENM3_NR3C2

check button Fusion gene summary
Fusion gene informationFusion gene name: TENM3_NR3C2
Fusion gene ID: 37725
HgeneTgene
Gene symbol

TENM3

NR3C2

Gene ID

55714

4306

Gene nameteneurin transmembrane protein 3nuclear receptor subfamily 3 group C member 2
SynonymsMCOPCB9|ODZ3|TNM3|Ten-m3|ten-3MCR|MLR|MR|NR3C2VIT
Cytomap

4q34.3-q35.1

4q31.23

Type of geneprotein-codingprotein-coding
Descriptionteneurin-3ODZ3-like proteinodz, odd Oz/ten-m homolog 3protein Odd Oz/ten-m homolog 3tenascin-M3testicular tissue protein Li 195mineralocorticoid receptoraldosterone receptormineralocorticoid receptor 1mineralocorticoid receptor 2mineralocorticoid receptor deltanuclear receptor subfamily 3, group C, member 2 variant 3
Modification date2018052320180519
UniProtAcc

Q9P273

P08235

Ensembl transtripts involved in fusion geneENST00000511685, ENST00000406950, 
ENST00000502950, 
ENST00000344721, 
ENST00000355292, ENST00000358102, 
ENST00000512865, ENST00000511528, 
ENST00000503313, 
Fusion gene scores* DoF score6 X 6 X 2=723 X 3 X 3=27
# samples 64
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TENM3 [Title/Abstract] AND NR3C2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-QK-A8Z9-01BTENM3chr4

183370236

+NR3C2chr4

149116013

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000511685ENST00000344721TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000511685ENST00000355292TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000511685ENST00000358102TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000511685ENST00000512865TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000511685ENST00000511528TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-5UTRENST00000511685ENST00000503313TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000406950ENST00000344721TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000406950ENST00000355292TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000406950ENST00000358102TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000406950ENST00000512865TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000406950ENST00000511528TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-5UTRENST00000406950ENST00000503313TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000502950ENST00000344721TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000502950ENST00000355292TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000502950ENST00000358102TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000502950ENST00000512865TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-3CDSENST00000502950ENST00000511528TENM3chr4

183370236

+NR3C2chr4

149116013

-
intron-5UTRENST00000502950ENST00000503313TENM3chr4

183370236

+NR3C2chr4

149116013

-

Top

FusionProtFeatures for TENM3_NR3C2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TENM3

Q9P273

NR3C2

P08235

Involved in neural development by regulating theestablishment of proper connectivity within the nervous system.Acts in both pre- and postsynaptic neurons in the hippocampus tocontrol the assembly of a precise topographic projection: requiredin both CA1 and subicular neurons for the precise targeting ofproximal CA1 axons to distal subiculum, probably by promotinghomophilic cell adhesion. Required for proper dendritemorphogenesis and axon targeting in the vertebrate visual system,thereby playing a key role in the development of the visualpathway. Regulates the formation in ipsilateral retinal mapping toboth the dorsal lateral geniculate nucleus (dLGN) and the superiorcolliculus (SC). May also be involved in the differentiation ofthe fibroblast-like cells in the superficial layer of mandibularcondylar cartilage into chondrocytes.{ECO:0000250|UniProtKB:Q9WTS6}. Receptor for both mineralocorticoids (MC) such asaldosterone and glucocorticoids (GC) such as corticosterone orcortisol. Binds to mineralocorticoid response elements (MRE) andtransactivates target genes. The effect of MC is to increase ionand water transport and thus raise extracellular fluid volume andblood pressure and lower potassium levels.{ECO:0000269|PubMed:3037703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TENM3_NR3C2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TENM3_NR3C2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TENM3SMAD4, SIAE, GAN, CDH1, CLU, LMAN2L, PSG8, SCGB2A2, MME, SERPINA12NR3C2TRIM24, NR3C1, PTGES3, PROX1, CAND1, UBE2I, SUMO1, NRIP1, STUB1, FKBP5, FKBP4, PPP5C, DNAJC7, PPID, AIP, HSP90AA1, ACSL1, RXRA, RABAC1, C9orf41, PSMC5, NCOA1, CREBBP, EP300, KAT2B, CAV1, PPP1CA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TENM3_NR3C2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNR3C2P08235DB00421SpironolactoneMineralocorticoid receptorsmall moleculeapproved
TgeneNR3C2P08235DB00700EplerenoneMineralocorticoid receptorsmall moleculeapproved
TgeneNR3C2P08235DB01395DrospirenoneMineralocorticoid receptorsmall moleculeapproved
TgeneNR3C2P08235DB00393NimodipineMineralocorticoid receptorsmall moleculeapproved|investigational
TgeneNR3C2P08235DB00624TestosteroneMineralocorticoid receptorsmall moleculeapproved|investigational
TgeneNR3C2P08235DB00687FludrocortisoneMineralocorticoid receptorsmall moleculeapproved|investigational
TgeneNR3C2P08235DB01023FelodipineMineralocorticoid receptorsmall moleculeapproved|investigational
TgeneNR3C2P08235DB00396ProgesteroneMineralocorticoid receptorsmall moleculeapproved|vet_approved

Top

RelatedDiseases for TENM3_NR3C2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTENM3C0236736Cocaine-Related Disorders1CTD_human
HgeneTENM3C0264423Asthma, Occupational1CTD_human
TgeneNR3C2C0011570Mental Depression5PSYGENET
TgeneNR3C2C0011581Depressive disorder5PSYGENET
TgeneNR3C2C0041696Unipolar Depression4PSYGENET
TgeneNR3C2C1269683Major Depressive Disorder4PSYGENET
TgeneNR3C2C1449842Pseudohypoaldosteronism, Type I, Autosomal Dominant4ORPHANET;UNIPROT
TgeneNR3C2C1854631Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy3CTD_human;ORPHANET;UNIPROT
TgeneNR3C2C0018801Heart failure2CTD_human
TgeneNR3C2C0027051Myocardial Infarction2CTD_human
TgeneNR3C2C0001969Alcoholic Intoxication1PSYGENET
TgeneNR3C2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNR3C2C0005586Bipolar Disorder1PSYGENET
TgeneNR3C2C0007193Cardiomyopathy, Dilated1CTD_human
TgeneNR3C2C0014175Endometriosis1CTD_human
TgeneNR3C2C0242698Ventricular Dysfunction, Left1CTD_human
TgeneNR3C2C0338831Manic1PSYGENET