|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37723 |
FusionGeneSummary for TENM3_CORO2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TENM3_CORO2A | Fusion gene ID: 37723 | Hgene | Tgene | Gene symbol | TENM3 | CORO2A | Gene ID | 55714 | 7464 |
| Gene name | teneurin transmembrane protein 3 | coronin 2A | |
| Synonyms | MCOPCB9|ODZ3|TNM3|Ten-m3|ten-3 | CLIPINB|IR10|WDR2 | |
| Cytomap | 4q34.3-q35.1 | 9q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | teneurin-3ODZ3-like proteinodz, odd Oz/ten-m homolog 3protein Odd Oz/ten-m homolog 3tenascin-M3testicular tissue protein Li 195 | coronin-2AWD protein IR10WD repeat-containing protein 2WD-repeat protein 2coronin, actin binding protein, 2Acoronin-like protein B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9P273 | Q92828 | |
| Ensembl transtripts involved in fusion gene | ENST00000511685, ENST00000406950, ENST00000502950, | ENST00000343933, ENST00000375077, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 4 X 4 X 3=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TENM3 [Title/Abstract] AND CORO2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU624193 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000511685 | ENST00000343933 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
| intron-3UTR | ENST00000511685 | ENST00000375077 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
| intron-3UTR | ENST00000406950 | ENST00000343933 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
| intron-3UTR | ENST00000406950 | ENST00000375077 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
| intron-3UTR | ENST00000502950 | ENST00000343933 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
| intron-3UTR | ENST00000502950 | ENST00000375077 | TENM3 | chr4 | 183272031 | - | CORO2A | chr9 | 100886943 | + |
Top |
FusionProtFeatures for TENM3_CORO2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TENM3 | CORO2A |
| Involved in neural development by regulating theestablishment of proper connectivity within the nervous system.Acts in both pre- and postsynaptic neurons in the hippocampus tocontrol the assembly of a precise topographic projection: requiredin both CA1 and subicular neurons for the precise targeting ofproximal CA1 axons to distal subiculum, probably by promotinghomophilic cell adhesion. Required for proper dendritemorphogenesis and axon targeting in the vertebrate visual system,thereby playing a key role in the development of the visualpathway. Regulates the formation in ipsilateral retinal mapping toboth the dorsal lateral geniculate nucleus (dLGN) and the superiorcolliculus (SC). May also be involved in the differentiation ofthe fibroblast-like cells in the superficial layer of mandibularcondylar cartilage into chondrocytes.{ECO:0000250|UniProtKB:Q9WTS6}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TENM3_CORO2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TENM3_CORO2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TENM3_CORO2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TENM3_CORO2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TENM3 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Hgene | TENM3 | C0264423 | Asthma, Occupational | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|