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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37702

FusionGeneSummary for TEC_NCAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: TEC_NCAM2
Fusion gene ID: 37702
HgeneTgene
Gene symbol

TEC

NCAM2

Gene ID

79651

4685

Gene namerhomboid 5 homolog 2neural cell adhesion molecule 2
SynonymsRHBDL5|RHBDL6|TEC|TOC|TOCG|iRhom2NCAM21
Cytomap

17q25.1

21q21.1

Type of geneprotein-codingprotein-coding
Descriptioninactive rhomboid protein 2rhomboid family member 2rhomboid veinlet-like protein 5rhomboid veinlet-like protein 6neural cell adhesion molecule 2N-CAM-2NCAM-2
Modification date2018052320180523
UniProtAcc

P42680

O15394

Ensembl transtripts involved in fusion geneENST00000381501, ENST00000511471, 
ENST00000400546, ENST00000284894, 
ENST00000535285, ENST00000486367, 
Fusion gene scores* DoF score4 X 3 X 4=488 X 7 X 3=168
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEC [Title/Abstract] AND NCAM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-93-A4JQ-01ATECchr4

48271769

-NCAM2chr21

22746183

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000381501ENST00000400546TECchr4

48271769

-NCAM2chr21

22746183

+
5UTR-3CDSENST00000381501ENST00000284894TECchr4

48271769

-NCAM2chr21

22746183

+
5UTR-3CDSENST00000381501ENST00000535285TECchr4

48271769

-NCAM2chr21

22746183

+
5UTR-intronENST00000381501ENST00000486367TECchr4

48271769

-NCAM2chr21

22746183

+
intron-3CDSENST00000511471ENST00000400546TECchr4

48271769

-NCAM2chr21

22746183

+
intron-3CDSENST00000511471ENST00000284894TECchr4

48271769

-NCAM2chr21

22746183

+
intron-3CDSENST00000511471ENST00000535285TECchr4

48271769

-NCAM2chr21

22746183

+
intron-intronENST00000511471ENST00000486367TECchr4

48271769

-NCAM2chr21

22746183

+

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FusionProtFeatures for TEC_NCAM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TEC

P42680

NCAM2

O15394

Non-receptor tyrosine kinase that contributes tosignaling from many receptors and participates as a signaltransducer in multiple downstream pathways, including regulationof the actin cytoskeleton. Plays a redundant role to ITK inregulation of the adaptive immune response. Regulates thedevelopment, function and differentiation of conventional T-cellsand nonconventional NKT-cells. Required for TCR-dependent IL2 geneinduction. Phosphorylates DOK1, one CD28-specific substrate, andcontributes to CD28-signaling. Mediates signals that negativelyregulate IL2RA expression induced by TCR cross-linking. Plays aredundant role to BTK in BCR-signaling for B-cell development andactivation, especially by phosphorylating STAP1, a BCR-signalingprotein. Required in mast cells for efficient cytokine production.Involved in both growth and differentiation mechanisms of myeloidcells through activation by the granulocyte colony-stimulatingfactor CSF3, a critical cytokine to promoting the growth,differentiation, and functional activation of myeloid cells.Participates in platelet signaling downstream of integrinactivation. Cooperates with JAK2 through reciprocalphosphorylation to mediate cytokine-driven activation of FOStranscription. GRB10, a negative modifier of the FOS activationpathway, is another substrate of TEC. TEC is involved in Gprotein-coupled receptor- and integrin-mediated signalings inblood platelets. Plays a role in hepatocyte proliferation andliver regeneration and is involved in HGF-induced ERK signalingpathway. TEC regulates also FGF2 unconventional secretion(endoplasmic reticulum (ER)/Golgi-independent mechanism) undervarious physiological conditions through phosphorylation of FGF2'Tyr-215'. May also be involved in the regulation of osteoclastdifferentiation. {ECO:0000269|PubMed:10518561,ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531,ECO:0000269|PubMed:9753425}. May play important roles in selective fasciculation andzone-to-zone projection of the primary olfactory axons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TEC_NCAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TEC_NCAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TECPRLR, VAV1, RAC1, JAK1, JAK2, PIK3R2, LYN, KIT, DOK1, WAS, SOCS1, GNA12, GNA13, ARHGEF12, IKBKG, FASLG, SHC1, MED28, GRB2, ERBB2, RPE, SORT1NCAM2QDPR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TEC_NCAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEC_NCAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource