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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37696

FusionGeneSummary for TECR_PKN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TECR_PKN1
Fusion gene ID: 37696
HgeneTgene
Gene symbol

TECR

PKN1

Gene ID

9524

5585

Gene nametrans-2,3-enoyl-CoA reductaseprotein kinase N1
SynonymsGPSN2|MRT14|SC2|TERDBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionvery-long-chain enoyl-CoA reductaseglycoprotein, synaptic 2synaptic glycoprotein SC2serine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase N
Modification date2018052320180523
UniProtAcc

Q9NZ01

Q16512

Ensembl transtripts involved in fusion geneENST00000215567, ENST00000596073, 
ENST00000600083, ENST00000436007, 
ENST00000596164, 
ENST00000242783, 
ENST00000587429, ENST00000342216, 
Fusion gene scores* DoF score6 X 1 X 7=424 X 5 X 5=100
# samples 76
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TECR [Title/Abstract] AND PKN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTECR

GO:0030497

fatty acid elongation

12482854

HgeneTECR

GO:0042761

very long-chain fatty acid biosynthetic process

12482854

TgenePKN1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

TgenePKN1

GO:0006468

protein phosphorylation

17332740

TgenePKN1

GO:0035407

histone H3-T11 phosphorylation

18066052


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1R4-01ATECRchr19

14640523

+PKN1chr19

14574479

+
TCGARVLUSCTCGA-43-7658-01ATECRchr19

14640523

+PKN1chr19

14574479

+
TCGARVUCECTCGA-A5-A3LP-01ATECRchr19

14640523

+PKN1chr19

14580153

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000215567ENST00000242783TECRchr19

14640523

+PKN1chr19

14574479

+
5CDS-intronENST00000215567ENST00000587429TECRchr19

14640523

+PKN1chr19

14574479

+
5CDS-intronENST00000215567ENST00000342216TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-3CDSENST00000596073ENST00000242783TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-intronENST00000596073ENST00000587429TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-intronENST00000596073ENST00000342216TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-3CDSENST00000600083ENST00000242783TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-intronENST00000600083ENST00000587429TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-intronENST00000600083ENST00000342216TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-3CDSENST00000436007ENST00000242783TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-intronENST00000436007ENST00000587429TECRchr19

14640523

+PKN1chr19

14574479

+
5UTR-intronENST00000436007ENST00000342216TECRchr19

14640523

+PKN1chr19

14574479

+
3UTR-3CDSENST00000596164ENST00000242783TECRchr19

14640523

+PKN1chr19

14574479

+
3UTR-intronENST00000596164ENST00000587429TECRchr19

14640523

+PKN1chr19

14574479

+
3UTR-intronENST00000596164ENST00000342216TECRchr19

14640523

+PKN1chr19

14574479

+
Frame-shiftENST00000215567ENST00000242783TECRchr19

14640523

+PKN1chr19

14580153

+
5CDS-intronENST00000215567ENST00000587429TECRchr19

14640523

+PKN1chr19

14580153

+
5CDS-intronENST00000215567ENST00000342216TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-3CDSENST00000596073ENST00000242783TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-intronENST00000596073ENST00000587429TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-intronENST00000596073ENST00000342216TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-3CDSENST00000600083ENST00000242783TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-intronENST00000600083ENST00000587429TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-intronENST00000600083ENST00000342216TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-3CDSENST00000436007ENST00000242783TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-intronENST00000436007ENST00000587429TECRchr19

14640523

+PKN1chr19

14580153

+
5UTR-intronENST00000436007ENST00000342216TECRchr19

14640523

+PKN1chr19

14580153

+
3UTR-3CDSENST00000596164ENST00000242783TECRchr19

14640523

+PKN1chr19

14580153

+
3UTR-intronENST00000596164ENST00000587429TECRchr19

14640523

+PKN1chr19

14580153

+
3UTR-intronENST00000596164ENST00000342216TECRchr19

14640523

+PKN1chr19

14580153

+

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FusionProtFeatures for TECR_PKN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TECR

Q9NZ01

PKN1

Q16512

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to thechain of long- and very long-chain fatty acids/VLCFAs per cycle.This enzyme reduces the trans-2,3-enoyl-CoA fatty acidintermediate to an acyl-CoA that can be further elongated byentering a new cycle of elongation. Thereby, it participates inthe production of VLCFAs of different chain lengths that areinvolved in multiple biological processes as precursors ofmembrane lipids and lipid mediators.{ECO:0000269|PubMed:12482854}. PKC-related serine/threonine-protein kinase involved invarious processes such as regulation of the intermediate filamentsof the actin cytoskeleton, cell migration, tumor cell invasion andtranscription regulation. Part of a signaling cascade that beginswith the activation of the adrenergic receptor ADRA1B and leads tothe activation of MAPK14. Regulates the cytoskeletal network byphosphorylating proteins such as VIM and neurofilament proteinsNEFH, NEFL and NEFM, leading to inhibit their polymerization.Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau,lowering its ability to bind to microtubules, resulting indisruption of tubulin assembly. Acts as a key coactivator ofandrogen receptor (ANDR)-dependent transcription, by beingrecruited to ANDR target genes and specifically mediatingphosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specifictag for epigenetic transcriptional activation that promotesdemethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair theirimport in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able tophosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762,ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740,ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095,ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995,ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118,ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+822615_874473943DomainProtein kinase
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+822875_942473943DomainNote=AGC-kinase C-terminal
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+822615_874479949DomainProtein kinase
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+822875_942479949DomainNote=AGC-kinase C-terminal
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+822621_629473943Nucleotide bindingATP
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+822621_629479949Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTECRchr19:14640523chr19:14574479ENST00000215567+113194_2145309TransmembraneHelical
HgeneTECRchr19:14640523chr19:14574479ENST00000215567+113255_2755309TransmembraneHelical
HgeneTECRchr19:14640523chr19:14574479ENST00000215567+11387_1075309TransmembraneHelical
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+822112_193473943DomainREM-1 2
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+822201_280473943DomainREM-1 3
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+82225_100473943DomainREM-1 1
TgenePKN1chr19:14640523chr19:14574479ENST00000242783+822325_461473943DomainNote=C2
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+822112_193479949DomainREM-1 2
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+822201_280479949DomainREM-1 3
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+82225_100479949DomainREM-1 1
TgenePKN1chr19:14640523chr19:14574479ENST00000342216+822325_461479949DomainNote=C2


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FusionGeneSequence for TECR_PKN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TECR_PKN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TECRCUL3, CAND1, NOS3, PAXIP1, RPN1, RHOT2, MOGS, DSP, ESR1, UBL4A, CLN3, EGFR, ELOVL1, CERS2, DYRK4, HIPK4, MAPK4, DYRK1B, HECW2, ILK, PTPLB, CUL7, RNF2, ARAF, ABCE1, NTRK1, ACADM, ATP5C1, CANX, CCT6A, CISD1, CLTC, DDOST, DDX39B, EHD1, GORASP2, HSD17B12, HSPA8, JAGN1, RAB1A, RAB1B, SCAMP3, SEC61A1, SGPL1, SLC25A3, SSR1, SSR4, ATP1A1, MAGT1, NDUFS1, VDAC3, TOMM22, UQCRC2, VDAC1, VDAC2, TCTN2, CREB3, XRCC3, MBOAT1, DPF3, COX15, DLST, SOAT1, RNF157PKN1CCDC85B, RHOA, NEFL, NEFH, ACTN1, PLD1, VIM, PDK1, NEUROD2, AKAP9, PDPK1, CDR2, HDAC5, HDAC6, HIST2H3C, ZNF282, SPRR2D, TUBA1A, TUBB, MYC, TRAF2, PKN1, MAPK9, TOM1L1, CCNT2, CASP3, MAPT, TRAF1, TNFRSF1B, MAPK12, MAPK11, MAP2K3, MAP2K6, HSP90AA1, MARCKS, CD81, CDC25C, MBP, WBSCR22, TBXA2R, HIST1H1A, PA2G4, GOLGA2, KRT15, KRT31, MID1, HOMER3, SSX2IP, CEP57L1, WDR5, KMT2A, RBBP5, ASH2L, MAGEA10, PLAUR, C1orf186, PPM1A, PPM1G, NTRK1, KBTBD8, COG6, AEN, FUOM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TECR_PKN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TECR_PKN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTECRC3151462MENTAL RETARDATION, AUTOSOMAL RECESSIVE 141UNIPROT