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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37692

FusionGeneSummary for TECR_GIPC1

check button Fusion gene summary
Fusion gene informationFusion gene name: TECR_GIPC1
Fusion gene ID: 37692
HgeneTgene
Gene symbol

TECR

GIPC1

Gene ID

9524

10755

Gene nametrans-2,3-enoyl-CoA reductaseGIPC PDZ domain containing family member 1
SynonymsGPSN2|MRT14|SC2|TERC19orf3|GIPC|GLUT1CBP|Hs.6454|IIP-1|NIP|RGS19IP1|SEMCAP|SYNECTIIN|SYNECTIN|TIP-2
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionvery-long-chain enoyl-CoA reductaseglycoprotein, synaptic 2synaptic glycoprotein SC2PDZ domain-containing protein GIPC1GAIP C-terminus-interacting proteinGLUT1 C-terminal binding proteinIGF-1 receptor interacting protein 1RGS-GAIP-interacting proteinRGS19-interacting protein 1regulator of G-protein signalling 19 interacting protein
Modification date2018052320180522
UniProtAcc

Q9NZ01

O14908

Ensembl transtripts involved in fusion geneENST00000215567, ENST00000596073, 
ENST00000600083, ENST00000436007, 
ENST00000596164, 		ENST00000393029, 
ENST00000393028, ENST00000345425, 
ENST00000393033, ENST00000591349, 
ENST00000586027, 
Fusion gene scores* DoF score6 X 1 X 7=425 X 3 X 5=75
# samples 75
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TECR [Title/Abstract] AND GIPC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTECR

GO:0030497

fatty acid elongation

12482854

HgeneTECR

GO:0042761

very long-chain fatty acid biosynthetic process

12482854


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8289-01ATECRchr19

14640523

+GIPC1chr19

14593818

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000215567ENST00000393029TECRchr19

14640523

+GIPC1chr19

14593818

-
5CDS-intronENST00000215567ENST00000393028TECRchr19

14640523

+GIPC1chr19

14593818

-
5CDS-5UTRENST00000215567ENST00000345425TECRchr19

14640523

+GIPC1chr19

14593818

-
5CDS-5UTRENST00000215567ENST00000393033TECRchr19

14640523

+GIPC1chr19

14593818

-
5CDS-intronENST00000215567ENST00000591349TECRchr19

14640523

+GIPC1chr19

14593818

-
5CDS-5UTRENST00000215567ENST00000586027TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000596073ENST00000393029TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000596073ENST00000393028TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000596073ENST00000345425TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000596073ENST00000393033TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000596073ENST00000591349TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000596073ENST00000586027TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000600083ENST00000393029TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000600083ENST00000393028TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000600083ENST00000345425TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000600083ENST00000393033TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000600083ENST00000591349TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000600083ENST00000586027TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000436007ENST00000393029TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000436007ENST00000393028TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000436007ENST00000345425TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000436007ENST00000393033TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-intronENST00000436007ENST00000591349TECRchr19

14640523

+GIPC1chr19

14593818

-
5UTR-5UTRENST00000436007ENST00000586027TECRchr19

14640523

+GIPC1chr19

14593818

-
3UTR-intronENST00000596164ENST00000393029TECRchr19

14640523

+GIPC1chr19

14593818

-
3UTR-intronENST00000596164ENST00000393028TECRchr19

14640523

+GIPC1chr19

14593818

-
3UTR-5UTRENST00000596164ENST00000345425TECRchr19

14640523

+GIPC1chr19

14593818

-
3UTR-5UTRENST00000596164ENST00000393033TECRchr19

14640523

+GIPC1chr19

14593818

-
3UTR-intronENST00000596164ENST00000591349TECRchr19

14640523

+GIPC1chr19

14593818

-
3UTR-5UTRENST00000596164ENST00000586027TECRchr19

14640523

+GIPC1chr19

14593818

-

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FusionProtFeatures for TECR_GIPC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TECR

Q9NZ01

GIPC1

O14908

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to thechain of long- and very long-chain fatty acids/VLCFAs per cycle.This enzyme reduces the trans-2,3-enoyl-CoA fatty acidintermediate to an acyl-CoA that can be further elongated byentering a new cycle of elongation. Thereby, it participates inthe production of VLCFAs of different chain lengths that areinvolved in multiple biological processes as precursors ofmembrane lipids and lipid mediators.{ECO:0000269|PubMed:12482854}. May be involved in G protein-linked signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TECR_GIPC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TECR_GIPC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TECRCUL3, CAND1, NOS3, PAXIP1, RPN1, RHOT2, MOGS, DSP, ESR1, UBL4A, CLN3, EGFR, ELOVL1, CERS2, DYRK4, HIPK4, MAPK4, DYRK1B, HECW2, ILK, PTPLB, CUL7, RNF2, ARAF, ABCE1, NTRK1, ACADM, ATP5C1, CANX, CCT6A, CISD1, CLTC, DDOST, DDX39B, EHD1, GORASP2, HSD17B12, HSPA8, JAGN1, RAB1A, RAB1B, SCAMP3, SEC61A1, SGPL1, SLC25A3, SSR1, SSR4, ATP1A1, MAGT1, NDUFS1, VDAC3, TOMM22, UQCRC2, VDAC1, VDAC2, TCTN2, CREB3, XRCC3, MBOAT1, DPF3, COX15, DLST, SOAT1, RNF157GIPC1ADRB1, MYO6, SH3BP4, GEMIN4, NUP93, MCM7, MARS, MMS19, TAGLN, PDXDC1, MYO1C, LHCGR, DRD3, LRP2, LRP1, LRP8, TPBG, ITGA6, ITGA5, SDC4, KIF1B, SLC2A1, ACTN1, TYRP1, NTRK1, NTRK2, RGS19, GSK3B, CDV3, CD93, ZNF408, HECW2, DDIT3, GGA1, GNAS, OGT, TSTA3, EWSR1, CDH1, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TECR_GIPC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TECR_GIPC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTECRC3151462MENTAL RETARDATION, AUTOSOMAL RECESSIVE 141UNIPROT