FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37664

FusionGeneSummary for TDRD7_PRR16

check button Fusion gene summary
Fusion gene informationFusion gene name: TDRD7_PRR16
Fusion gene ID: 37664
HgeneTgene
Gene symbol

TDRD7

PRR16

Gene ID

23424

51334

Gene nametudor domain containing 7proline rich 16
SynonymsCATC4|PCTAIRE2BP|TRAPDSC54|LARGEN
Cytomap

9q22.33

5q23.1

Type of geneprotein-codingprotein-coding
Descriptiontudor domain-containing protein 7PCTAIRE2-binding proteintudor repeat associator with PCTAIRE 2protein Largenmesenchymal stem cell protein DSC54proline-rich protein 16
Modification date2018051920180519
UniProtAcc

Q8NHU6

Q569H4

Ensembl transtripts involved in fusion geneENST00000355295, ENST00000422139, 
ENST00000540902, ENST00000492428, 
ENST00000407149, ENST00000379551, 
ENST00000505123, ENST00000446965, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 2 X 4=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TDRD7 [Title/Abstract] AND PRR16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRR16

GO:0045727

positive regulation of translation

24656129

TgenePRR16

GO:0045793

positive regulation of cell size

24656129


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG117378TDRD7chr9

100255175

-PRR16chr5

120022337

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000355295ENST00000407149TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000355295ENST00000379551TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000355295ENST00000505123TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000355295ENST00000446965TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000422139ENST00000407149TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000422139ENST00000379551TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000422139ENST00000505123TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000422139ENST00000446965TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000540902ENST00000407149TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000540902ENST00000379551TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000540902ENST00000505123TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000540902ENST00000446965TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000492428ENST00000407149TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000492428ENST00000379551TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000492428ENST00000505123TDRD7chr9

100255175

-PRR16chr5

120022337

+
intron-3CDSENST00000492428ENST00000446965TDRD7chr9

100255175

-PRR16chr5

120022337

+

Top

FusionProtFeatures for TDRD7_PRR16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TDRD7

Q8NHU6

PRR16

Q569H4

Regulator of cell size that promotes cell size increaseindependently of mTOR and Hippo signaling pathways. Acts bystimulating the translation of specific mRNAs, including thoseencoding proteins affecting mitochondrial functions. Increasesmitochondrial mass and respiration. {ECO:0000269|PubMed:24656129}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TDRD7_PRR16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TDRD7_PRR16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TDRD7_PRR16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TDRD7_PRR16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTDRD7C0017601Glaucoma1CTD_human
HgeneTDRD7C0021364Male infertility1CTD_human
HgeneTDRD7C0021400Influenza1CTD_human
HgeneTDRD7C0086543Cataract1CTD_human;HPO