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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37657

FusionGeneSummary for TDRD3_CUL4A

check button Fusion gene summary
Fusion gene informationFusion gene name: TDRD3_CUL4A
Fusion gene ID: 37657
HgeneTgene
Gene symbol

TDRD3

CUL4A

Gene ID

81550

8451

Gene nametudor domain containing 3cullin 4A
Synonyms--
Cytomap

13q21.2

13q34

Type of geneprotein-codingprotein-coding
Descriptiontudor domain-containing protein 3cullin-4ACUL-4A
Modification date2018052220180523
UniProtAcc

Q9H7E2

Q13619

Ensembl transtripts involved in fusion geneENST00000196169, ENST00000377894, 
ENST00000535286, ENST00000377881, 
ENST00000463109, 
ENST00000375441, 
ENST00000451881, ENST00000326335, 
ENST00000375440, ENST00000463426, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 7 X 5=175
# samples 78
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TDRD3 [Title/Abstract] AND CUL4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A5GR-06ATDRD3chr13

60971539

+CUL4Achr13

113907396

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000196169ENST00000375441TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000196169ENST00000451881TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000196169ENST00000326335TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000196169ENST00000375440TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-intronENST00000196169ENST00000463426TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000377894ENST00000375441TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000377894ENST00000451881TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000377894ENST00000326335TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000377894ENST00000375440TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-intronENST00000377894ENST00000463426TDRD3chr13

60971539

+CUL4Achr13

113907396

+
Frame-shitENST00000535286ENST00000375441TDRD3chr13

60971539

+CUL4Achr13

113907396

+
Frame-shitENST00000535286ENST00000451881TDRD3chr13

60971539

+CUL4Achr13

113907396

+
Frame-shitENST00000535286ENST00000326335TDRD3chr13

60971539

+CUL4Achr13

113907396

+
Frame-shitENST00000535286ENST00000375440TDRD3chr13

60971539

+CUL4Achr13

113907396

+
5CDS-intronENST00000535286ENST00000463426TDRD3chr13

60971539

+CUL4Achr13

113907396

+
5UTR-3CDSENST00000377881ENST00000375441TDRD3chr13

60971539

+CUL4Achr13

113907396

+
5UTR-3CDSENST00000377881ENST00000451881TDRD3chr13

60971539

+CUL4Achr13

113907396

+
5UTR-3CDSENST00000377881ENST00000326335TDRD3chr13

60971539

+CUL4Achr13

113907396

+
5UTR-3CDSENST00000377881ENST00000375440TDRD3chr13

60971539

+CUL4Achr13

113907396

+
5UTR-intronENST00000377881ENST00000463426TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000463109ENST00000375441TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000463109ENST00000451881TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000463109ENST00000326335TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-3CDSENST00000463109ENST00000375440TDRD3chr13

60971539

+CUL4Achr13

113907396

+
intron-intronENST00000463109ENST00000463426TDRD3chr13

60971539

+CUL4Achr13

113907396

+

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FusionProtFeatures for TDRD3_CUL4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TDRD3

Q9H7E2

CUL4A

Q13619

Scaffolding protein that specifically recognizes andbinds dimethylarginine-containing proteins. In nucleus, acts as acoactivator: recognizes and binds asymmetric dimethylation on thecore histone tails associated with transcriptional activation(H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assemblyand/or disassembly of mRNA stress granules and in the regulationof translation of target mRNAs by binding Arg/Gly-rich motifs(GAR) in dimethylarginine-containing proteins.{ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687,ECO:0000269|PubMed:21172665}. Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TDRD3_CUL4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TDRD3_CUL4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TDRD3HIST3H3, FMR1, FXR1, FXR2, RPL28, RPS6, EWSR1, DDX3X, EEF1A1, FUS, SERBP1, WWOX, KCTD2, FAM96A, FAM96B, PABPC1, MAGOH, RBM8A, DHX15, SND1, TOP3B, CC2D2A, NINL, DCTN1, LCA5, POC1A, THOC1, RNPS1, FIGNL1, POLR2A, USP9X, CDC14ACUL4ARNF7, DET1, RFWD2, CAND1, RBX1, HSPA1A, HSP90AA1, NEDD8, TUBA1B, CDKN1A, DDB1, DDB2, CUL4B, FBXW5, NF2, SAP130, CDKN1B, COPS5, COPS6, PTGS2, UBC, PCNA, TRPC4AP, DDA1, CRBN, COPS3, COPS4, COPS2, COPS8, COPS7B, COPS7A, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, SKP2, TOR1AIP2, BANF1, EMD, DTL, WDR26, GRWD1, RBBP5, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR82, WDR5, TLE2, EED, HIST1H3A, CDT1, CHEK1, COMMD1, DNMT3B, VPRBP, UBXN7, MYC, KAT2A, RASSF1, RAG1, SALL2, RAD21, HOXA9, HOXB4, GPS1, GLMN, MCM10, NACC1, CTNNB1, TP53, MDM2, CUL1, RBBP7, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, ERCC8, CUL4A, DCUN1D1, AK9, DCST1, DCAF8, AMBRA1, DCAF12L2, DCAF16, CUL5, DCAF4L1, IGF2BP1, IGHV3OR15-7, MYEOV2, ANAPC5, CDY2B, CDY2A, OTULIN, LOC285556, NXPH3, RGS12, SCAF11, SH3RF2, SLA, TCHP, USP7, MAP4, ABCA10, XXYLT1, SYNM, ZNF407, ZNF525, CSRP2BP, RPL26, SLC25A22, SFXN1, HSPA8, TFG, CUL3, KRT10, DCAF7, CA2, KLHL9, KRT1, TUBA4B, FUS, HSPA1B, KRT9, TUBB4B, HSP90B1, PSMC6, SKP1, TUBA4A, EWSR1, H2AFV, HAX1, HNRNPA2B1, HNRNPUL1, HSPA1L, IARS, KRT2, KRT24, PCBD1, SNRPD1, TUBA1C, TUBB1, HNRNPH1, HNRNPH3, HSPA5, LGALS3BP, NCL, PABPC1, PPP2R1A, SNRPA, SNRPB, CCT5, DNAJC10, EEF1A1, EEF1A2, ENO1, HNRNPAB, HNRNPF, HNRNPDL, HSPA7, HSPA9, KRT76, PRDX1, QPCT, RPL15, RPL7A, RPLP2, RPS2, SRSF3, SLC25A5, SLC25A6, SSBP1, TAF15, TUBB, BAG4, C1QBP, DDX21, DDX5, DHX15, DHX9, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HNRNPD, HSP90AB1, HSPD1, KRT75, NFKB1, NPM1, PABPC4, RPL10A, RPL11, RPL19, RPL22, RPL23A, RPL38, RPL4, RPL7AP27, RPLP1, RPS14, RPS15A, RPS18, RPS20, RPS3, SDHA, SNRNP70, SNRPD3, SNRPE, TIA1, TIAL1, CSN1S1, MYB, LRWD1, ERCC6, UBE2E3, GRK5, SENP8, DCAF15, SUGT1, CHEK2, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DDIT4, SF3B3, DICER1, DLC1, CAST, PRMT5, ASB4, HIST1H1C, DAB2IP, DCAF17, IP6K1, HIST1H1A, VCP, ARIH1, ABCE1, CLCN1, DCAF4L2, C9orf41, MRPS11, CCNG1, TUBG1, SAMHD1, UNK, MTM1, IFI16, CENPA, HIST1H2BG, PYGO2, GNB2, GNB1, GNB3, GNB4, GNB5, MCM2, DPPA4, NANOG, POU5F1, UVRAG, SLBP, FKBP8, IKZF3, ATP6V0D1, TMCO3, CRYBA4, TRIM16, TRIM25, LATS1, TWIST1, TES, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TDRD3_CUL4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TDRD3_CUL4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCUL4AC0038325Stevens-Johnson Syndrome1CTD_human