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Fusion gene ID: 37654 |
FusionGeneSummary for TDP2_DCDC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TDP2_DCDC2 | Fusion gene ID: 37654 | Hgene | Tgene | Gene symbol | TDP2 | DCDC2 | Gene ID | 51567 | 51473 |
| Gene name | tyrosyl-DNA phosphodiesterase 2 | doublecortin domain containing 2 | |
| Synonyms | AD022|EAP2|EAPII|TTRAP|dJ30M3.3|hTDP2 | DCDC2A|DFNB66|NPHP19|NSC|RU2|RU2S | |
| Cytomap | 6p22.3 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosyl-DNA phosphodiesterase 25'-Tyr-DNA phosphodiesterase5'-tyrosyl-DNA phosphodiesteraseETS1-associated protein 2ETS1-associated protein IITRAF and TNF receptor-associated proteinVPg unlinkasetyr-DNA phosphodiesterase 2tyrosyl-RNA phosphodieste | doublecortin domain-containing protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95551 | Q9UHG0 | |
| Ensembl transtripts involved in fusion gene | ENST00000378198, ENST00000545995, ENST00000341060, ENST00000478285, | ENST00000378454, ENST00000378450, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 5 X 8=360 |
| # samples | 2 | 11 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TDP2 [Title/Abstract] AND DCDC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TDP2 | GO:0006302 | double-strand break repair | 19794497 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-HZ-A77P-01A | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378198 | ENST00000378454 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| 5CDS-intron | ENST00000378198 | ENST00000378450 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| In-frame | ENST00000545995 | ENST00000378454 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| 5CDS-intron | ENST00000545995 | ENST00000378450 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| In-frame | ENST00000341060 | ENST00000378454 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| 5CDS-intron | ENST00000341060 | ENST00000378450 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| intron-3CDS | ENST00000478285 | ENST00000378454 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
| intron-intron | ENST00000478285 | ENST00000378450 | TDP2 | chr6 | 24653211 | - | DCDC2 | chr6 | 24302272 | - |
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FusionProtFeatures for TDP2_DCDC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TDP2 | DCDC2 |
| DNA repair enzyme that can remove a variety of covalentadducts from DNA through hydrolysis of a 5'-phosphodiester bond,giving rise to DNA with a free 5' phosphate. Catalyzes thehydrolysis of dead-end complexes between DNA and the topoisomerase2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNAphosphodiesterase activity can enable the repair of TOP2-inducedDNA double-strand breaks/DSBs without the need for nucleaseactivity, creating a 'clean' DSB with 5'-phosphate termini thatare ready for ligation. Thereby, protects the transcription ofmany genes involved in neurological development and maintenancefrom the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damageby radiation and free radicals. Has preference for single-strandedDNA or duplex DNA with a 4 base pair overhang as substrate. Actsas a regulator of ribosome biogenesis following stress. Has also3'-tyrosyl DNA phosphodiesterase activity, but less efficientlyand much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter byparticipating in the specific activation of MAP3K7/TAK1 inresponse to TGF-beta: associates with components of the TGF-betareceptor-TRAF6-TAK1 signaling module and promotes theirubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as anegative regulator of ETS1 and may inhibit NF-kappa-B activation.{ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584,ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489,ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062,ECO:0000269|PubMed:24658003}. (Microbial infection) Also acts as a 5'-tyrosyl-RNAphosphodiesterase following picornavirus infection: its activityis hijacked by picornavirus and acts by specifically cleaving theprotein-RNA covalent linkage generated during the viral genomicRNA replication steps of a picornavirus infection, withoutimpairing the integrity of viral RNA.{ECO:0000269|PubMed:22908287}. | Protein that plays a role in the inhibition of canonicalWnt signaling pathway (PubMed:25557784). May be involved inneuronal migration during development of the cerebral neocortex(By similarity). Involved in the control of ciliogenesis andciliary length (PubMed:25601850, PubMed:27319779).{ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784,ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >DCDC2 | chr6:24653211 | chr6:24302272 | ENST00000378450 | - | 0 | 3 | 139_221 | -7 | 230 | Domain | Doublecortin 2 |
| Tgene | >DCDC2 | chr6:24653211 | chr6:24302272 | ENST00000378450 | - | 0 | 3 | 17_100 | -7 | 230 | Domain | Doublecortin 1 |
| Tgene | >DCDC2 | chr6:24653211 | chr6:24302272 | ENST00000378454 | - | 1 | 10 | 139_221 | 116 | 477 | Domain | Doublecortin 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DCDC2 | chr6:24653211 | chr6:24302272 | ENST00000378454 | - | 1 | 10 | 17_100 | 116 | 477 | Domain | Doublecortin 1 |
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FusionGeneSequence for TDP2_DCDC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TDP2_ENST00000378198_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_630aa MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNE ETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREV KPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFY VAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKL KNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQ VEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVAX >In-frame_TDP2_ENST00000545995_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_660aa MRERHDTGACAEPRVGLLFRLKGRCRGGRKMELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFL QEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ LKMVLKKMQEAPESATVIFAGDTNLRDREVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKI TLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSD NSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKAN KDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDP >In-frame_TDP2_ENST00000341060_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_572aa MATWKSPCFLYCLFILGPRLTGQNNSVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVI FLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERM NQLKMVLKKMQEAPESATVIFAGDTNLRDREVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTE KITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGS SDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK ANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TDP2_ENST00000378198_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_1890nt ATGGAGTTGGGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCTGAGGTGAAAAAGCGGCGACTTCTGTGTGTG GAGTTTGCCTCGGTCGCAAGCTGCGATGCCGCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAAAGGGCTCTGAACTCC TACTTCGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTATGTTGACCTAACCAATGAA GAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAAT ATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTA CAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACA GCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGT GTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAG TTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTA AAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGA GACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATC ACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTAT GTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAA GCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGAC AACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTA AAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTC CAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAAC AAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAA GTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAG CAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCT CAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAG >In-frame_TDP2_ENST00000545995_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_1980nt ATGCGGGAGCGCCATGACACAGGCGCCTGCGCAGAGCCGCGCGTTGGCCTCCTGTTCCGCTTAAAGGGGCGGTGCAGAGGCGGCAGGAAG ATGGAGTTGGGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCTGAGGTGAAAAAGCGGCGACTTCTGTGTGTG GAGTTTGCCTCGGTCGCAAGCTGCGATGCCGCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAAAGGGCTCTGAACTCC TACTTCGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTATGTTGACCTAACCAATGAA GAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAAT ATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTA CAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACA GCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGT GTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAG TTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTA AAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGA GACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATC ACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTAT GTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAA GCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGAC AACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTA AAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTC CAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAAC AAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAA GTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAG CAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCT CAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAG >In-frame_TDP2_ENST00000341060_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_1716nt ATGGCAACTTGGAAGTCTCCTTGCTTCCTGTATTGTTTATTTATTCTAGGCCCTAGGCTGACCGGCCAGAATAACAGTGTTGACCTAACC AATGAAGAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACC TGGAATATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATA TTTCTACAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATAT TTCACAGCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTT TTATGTGTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATG AATCAGTTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGA GAGGTAAAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCA AATGGAGACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAA AAAATCACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAG TTTTATGTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGT CAGAAAGCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCC AGTGACAACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTA AAATTAAAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCA GAAGTCCAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAG GCAAACAAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCT GAGCAAGTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAG CTGCAGCAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTA GACCCTCAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TDP2_ENST00000378198_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_5035nt GCACCCACCGCCCCGGCGGCTCCCTTGCGGCGCAGCTGCACCAGTTTTCCGAGAGCAGCGCATTTCCCCGCCGGGCGGTTGATGCGGGAG CGCCATGACACAGGCGCCTGCGCAGAGCCGCGCGTTGGCCTCCTGTTCCGCTTAAAGGGGCGGTGCAGAGGCGGCAGGAAGATGGAGTTG GGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCTGAGGTGAAAAAGCGGCGACTTCTGTGTGTGGAGTTTGCC TCGGTCGCAAGCTGCGATGCCGCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAAAGGGCTCTGAACTCCTACTTCGAG CCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTATGTTGACCTAACCAATGAAGAAACAACT GATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAATATTGATGGA TTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTACAGGAAGTT ATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACAGCTATAATG TTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGTGTGCATGTG AACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAGTTAAAAATG GTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTAAAACCAGTA ATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGAGACCTCATA AACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATCACTCTGAGG AGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTATGTGGCTGTT GGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAAGCTTCTTCA CTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGACAACTCATCT CCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTAAAGAATTCA CAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTCCAAGAAGAT GAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAACAAGGATGCA GAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAAGTCGAGGAG ATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAGCAGGTTAAT AATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCTCAAAGACCA CCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAGAACATTTTT AAAAAGAGAGTATATGGATCGCAAGAAAAATGAAGGGTTATCATACTTGAAAGATAAGCACATAGTTATTGCTGAATATAATGTGACACT ATGGTCGAATACTACCTACGAATTATAACATTAGAAGCCTAGTGGAAAGACCAGATAACTTTAAATGGCTACTAAAGGATAATTACTTAC TTTTATTGCATGTGTTTTAAAAGTCATATAGAAATATTAAATAAGACGGACAGAGGAGAATTTGCACTGGAAGACAATTGCCACTTGTAA AGGATGAAAAATAGGATCACTCTTATTGTACGCTTTATTATAAGTTTAGAAGGCAGTTTATTCTAAATAATTTTTCTCTAGGAAGGCGTA GAATTTTAAAGAACTGGTAATAGGAAAGCATGTACTATTTTCTTAAAGCAATAAACTCTTGAATGAACAGATTGCGATTTACTTTCAGAC ATAATTTGGAGATGGCAGTAGATCAAAATGTGTCCATGACTTGTTAACATGCCTTTCTTTCTTCCTCCTTAGCCAAAATCCACCTTTGAA CTACAAAGACAGAGCAAGGCGTTCATTTTGGTGGGAGGAAGCATTGGTTCAGAGTGTTAGTGACTAGTATCGCCATGCCGTCACTTAAAT GCTTTCAGGCTTGCATGCTTGTGGCTCCAATGGCGCACACTCAGGAAGGAATTGTAAAGGAGCACCCAGTTATATTATAAAGCCTGGATG TATGGTTTGCAGATAATGGAAATCCTGTGGATTTTCACTGATCCAGTCTATCTTTACCAATAGTATCTCTCTCTTCTCCCTTATGTTATT AGAGAACCTGATATTGGCTATTCCAAAGATTAAATTATTTTCAAATAGTTTTCAACAAAAATAAAAGTGTATTAGGAAGAAAAAAGTAGA CTATATGAAGAGTTTGTGACTGCTCAATTTAACTTGTTTTTTGCCTTATTTCTATTAAGACTGTTTTACTATGTTTTTGCCCTAGGGATA TCAGCAAATATTTATTTTTCCTAGCATGATATAGTTAGAATTTCAAGCAGATTTCTTTGTAATTAGAAGGCATCTGATAGAAATTGTAAA ACTTTAGAAGTTATTATAATGAAACCAATTCCTGAATCACAACTTCATGGACTGACTAAATTGATTTATAGTTGCCTTGTGAGGTATGTA TGGGGAAAACATAAAAACATAATTAAAACATAATTTCGTCCTTTTTATGAATTCTTAAGAGATGTTCTTCCATAAATATAGAAATAATAT ATTTTTCTTAAAGGATATATTTTTAATTATGTGGAAGTTGTAAGCTTGAAATTTTAACTTCTAGTGCTTTTCTAAAATTCACAATTACAA GTTTAAAACATTTTTTCTCTTCCAGGTTTCATTTGGAATAAAGAGTTGGCAGTTATATAAAGCACTTAATAATACTATAGAAAATAGATG TGTTTTTTCTTAATATGATTTTGGTATTTTCCACAGATCAGAAGTGTAAACAGAGAGATAATGTAACAGTATTTGGAAGAGATAATGACA CAAGGATATAGTGATCTGGGAGCATGAATTAGAAACAGGGTACTATGTTTCTGGTGTAAAATCTAAATTGTGCTTTCTACTAGCGTTACT TTTTCAAATGGGATGATATAAAGCACTGTGGGCTATAAGCAACAATCTTGGGTTGGTAGGCAAATAGACCAATTGATCTTTATTATTATT ATTATTATTATTATTATTATTTTTTGAGATGAAGTCTTGCTCTTGTCGCCCAGGCTGGGTGCAGTGGCATGATCTTGGCTTACTGCAACC TCTGCCTCCTGGGTTCAAGCACCTGAGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCCACCACACCTGGCTAATTTTTGTATTTTTTG TAGAGACAGATGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTTTGCATCCCAAAATGCTGGG ATTACAGGTGTGAGCCACAGCACCCGGTCCCAGTTGGTCTTTTAATATTAAATTTGTGCACTATTACTGGGTCTGGAGTTAATGATTTCA AATAGTTTCTAAAAATAACTGATTAAATGTAAGAAATTATAACTAATTATCAAGGTGATTCTCTTTTGTTTCTTCAATGGAGAGTTTCTC TTTCTCTTTTCCTCCTCTAATAAAAATATTTCTTTTTTTCCTGTCCTTTTATTCATTATATTATGAAACTTAGGTTTTAGGAAACACCTT AAGCGTCATTTTAATGAAGCACAACATTGATATTTTACATGAATAATAACGTTTGGTATTTTAAATATACTTCAAGGGGGTAATAAGCCA CAATAACTGTACCAAAAAAACTTAAAAATGGGGACATATTCATCCCTTGTGTGTGCATATTTTACCACTTGTTGACAAGATACAATTGTG ACCTACTTTGAGGGGATGAATAACGACTTATCACTTTAAGACACTTTGCAAACATGTTACTAAAAAAAGGTGCCTAGCCAAGGAAAAAAC CATTCACTTGGAATTAAAATTGTGGATGTCACTTCAGAGATGACTTTAACATAAATGCTGAAAGTTCATTCACCTCACAAATGTGGCAGT TTTCTCTGTGGAGAATGGTGGTCTCCGTGGCAGACTGGCTCTCCAAATTAAATGAAACTCATTGACAGACCTGGGACCTTTTATGTGAGT GGACAGACAAGATCTTGGTTTGGCTTCATGTACTGTTTTCTAGAGAGAGTGCTACGAAAAACTTATGATGCTTTTATGTGATAACCAATA TAATGCTTTAATATGTTAATTCTTTGTGATGCTATATACATAGTTTTTATAGTTTTATGAAACCACTTTGTTAAACTTATCTGGATTTTA >In-frame_TDP2_ENST00000545995_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_4954nt ATGCGGGAGCGCCATGACACAGGCGCCTGCGCAGAGCCGCGCGTTGGCCTCCTGTTCCGCTTAAAGGGGCGGTGCAGAGGCGGCAGGAAG ATGGAGTTGGGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCTGAGGTGAAAAAGCGGCGACTTCTGTGTGTG GAGTTTGCCTCGGTCGCAAGCTGCGATGCCGCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAAAGGGCTCTGAACTCC TACTTCGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTATGTTGACCTAACCAATGAA GAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAAT ATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTA CAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGTAATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACA GCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGT GTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAG TTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTA AAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGA GACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATC ACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTAT GTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAA GCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGTGGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGAC AACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTA AAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTC CAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAAC AAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAA GTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAG CAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCT CAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAG AACATTTTTAAAAAGAGAGTATATGGATCGCAAGAAAAATGAAGGGTTATCATACTTGAAAGATAAGCACATAGTTATTGCTGAATATAA TGTGACACTATGGTCGAATACTACCTACGAATTATAACATTAGAAGCCTAGTGGAAAGACCAGATAACTTTAAATGGCTACTAAAGGATA ATTACTTACTTTTATTGCATGTGTTTTAAAAGTCATATAGAAATATTAAATAAGACGGACAGAGGAGAATTTGCACTGGAAGACAATTGC CACTTGTAAAGGATGAAAAATAGGATCACTCTTATTGTACGCTTTATTATAAGTTTAGAAGGCAGTTTATTCTAAATAATTTTTCTCTAG GAAGGCGTAGAATTTTAAAGAACTGGTAATAGGAAAGCATGTACTATTTTCTTAAAGCAATAAACTCTTGAATGAACAGATTGCGATTTA CTTTCAGACATAATTTGGAGATGGCAGTAGATCAAAATGTGTCCATGACTTGTTAACATGCCTTTCTTTCTTCCTCCTTAGCCAAAATCC ACCTTTGAACTACAAAGACAGAGCAAGGCGTTCATTTTGGTGGGAGGAAGCATTGGTTCAGAGTGTTAGTGACTAGTATCGCCATGCCGT CACTTAAATGCTTTCAGGCTTGCATGCTTGTGGCTCCAATGGCGCACACTCAGGAAGGAATTGTAAAGGAGCACCCAGTTATATTATAAA GCCTGGATGTATGGTTTGCAGATAATGGAAATCCTGTGGATTTTCACTGATCCAGTCTATCTTTACCAATAGTATCTCTCTCTTCTCCCT TATGTTATTAGAGAACCTGATATTGGCTATTCCAAAGATTAAATTATTTTCAAATAGTTTTCAACAAAAATAAAAGTGTATTAGGAAGAA AAAAGTAGACTATATGAAGAGTTTGTGACTGCTCAATTTAACTTGTTTTTTGCCTTATTTCTATTAAGACTGTTTTACTATGTTTTTGCC CTAGGGATATCAGCAAATATTTATTTTTCCTAGCATGATATAGTTAGAATTTCAAGCAGATTTCTTTGTAATTAGAAGGCATCTGATAGA AATTGTAAAACTTTAGAAGTTATTATAATGAAACCAATTCCTGAATCACAACTTCATGGACTGACTAAATTGATTTATAGTTGCCTTGTG AGGTATGTATGGGGAAAACATAAAAACATAATTAAAACATAATTTCGTCCTTTTTATGAATTCTTAAGAGATGTTCTTCCATAAATATAG AAATAATATATTTTTCTTAAAGGATATATTTTTAATTATGTGGAAGTTGTAAGCTTGAAATTTTAACTTCTAGTGCTTTTCTAAAATTCA CAATTACAAGTTTAAAACATTTTTTCTCTTCCAGGTTTCATTTGGAATAAAGAGTTGGCAGTTATATAAAGCACTTAATAATACTATAGA AAATAGATGTGTTTTTTCTTAATATGATTTTGGTATTTTCCACAGATCAGAAGTGTAAACAGAGAGATAATGTAACAGTATTTGGAAGAG ATAATGACACAAGGATATAGTGATCTGGGAGCATGAATTAGAAACAGGGTACTATGTTTCTGGTGTAAAATCTAAATTGTGCTTTCTACT AGCGTTACTTTTTCAAATGGGATGATATAAAGCACTGTGGGCTATAAGCAACAATCTTGGGTTGGTAGGCAAATAGACCAATTGATCTTT ATTATTATTATTATTATTATTATTATTATTTTTTGAGATGAAGTCTTGCTCTTGTCGCCCAGGCTGGGTGCAGTGGCATGATCTTGGCTT ACTGCAACCTCTGCCTCCTGGGTTCAAGCACCTGAGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCCACCACACCTGGCTAATTTTTG TATTTTTTGTAGAGACAGATGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTTTGCATCCCAA AATGCTGGGATTACAGGTGTGAGCCACAGCACCCGGTCCCAGTTGGTCTTTTAATATTAAATTTGTGCACTATTACTGGGTCTGGAGTTA ATGATTTCAAATAGTTTCTAAAAATAACTGATTAAATGTAAGAAATTATAACTAATTATCAAGGTGATTCTCTTTTGTTTCTTCAATGGA GAGTTTCTCTTTCTCTTTTCCTCCTCTAATAAAAATATTTCTTTTTTTCCTGTCCTTTTATTCATTATATTATGAAACTTAGGTTTTAGG AAACACCTTAAGCGTCATTTTAATGAAGCACAACATTGATATTTTACATGAATAATAACGTTTGGTATTTTAAATATACTTCAAGGGGGT AATAAGCCACAATAACTGTACCAAAAAAACTTAAAAATGGGGACATATTCATCCCTTGTGTGTGCATATTTTACCACTTGTTGACAAGAT ACAATTGTGACCTACTTTGAGGGGATGAATAACGACTTATCACTTTAAGACACTTTGCAAACATGTTACTAAAAAAAGGTGCCTAGCCAA GGAAAAAACCATTCACTTGGAATTAAAATTGTGGATGTCACTTCAGAGATGACTTTAACATAAATGCTGAAAGTTCATTCACCTCACAAA TGTGGCAGTTTTCTCTGTGGAGAATGGTGGTCTCCGTGGCAGACTGGCTCTCCAAATTAAATGAAACTCATTGACAGACCTGGGACCTTT TATGTGAGTGGACAGACAAGATCTTGGTTTGGCTTCATGTACTGTTTTCTAGAGAGAGTGCTACGAAAAACTTATGATGCTTTTATGTGA TAACCAATATAATGCTTTAATATGTTAATTCTTTGTGATGCTATATACATAGTTTTTATAGTTTTATGAAACCACTTTGTTAAACTTATC TGGATTTTAAGACACTTGTAAACAAATGGTTTGTTAGTAAAATTGGGGCATTAAGAGTTTTACAGAGCAAATAAAGAAGATTTTGACAAA >In-frame_TDP2_ENST00000341060_chr6_24653211_-_DCDC2_ENST00000378454_chr6_24302272_-_5086nt CGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAGCCCAAGACCTAGTAAGTGATGAGGGGAGCGGGAGC CAGTCCGCACGGAGGCAGTTTGATACCAGGTAGCCCTGCGCGTCCTGGGACCTGCCGTGGAGCTGGGCGGACGATGCTGAGGCAGATCTC CAAGCTGCGTAGCCAGAGGAGCAGGGCTTGCGTTGCTGCTGCTGCGCGGAGTTGCGCCCCAGCAGCGGATCTAACACTGCACCAGACTGT CGCTTCGAACGTGATTTGGGGTCCAGGGAGGAAAAGATGGAAATGTAATGTTTAACTCAAATGAAAGGAAATAAGTAAGCGAGAGGTTTG AAACAAATGAACGAAGGCTAAACCTTCTATCGAAAAATGGCAACTTGGAAGTCTCCTTGCTTCCTGTATTGTTTATTTATTCTAGGCCCT AGGCTGACCGGCCAGAATAACAGTGTTGACCTAACCAATGAAGAAACAACTGATTCCACCACTTCTAAAATCAGCCCATCTGAAGATACT CAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAATATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTG TGTTCCTACTTAGCTTTGTACAGCCCAGATGTGATATTTCTACAGGAAGTTATTCCCCCATATTATAGCTACCTAAAGAAGAGATCAAGT AATTATGAGATTATTACAGGTCATGAAGAAGGATATTTCACAGCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATT ATTCCTTTTCCAAGTACCAAAATGATGAGAAACCTTTTATGTGTGCATGTGAACGTGTCAGGAAATGAGCTTTGCCTTATGACATCCCAT TTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAGTTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACA GTTATATTTGCAGGAGATACAAATCTAAGGGATCGAGAGGTAAAACCAGTAATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAA CCGCTTCAGGAGCCGTGCACTATCTTCTTGATTGCAAATGGAGACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGAAAAACCTTG AATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATCACTCTGAGGAGCGGGGCTGTTCACAGGCTTTATACTTTAGAAGGAAAA CTTGTTGAGAGTGGAGCAGAGTTGGAGAATGGGCAGTTTTATGTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTACAGTGAGTTA CTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGGTCAGAAAGCTTCTTCACTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGT GGAAATGATCGCCACTCTAAGTCAACAGTTGGATCCAGTGACAACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAAGAAGACGTG AATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTAAAGAATTCACAAGAAACCATTCCAAATAGTGATGAAGGCATTTTCAAA GCTGGAGCAGAGAGGTCTGAAACACGGGGGGCAGCAGAAGTCCAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGATCAGAGGCCA GCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAACAAGGATGCAGAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTT GAAGAGGAAGGAGGTAGGGAGGCTACAGATGCCCCTGAGCAAGTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGCCCTGCTCGT GTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAGCAGGTTAATAATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCT CAAGGAGCTGGCAGTGGACAAGATGAGGCTGATGTAGACCCTCAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCAGAAGAAAAT GAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAGAACATTTTTAAAAAGAGAGTATATGGATCGCAAGAAAAATGAAGGGTT ATCATACTTGAAAGATAAGCACATAGTTATTGCTGAATATAATGTGACACTATGGTCGAATACTACCTACGAATTATAACATTAGAAGCC TAGTGGAAAGACCAGATAACTTTAAATGGCTACTAAAGGATAATTACTTACTTTTATTGCATGTGTTTTAAAAGTCATATAGAAATATTA AATAAGACGGACAGAGGAGAATTTGCACTGGAAGACAATTGCCACTTGTAAAGGATGAAAAATAGGATCACTCTTATTGTACGCTTTATT ATAAGTTTAGAAGGCAGTTTATTCTAAATAATTTTTCTCTAGGAAGGCGTAGAATTTTAAAGAACTGGTAATAGGAAAGCATGTACTATT TTCTTAAAGCAATAAACTCTTGAATGAACAGATTGCGATTTACTTTCAGACATAATTTGGAGATGGCAGTAGATCAAAATGTGTCCATGA CTTGTTAACATGCCTTTCTTTCTTCCTCCTTAGCCAAAATCCACCTTTGAACTACAAAGACAGAGCAAGGCGTTCATTTTGGTGGGAGGA AGCATTGGTTCAGAGTGTTAGTGACTAGTATCGCCATGCCGTCACTTAAATGCTTTCAGGCTTGCATGCTTGTGGCTCCAATGGCGCACA CTCAGGAAGGAATTGTAAAGGAGCACCCAGTTATATTATAAAGCCTGGATGTATGGTTTGCAGATAATGGAAATCCTGTGGATTTTCACT GATCCAGTCTATCTTTACCAATAGTATCTCTCTCTTCTCCCTTATGTTATTAGAGAACCTGATATTGGCTATTCCAAAGATTAAATTATT TTCAAATAGTTTTCAACAAAAATAAAAGTGTATTAGGAAGAAAAAAGTAGACTATATGAAGAGTTTGTGACTGCTCAATTTAACTTGTTT TTTGCCTTATTTCTATTAAGACTGTTTTACTATGTTTTTGCCCTAGGGATATCAGCAAATATTTATTTTTCCTAGCATGATATAGTTAGA ATTTCAAGCAGATTTCTTTGTAATTAGAAGGCATCTGATAGAAATTGTAAAACTTTAGAAGTTATTATAATGAAACCAATTCCTGAATCA CAACTTCATGGACTGACTAAATTGATTTATAGTTGCCTTGTGAGGTATGTATGGGGAAAACATAAAAACATAATTAAAACATAATTTCGT CCTTTTTATGAATTCTTAAGAGATGTTCTTCCATAAATATAGAAATAATATATTTTTCTTAAAGGATATATTTTTAATTATGTGGAAGTT GTAAGCTTGAAATTTTAACTTCTAGTGCTTTTCTAAAATTCACAATTACAAGTTTAAAACATTTTTTCTCTTCCAGGTTTCATTTGGAAT AAAGAGTTGGCAGTTATATAAAGCACTTAATAATACTATAGAAAATAGATGTGTTTTTTCTTAATATGATTTTGGTATTTTCCACAGATC AGAAGTGTAAACAGAGAGATAATGTAACAGTATTTGGAAGAGATAATGACACAAGGATATAGTGATCTGGGAGCATGAATTAGAAACAGG GTACTATGTTTCTGGTGTAAAATCTAAATTGTGCTTTCTACTAGCGTTACTTTTTCAAATGGGATGATATAAAGCACTGTGGGCTATAAG CAACAATCTTGGGTTGGTAGGCAAATAGACCAATTGATCTTTATTATTATTATTATTATTATTATTATTATTTTTTGAGATGAAGTCTTG CTCTTGTCGCCCAGGCTGGGTGCAGTGGCATGATCTTGGCTTACTGCAACCTCTGCCTCCTGGGTTCAAGCACCTGAGCCTCCCGAGTAG CTGGGATTACAGGCATCTGCCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGACAGATGTTTCACCATGTTGGCCAGGCTGGTCTC AAACTCCTGACCTCAGGTGATCCGCCCGCCTTTGCATCCCAAAATGCTGGGATTACAGGTGTGAGCCACAGCACCCGGTCCCAGTTGGTC TTTTAATATTAAATTTGTGCACTATTACTGGGTCTGGAGTTAATGATTTCAAATAGTTTCTAAAAATAACTGATTAAATGTAAGAAATTA TAACTAATTATCAAGGTGATTCTCTTTTGTTTCTTCAATGGAGAGTTTCTCTTTCTCTTTTCCTCCTCTAATAAAAATATTTCTTTTTTT CCTGTCCTTTTATTCATTATATTATGAAACTTAGGTTTTAGGAAACACCTTAAGCGTCATTTTAATGAAGCACAACATTGATATTTTACA TGAATAATAACGTTTGGTATTTTAAATATACTTCAAGGGGGTAATAAGCCACAATAACTGTACCAAAAAAACTTAAAAATGGGGACATAT TCATCCCTTGTGTGTGCATATTTTACCACTTGTTGACAAGATACAATTGTGACCTACTTTGAGGGGATGAATAACGACTTATCACTTTAA GACACTTTGCAAACATGTTACTAAAAAAAGGTGCCTAGCCAAGGAAAAAACCATTCACTTGGAATTAAAATTGTGGATGTCACTTCAGAG ATGACTTTAACATAAATGCTGAAAGTTCATTCACCTCACAAATGTGGCAGTTTTCTCTGTGGAGAATGGTGGTCTCCGTGGCAGACTGGC TCTCCAAATTAAATGAAACTCATTGACAGACCTGGGACCTTTTATGTGAGTGGACAGACAAGATCTTGGTTTGGCTTCATGTACTGTTTT CTAGAGAGAGTGCTACGAAAAACTTATGATGCTTTTATGTGATAACCAATATAATGCTTTAATATGTTAATTCTTTGTGATGCTATATAC ATAGTTTTTATAGTTTTATGAAACCACTTTGTTAAACTTATCTGGATTTTAAGACACTTGTAAACAAATGGTTTGTTAGTAAAATTGGGG |
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FusionGenePPI for TDP2_DCDC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TDP2 | UBE2I, SUMO1, ETS1, TNFRSF1B, TNFRSF8, CD40, TRAF2, TRAF3, TRAF5, TRAF6, MAPK6, PARK7, ATXN1, SKIL, JAM2, ATP5G2, TAP1, DLX3, EPS8, SMAD3, PSEN1, RAB11A, AKAP9, SNX13, C2orf88, SUMO2, SUMO3, SRPK2, AZIN1, TCEAL1, OTUB1, PLA2G10, LYPD4, GORASP1, RSBN1, WBP2 | DCDC2 | APP, NIF3L1, MRFAP1, DCTN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TDP2_DCDC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TDP2_DCDC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DCDC2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | DCDC2 | C1857750 | DEAFNESS, AUTOSOMAL RECESSIVE 66 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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