![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 37653 |
FusionGeneSummary for TDO2_GZMB |
![]() |
Fusion gene information | Fusion gene name: TDO2_GZMB | Fusion gene ID: 37653 | Hgene | Tgene | Gene symbol | TDO2 | GZMB | Gene ID | 6999 | 3002 |
Gene name | tryptophan 2,3-dioxygenase | granzyme B | |
Synonyms | HYPTRP|TDO|TO|TPH2|TRPO | C11|CCPI|CGL-1|CGL1|CSP-B|CSPB|CTLA1|CTSGL1|HLP|SECT | |
Cytomap | 4q32.1 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | tryptophan 2,3-dioxygenasetryptamin 2,3-dioxygenasetryptophan oxygenasetryptophan pyrrolasetryptophanase | granzyme BT-cell serine protease 1-3Ecathepsin G-like 1cytotoxic T-lymphocyte proteinase 2cytotoxic serine protease Bfragmentin 2granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)human lymphocyte protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P48775 | P10144 | |
Ensembl transtripts involved in fusion gene | ENST00000506181, ENST00000536354, | ENST00000415355, ENST00000216341, ENST00000382540, ENST00000382542, ENST00000526004, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TDO2 [Title/Abstract] AND GZMB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TDO2 | GO:0019441 | tryptophan catabolic process to kynurenine | 27762317 |
Hgene | TDO2 | GO:0051289 | protein homotetramerization | 27762317|28285122 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG314637 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000506181 | ENST00000415355 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
intron-3CDS | ENST00000506181 | ENST00000216341 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
intron-3CDS | ENST00000506181 | ENST00000382540 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
intron-3CDS | ENST00000506181 | ENST00000382542 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
intron-3UTR | ENST00000506181 | ENST00000526004 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
In-frame | ENST00000536354 | ENST00000415355 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
In-frame | ENST00000536354 | ENST00000216341 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
In-frame | ENST00000536354 | ENST00000382540 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
In-frame | ENST00000536354 | ENST00000382542 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
5CDS-3UTR | ENST00000536354 | ENST00000526004 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
Top |
FusionProtFeatures for TDO2_GZMB |
![]() |
Hgene | Tgene |
TDO2 | GZMB |
Heme-dependent dioxygenase that catalyzes the oxidativecleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidativecleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020,ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317,ECO:0000269|PubMed:28285122}. | This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to belinked to an activation cascade of caspases (aspartate-specificcysteine proteases) responsible for apoptosis execution. Cleavescaspase-3, -7, -9 and 10 to give rise to active enzymes mediatingapoptosis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TDO2_GZMB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000415355_chr14_25101153_+_0aa >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000216341_chr14_25101153_+_0aa >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382540_chr14_25101153_+_0aa >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382542_chr14_25101153_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000415355_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000216341_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382540_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382542_chr14_25101153_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000415355_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000216341_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382540_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382542_chr14_25101153_+_0nt |
Top |
FusionGenePPI for TDO2_GZMB |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TDO2_GZMB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TDO2_GZMB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TDO2 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | TDO2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | TDO2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | TDO2 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | TDO2 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | TDO2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | TDO2 | C0038187 | Starvation | 1 | CTD_human |
Hgene | TDO2 | C0220702 | SCHIZOPHRENIA 1 (disorder) | 1 | PSYGENET |
Hgene | TDO2 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | GZMB | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | GZMB | C0013182 | Drug Allergy | 1 | CTD_human |
Tgene | GZMB | C0019158 | Hepatitis | 1 | CTD_human |
Tgene | GZMB | C1458155 | Mammary Neoplasms | 1 | CTD_human |