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Fusion gene ID: 37653 |
FusionGeneSummary for TDO2_GZMB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TDO2_GZMB | Fusion gene ID: 37653 | Hgene | Tgene | Gene symbol | TDO2 | GZMB | Gene ID | 6999 | 3002 |
| Gene name | tryptophan 2,3-dioxygenase | granzyme B | |
| Synonyms | HYPTRP|TDO|TO|TPH2|TRPO | C11|CCPI|CGL-1|CGL1|CSP-B|CSPB|CTLA1|CTSGL1|HLP|SECT | |
| Cytomap | 4q32.1 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tryptophan 2,3-dioxygenasetryptamin 2,3-dioxygenasetryptophan oxygenasetryptophan pyrrolasetryptophanase | granzyme BT-cell serine protease 1-3Ecathepsin G-like 1cytotoxic T-lymphocyte proteinase 2cytotoxic serine protease Bfragmentin 2granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)human lymphocyte protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P48775 | P10144 | |
| Ensembl transtripts involved in fusion gene | ENST00000506181, ENST00000536354, | ENST00000415355, ENST00000216341, ENST00000382540, ENST00000382542, ENST00000526004, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: TDO2 [Title/Abstract] AND GZMB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TDO2 | GO:0019441 | tryptophan catabolic process to kynurenine | 27762317 |
| Hgene | TDO2 | GO:0051289 | protein homotetramerization | 27762317|28285122 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG314637 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000506181 | ENST00000415355 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| intron-3CDS | ENST00000506181 | ENST00000216341 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| intron-3CDS | ENST00000506181 | ENST00000382540 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| intron-3CDS | ENST00000506181 | ENST00000382542 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| intron-3UTR | ENST00000506181 | ENST00000526004 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| In-frame | ENST00000536354 | ENST00000415355 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| In-frame | ENST00000536354 | ENST00000216341 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| In-frame | ENST00000536354 | ENST00000382540 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| In-frame | ENST00000536354 | ENST00000382542 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
| 5CDS-3UTR | ENST00000536354 | ENST00000526004 | TDO2 | chr4 | 156828925 | - | GZMB | chr14 | 25101153 | + |
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FusionProtFeatures for TDO2_GZMB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TDO2 | GZMB |
| Heme-dependent dioxygenase that catalyzes the oxidativecleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidativecleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020,ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317,ECO:0000269|PubMed:28285122}. | This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to belinked to an activation cascade of caspases (aspartate-specificcysteine proteases) responsible for apoptosis execution. Cleavescaspase-3, -7, -9 and 10 to give rise to active enzymes mediatingapoptosis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TDO2_GZMB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000415355_chr14_25101153_+_0aa >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000216341_chr14_25101153_+_0aa >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382540_chr14_25101153_+_0aa >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382542_chr14_25101153_+_0aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000415355_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000216341_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382540_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382542_chr14_25101153_+_0nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000415355_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000216341_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382540_chr14_25101153_+_0nt >In-frame_TDO2_ENST00000536354_chr4_156828925_-_GZMB_ENST00000382542_chr14_25101153_+_0nt |
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FusionGenePPI for TDO2_GZMB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TDO2_GZMB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TDO2_GZMB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TDO2 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | TDO2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Hgene | TDO2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Hgene | TDO2 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | TDO2 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | TDO2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | TDO2 | C0038187 | Starvation | 1 | CTD_human |
| Hgene | TDO2 | C0220702 | SCHIZOPHRENIA 1 (disorder) | 1 | PSYGENET |
| Hgene | TDO2 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | GZMB | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | GZMB | C0013182 | Drug Allergy | 1 | CTD_human |
| Tgene | GZMB | C0019158 | Hepatitis | 1 | CTD_human |
| Tgene | GZMB | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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