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Fusion gene ID: 37650 |
FusionGeneSummary for TDGF1P3_TDGF1 |
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Fusion gene information | Fusion gene name: TDGF1P3_TDGF1 | Fusion gene ID: 37650 | Hgene | Tgene | Gene symbol | TDGF1P3 | TDGF1 | Gene ID | 6998 | 6998 |
Gene name | teratocarcinoma-derived growth factor 1 pseudogene 3 | teratocarcinoma-derived growth factor 1 pseudogene 3 | |
Synonyms | CR-3|CRIPTO|CRIPTO-3|CRIPTO3|TDGF1|TDGF2|TDGF3 | CR-3|CRIPTO|CRIPTO-3|CRIPTO3|TDGF1|TDGF2|TDGF3 | |
Cytomap | Xq23 | Xq23 | |
Type of gene | pseudo | pseudo | |
Description | Teratocarcinoma-derived growth factor-2teratocarcinoma-derived growth factor 2 (retroposin, possibly expressed)teratocarcinoma-derived growth factor 3, pseudogene | Teratocarcinoma-derived growth factor-2teratocarcinoma-derived growth factor 2 (retroposin, possibly expressed)teratocarcinoma-derived growth factor 3, pseudogene | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P13385 | ||
Ensembl transtripts involved in fusion gene | ENST00000602699, | ENST00000444264, ENST00000542931, ENST00000296145, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: TDGF1P3 [Title/Abstract] AND TDGF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TDGF1P3 | GO:0007165 | signal transduction | 18835250 |
Tgene | TDGF1 | GO:0007165 | signal transduction | 18835250 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN274377 | TDGF1P3 | chrX | 109765819 | + | TDGF1 | chr3 | 46622853 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000602699 | ENST00000444264 | TDGF1P3 | chrX | 109765819 | + | TDGF1 | chr3 | 46622853 | + |
3UTR-3UTR | ENST00000602699 | ENST00000542931 | TDGF1P3 | chrX | 109765819 | + | TDGF1 | chr3 | 46622853 | + |
3UTR-3UTR | ENST00000602699 | ENST00000296145 | TDGF1P3 | chrX | 109765819 | + | TDGF1 | chr3 | 46622853 | + |
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FusionProtFeatures for TDGF1P3_TDGF1 |
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Hgene | Tgene |
TDGF1P3 | TDGF1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | GPI-anchored cell membrane protein involved in Nodalsignaling. Cell-associated TDGF1 acts as a Nodal coreceptor incis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling byallowing soluble TDGF1 to act as a Nodal coreceptor on other cells(PubMed:27881714). Could play a role in the determination of theepiblastic cells that subsequently give rise to the mesoderm(PubMed:11909953). {ECO:0000269|PubMed:11909953,ECO:0000269|PubMed:27881714}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TDGF1P3_TDGF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TDGF1P3_TDGF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TDGF1P3_TDGF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TDGF1P3_TDGF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TDGF1 | C0079541 | Holoprosencephaly | 1 | CTD_human |
Tgene | TDGF1 | C3178805 | Heterotaxy Syndrome | 1 | CTD_human |