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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37650

FusionGeneSummary for TDGF1P3_TDGF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TDGF1P3_TDGF1
Fusion gene ID: 37650
HgeneTgene
Gene symbol

TDGF1P3

TDGF1

Gene ID

6998

6998

Gene nameteratocarcinoma-derived growth factor 1 pseudogene 3teratocarcinoma-derived growth factor 1 pseudogene 3
SynonymsCR-3|CRIPTO|CRIPTO-3|CRIPTO3|TDGF1|TDGF2|TDGF3CR-3|CRIPTO|CRIPTO-3|CRIPTO3|TDGF1|TDGF2|TDGF3
Cytomap

Xq23

Xq23

Type of genepseudopseudo
DescriptionTeratocarcinoma-derived growth factor-2teratocarcinoma-derived growth factor 2 (retroposin, possibly expressed)teratocarcinoma-derived growth factor 3, pseudogeneTeratocarcinoma-derived growth factor-2teratocarcinoma-derived growth factor 2 (retroposin, possibly expressed)teratocarcinoma-derived growth factor 3, pseudogene
Modification date2018052320180523
UniProtAcc

P13385

Ensembl transtripts involved in fusion geneENST00000602699, ENST00000444264, 
ENST00000542931, ENST00000296145, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: TDGF1P3 [Title/Abstract] AND TDGF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTDGF1P3

GO:0007165

signal transduction

18835250

TgeneTDGF1

GO:0007165

signal transduction

18835250


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN274377TDGF1P3chrX

109765819

+TDGF1chr3

46622853

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000602699ENST00000444264TDGF1P3chrX

109765819

+TDGF1chr3

46622853

+
3UTR-3UTRENST00000602699ENST00000542931TDGF1P3chrX

109765819

+TDGF1chr3

46622853

+
3UTR-3UTRENST00000602699ENST00000296145TDGF1P3chrX

109765819

+TDGF1chr3

46622853

+

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FusionProtFeatures for TDGF1P3_TDGF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TDGF1P3

TDGF1

P13385

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. GPI-anchored cell membrane protein involved in Nodalsignaling. Cell-associated TDGF1 acts as a Nodal coreceptor incis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling byallowing soluble TDGF1 to act as a Nodal coreceptor on other cells(PubMed:27881714). Could play a role in the determination of theepiblastic cells that subsequently give rise to the mesoderm(PubMed:11909953). {ECO:0000269|PubMed:11909953,ECO:0000269|PubMed:27881714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TDGF1P3_TDGF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TDGF1P3_TDGF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TDGF1P3_TDGF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TDGF1P3_TDGF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTDGF1C0079541Holoprosencephaly1CTD_human
TgeneTDGF1C3178805Heterotaxy Syndrome1CTD_human