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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3764

FusionGeneSummary for BAALC_RGS12

check button Fusion gene summary
Fusion gene informationFusion gene name: BAALC_RGS12
Fusion gene ID: 3764
HgeneTgene
Gene symbol

BAALC

RGS12

Gene ID

79870

6002

Gene nameBAALC, MAP3K1 and KLF4 bindingregulator of G protein signaling 12
Synonyms--
Cytomap

8q22.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionbrain and acute leukemia cytoplasmic proteinBAALC, MEKK1 and KLF4 bindingbrain and acute leukemia, cytoplasmicregulator of G-protein signaling 12regulator of G-protein signalling 12
Modification date2018051920180519
UniProtAcc

Q8WXS3

O14924

Ensembl transtripts involved in fusion geneENST00000309982, ENST00000438105, 
ENST00000297574, ENST00000330955, 
ENST00000306391, ENST00000523754, 
ENST00000543385, ENST00000336727, 
ENST00000344733, ENST00000382788, 
ENST00000306648, ENST00000338806, 
ENST00000508158, ENST00000538395, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 5 X 3=60
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BAALC [Title/Abstract] AND RGS12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI058636BAALCchr8

104178201

-RGS12chr4

3389909

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000309982ENST00000543385BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000336727BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000344733BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000382788BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000306648BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000338806BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000508158BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000309982ENST00000538395BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000543385BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000336727BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000344733BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000382788BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000306648BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000338806BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000508158BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000438105ENST00000538395BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000543385BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000336727BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000344733BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000382788BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000306648BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000338806BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000508158BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000297574ENST00000538395BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000543385BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000336727BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000344733BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000382788BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000306648BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000338806BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000508158BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000330955ENST00000538395BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000543385BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000336727BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000344733BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000382788BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000306648BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000338806BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000508158BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000306391ENST00000538395BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000543385BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000336727BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000344733BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000382788BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000306648BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000338806BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000508158BAALCchr8

104178201

-RGS12chr4

3389909

+
intron-intronENST00000523754ENST00000538395BAALCchr8

104178201

-RGS12chr4

3389909

+

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FusionProtFeatures for BAALC_RGS12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAALC

Q8WXS3

RGS12

O14924

May play a synaptic role at the postsynaptic lipid raftspossibly through interaction with CAMK2A.{ECO:0000250|UniProtKB:Q920K5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAALC_RGS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAALC_RGS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAALC_RGS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAALC_RGS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAALCC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneRGS12C0036341Schizophrenia1CTD_human