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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37636

FusionGeneSummary for TCTA_ARIH2

check button Fusion gene summary
Fusion gene informationFusion gene name: TCTA_ARIH2
Fusion gene ID: 37636
HgeneTgene
Gene symbol

TCTA

ARIH2

Gene ID

6988

10425

Gene nameT cell leukemia translocation alteredariadne RBR E3 ubiquitin protein ligase 2
Synonyms-ARI2|TRIAD1
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionT-cell leukemia translocation-altered gene proteinT-cell leukemia translocation-associated gene proteinE3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homolog
Modification date2018052320180523
UniProtAcc

P57738

O95376

Ensembl transtripts involved in fusion geneENST00000273590, ENST00000493381, 
ENST00000356401, ENST00000449376, 
ENST00000490095, 
Fusion gene scores* DoF score3 X 4 X 3=369 X 10 X 4=360
# samples 511
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCTA [Title/Abstract] AND ARIH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCTA

GO:0045671

negative regulation of osteoclast differentiation

19560569

HgeneTCTA

GO:0072675

osteoclast fusion

19560569

TgeneARIH2

GO:0000209

protein polyubiquitination

16118314|19340006

TgeneARIH2

GO:0006511

ubiquitin-dependent protein catabolic process

16118314

TgeneARIH2

GO:0016567

protein ubiquitination

24076655

TgeneARIH2

GO:0048588

developmental cell growth

19340006

TgeneARIH2

GO:0070534

protein K63-linked ubiquitination

19340006

TgeneARIH2

GO:0070936

protein K48-linked ubiquitination

16118314|19340006

TgeneARIH2

GO:0071425

hematopoietic stem cell proliferation

16118314|19340006


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A132-01ATCTAchr3

49450543

+ARIH2chr3

49019093

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000273590ENST00000356401TCTAchr3

49450543

+ARIH2chr3

49019093

+
Frame-shitENST00000273590ENST00000449376TCTAchr3

49450543

+ARIH2chr3

49019093

+
5CDS-intronENST00000273590ENST00000490095TCTAchr3

49450543

+ARIH2chr3

49019093

+
3UTR-3CDSENST00000493381ENST00000356401TCTAchr3

49450543

+ARIH2chr3

49019093

+
3UTR-3CDSENST00000493381ENST00000449376TCTAchr3

49450543

+ARIH2chr3

49019093

+
3UTR-intronENST00000493381ENST00000490095TCTAchr3

49450543

+ARIH2chr3

49019093

+

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FusionProtFeatures for TCTA_ARIH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCTA

P57738

ARIH2

O95376

May be required for cellular fusion duringosteoclastogenesis. {ECO:0000269|PubMed:19560569}. E3 ubiquitin-protein ligase, which catalyzesubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546,PubMed:19340006, PubMed:24076655). Acts as an atypical E3ubiquitin-protein ligase by working together with cullin-5-RINGubiquitin ligase complex (ECS complex, also named CRL5 complex)and initiating ubiquitination of ECS substrates: associates withECS complex and specifically mediates addition of the firstubiquitin on ECS targets (By similarity). The initial ubiquitin isthen elongated (By similarity). E3 ubiquitin-protein ligaseactivity is activated upon binding to neddylated form of the ECScomplex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546,PubMed:19340006). May play a role in myelopoiesis(PubMed:19340006). {ECO:0000250|UniProtKB:Q9Y4X5,ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546,ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCTA_ARIH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCTA_ARIH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCTAATXN1, SMAD4ARIH2UGP2, BUB1, EML4, WDR91, KCNQ2, LOC147791, SGCE, CBR3, ENSA, IL4R, PPP2R1A, SLC1A6, ARAP1, DLST, KAT5, SCAMP2, UTP14A, KIAA1377, PTN, RPL8, TP53, EEF1A1, EEF1G, UBE2L3, GFI1, UBE2L6, UBE2E2, UBE2T, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2V1, UBE2R2, DISC1, PML, UBE2N, UBC, MDM2, NOTCH1, VCP, TRIM27, PHF7, RHEB, CUL5, NEDD8, ARIH2, APEX1, EHD1, PAPSS2, PARP6, PDLIM1, HK2, NUBP1, TWF2, PABPN1, REL, CCDC33, TCEB2, TCEB1, SOCS6, RAB40A, ASB9, ZFP41, NTRK1, BMX, TULP3, WSB2, PYCARD, NLRP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCTA_ARIH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCTA_ARIH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource