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Fusion gene ID: 37636 |
FusionGeneSummary for TCTA_ARIH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCTA_ARIH2 | Fusion gene ID: 37636 | Hgene | Tgene | Gene symbol | TCTA | ARIH2 | Gene ID | 6988 | 10425 |
| Gene name | T cell leukemia translocation altered | ariadne RBR E3 ubiquitin protein ligase 2 | |
| Synonyms | - | ARI2|TRIAD1 | |
| Cytomap | 3p21.31 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-cell leukemia translocation-altered gene proteinT-cell leukemia translocation-associated gene protein | E3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P57738 | O95376 | |
| Ensembl transtripts involved in fusion gene | ENST00000273590, ENST00000493381, | ENST00000356401, ENST00000449376, ENST00000490095, | |
| Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 9 X 10 X 4=360 |
| # samples | 5 | 11 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TCTA [Title/Abstract] AND ARIH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCTA | GO:0045671 | negative regulation of osteoclast differentiation | 19560569 |
| Hgene | TCTA | GO:0072675 | osteoclast fusion | 19560569 |
| Tgene | ARIH2 | GO:0000209 | protein polyubiquitination | 16118314|19340006 |
| Tgene | ARIH2 | GO:0006511 | ubiquitin-dependent protein catabolic process | 16118314 |
| Tgene | ARIH2 | GO:0016567 | protein ubiquitination | 24076655 |
| Tgene | ARIH2 | GO:0048588 | developmental cell growth | 19340006 |
| Tgene | ARIH2 | GO:0070534 | protein K63-linked ubiquitination | 19340006 |
| Tgene | ARIH2 | GO:0070936 | protein K48-linked ubiquitination | 16118314|19340006 |
| Tgene | ARIH2 | GO:0071425 | hematopoietic stem cell proliferation | 16118314|19340006 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A132-01A | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000273590 | ENST00000356401 | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
| Frame-shift | ENST00000273590 | ENST00000449376 | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
| 5CDS-intron | ENST00000273590 | ENST00000490095 | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
| 3UTR-3CDS | ENST00000493381 | ENST00000356401 | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
| 3UTR-3CDS | ENST00000493381 | ENST00000449376 | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
| 3UTR-intron | ENST00000493381 | ENST00000490095 | TCTA | chr3 | 49450543 | + | ARIH2 | chr3 | 49019093 | + |
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FusionProtFeatures for TCTA_ARIH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCTA | ARIH2 |
| May be required for cellular fusion duringosteoclastogenesis. {ECO:0000269|PubMed:19560569}. | E3 ubiquitin-protein ligase, which catalyzesubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546,PubMed:19340006, PubMed:24076655). Acts as an atypical E3ubiquitin-protein ligase by working together with cullin-5-RINGubiquitin ligase complex (ECS complex, also named CRL5 complex)and initiating ubiquitination of ECS substrates: associates withECS complex and specifically mediates addition of the firstubiquitin on ECS targets (By similarity). The initial ubiquitin isthen elongated (By similarity). E3 ubiquitin-protein ligaseactivity is activated upon binding to neddylated form of the ECScomplex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546,PubMed:19340006). May play a role in myelopoiesis(PubMed:19340006). {ECO:0000250|UniProtKB:Q9Y4X5,ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546,ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCTA_ARIH2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCTA_ARIH2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TCTA | ATXN1, SMAD4 | ARIH2 | UGP2, BUB1, EML4, WDR91, KCNQ2, LOC147791, SGCE, CBR3, ENSA, IL4R, PPP2R1A, SLC1A6, ARAP1, DLST, KAT5, SCAMP2, UTP14A, KIAA1377, PTN, RPL8, TP53, EEF1A1, EEF1G, UBE2L3, GFI1, UBE2L6, UBE2E2, UBE2T, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2V1, UBE2R2, DISC1, PML, UBE2N, UBC, MDM2, NOTCH1, VCP, TRIM27, PHF7, RHEB, CUL5, NEDD8, ARIH2, APEX1, EHD1, PAPSS2, PARP6, PDLIM1, HK2, NUBP1, TWF2, PABPN1, REL, CCDC33, TCEB2, TCEB1, SOCS6, RAB40A, ASB9, ZFP41, NTRK1, BMX, TULP3, WSB2, PYCARD, NLRP3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCTA_ARIH2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCTA_ARIH2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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