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Fusion gene ID: 37618 |
FusionGeneSummary for TCHP_PPTC7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCHP_PPTC7 | Fusion gene ID: 37618 | Hgene | Tgene | Gene symbol | TCHP | PPTC7 | Gene ID | 84260 | 160760 |
| Gene name | trichoplein keratin filament binding | PTC7 protein phosphatase homolog | |
| Synonyms | TpMs | TA-PP2C|TAPP2C | |
| Cytomap | 12q24.11 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trichoplein keratin filament-binding proteinmitochondrial protein with oncostatic activitymitostatintumor suppressor protein | protein phosphatase PTC7 homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BT92 | Q8NI37 | |
| Ensembl transtripts involved in fusion gene | ENST00000405876, ENST00000312777, ENST00000550780, | ENST00000354300, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TCHP [Title/Abstract] AND PPTC7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCHP | GO:0006915 | apoptotic process | 18931701 |
| Hgene | TCHP | GO:0030308 | negative regulation of cell growth | 18931701 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-YL-A8SP-01B | TCHP | chr12 | 110342598 | + | PPTC7 | chr12 | 110976078 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000405876 | ENST00000354300 | TCHP | chr12 | 110342598 | + | PPTC7 | chr12 | 110976078 | - |
| In-frame | ENST00000312777 | ENST00000354300 | TCHP | chr12 | 110342598 | + | PPTC7 | chr12 | 110976078 | - |
| intron-3CDS | ENST00000550780 | ENST00000354300 | TCHP | chr12 | 110342598 | + | PPTC7 | chr12 | 110976078 | - |
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FusionProtFeatures for TCHP_PPTC7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCHP | PPTC7 |
| Tumor suppressor which has the ability to inhibit cellgrowth and be pro-apoptotic during cell stress. Inhibits cellgrowth in bladder and prostate cancer cells by a down-regulationof HSPB1 by inhibiting its phosphorylation. May act as a 'capping'or 'branching' protein for keratin filaments in the cellperiphery. May regulate K8/K18 filament and desmosome organizationmainly at the apical or peripheral regions of simple epithelialcells (PubMed:15731013, PubMed:18931701). Is a negative regulatorof ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013,ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 11_39 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 66_136 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 11_39 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 66_136 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 163_353 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 380_479 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 163_353 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 380_479 | 152 | 499 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 70_482 | 152 | 499 | Compositional bias | Glu-rich |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 70_482 | 152 | 499 | Compositional bias | Glu-rich |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 259_425 | 152 | 499 | Region | Trichohyalin/plectin homology domain |
| Hgene | >TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 259_425 | 152 | 499 | Region | Trichohyalin/plectin homology domain |
| Tgene | PPTC7 | chr12:110342598 | chr12:110976078 | ENST00000354300 | - | 3 | 6 | 17_87 | 242 | 305 | Compositional bias | Note=Gly-rich |
| Tgene | PPTC7 | chr12:110342598 | chr12:110976078 | ENST00000354300 | - | 3 | 6 | 33_299 | 242 | 305 | Domain | PPM-type phosphatase |
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FusionGeneSequence for TCHP_PPTC7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TCHP_ENST00000405876_chr12_110342598_+_PPTC7_ENST00000354300_chr12_110976078_-_215aa MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQL MQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLRENSNYESIQQTARSIAEQAHELAYDPNYM >In-frame_TCHP_ENST00000312777_chr12_110342598_+_PPTC7_ENST00000354300_chr12_110976078_-_215aa MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQL MQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLRENSNYESIQQTARSIAEQAHELAYDPNYM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TCHP_ENST00000405876_chr12_110342598_+_PPTC7_ENST00000354300_chr12_110976078_-_645nt ATGGCGCTCCCGACGCTGCCGTCCTACTGGTGCAGCCAGCAGCGCCTGAATCAGCAGCTAGCACGACAGCGAGAGCAGGAGGCCCGGCTT CGGCAGCAGTGGGAGCAGAACAGCCGTTACTTCAGGATGTCTGACATCTGCAGCTCCAAACAGGCAGAATGGAGCTCTAAAACCTCCTAC CAGCGGAGCATGCATGCCTATCAGCGGGAGAAGATGAAGGAGGAGAAGAGGAGGAGTCTGGAGGCCCGACGGGAAAAGCTCAGGCAGCTC ATGCAGGAGGAGCAGGACCTGCTGGCCAGAGAACTGGAGGAGCTGAGGCTGAGCATGAACTTGCAGGAAAGAAGAATCCGGGAGCAGCAC GGGAAGCTGAAATCAGCCAAAGAAGAGCAGAGGAAACTGATTGCTGAACAACTTTTGTACGAACACTGGAAAAAGAACAACCCGAAACTT CGAGAGAATTCAAATTATGAGAGTATACAACAGACTGCCAGAAGCATTGCTGAGCAAGCTCATGAGCTGGCCTATGACCCAAATTATATG TCACCTTTTGCACAGTTTGCATGTGACAATGGATTGAATGTGAGAGGTGGAAAGCCAGATGACATCACCGTCCTTCTTTCAATAGTGGCT >In-frame_TCHP_ENST00000312777_chr12_110342598_+_PPTC7_ENST00000354300_chr12_110976078_-_645nt ATGGCGCTCCCGACGCTGCCGTCCTACTGGTGCAGCCAGCAGCGCCTGAATCAGCAGCTAGCACGACAGCGAGAGCAGGAGGCCCGGCTT CGGCAGCAGTGGGAGCAGAACAGCCGTTACTTCAGGATGTCTGACATCTGCAGCTCCAAACAGGCAGAATGGAGCTCTAAAACCTCCTAC CAGCGGAGCATGCATGCCTATCAGCGGGAGAAGATGAAGGAGGAGAAGAGGAGGAGTCTGGAGGCCCGACGGGAAAAGCTCAGGCAGCTC ATGCAGGAGGAGCAGGACCTGCTGGCCAGAGAACTGGAGGAGCTGAGGCTGAGCATGAACTTGCAGGAAAGAAGAATCCGGGAGCAGCAC GGGAAGCTGAAATCAGCCAAAGAAGAGCAGAGGAAACTGATTGCTGAACAACTTTTGTACGAACACTGGAAAAAGAACAACCCGAAACTT CGAGAGAATTCAAATTATGAGAGTATACAACAGACTGCCAGAAGCATTGCTGAGCAAGCTCATGAGCTGGCCTATGACCCAAATTATATG TCACCTTTTGCACAGTTTGCATGTGACAATGGATTGAATGTGAGAGGTGGAAAGCCAGATGACATCACCGTCCTTCTTTCAATAGTGGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TCHP_ENST00000405876_chr12_110342598_+_PPTC7_ENST00000354300_chr12_110976078_-_6514nt GGGCTCGTTGCCGGTGCAAACAGGGAGGAAACAGCCGGCGTTGCTGTAGCGCGTCTGGGAATTACACCGGGGGACTGGCCGGCCCGCTTC GTGCCTGCGGGAAGTCGGGCCGGGGGACTCTTCGGAAACTCCGAGCCTCAGAGAAATATGGCGCTCCCGACGCTGCCGTCCTACTGGTGC AGCCAGCAGCGCCTGAATCAGCAGCTAGCACGACAGCGAGAGCAGGAGGCCCGGCTTCGGCAGCAGTGGGAGCAGAACAGCCGTTACTTC AGGATGTCTGACATCTGCAGCTCCAAACAGGCAGAATGGAGCTCTAAAACCTCCTACCAGCGGAGCATGCATGCCTATCAGCGGGAGAAG ATGAAGGAGGAGAAGAGGAGGAGTCTGGAGGCCCGACGGGAAAAGCTCAGGCAGCTCATGCAGGAGGAGCAGGACCTGCTGGCCAGAGAA CTGGAGGAGCTGAGGCTGAGCATGAACTTGCAGGAAAGAAGAATCCGGGAGCAGCACGGGAAGCTGAAATCAGCCAAAGAAGAGCAGAGG AAACTGATTGCTGAACAACTTTTGTACGAACACTGGAAAAAGAACAACCCGAAACTTCGAGAGAATTCAAATTATGAGAGTATACAACAG ACTGCCAGAAGCATTGCTGAGCAAGCTCATGAGCTGGCCTATGACCCAAATTATATGTCACCTTTTGCACAGTTTGCATGTGACAATGGA TTGAATGTGAGAGGTGGAAAGCCAGATGACATCACCGTCCTTCTTTCAATAGTGGCTGAGTATACAGACTAGCTGAGGTGTCAAGTCCTG CCTTTCCTTTCATCATCCCAAATTTCCCCTGCCATGTGTGCTGATCCTGCTGGCAGGACCACATTTCTTTGCCACTGATCTCAATGGCCA GTGATGTAAGTCTTTTGCCTGTCTTCTTGAGACTCGTTGAGATCTTTGTTGAGAACCACTACTATCATTCACTAGCTCATATCTGCCGGC AGCAATTGAAGAGATCCAATATTTGAAGATTGGCCTTCATTTCTCGATGTTCTTTCCATGATGGGGATGGAGGTGTTCAGTGCCACCGTG GCTGTTACTTTTCAAAGTAGTTGAAGTATTGAAAATGAGTAATGTTGGTAAAGTGAATTCAAAATCCTAGTATGCTAAAGGGATGGTACA AGTCTAACACAAATTGTACGTAATGATACATCTACTAGAAACATACATTATTCATCAAAAGAAATGTTACATGTGTACTCCACAGGCATA GTCTTTGTTATGATGATTGGTGTGGCTTTATGTCTTTGTTATAAACTCCTATTTTTCAGGGGCTTATGATTCTGCTCTAAAACATTGCTC TGGGTTATACAGTTTTGATCCCAAAAGCTTTTTTGTTACAAATCGGGAGAAAAATCCATTTTAGTTCTATGGATGGAAATATTTCATGCT TTTAAAAAGATGTTTGTGTTCCTGTGGTTAAAGTTTTGGCAGTTTATTGATTAGTCCAAATCACAGGCTAAGGCCTGATCTCCAGGAGGG GTAGGGGAGACACTTTACCAGTATTTTTTTATGGAAATAATACTCAAGGTTGTAAAACCCCTCAAAGCCTAGAAATTTAATTGTTATGGC TGAAATTCCTCCTAGTTGTCTGATAGAATGCCCCTGAATGGGAACTCTAGGTCCCAAGGCCTGAAGGGTTGAGAACAGACAGCTGTAACT TTGAATTTTGTTGGCTTTCAGTGGTCATGCTACCTACCCATACTCGTACTCTCAGACCTTTTATTAGTAGCCTTGCTTTCTATAGAGCAT GCACCAAATCCAGTGAGTCCATGTGGAGAGAGCACTGTGTGCGCAGCGGCAGCAGCACAGACGTCCATGAGGAAAACTCCCAGTGATGAT CTGACATTTACAATTACCCCACATGGAAATTTAGGGGTTTCTGAATCAAGCTTAATGTTTACAGTTTCCAAATAGCCATTTTGCAGTGTA TAGTTTCCTTACAAAACTACCCCGCATTCAGTTTTCACATTATCTGCAAGCTGAAACTTATTTTTAAGTTTTGTGTACAAGTTGACTGCT GTAAAGATATATATTTTTGGGTCAGTTTTTTTCCTTCATTAACTTGGTGGTAGAAAAAAATATATACTTAGAAATCCTTAAATTAAAGCC ATGTTTTATATATAAGTCAGGTAACATTGGTGTATAGATGAGAATGCAATTAAACCTGATGAGAATCTACTTGAGAATATAGAAAGTCTT TCTCTAAAGGAGATACTGACTCCCTGGTTTATTGCATTAAAATTTATGTTTGAGGTTACCTCAACTTGTTTTAAAAGATTTTGTTTTGTG AATTTGTACTGTATATTTGAGTAACTGTCAGGCTTTTATTTAAAATTGTTTAACATGTACCATGTACATGTCATTACTATATTTCAATGC ATCATGCTTGTAACAGGCATTTCATTTATAATAAGAATGAGTTATTCATTTGTAAGCCGTTCAGTAATTTATCTACTATTCCTAAATTGG CATAATGTTAGATAATCTATTTTGAATCACCTTTAATTACATGTCAGAATGCCTTAACTACCCTAACTTGACAAAACAGAATTCTTTGGT AGACGCGGTGGGGGCGGGGTGGGGGGTCTGGACGGAGTCTCTATTTAAGGAGAAATCATCATGCTATGATAAAACACAGAAGCATGAGTG GCAAGTGGCGGGGTATTTATTTTGCACAAACTATTTGCAGTCTCTGTGTATTTAAAAAGTAAAGAAAGTTGCATCCAGAAGGGTTTTGTT AGAATGAATACATTTATATTAGGACTGACAACTTCAGCTCTTTTGTTTAGGTTTTCAATTATTTTTGGTAAGAGTATGTAGCCTTATGAT CTGGATATATTTTGCATTCATTTTCCAACGCCTACATTTAATTCCTGGTAAGAGCAGTGCTCGTCAAGTTTCTGGTTTTTCTCTGCTCTC ATTTAACCCGTCAAACACAATCTTTGTAAAGCTAGATTGGTGGTGTTTTATACAACTTATTTACTCAGCTTACCTTTTTGAGAAACGATT GTTAGAAATTGACGATGTGTTTGTTCCAGTGATACTGAAAGTAGTGGGGGCAAGAATTGAGTTTCACAGTGGAATTGGCTTTGGATCTGG CCTATAGATTAGTGACATAAAATATTTTCTCTATTTTCCCCTGTTCTTTTTGTGTTATGCACTTAATTTTATGACTGCCGGGGGGGTCAG CTGGAGTGCTGCTTAACAAGTATCTCTCCTACTCTCAGTGGTCAGAGGCTGTGTTGGACCCATAGTAGAATTTTCCAGGTCACAGACCCA AGCTTCCATGGGTTGTTACTGTGCTGTACCACTTGGTGGGTCTGATTCTGAACCTGATGTGTGTGTTAATTATATTTTAAGCAACACACA CACACACACACGCCTCATGTAATGGACTTTTATAACAAAAGAAAAAATTTGGATTTCTAATTTACAAATGGCAAATTATTTATCCCTCTC TGGATGCACCAAAGACCAGTAAAGTTTATAGCTTTTCCATCTATATTTATAAAGCAATACTGTATTATAAAAATCAATATTTTTATCACA TGCTTGAAATTTTTATTTTGTTGTTTTAAAATGTGCACTCTAAACATATCAGAACCTTATTTCTTCCTATGAACTTAAGCTGCCTGCGCA CAAAAAAAAAAAAAATTTACCAAATGGAGATGCAGTAGAGTCCATAGGCTCTAAAAACTAAAAGAAATGGGATGCAGGGGGAACAAGTTA TTTGTCCTGAGTTACTGTACTTGCTTGACATGGTTGTTGGGTACTAAATCACAAAAGAATCCATTCCAGGTATGCATGTCTGGGGGTTGG GCTGTGTCTAGATTAGAAACTGGGTTTCAAGCTTTGCATGATGGGAGAGCGTCCTCTCCTCTATCAGCTGCGTGTGTTCTGGATAGGACA GTAGCCCGGAGATGGAAACCACCTTCAGTACCATTAGCCCACCATACCAAGTAACAAGTTAGGCAGGAATCGTGGGAATTTATTGAGTCA GCTTTGAGTGTTTGAGAGAATGTAAACAAGATTGGCTCGAATTGTAAACGTTTGTACTTTGGATGAGTTCATGGTTCTTTAGGTCACCTT AATACCAGCTATCTTTGGTAGAAGCTACAGCATTCAGTTTCTCTGGAAACTGTATCACATTTTTGCATTTTAAAAATTTTACAGTATCAA AAAACCAAAATCTGCTTATGAAACAAAACATGAAGCAGGACATATTTGGATTCTATTTATTTAAAATTAAATTCTTTGCAAAATTGAACT TCTCAACTAAAACGTGTCCATGTCAGAATTTTAACTGTTAGCAGGTAGTTTGTGGCAAAGATGGCTAAATAATGAAGCAAATTAGAATCT GTGTGTATACTAATGAGCTGCTTTTTTTCTGTTGAGACTATCATTATTTGTCTTATTACCCAAGAGGCAATTACCTGAATTTGGATGTCT GAATTATAACTTATGCAGGAATAGTTCTGTAAATACATTTAAATAAACTGTAAAGATATTTAATAAATATAGTATTTATACTAATCTGTG TGCTTCTTTTGGTTTGAATAGTAACTAAATGAGACACCAGCCCTTGACATTGAGTTTGTTGGTCACTATCAGGTCCTCATTTCCAAGCCT CCTAGTCATTCTAGCACTGATTATATGCTGCTACTTTAACTGGCTCCAGCTGCTTCACTACATCAGTTTAGCTTCCTCAGAAATTCATCA AAATGGACGGACAATTAAATGTAAATTATAGAACTTTTTCCCAGCTGAGGCTTTGCACCTTCCGTATAGTATAGAGGGAAGCTACAAAAA AAATCTGCTGTACAGTCAGTCGTGTTGTTTAACAGAGATGTTCTGACAGATGCATCCTTAGCAATTTCATCATTGTGTACTGACACAAGC CTAGATGGTCTAGCCTACTACACATCTGGGCTATATGAATAGCCTGTTGCTCCTAGGCGACAAACCTGTATAACATGTTACTGTACTGAA TACTGTAGGCAGTTGTAACACAACAGTAAGCATCTGTATATCTAAACATAGAAATGTTTCAGCAAAACTATGGTATGAAAGACAAAAAAA TGGTACACCTGTATAGGGCAGCTCCATTATCTTATGGGACCACCACTGTCTGTGCAGTCCATCGTTGACCAAAACGTTGTTATGCAGCAC ATGACTGTATTTCAGCTTAGCACTCTGTATCCAAATTCTAAAATCCAAAGTGCCCAGCTAATTTTTGTAGAGATGGGATCTCACCATGTT GCCCAGGCTAGTCTTGAACTGCTGGGCTCAACTGATCCGCCCACCTGGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTACACC CCGCCAGTATTAACTATAATAATAGTCCAATGCTGCATCCAGGCTATTACTGATGATGATGCCTTTAAGACCTAAACCCCTCTGCCTACT TCAATGAATGAACCAGAAATGTTATCCTCAGCAAAGAGACCTACAGAGTTACTTTTGTGTATAAAAGCTCCCTGTGTAGGCATCTGCATT TGTTAGAAATACCAGAAATTCAGTGTTAATCATCAGTGTAAGCATAAGATACATATATCTTCCCCTACCATGTGATGAAAGGACTTAGTT GAAATTATGTGGGCATTGCCAGTTACCACAAAAAGCTTGGTTAAGGCCCATTTTCATTCACTAAGGAACATCTTGGGATGAACTTGAGTT TTTATTAGGTTATTGTGGGTAGCTATGACTCATTACTAAGCTACAAGAGCCAAATTAATTCTGGTTTCAGTTAGAACTCTATTCACAGTT CTAAAGCATGCAAATCCACTCAGCCACCTTTATGAATTTCTCACAAAGTCTAAAGTACAACTGCTTGCCAGTTAACACTTCCTTACGGTT TGAAGGTTTCAGAAAGATGTAACAATAATATGTTACAAAAGTCTCGTTTGTCAGGTTATAATTGACTGTAAACAGGTTTGGGGGAGGGAG AGGCACACATCATAAGACATTACATAACAATGTTTTGTGCCAGATTTTTTAGTCCATTTGTGCAGGTAAAAAGCTAACTCTTAAAGGGCC AAAGAACAGAGACATTTGTCTTCCACCTTATTCCACTCCAAACTCAGGCTGTCTTGGCAGTGGAGGATACTGTTCTATGTCAGATAATAC AGAAATATTTGGCATCACTTCCATTAAATTCTTTCCTGCAGCACACTGCAAAATAAAAAATCACATCTGAAAATCAGAACAATTTGAGGT TAGGAAATAAAATTTTACAATATGTAAAAACACTCCAGGTTGGGCGCAGTGGCTCAAGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGT GGGCAGATCACTTGAGGCCAGGAGTTCAAGACCACCCTGGCCAACATGGCGAAACCCTGTCTCTACAAAATACCAGAAATTAGCCAGGCA >In-frame_TCHP_ENST00000312777_chr12_110342598_+_PPTC7_ENST00000354300_chr12_110976078_-_6581nt GGGCGCGAGCTCAGGGCGCCTCCGGGGTCCTCACTGCGCTCCCCACGCGCTGTGACCCCATTTGTTGCACGTGCATGTTCAGGTCGAGAG AGGGATGCGACGTGTTCGGGGAGCAGCCCACCTTGTGGGTGGCCAATCCGGGACGGGAATCTTAAACTTTTAACTCTTGGTGCAAAGACT GATCCACTGGCGGCTTTACGGGAGCGGGAAAAAAATGGCGCTCCCGACGCTGCCGTCCTACTGGTGCAGCCAGCAGCGCCTGAATCAGCA GCTAGCACGACAGCGAGAGCAGGAGGCCCGGCTTCGGCAGCAGTGGGAGCAGAACAGCCGTTACTTCAGGATGTCTGACATCTGCAGCTC CAAACAGGCAGAATGGAGCTCTAAAACCTCCTACCAGCGGAGCATGCATGCCTATCAGCGGGAGAAGATGAAGGAGGAGAAGAGGAGGAG TCTGGAGGCCCGACGGGAAAAGCTCAGGCAGCTCATGCAGGAGGAGCAGGACCTGCTGGCCAGAGAACTGGAGGAGCTGAGGCTGAGCAT GAACTTGCAGGAAAGAAGAATCCGGGAGCAGCACGGGAAGCTGAAATCAGCCAAAGAAGAGCAGAGGAAACTGATTGCTGAACAACTTTT GTACGAACACTGGAAAAAGAACAACCCGAAACTTCGAGAGAATTCAAATTATGAGAGTATACAACAGACTGCCAGAAGCATTGCTGAGCA AGCTCATGAGCTGGCCTATGACCCAAATTATATGTCACCTTTTGCACAGTTTGCATGTGACAATGGATTGAATGTGAGAGGTGGAAAGCC AGATGACATCACCGTCCTTCTTTCAATAGTGGCTGAGTATACAGACTAGCTGAGGTGTCAAGTCCTGCCTTTCCTTTCATCATCCCAAAT TTCCCCTGCCATGTGTGCTGATCCTGCTGGCAGGACCACATTTCTTTGCCACTGATCTCAATGGCCAGTGATGTAAGTCTTTTGCCTGTC TTCTTGAGACTCGTTGAGATCTTTGTTGAGAACCACTACTATCATTCACTAGCTCATATCTGCCGGCAGCAATTGAAGAGATCCAATATT TGAAGATTGGCCTTCATTTCTCGATGTTCTTTCCATGATGGGGATGGAGGTGTTCAGTGCCACCGTGGCTGTTACTTTTCAAAGTAGTTG AAGTATTGAAAATGAGTAATGTTGGTAAAGTGAATTCAAAATCCTAGTATGCTAAAGGGATGGTACAAGTCTAACACAAATTGTACGTAA TGATACATCTACTAGAAACATACATTATTCATCAAAAGAAATGTTACATGTGTACTCCACAGGCATAGTCTTTGTTATGATGATTGGTGT GGCTTTATGTCTTTGTTATAAACTCCTATTTTTCAGGGGCTTATGATTCTGCTCTAAAACATTGCTCTGGGTTATACAGTTTTGATCCCA AAAGCTTTTTTGTTACAAATCGGGAGAAAAATCCATTTTAGTTCTATGGATGGAAATATTTCATGCTTTTAAAAAGATGTTTGTGTTCCT GTGGTTAAAGTTTTGGCAGTTTATTGATTAGTCCAAATCACAGGCTAAGGCCTGATCTCCAGGAGGGGTAGGGGAGACACTTTACCAGTA TTTTTTTATGGAAATAATACTCAAGGTTGTAAAACCCCTCAAAGCCTAGAAATTTAATTGTTATGGCTGAAATTCCTCCTAGTTGTCTGA TAGAATGCCCCTGAATGGGAACTCTAGGTCCCAAGGCCTGAAGGGTTGAGAACAGACAGCTGTAACTTTGAATTTTGTTGGCTTTCAGTG GTCATGCTACCTACCCATACTCGTACTCTCAGACCTTTTATTAGTAGCCTTGCTTTCTATAGAGCATGCACCAAATCCAGTGAGTCCATG TGGAGAGAGCACTGTGTGCGCAGCGGCAGCAGCACAGACGTCCATGAGGAAAACTCCCAGTGATGATCTGACATTTACAATTACCCCACA TGGAAATTTAGGGGTTTCTGAATCAAGCTTAATGTTTACAGTTTCCAAATAGCCATTTTGCAGTGTATAGTTTCCTTACAAAACTACCCC GCATTCAGTTTTCACATTATCTGCAAGCTGAAACTTATTTTTAAGTTTTGTGTACAAGTTGACTGCTGTAAAGATATATATTTTTGGGTC AGTTTTTTTCCTTCATTAACTTGGTGGTAGAAAAAAATATATACTTAGAAATCCTTAAATTAAAGCCATGTTTTATATATAAGTCAGGTA ACATTGGTGTATAGATGAGAATGCAATTAAACCTGATGAGAATCTACTTGAGAATATAGAAAGTCTTTCTCTAAAGGAGATACTGACTCC CTGGTTTATTGCATTAAAATTTATGTTTGAGGTTACCTCAACTTGTTTTAAAAGATTTTGTTTTGTGAATTTGTACTGTATATTTGAGTA ACTGTCAGGCTTTTATTTAAAATTGTTTAACATGTACCATGTACATGTCATTACTATATTTCAATGCATCATGCTTGTAACAGGCATTTC ATTTATAATAAGAATGAGTTATTCATTTGTAAGCCGTTCAGTAATTTATCTACTATTCCTAAATTGGCATAATGTTAGATAATCTATTTT GAATCACCTTTAATTACATGTCAGAATGCCTTAACTACCCTAACTTGACAAAACAGAATTCTTTGGTAGACGCGGTGGGGGCGGGGTGGG GGGTCTGGACGGAGTCTCTATTTAAGGAGAAATCATCATGCTATGATAAAACACAGAAGCATGAGTGGCAAGTGGCGGGGTATTTATTTT GCACAAACTATTTGCAGTCTCTGTGTATTTAAAAAGTAAAGAAAGTTGCATCCAGAAGGGTTTTGTTAGAATGAATACATTTATATTAGG ACTGACAACTTCAGCTCTTTTGTTTAGGTTTTCAATTATTTTTGGTAAGAGTATGTAGCCTTATGATCTGGATATATTTTGCATTCATTT TCCAACGCCTACATTTAATTCCTGGTAAGAGCAGTGCTCGTCAAGTTTCTGGTTTTTCTCTGCTCTCATTTAACCCGTCAAACACAATCT TTGTAAAGCTAGATTGGTGGTGTTTTATACAACTTATTTACTCAGCTTACCTTTTTGAGAAACGATTGTTAGAAATTGACGATGTGTTTG TTCCAGTGATACTGAAAGTAGTGGGGGCAAGAATTGAGTTTCACAGTGGAATTGGCTTTGGATCTGGCCTATAGATTAGTGACATAAAAT ATTTTCTCTATTTTCCCCTGTTCTTTTTGTGTTATGCACTTAATTTTATGACTGCCGGGGGGGTCAGCTGGAGTGCTGCTTAACAAGTAT CTCTCCTACTCTCAGTGGTCAGAGGCTGTGTTGGACCCATAGTAGAATTTTCCAGGTCACAGACCCAAGCTTCCATGGGTTGTTACTGTG CTGTACCACTTGGTGGGTCTGATTCTGAACCTGATGTGTGTGTTAATTATATTTTAAGCAACACACACACACACACACGCCTCATGTAAT GGACTTTTATAACAAAAGAAAAAATTTGGATTTCTAATTTACAAATGGCAAATTATTTATCCCTCTCTGGATGCACCAAAGACCAGTAAA GTTTATAGCTTTTCCATCTATATTTATAAAGCAATACTGTATTATAAAAATCAATATTTTTATCACATGCTTGAAATTTTTATTTTGTTG TTTTAAAATGTGCACTCTAAACATATCAGAACCTTATTTCTTCCTATGAACTTAAGCTGCCTGCGCACAAAAAAAAAAAAAATTTACCAA ATGGAGATGCAGTAGAGTCCATAGGCTCTAAAAACTAAAAGAAATGGGATGCAGGGGGAACAAGTTATTTGTCCTGAGTTACTGTACTTG CTTGACATGGTTGTTGGGTACTAAATCACAAAAGAATCCATTCCAGGTATGCATGTCTGGGGGTTGGGCTGTGTCTAGATTAGAAACTGG GTTTCAAGCTTTGCATGATGGGAGAGCGTCCTCTCCTCTATCAGCTGCGTGTGTTCTGGATAGGACAGTAGCCCGGAGATGGAAACCACC TTCAGTACCATTAGCCCACCATACCAAGTAACAAGTTAGGCAGGAATCGTGGGAATTTATTGAGTCAGCTTTGAGTGTTTGAGAGAATGT AAACAAGATTGGCTCGAATTGTAAACGTTTGTACTTTGGATGAGTTCATGGTTCTTTAGGTCACCTTAATACCAGCTATCTTTGGTAGAA GCTACAGCATTCAGTTTCTCTGGAAACTGTATCACATTTTTGCATTTTAAAAATTTTACAGTATCAAAAAACCAAAATCTGCTTATGAAA CAAAACATGAAGCAGGACATATTTGGATTCTATTTATTTAAAATTAAATTCTTTGCAAAATTGAACTTCTCAACTAAAACGTGTCCATGT CAGAATTTTAACTGTTAGCAGGTAGTTTGTGGCAAAGATGGCTAAATAATGAAGCAAATTAGAATCTGTGTGTATACTAATGAGCTGCTT TTTTTCTGTTGAGACTATCATTATTTGTCTTATTACCCAAGAGGCAATTACCTGAATTTGGATGTCTGAATTATAACTTATGCAGGAATA GTTCTGTAAATACATTTAAATAAACTGTAAAGATATTTAATAAATATAGTATTTATACTAATCTGTGTGCTTCTTTTGGTTTGAATAGTA ACTAAATGAGACACCAGCCCTTGACATTGAGTTTGTTGGTCACTATCAGGTCCTCATTTCCAAGCCTCCTAGTCATTCTAGCACTGATTA TATGCTGCTACTTTAACTGGCTCCAGCTGCTTCACTACATCAGTTTAGCTTCCTCAGAAATTCATCAAAATGGACGGACAATTAAATGTA AATTATAGAACTTTTTCCCAGCTGAGGCTTTGCACCTTCCGTATAGTATAGAGGGAAGCTACAAAAAAAATCTGCTGTACAGTCAGTCGT GTTGTTTAACAGAGATGTTCTGACAGATGCATCCTTAGCAATTTCATCATTGTGTACTGACACAAGCCTAGATGGTCTAGCCTACTACAC ATCTGGGCTATATGAATAGCCTGTTGCTCCTAGGCGACAAACCTGTATAACATGTTACTGTACTGAATACTGTAGGCAGTTGTAACACAA CAGTAAGCATCTGTATATCTAAACATAGAAATGTTTCAGCAAAACTATGGTATGAAAGACAAAAAAATGGTACACCTGTATAGGGCAGCT CCATTATCTTATGGGACCACCACTGTCTGTGCAGTCCATCGTTGACCAAAACGTTGTTATGCAGCACATGACTGTATTTCAGCTTAGCAC TCTGTATCCAAATTCTAAAATCCAAAGTGCCCAGCTAATTTTTGTAGAGATGGGATCTCACCATGTTGCCCAGGCTAGTCTTGAACTGCT GGGCTCAACTGATCCGCCCACCTGGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTACACCCCGCCAGTATTAACTATAATAAT AGTCCAATGCTGCATCCAGGCTATTACTGATGATGATGCCTTTAAGACCTAAACCCCTCTGCCTACTTCAATGAATGAACCAGAAATGTT ATCCTCAGCAAAGAGACCTACAGAGTTACTTTTGTGTATAAAAGCTCCCTGTGTAGGCATCTGCATTTGTTAGAAATACCAGAAATTCAG TGTTAATCATCAGTGTAAGCATAAGATACATATATCTTCCCCTACCATGTGATGAAAGGACTTAGTTGAAATTATGTGGGCATTGCCAGT TACCACAAAAAGCTTGGTTAAGGCCCATTTTCATTCACTAAGGAACATCTTGGGATGAACTTGAGTTTTTATTAGGTTATTGTGGGTAGC TATGACTCATTACTAAGCTACAAGAGCCAAATTAATTCTGGTTTCAGTTAGAACTCTATTCACAGTTCTAAAGCATGCAAATCCACTCAG CCACCTTTATGAATTTCTCACAAAGTCTAAAGTACAACTGCTTGCCAGTTAACACTTCCTTACGGTTTGAAGGTTTCAGAAAGATGTAAC AATAATATGTTACAAAAGTCTCGTTTGTCAGGTTATAATTGACTGTAAACAGGTTTGGGGGAGGGAGAGGCACACATCATAAGACATTAC ATAACAATGTTTTGTGCCAGATTTTTTAGTCCATTTGTGCAGGTAAAAAGCTAACTCTTAAAGGGCCAAAGAACAGAGACATTTGTCTTC CACCTTATTCCACTCCAAACTCAGGCTGTCTTGGCAGTGGAGGATACTGTTCTATGTCAGATAATACAGAAATATTTGGCATCACTTCCA TTAAATTCTTTCCTGCAGCACACTGCAAAATAAAAAATCACATCTGAAAATCAGAACAATTTGAGGTTAGGAAATAAAATTTTACAATAT GTAAAAACACTCCAGGTTGGGCGCAGTGGCTCAAGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGCCAGGA GTTCAAGACCACCCTGGCCAACATGGCGAAACCCTGTCTCTACAAAATACCAGAAATTAGCCAGGCATGGTGGCACGCACCTGCAATCCC |
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FusionGenePPI for TCHP_PPTC7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TCHP | VIM, KRT15, NME7, CCDC85B, TEX11, CUL4A, LATS2, CDR2, NAB2, TRIM27, MKRN3, NDOR1, LZTS2, KRT40, DYDC1, MIPOL1, CCDC172, GLUL, LTBR, BTRC, MED4, SSX2IP, OFD1, PCM1, CEP170, KIAA0753, CEP104, CEP162, CEP290, CEP152, CNTROB, SPICE1, CEP128, CEP135, CEP44, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, LCA5, POC1A, STIL, CENPJ, IFFO1, KCTD17, SPAG16, TUBG1, AMPD2 | PPTC7 | ELAVL1, ZDHHC17, PPTC7, BNIP3, BNIP3L, TRMT61B, TRMT2B, MRPL22, MRPS18C, SARS2, SPHKAP, C1QBP, RTN4IP1, ASF1B, ASF1A, CD70, DBT, FAM174A, LPAR4, HSDL1, UBB, LAMP2, AIFM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TCHP | chr12:110342598 | chr12:110976078 | ENST00000312777 | + | 4 | 13 | 73_498 | 152 | 499 | keratin proteins |
| Hgene | TCHP | chr12:110342598 | chr12:110976078 | ENST00000405876 | + | 4 | 13 | 73_498 | 152 | 499 | keratin proteins |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCHP_PPTC7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCHP_PPTC7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PPTC7 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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