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Fusion gene ID: 37611 |
FusionGeneSummary for TCF7_S100A14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF7_S100A14 | Fusion gene ID: 37611 | Hgene | Tgene | Gene symbol | TCF7 | S100A14 | Gene ID | 6932 | 57402 |
| Gene name | transcription factor 7 | S100 calcium binding protein A14 | |
| Synonyms | TCF-1 | BCMP84|S100A15 | |
| Cytomap | 5q31.1 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 7T-cell-factor-7T-cell-specific transcription factor 1transcription factor 7 (T-cell specific, HMG-box) | protein S100-A14S114breast cancer membrane protein 84 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P36402 | Q9HCY8 | |
| Ensembl transtripts involved in fusion gene | ENST00000378564, ENST00000321584, ENST00000321603, ENST00000342854, ENST00000395029, ENST00000432532, ENST00000378560, ENST00000520958, ENST00000518915, ENST00000395023, ENST00000517478, | ENST00000476873, ENST00000368701, ENST00000368702, ENST00000344616, ENST00000368700, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 3 X 3 X 1=9 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TCF7 [Title/Abstract] AND S100A14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCF7 | GO:0071353 | cellular response to interleukin-4 | 18579517 |
| Tgene | S100A14 | GO:0034142 | toll-like receptor 4 signaling pathway | 17625598 |
| Tgene | S100A14 | GO:0071624 | positive regulation of granulocyte chemotaxis | 18606705 |
| Tgene | S100A14 | GO:0090026 | positive regulation of monocyte chemotaxis | 18606705 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF799331 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000378564 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378564 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378564 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378564 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000378564 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000321584 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000321603 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000342854 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000395029 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000432532 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000378560 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000520958 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000518915 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000395023 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-5UTR | ENST00000517478 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
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FusionProtFeatures for TCF7_S100A14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF7 | S100A14 |
| Transcriptional activator involved in T-cell lymphocytedifferentiation. Necessary for the survival of CD4(+) CD8(+)immature thymocytes. Isoforms lacking the N-terminal CTNNB1binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in thepromoter of the CD3E gene. May also act as feedbacktranscriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1,TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 andCTNNB1. | Modulates P53/TP53 protein levels, and thereby plays arole in the regulation of cell survival and apoptosis. Dependingon the context, it can promote cell proliferation or apoptosis.Plays a role in the regulation of cell migration by modulating thelevels of MMP2, a matrix protease that is under transcriptionalcontrol of P53/TP53. Does not bind calcium.{ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898,ECO:0000269|PubMed:22451655}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCF7_S100A14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCF7_S100A14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCF7_S100A14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCF7_S100A14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TCF7 | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | TCF7 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
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