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Fusion gene ID: 37599 |
FusionGeneSummary for TCF7L1_WIF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF7L1_WIF1 | Fusion gene ID: 37599 | Hgene | Tgene | Gene symbol | TCF7L1 | WIF1 | Gene ID | 83439 | 11197 |
| Gene name | transcription factor 7 like 1 | WNT inhibitory factor 1 | |
| Synonyms | TCF-3|TCF3 | WIF-1 | |
| Cytomap | 2p11.2 | 12q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box) | wnt inhibitory factor 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HCS4 | Q9Y5W5 | |
| Ensembl transtripts involved in fusion gene | ENST00000282111, ENST00000494519, | ENST00000286574, | |
| Fusion gene scores | * DoF score | 9 X 5 X 8=360 | 8 X 8 X 4=256 |
| # samples | 9 | 12 | |
| ** MAII score | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/256*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TCF7L1 [Title/Abstract] AND WIF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A1LI-01A | TCF7L1 | chr2 | 85361573 | + | WIF1 | chr12 | 65471634 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000282111 | ENST00000286574 | TCF7L1 | chr2 | 85361573 | + | WIF1 | chr12 | 65471634 | - |
| 3UTR-3CDS | ENST00000494519 | ENST00000286574 | TCF7L1 | chr2 | 85361573 | + | WIF1 | chr12 | 65471634 | - |
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FusionProtFeatures for TCF7L1_WIF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF7L1 | WIF1 |
| Participates in the Wnt signaling pathway. Binds to DNAand acts as a repressor in the absence of CTNNB1, and as anactivator in its presence. Necessary for the terminaldifferentiation of epidermal cells, the formation of keratohyalingranules and the development of the barrier function of theepidermis (By similarity). Down-regulates NQO1, leading toincreased mitomycin c resistance. {ECO:0000250}. | Binds to WNT proteins and inhibits their activities. Maybe involved in mesoderm segmentation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TCF7L1 | chr2:85361573 | chr12:65471634 | ENST00000282111 | + | 3 | 12 | 5_29 | 147 | 589 | Compositional bias | Note=Gly-rich |
| Hgene | TCF7L1 | chr2:85361573 | chr12:65471634 | ENST00000282111 | + | 3 | 12 | 1_74 | 147 | 589 | Region | CTNNB1-binding |
| Tgene | >WIF1 | chr2:85361573 | chr12:65471634 | ENST00000286574 | - | 1 | 10 | 178_210 | 96 | 380 | Domain | EGF-like 1 |
| Tgene | >WIF1 | chr2:85361573 | chr12:65471634 | ENST00000286574 | - | 1 | 10 | 211_242 | 96 | 380 | Domain | EGF-like 2 |
| Tgene | >WIF1 | chr2:85361573 | chr12:65471634 | ENST00000286574 | - | 1 | 10 | 243_271 | 96 | 380 | Domain | EGF-like 3 |
| Tgene | >WIF1 | chr2:85361573 | chr12:65471634 | ENST00000286574 | - | 1 | 10 | 274_306 | 96 | 380 | Domain | EGF-like 4 |
| Tgene | >WIF1 | chr2:85361573 | chr12:65471634 | ENST00000286574 | - | 1 | 10 | 307_338 | 96 | 380 | Domain | EGF-like 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TCF7L1 | chr2:85361573 | chr12:65471634 | ENST00000282111 | + | 3 | 12 | 117_326 | 147 | 589 | Compositional bias | Note=Pro-rich |
| Hgene | >TCF7L1 | chr2:85361573 | chr12:65471634 | ENST00000282111 | + | 3 | 12 | 346_414 | 147 | 589 | DNA binding | HMG box |
| Hgene | >TCF7L1 | chr2:85361573 | chr12:65471634 | ENST00000282111 | + | 3 | 12 | 421_427 | 147 | 589 | Motif | Nuclear localization signal |
| Tgene | WIF1 | chr2:85361573 | chr12:65471634 | ENST00000286574 | - | 1 | 10 | 38_177 | 96 | 380 | Domain | WIF |
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FusionGeneSequence for TCF7L1_WIF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TCF7L1_ENST00000282111_chr2_85361573_+_WIF1_ENST00000286574_chr12_65471634_-_431aa MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQP VRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPH KASVVQVGFPCLGKQDGVAAFEVDVIVMNSEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRCM NGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TCF7L1_ENST00000282111_chr2_85361573_+_WIF1_ENST00000286574_chr12_65471634_-_1293nt ATGCCCCAGCTCGGCGGCGGGGGCGGCGGCGGCGGCGGCGGCAGCGGGGGAGGCGGCGGCTCCAGCGCCGGGGCGGCCGGCGGAGGGGAC GACCTCGGGGCGAACGACGAGCTGATCCCCTTCCAGGACGAGGGGGGCGAGGAGCAGGAGCCGAGCAGCGATAGCGCCTCGGCGCAGCGG GACCTAGACGAGGTCAAGTCGTCCCTGGTCAACGAGTCGGAGAACCAGAGCAGCAGCTCGGACTCGGAGGCGGAGAGGCGCCCGCAGCCC GTCCGGGACACTTTCCAGAAGCCGCGGGACTATTTCGCCGAAGTGAGAAGGCCTCAGGACAGCGCGTTCTTTAAAGGACCCCCGTACCCT GGGTACCCCTTCCTGATGATCCCGGACCTGAGCAGCCCGTACCTCTCCAACGGACCCCTGTCTCCCGGAGGAGCGCGCACCGCAGAATAC TTCTATGAATTCCTGTCCTTGCGCTCCCTGGATAAAGGCATCATGGCAGATCCAACCGTCAATGTCCCTCTGCTGGGAACAGTGCCTCAC AAGGCATCAGTTGTTCAAGTTGGTTTCCCATGTCTTGGAAAACAGGATGGGGTGGCAGCATTTGAAGTGGATGTGATTGTTATGAATTCT GAAGGCAACACCATTCTCCAAACACCTCAAAATGCTATCTTCTTTAAAACATGTCAACAAGCTGAGTGCCCAGGCGGGTGCCGAAATGGA GGCTTTTGTAATGAAAGACGCATCTGCGAGTGTCCTGATGGGTTCCACGGACCTCACTGTGAGAAAGCCCTTTGTACCCCACGATGTATG AATGGTGGACTTTGTGTGACTCCTGGTTTCTGCATCTGCCCACCTGGATTCTATGGAGTGAACTGTGACAAAGCAAACTGCTCAACCACC TGCTTTAATGGAGGGACCTGTTTCTACCCTGGAAAATGTATTTGCCCTCCAGGACTAGAGGGAGAGCAGTGTGAAATCAGCAAATGCCCA CAACCCTGTCGAAATGGAGGTAAATGCATTGGTAAAAGCAAATGTAAGTGTTCCAAAGGTTACCAGGGAGACCTCTGTTCAAAGCCTGTC TGCGAGCCTGGCTGTGGTGCACATGGAACCTGCCATGAACCCAACAAATGCCAATGTCAAGAAGGTTGGCATGGAAGACACTGCAATAAA AGGTACGAAGCCAGCCTCATACATGCCCTGAGGCCAGCAGGCGCCCAGCTCAGGCAGCACACGCCTTCACTTAAAAAGGCCGAGGAGCGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TCF7L1_ENST00000282111_chr2_85361573_+_WIF1_ENST00000286574_chr12_65471634_-_2291nt GGCCAGGGGCTGGGACGCCCCGGCGGAGCAGGCGGCGGCGGTGGCGAGTTGGGGAGCCCTAGGCTCGGCGCTGCCGGAGGGGCCCGAGCC GAGCCGCCTGCGCCCCGGCCGGGCAGCGCCGGGCCCGCTTCCCGCGGGGCCACGCCCTGTCAAACTTTGTTGCGGCGGCTAGCGCAGCGG GCCCGCAAGCGGGCGGGAGGGGCGCCGGGCCGGGCCGGGCAGGGCGCGGGCGGCTAGGGGCTCCGAGAGCGGCGGCCCCGGCCCGCGGCC CCACCATGCCCCAGCTCGGCGGCGGGGGCGGCGGCGGCGGCGGCGGCAGCGGGGGAGGCGGCGGCTCCAGCGCCGGGGCGGCCGGCGGAG GGGACGACCTCGGGGCGAACGACGAGCTGATCCCCTTCCAGGACGAGGGGGGCGAGGAGCAGGAGCCGAGCAGCGATAGCGCCTCGGCGC AGCGGGACCTAGACGAGGTCAAGTCGTCCCTGGTCAACGAGTCGGAGAACCAGAGCAGCAGCTCGGACTCGGAGGCGGAGAGGCGCCCGC AGCCCGTCCGGGACACTTTCCAGAAGCCGCGGGACTATTTCGCCGAAGTGAGAAGGCCTCAGGACAGCGCGTTCTTTAAAGGACCCCCGT ACCCTGGGTACCCCTTCCTGATGATCCCGGACCTGAGCAGCCCGTACCTCTCCAACGGACCCCTGTCTCCCGGAGGAGCGCGCACCGCAG AATACTTCTATGAATTCCTGTCCTTGCGCTCCCTGGATAAAGGCATCATGGCAGATCCAACCGTCAATGTCCCTCTGCTGGGAACAGTGC CTCACAAGGCATCAGTTGTTCAAGTTGGTTTCCCATGTCTTGGAAAACAGGATGGGGTGGCAGCATTTGAAGTGGATGTGATTGTTATGA ATTCTGAAGGCAACACCATTCTCCAAACACCTCAAAATGCTATCTTCTTTAAAACATGTCAACAAGCTGAGTGCCCAGGCGGGTGCCGAA ATGGAGGCTTTTGTAATGAAAGACGCATCTGCGAGTGTCCTGATGGGTTCCACGGACCTCACTGTGAGAAAGCCCTTTGTACCCCACGAT GTATGAATGGTGGACTTTGTGTGACTCCTGGTTTCTGCATCTGCCCACCTGGATTCTATGGAGTGAACTGTGACAAAGCAAACTGCTCAA CCACCTGCTTTAATGGAGGGACCTGTTTCTACCCTGGAAAATGTATTTGCCCTCCAGGACTAGAGGGAGAGCAGTGTGAAATCAGCAAAT GCCCACAACCCTGTCGAAATGGAGGTAAATGCATTGGTAAAAGCAAATGTAAGTGTTCCAAAGGTTACCAGGGAGACCTCTGTTCAAAGC CTGTCTGCGAGCCTGGCTGTGGTGCACATGGAACCTGCCATGAACCCAACAAATGCCAATGTCAAGAAGGTTGGCATGGAAGACACTGCA ATAAAAGGTACGAAGCCAGCCTCATACATGCCCTGAGGCCAGCAGGCGCCCAGCTCAGGCAGCACACGCCTTCACTTAAAAAGGCCGAGG AGCGGCGGGATCCACCTGAATCCAATTACATCTGGTGAACTCCGACATCTGAAACGTTTTAAGTTACACCAAGTTCATAGCCTTTGTTAA CCTTTCATGTGTTGAATGTTCAAATAATGTTCATTACACTTAAGAATACTGGCCTGAATTTTATTAGCTTCATTATAAATCACTGAGCTG ATATTTACTCTTCCTTTTAAGTTTTCTAAGTACGTCTGTAGCATGATGGTATAGATTTTCTTGTTTCAGTGCTTTGGGACAGATTTTATA TTATGTCAATTGATCAGGTTAAAATTTTCAGTGTGTAGTTGGCAGATATTTTCAAAATTACAATGCATTTATGGTGTCTGGGGGCAGGGG AACATCAGAAAGGTTAAATTGGGCAAAAATGCGTAAGTCACAAGAATTTGGATGGTGCAGTTAATGTTGAAGTTACAGCATTTCAGATTT TATTGTCAGATATTTAGATGTTTGTTACATTTTTAAAAATTGCTCTTAATTTTTAAACTCTCAATACAATATATTTTGACCTTACCATTA TTCCAGAGATTCAGTATTAAAAAAAAAAAAATTACACTGTGGTAGTGGCATTTAAACAATATAATATATTCTAAACACAATGAAATAGGG AATATAATGTATGAACTTTTTGCATTGGCTTGAAGCAATATAATATATTGTAAACAAAACACAGCTCTTACCTAATAAACATTTTATACT |
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FusionGenePPI for TCF7L1_WIF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TCF7L1 | CTNNB1, DAZAP2, NANOG, POU5F1 | WIF1 | WNT1, RPL37, ICOS, KRTAP10-8, KRTAP10-3, AURKA, FGFR4, RB1CC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCF7L1_WIF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCF7L1_WIF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TCF7L1 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| Tgene | WIF1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | WIF1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | WIF1 | C0027439 | Nasopharyngeal Neoplasms | 1 | CTD_human |
| Tgene | WIF1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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