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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37598

FusionGeneSummary for TCF7L1_TMEM182

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF7L1_TMEM182
Fusion gene ID: 37598
HgeneTgene
Gene symbol

TCF7L1

TMEM182

Gene ID

83439

130827

Gene nametranscription factor 7 like 1transmembrane protein 182
SynonymsTCF-3|TCF3-
Cytomap

2p11.2

2q12.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)transmembrane protein 182
Modification date2018052320180519
UniProtAcc

Q9HCS4

Q6ZP80

Ensembl transtripts involved in fusion geneENST00000282111, ENST00000494519, 
ENST00000409528, ENST00000409173, 
ENST00000412401, ENST00000486293, 
Fusion gene scores* DoF score9 X 5 X 8=3602 X 2 X 2=8
# samples 92
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TCF7L1 [Title/Abstract] AND TMEM182 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-68-8250-01ATCF7L1chr2

85510701

+TMEM182chr2

103549343

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282111ENST00000409528TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
5CDS-intronENST00000282111ENST00000409173TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
5CDS-intronENST00000282111ENST00000412401TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
5CDS-intronENST00000282111ENST00000486293TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
intron-intronENST00000494519ENST00000409528TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
intron-intronENST00000494519ENST00000409173TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
intron-intronENST00000494519ENST00000412401TCF7L1chr2

85510701

+TMEM182chr2

103549343

+
intron-intronENST00000494519ENST00000486293TCF7L1chr2

85510701

+TMEM182chr2

103549343

+

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FusionProtFeatures for TCF7L1_TMEM182


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF7L1

Q9HCS4

TMEM182

Q6ZP80

Participates in the Wnt signaling pathway. Binds to DNAand acts as a repressor in the absence of CTNNB1, and as anactivator in its presence. Necessary for the terminaldifferentiation of epidermal cells, the formation of keratohyalingranules and the development of the barrier function of theepidermis (By similarity). Down-regulates NQO1, leading toincreased mitomycin c resistance. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF7L1_TMEM182


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF7L1_TMEM182


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF7L1CTNNB1, DAZAP2, NANOG, POU5F1TMEM182SYNE4, LGALS3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF7L1_TMEM182


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF7L1_TMEM182


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF7L1C0040136Thyroid Neoplasm1CTD_human