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Fusion gene ID: 37590 |
FusionGeneSummary for TCF4_ZC3H6 |
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Fusion gene information | Fusion gene name: TCF4_ZC3H6 | Fusion gene ID: 37590 | Hgene | Tgene | Gene symbol | TCF4 | ZC3H6 | Gene ID | 6934 | 376940 |
Gene name | transcription factor 7 like 2 | zinc finger CCCH-type containing 6 | |
Synonyms | TCF-4|TCF4 | ZC3HDC6 | |
Cytomap | 10q25.2-q25.3 | 2q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box) | zinc finger CCCH domain-containing protein 6zinc finger CCCH-type domain containing 6 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P15884 | P61129 | |
Ensembl transtripts involved in fusion gene | ENST00000354452, ENST00000356073, ENST00000568673, ENST00000457482, ENST00000543082, ENST00000540999, ENST00000537578, ENST00000564999, ENST00000568740, ENST00000537856, ENST00000544241, ENST00000561992, ENST00000561831, ENST00000565018, ENST00000570287, ENST00000564228, ENST00000567880, ENST00000566286, ENST00000566279, ENST00000564403, ENST00000398339, ENST00000570177, ENST00000563760, | ENST00000409871, ENST00000343936, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 1=4 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: TCF4 [Title/Abstract] AND ZC3H6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TCF4 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12799378 |
Hgene | TCF4 | GO:0006357 | regulation of transcription by RNA polymerase II | 9727977 |
Hgene | TCF4 | GO:0032092 | positive regulation of protein binding | 12799378 |
Hgene | TCF4 | GO:0032350 | regulation of hormone metabolic process | 15525634 |
Hgene | TCF4 | GO:0042593 | glucose homeostasis | 15525634 |
Hgene | TCF4 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 12799378 |
Hgene | TCF4 | GO:0045444 | fat cell differentiation | 10937998 |
Hgene | TCF4 | GO:0045892 | negative regulation of transcription, DNA-templated | 12799378|15525634 |
Hgene | TCF4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065401|19168596 |
Hgene | TCF4 | GO:0048625 | myoblast fate commitment | 10937998 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE161960 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000354452 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000354452 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000356073 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000356073 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000568673 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000568673 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000457482 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000457482 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000543082 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000543082 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000540999 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000540999 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000537578 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000537578 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000564999 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000564999 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000568740 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000568740 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000537856 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000537856 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000544241 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000544241 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000561992 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000561992 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000561831 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000561831 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000565018 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000565018 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000570287 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000570287 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000564228 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000564228 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000567880 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000567880 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000566286 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000566286 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000566279 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000566279 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000564403 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000564403 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000398339 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000398339 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000570177 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000570177 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000563760 | ENST00000409871 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
intron-3UTR | ENST00000563760 | ENST00000343936 | TCF4 | chr18 | 52893027 | + | ZC3H6 | chr2 | 113096787 | + |
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FusionProtFeatures for TCF4_ZC3H6 |
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Hgene | Tgene |
TCF4 | ZC3H6 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCF4_ZC3H6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCF4_ZC3H6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCF4_ZC3H6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCF4_ZC3H6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TCF4 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | TCF4 | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | TCF4 | C1970431 | PITT-HOPKINS SYNDROME | 4 | CTD_human;ORPHANET;UNIPROT |
Hgene | TCF4 | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | TCF4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | TCF4 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | TCF4 | C0025958 | Microcephaly | 1 | CTD_human |
Hgene | TCF4 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | TCF4 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | TCF4 | C0036572 | Seizures | 1 | CTD_human;HPO |
Hgene | TCF4 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | TCF4 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | TCF4 | C1456784 | Paranoia | 1 | PSYGENET |