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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37590

FusionGeneSummary for TCF4_ZC3H6

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF4_ZC3H6
Fusion gene ID: 37590
HgeneTgene
Gene symbol

TCF4

ZC3H6

Gene ID

6934

376940

Gene nametranscription factor 7 like 2zinc finger CCCH-type containing 6
SynonymsTCF-4|TCF4ZC3HDC6
Cytomap

10q25.2-q25.3

2q14.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)zinc finger CCCH domain-containing protein 6zinc finger CCCH-type domain containing 6
Modification date2018052720180523
UniProtAcc

P15884

P61129

Ensembl transtripts involved in fusion geneENST00000354452, ENST00000356073, 
ENST00000568673, ENST00000457482, 
ENST00000543082, ENST00000540999, 
ENST00000537578, ENST00000564999, 
ENST00000568740, ENST00000537856, 
ENST00000544241, ENST00000561992, 
ENST00000561831, ENST00000565018, 
ENST00000570287, ENST00000564228, 
ENST00000567880, ENST00000566286, 
ENST00000566279, ENST00000564403, 
ENST00000398339, ENST00000570177, 
ENST00000563760, 		ENST00000409871, 
ENST00000343936, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: TCF4 [Title/Abstract] AND ZC3H6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF4

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

HgeneTCF4

GO:0006357

regulation of transcription by RNA polymerase II

9727977

HgeneTCF4

GO:0032092

positive regulation of protein binding

12799378

HgeneTCF4

GO:0032350

regulation of hormone metabolic process

15525634

HgeneTCF4

GO:0042593

glucose homeostasis

15525634

HgeneTCF4

GO:0043433

negative regulation of DNA binding transcription factor activity

12799378

HgeneTCF4

GO:0045444

fat cell differentiation

10937998

HgeneTCF4

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

HgeneTCF4

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

HgeneTCF4

GO:0048625

myoblast fate commitment

10937998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE161960TCF4chr18

52893027

+ZC3H6chr2

113096787

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000354452ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000354452ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000356073ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000356073ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000568673ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000568673ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000457482ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000457482ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000543082ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000543082ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000540999ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000540999ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000537578ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000537578ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000564999ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000564999ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000568740ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000568740ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000537856ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000537856ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000544241ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000544241ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000561992ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000561992ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000561831ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000561831ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000565018ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000565018ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000570287ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000570287ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000564228ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000564228ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000567880ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000567880ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000566286ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000566286ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000566279ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000566279ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000564403ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000564403ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000398339ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000398339ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000570177ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000570177ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000563760ENST00000409871TCF4chr18

52893027

+ZC3H6chr2

113096787

+
intron-3UTRENST00000563760ENST00000343936TCF4chr18

52893027

+ZC3H6chr2

113096787

+

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FusionProtFeatures for TCF4_ZC3H6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF4

P15884

ZC3H6

P61129


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF4_ZC3H6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF4_ZC3H6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF4_ZC3H6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF4_ZC3H6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF4C0005586Bipolar Disorder5PSYGENET
HgeneTCF4C0036341Schizophrenia4PSYGENET
HgeneTCF4C1970431PITT-HOPKINS SYNDROME4CTD_human;ORPHANET;UNIPROT
HgeneTCF4C0018799Heart Diseases1CTD_human
HgeneTCF4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTCF4C0023903Liver neoplasms1CTD_human
HgeneTCF4C0025958Microcephaly1CTD_human
HgeneTCF4C0031117Peripheral Neuropathy1CTD_human
HgeneTCF4C0033975Psychotic Disorders1PSYGENET
HgeneTCF4C0036572Seizures1CTD_human;HPO
HgeneTCF4C0349204Nonorganic psychosis1PSYGENET
HgeneTCF4C0376634Craniofacial Abnormalities1CTD_human
HgeneTCF4C1456784Paranoia1PSYGENET