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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37533

FusionGeneSummary for TCEAL3_TMEM179B

check button Fusion gene summary
Fusion gene informationFusion gene name: TCEAL3_TMEM179B
Fusion gene ID: 37533
HgeneTgene
Gene symbol

TCEAL3

TMEM179B

Gene ID

85012

374395

Gene nametranscription elongation factor A like 3transmembrane protein 179B
SynonymsWEX8-
Cytomap

Xq22.2

11q12.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription elongation factor A protein-like 3TCEA-like protein 3transcription elongation factor A (SII)-like 3transcription elongation factor S-II protein-like 3transmembrane protein 179B
Modification date2018052320180524
UniProtAcc

Q969E4

Q7Z7N9

Ensembl transtripts involved in fusion geneENST00000372628, ENST00000243286, 
ENST00000372627, ENST00000477014, 
ENST00000533861, ENST00000333449, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: TCEAL3 [Title/Abstract] AND TMEM179B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB053893TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000372628ENST00000533861TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
5CDS-3UTRENST00000372628ENST00000333449TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
5CDS-3UTRENST00000243286ENST00000533861TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
5CDS-3UTRENST00000243286ENST00000333449TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
5CDS-3UTRENST00000372627ENST00000533861TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
5CDS-3UTRENST00000372627ENST00000333449TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
intron-3UTRENST00000477014ENST00000533861TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+
intron-3UTRENST00000477014ENST00000333449TCEAL3chrX

102864548

-TMEM179Bchr11

62557651

+

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FusionProtFeatures for TCEAL3_TMEM179B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCEAL3

Q969E4

TMEM179B

Q7Z7N9

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCEAL3_TMEM179B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCEAL3_TMEM179B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCEAL3_TMEM179B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCEAL3_TMEM179B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource