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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37532

FusionGeneSummary for TCEAL2_DLG2

check button Fusion gene summary
Fusion gene informationFusion gene name: TCEAL2_DLG2
Fusion gene ID: 37532
HgeneTgene
Gene symbol

TCEAL2

DLG2

Gene ID

140597

4355

Gene nametranscription elongation factor A like 2membrane palmitoylated protein 2
SynonymsMY0876G05|WEX1|my048DLG2
Cytomap

Xq22.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptiontranscription elongation factor A protein-like 2TCEA-like protein 2transcription elongation factor A (SII)-like 2transcription elongation factor S-II protein-like 2MAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Modification date2018052320180519
UniProtAcc

Q9H3H9

Q15700

Ensembl transtripts involved in fusion geneENST00000476749, ENST00000372780, 
ENST00000329035, 
ENST00000398309, 
ENST00000376104, ENST00000418306, 
ENST00000280241, ENST00000543673, 
ENST00000376106, ENST00000330014, 
ENST00000537455, ENST00000524982, 
ENST00000532653, ENST00000531015, 
ENST00000398301, ENST00000426717, 
ENST00000404783, ENST00000398304, 
ENST00000530800, ENST00000472545, 
Fusion gene scores* DoF score1 X 1 X 1=116 X 15 X 6=1440
# samples 120
** MAII scorelog2(1/1*10)=3.32192809488736log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCEAL2 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA757827TCEAL2chrX

101382471

-DLG2chr11

84132425

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000476749ENST00000398309TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000376104TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000418306TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000280241TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000543673TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000376106TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000330014TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000537455TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000524982TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000532653TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000531015TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000398301TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000426717TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000404783TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000398304TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000530800TCEAL2chrX

101382471

-DLG2chr11

84132425

+
intron-intronENST00000476749ENST00000472545TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000398309TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000376104TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000418306TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000280241TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000543673TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000376106TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000330014TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000537455TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000524982TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000532653TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000531015TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000398301TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000426717TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000404783TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000398304TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000530800TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000372780ENST00000472545TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000398309TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000376104TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000418306TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000280241TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000543673TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000376106TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000330014TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000537455TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000524982TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000532653TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000531015TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000398301TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000426717TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000404783TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000398304TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000530800TCEAL2chrX

101382471

-DLG2chr11

84132425

+
5CDS-intronENST00000329035ENST00000472545TCEAL2chrX

101382471

-DLG2chr11

84132425

+

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FusionProtFeatures for TCEAL2_DLG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCEAL2

Q9H3H9

DLG2

Q15700

May be involved in transcriptional regulation. Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCEAL2_DLG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCEAL2_DLG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCEAL2_DLG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCEAL2_DLG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLG2C0036341Schizophrenia4PSYGENET
TgeneDLG2C0005586Bipolar Disorder2PSYGENET
TgeneDLG2C0025202melanoma1CTD_human
TgeneDLG2C0041696Unipolar Depression1PSYGENET
TgeneDLG2C0809983Schizophrenia and related disorders1PSYGENET
TgeneDLG2C1269683Major Depressive Disorder1PSYGENET