	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 37532

FusionGeneSummary for TCEAL2_DLG2

Fusion gene summary

Fusion gene information	Fusion gene name: TCEAL2_DLG2
	Fusion gene ID: 37532
		Hgene	Tgene
	Gene symbol	TCEAL2	DLG2
	Gene ID	140597	4355
	Gene name	transcription elongation factor A like 2	membrane palmitoylated protein 2
	Synonyms	MY0876G05\|WEX1\|my048	DLG2
	Cytomap	Xq22.1	17q21.31
	Type of gene	protein-coding	protein-coding
	Description	transcription elongation factor A protein-like 2TCEA-like protein 2transcription elongation factor A (SII)-like 2transcription elongation factor S-II protein-like 2	MAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
	Modification date	20180523	20180519
	UniProtAcc	Q9H3H9	Q15700
	Ensembl transtripts involved in fusion gene	ENST00000476749, ENST00000372780, ENST00000329035,	ENST00000398309, ENST00000376104, ENST00000418306, ENST00000280241, ENST00000543673, ENST00000376106, ENST00000330014, ENST00000537455, ENST00000524982, ENST00000532653, ENST00000531015, ENST00000398301, ENST00000426717, ENST00000404783, ENST00000398304, ENST00000530800, ENST00000472545,
Fusion gene scores	* DoF score	1 X 1 X 1=1	16 X 15 X 6=1440
	# samples	1	20
	** MAII score	log2(1/1*10)=3.32192809488736	log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TCEAL2 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA757827	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000476749	ENST00000398309	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000376104	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000418306	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000280241	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000543673	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000376106	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000330014	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000537455	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000524982	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000532653	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000531015	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000398301	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000426717	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000404783	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000398304	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000530800	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
intron-intron	ENST00000476749	ENST00000472545	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000398309	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000376104	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000418306	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000280241	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000543673	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000376106	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000330014	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000537455	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000524982	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000532653	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000531015	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000398301	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000426717	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000404783	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000398304	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000530800	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000372780	ENST00000472545	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000398309	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000376104	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000418306	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000280241	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000543673	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000376106	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000330014	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000537455	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000524982	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000532653	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000531015	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000398301	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000426717	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000404783	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000398304	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000530800	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+
5CDS-intron	ENST00000329035	ENST00000472545	TCEAL2	chrX	101382471	-	DLG2	chr11	84132425	+

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FusionProtFeatures for TCEAL2_DLG2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TCEAL2 Q9H3H9	DLG2 Q15700
May be involved in transcriptional regulation.	Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TCEAL2_DLG2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCEAL2_DLG2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TCEAL2_DLG2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TCEAL2_DLG2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	DLG2	C0036341	Schizophrenia	4	PSYGENET
Tgene	DLG2	C0005586	Bipolar Disorder	2	PSYGENET
Tgene	DLG2	C0025202	melanoma	1	CTD_human
Tgene	DLG2	C0041696	Unipolar Depression	1	PSYGENET
Tgene	DLG2	C0809983	Schizophrenia and related disorders	1	PSYGENET
Tgene	DLG2	C1269683	Major Depressive Disorder	1	PSYGENET

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Fusion gene ID: 37532

FusionGeneSummary for TCEAL2_DLG2

FusionProtFeatures for TCEAL2_DLG2

FusionGeneSequence for TCEAL2_DLG2

FusionGenePPI for TCEAL2_DLG2

RelatedDrugs for TCEAL2_DLG2

RelatedDiseases for TCEAL2_DLG2