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Fusion gene ID: 37532 |
FusionGeneSummary for TCEAL2_DLG2 |
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Fusion gene information | Fusion gene name: TCEAL2_DLG2 | Fusion gene ID: 37532 | Hgene | Tgene | Gene symbol | TCEAL2 | DLG2 | Gene ID | 140597 | 4355 |
Gene name | transcription elongation factor A like 2 | membrane palmitoylated protein 2 | |
Synonyms | MY0876G05|WEX1|my048 | DLG2 | |
Cytomap | Xq22.1 | 17q21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription elongation factor A protein-like 2TCEA-like protein 2transcription elongation factor A (SII)-like 2transcription elongation factor S-II protein-like 2 | MAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H3H9 | Q15700 | |
Ensembl transtripts involved in fusion gene | ENST00000476749, ENST00000372780, ENST00000329035, | ENST00000398309, ENST00000376104, ENST00000418306, ENST00000280241, ENST00000543673, ENST00000376106, ENST00000330014, ENST00000537455, ENST00000524982, ENST00000532653, ENST00000531015, ENST00000398301, ENST00000426717, ENST00000404783, ENST00000398304, ENST00000530800, ENST00000472545, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 16 X 15 X 6=1440 |
# samples | 1 | 20 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TCEAL2 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA757827 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000476749 | ENST00000398309 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000376104 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000418306 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000280241 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000543673 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000376106 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000330014 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000537455 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000524982 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000532653 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000531015 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000398301 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000426717 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000404783 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000398304 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000530800 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
intron-intron | ENST00000476749 | ENST00000472545 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000398309 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000376104 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000418306 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000280241 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000543673 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000376106 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000330014 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000537455 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000524982 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000532653 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000531015 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000398301 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000426717 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000404783 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000398304 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000530800 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000372780 | ENST00000472545 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000398309 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000376104 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000418306 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000280241 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000543673 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000376106 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000330014 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000537455 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000524982 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000532653 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000531015 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000398301 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000426717 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000404783 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000398304 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000530800 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
5CDS-intron | ENST00000329035 | ENST00000472545 | TCEAL2 | chrX | 101382471 | - | DLG2 | chr11 | 84132425 | + |
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FusionProtFeatures for TCEAL2_DLG2 |
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Hgene | Tgene |
TCEAL2 | DLG2 |
May be involved in transcriptional regulation. | Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCEAL2_DLG2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCEAL2_DLG2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCEAL2_DLG2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCEAL2_DLG2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DLG2 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | DLG2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | DLG2 | C0025202 | melanoma | 1 | CTD_human |
Tgene | DLG2 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | DLG2 | C0809983 | Schizophrenia and related disorders | 1 | PSYGENET |
Tgene | DLG2 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |