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Fusion gene ID: 37480 |
FusionGeneSummary for TBL1XR1_LXN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBL1XR1_LXN | Fusion gene ID: 37480 | Hgene | Tgene | Gene symbol | TBL1XR1 | LXN | Gene ID | 79718 | 56925 |
| Gene name | transducin beta like 1 X-linked receptor 1 | latexin | |
| Synonyms | C21|DC42|IRA1|MRD41|TBLR1 | ECI|TCI | |
| Cytomap | 3q26.32 | 3q25.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box-like/WD repeat-containing protein TBL1XR1TBL1-related protein 1nuclear receptor co-repressor/HDAC3 complex subunitnuclear receptor corepressor/HDAC3 complex subunit TBLR1 | latexinMUMendogenous carboxypeptidase inhibitortissue carboxypeptidase inhibitor | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9BZK7 | Q9BS40 | |
| Ensembl transtripts involved in fusion gene | ENST00000430069, ENST00000457928, | ENST00000264265, | |
| Fusion gene scores | * DoF score | 24 X 9 X 12=2592 | 1 X 1 X 1=1 |
| # samples | 24 | 1 | |
| ** MAII score | log2(24/2592*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TBL1XR1 [Title/Abstract] AND LXN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TBL1XR1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12628926 |
| Hgene | TBL1XR1 | GO:0045893 | positive regulation of transcription, DNA-templated | 18193033 |
| Hgene | TBL1XR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18193033 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A08X-01A | TBL1XR1 | chr3 | 176750759 | - | LXN | chr3 | 158388808 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000430069 | ENST00000264265 | TBL1XR1 | chr3 | 176750759 | - | LXN | chr3 | 158388808 | - |
| Frame-shift | ENST00000457928 | ENST00000264265 | TBL1XR1 | chr3 | 176750759 | - | LXN | chr3 | 158388808 | - |
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FusionProtFeatures for TBL1XR1_LXN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBL1XR1 | LXN |
| F-box-like protein involved in the recruitment of theubiquitin/19S proteasome complex to nuclear receptor-regulatedtranscription units. Plays an essential role in transcriptionactivation mediated by nuclear receptors. Probably acts asintegral component of the N-Cor corepressor complex that mediatesthe recruitment of the 19S proteasome complex, leading to thesubsequent proteasomal degradation of N-Cor complex, therebyallowing cofactor exchange, and transcription activation.{ECO:0000269|PubMed:14980219}. | Hardly reversible, non-competitive, and potent inhibitorof CPA1, CPA2 and CPA4. May play a role in inflammation.{ECO:0000269|PubMed:15738388}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 108_118 | 472 | 515 | Compositional bias | Note=Poly-Ala |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 108_118 | 472 | 515 | Compositional bias | Note=Poly-Ala |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 41_86 | 472 | 515 | Domain | Note=F-box-like |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 4_36 | 472 | 515 | Domain | LisH |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 41_86 | 472 | 515 | Domain | Note=F-box-like |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 4_36 | 472 | 515 | Domain | LisH |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 167_206 | 472 | 515 | Repeat | Note=WD 1 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 223_262 | 472 | 515 | Repeat | Note=WD 2 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 264_303 | 472 | 515 | Repeat | Note=WD 3 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 306_344 | 472 | 515 | Repeat | Note=WD 4 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 347_386 | 472 | 515 | Repeat | Note=WD 5 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 389_437 | 472 | 515 | Repeat | Note=WD 6 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 167_206 | 472 | 515 | Repeat | Note=WD 1 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 223_262 | 472 | 515 | Repeat | Note=WD 2 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 264_303 | 472 | 515 | Repeat | Note=WD 3 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 306_344 | 472 | 515 | Repeat | Note=WD 4 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 347_386 | 472 | 515 | Repeat | Note=WD 5 |
| Hgene | TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 389_437 | 472 | 515 | Repeat | Note=WD 6 |
| Tgene | >LXN | chr3:176750759 | chr3:158388808 | ENST00000264265 | - | 0 | 6 | 118_222 | 43 | 223 | Region | Cystatin-like fold 2 |
| Tgene | >LXN | chr3:176750759 | chr3:158388808 | ENST00000264265 | - | 0 | 6 | 98_117 | 43 | 223 | Region | Alpha-helical linker |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 440_479 | 472 | 515 | Repeat | Note=WD 7 |
| Hgene | >TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000430069 | - | 14 | 16 | 481_513 | 472 | 515 | Repeat | Note=WD 8 |
| Hgene | >TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 440_479 | 472 | 515 | Repeat | Note=WD 7 |
| Hgene | >TBL1XR1 | chr3:176750759 | chr3:158388808 | ENST00000457928 | - | 14 | 16 | 481_513 | 472 | 515 | Repeat | Note=WD 8 |
| Tgene | LXN | chr3:176750759 | chr3:158388808 | ENST00000264265 | - | 0 | 6 | 1_97 | 43 | 223 | Region | Cystatin-like fold 1 |
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FusionGeneSequence for TBL1XR1_LXN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBL1XR1_ENST00000430069_chr3_176750759_-_LXN_ENST00000264265_chr3_158388808_-_180aa DIPGRGHKYHLKFAVEEIIQKQVKVNCTAEVLYPSTGQETAPEVNFTFEGETGKNPDEEDNTFYQRLKSMKEPLEAQNIPDNFGNVSPEM TLVLHLAWVACGYIIWQNSTEDTWYKMVKIQTVKQVQRNDDFIELDYTILLHNIASQEIIPWQMQVLWHPQYGTKVKHNSRLPKEVQLEX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBL1XR1_ENST00000430069_chr3_176750759_-_LXN_ENST00000264265_chr3_158388808_-_540nt GATATTCCAGGAAGAGGACATAAGTATCACCTTAAATTTGCTGTTGAAGAAATTATACAAAAACAAGTTAAGGTGAACTGCACAGCTGAA GTACTTTACCCTTCAACGGGACAAGAAACTGCACCAGAAGTCAACTTCACATTTGAAGGAGAAACTGGAAAGAATCCAGATGAAGAAGAC AACACATTTTATCAAAGACTTAAGTCCATGAAGGAACCGCTAGAAGCACAAAATATTCCAGACAATTTTGGAAATGTATCTCCAGAAATG ACGCTCGTTCTACATTTAGCCTGGGTTGCCTGTGGTTATATAATATGGCAAAATTCTACTGAAGACACATGGTATAAAATGGTAAAAATT CAAACTGTCAAGCAAGTGCAAAGAAATGATGACTTTATTGAATTAGACTACACCATTCTACTTCATAATATAGCATCTCAGGAGATTATT CCCTGGCAAATGCAAGTTCTCTGGCATCCACAATACGGCACTAAAGTAAAACATAATAGCCGTCTGCCAAAGGAAGTACAACTGGAATAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBL1XR1_ENST00000430069_chr3_176750759_-_LXN_ENST00000264265_chr3_158388808_-_2448nt GCGCGGCAGCCGGGCCTTGCTCCGGGACGTGTTTATTTGTAACTTAGTGCTTTTTATCGTCTTAAGGAGGTATTTGGTGGAGGCTCTTTG AAGTTGGGTTCAGGAGTGTAGAATTGGCAAAGTTATTGCCAGCTTCCTGCATCAACAACAGCAACTTGTGATTGGCGGTGACCGGATATT CAGTTGCACATCCCCACATCAATGCACTGCCAATGGGTTATATCCTGTGTTGTGACCTCATGGTTTAAGTGGGAATAAAGATGAGTATAA GCAGTGATGAGGTCAACTTCTTGGTATATAGATACTTGCAAGAGTCAGGATTTTCTCATTCAGCATTTACCTTTGGTATAGAAAGCCATA TCAGTCAGTCCAATATAAATGGTGCCCTCGTCCCACCCGCTGCATTGATTTCTATCATCCAGAAAGGTCTACAGTATGTAGAAGCAGAAG TTAGTATTAATGAGGATGGTACCTTGTTTGATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAA CAAGACAACAAGCTTATAGAGATAAGCTTGCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAACAAGGATCTG CAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGG ATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCC TAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATT GTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTT CCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAAT GGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGT TTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCT GTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCT TGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAA TTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTG TTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATG GCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTGGAACACGCAGGATATTCCAGGAAGAGGACATAAGTATCACCTTA AATTTGCTGTTGAAGAAATTATACAAAAACAAGTTAAGGTGAACTGCACAGCTGAAGTACTTTACCCTTCAACGGGACAAGAAACTGCAC CAGAAGTCAACTTCACATTTGAAGGAGAAACTGGAAAGAATCCAGATGAAGAAGACAACACATTTTATCAAAGACTTAAGTCCATGAAGG AACCGCTAGAAGCACAAAATATTCCAGACAATTTTGGAAATGTATCTCCAGAAATGACGCTCGTTCTACATTTAGCCTGGGTTGCCTGTG GTTATATAATATGGCAAAATTCTACTGAAGACACATGGTATAAAATGGTAAAAATTCAAACTGTCAAGCAAGTGCAAAGAAATGATGACT TTATTGAATTAGACTACACCATTCTACTTCATAATATAGCATCTCAGGAGATTATTCCCTGGCAAATGCAAGTTCTCTGGCATCCACAAT ACGGCACTAAAGTAAAACATAATAGCCGTCTGCCAAAGGAAGTACAACTGGAATAAACAAAAACCCTAACACTGGAAGTGTAAACATGTC TATTGATGTGTATGCCAATTTCACTGGCATCTAGCTTATGAGGCCAAATAATCCCAAAGTGTCACTTTATATAAATGTCTTGATTACAGT ATAGAACTTTATAGAGTCCATAATACAAAGTATCACTACATAAAAATGTCTTTAAAACAGTAATAGTGGTATGTATATCCAAAATAAAAA |
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FusionGenePPI for TBL1XR1_LXN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBL1XR1 | NCOR1, HIST2H4A, HIST2H2BE, HDAC3, TBL1X, SKI, UBE2E3, EMD, THRA, THRB, BCL3, HDAC5, PSMA3, SOX2, ELAVL1, UBE2D1, CTNNB1, TAB2, AR, ESR1, RARA, CHD4, CD2BP2, NOTCH1, KDM1A, GPS2, HDAC1, HDAC4, HDAC7, ABCF1, IRS4, ARL2, RNF2, SIRT6, QPRT, FKBP6, TTC29, TSC22D4, ACTL6A, EIF2A, NHP2L1, PPIF, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCD2, SMARCD3, NTRK1, NINL, XPO1, FOXK1, FOXK2, UBE2I, TBL1Y, NCAPH2, MKX, IL17RA, HAO2, USP44, TRIM25 | LXN | MAGEB2, CEP162, THRAP3, PPM1A, CIRBP, CLASP2, PANK2, CPA4, SH3BGRL, DPYD, MAGEA8, TMEM14A, TRIM39, GSG1L, ZKSCAN4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBL1XR1_LXN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBL1XR1_LXN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TBL1XR1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | TBL1XR1 | C1865644 | Plantar Lipomatosis, Unusual Facies, and Developmental Delay | 1 | UNIPROT |
| Tgene | LXN | C0025202 | melanoma | 1 | CTD_human |
| Tgene | LXN | C1257806 | Chromosomal Instability | 1 | CTD_human |
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