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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37462

FusionGeneSummary for TBCK_PAPSS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBCK_PAPSS1
Fusion gene ID: 37462
HgeneTgene
Gene symbol

TBCK

PAPSS1

Gene ID

93627

9061

Gene nameTBC1 domain containing kinase3'-phosphoadenosine 5'-phosphosulfate synthase 1
SynonymsHSPC302|IHPRF3|TBCKLATPSK1|PAPSS|SK1
Cytomap

4q24

4q25

Type of geneprotein-codingprotein-coding
DescriptionTBC domain-containing protein kinase-like proteinbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1
Modification date2018052320180523
UniProtAcc

Q8TEA7

O43252

Ensembl transtripts involved in fusion geneENST00000273980, ENST00000432496, 
ENST00000361687, ENST00000394706, 
ENST00000394708, ENST00000514689, 
ENST00000265174, ENST00000511304, 
Fusion gene scores* DoF score2 X 1 X 2=44 X 4 X 3=48
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBCK [Title/Abstract] AND PAPSS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePAPSS1

GO:0000103

sulfate assimilation

14747722

TgenePAPSS1

GO:0050428

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

14747722|23207770


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-21-5783-01ATBCKchr4

107092252

-PAPSS1chr4

108553016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000273980ENST00000265174TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5CDS-intronENST00000273980ENST00000511304TBCKchr4

107092252

-PAPSS1chr4

108553016

-
Frame-shiftENST00000432496ENST00000265174TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5CDS-intronENST00000432496ENST00000511304TBCKchr4

107092252

-PAPSS1chr4

108553016

-
Frame-shiftENST00000361687ENST00000265174TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5CDS-intronENST00000361687ENST00000511304TBCKchr4

107092252

-PAPSS1chr4

108553016

-
Frame-shiftENST00000394706ENST00000265174TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5CDS-intronENST00000394706ENST00000511304TBCKchr4

107092252

-PAPSS1chr4

108553016

-
Frame-shiftENST00000394708ENST00000265174TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5CDS-intronENST00000394708ENST00000511304TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5UTR-3CDSENST00000514689ENST00000265174TBCKchr4

107092252

-PAPSS1chr4

108553016

-
5UTR-intronENST00000514689ENST00000511304TBCKchr4

107092252

-PAPSS1chr4

108553016

-

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FusionProtFeatures for TBCK_PAPSS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBCK

Q8TEA7

PAPSS1

O43252

Bifunctional enzyme with both ATP sulfurylase and APSkinase activity, which mediates two steps in the sulfateactivation pathway. The first step is the transfer of a sulfategroup to ATP to yield adenosine 5'-phosphosulfate (APS), and thesecond step is the transfer of a phosphate group from ATP to APSyielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donorused by sulfotransferase). In mammals, PAPS is the sole source ofsulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121,PubMed:9648242, PubMed:14747722). Required for normal biosynthesisof sulfated L-selectin ligands in endothelial cells(PubMed:9576487). {ECO:0000269|PubMed:14747722,ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242,ECO:0000269|PubMed:9668121}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCKchr4:107092252chr4:108553016ENST00000273980-24271_273745894DomainProtein kinase
HgeneTBCKchr4:107092252chr4:108553016ENST00000273980-2427466_651745894DomainRab-GAP TBC
HgeneTBCKchr4:107092252chr4:108553016ENST00000361687-21241_273682831DomainProtein kinase
HgeneTBCKchr4:107092252chr4:108553016ENST00000361687-2124466_651682831DomainRab-GAP TBC
HgeneTBCKchr4:107092252chr4:108553016ENST00000394706-23261_273706855DomainProtein kinase
HgeneTBCKchr4:107092252chr4:108553016ENST00000394706-2326466_651706855DomainRab-GAP TBC
HgeneTBCKchr4:107092252chr4:108553016ENST00000394708-23261_273745894DomainProtein kinase
HgeneTBCKchr4:107092252chr4:108553016ENST00000394708-2326466_651745894DomainRab-GAP TBC
HgeneTBCKchr4:107092252chr4:108553016ENST00000432496-23261_273745894DomainProtein kinase
HgeneTBCKchr4:107092252chr4:108553016ENST00000432496-2326466_651745894DomainRab-GAP TBC
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-912521_525502625Nucleotide bindingATP 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCKchr4:107092252chr4:108553016ENST00000273980-2427790_889745894DomainRhodanese
HgeneTBCKchr4:107092252chr4:108553016ENST00000361687-2124790_889682831DomainRhodanese
HgeneTBCKchr4:107092252chr4:108553016ENST00000394706-2326790_889706855DomainRhodanese
HgeneTBCKchr4:107092252chr4:108553016ENST00000394708-2326790_889745894DomainRhodanese
HgeneTBCKchr4:107092252chr4:108553016ENST00000432496-2326790_889745894DomainRhodanese
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-912419_422502625Nucleotide bindingATP 2
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-91262_67502625Nucleotide bindingATP 1
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-912106_109502625RegionAdenylyl sulfate binding
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-912132_133502625RegionAdenylyl sulfate binding
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-912184_185502625RegionAdenylyl sulfate binding
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-9121_225502625RegionAdenylyl-sulfate kinase
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-912234_624502625RegionSulfate adenylyltransferase
TgenePAPSS1chr4:107092252chr4:108553016ENST00000265174-91289_92502625RegionAdenylyl sulfate binding


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FusionGeneSequence for TBCK_PAPSS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TBCK_ENST00000273980_chr4_107092252_-_PAPSS1_ENST00000265174_chr4_108553016_-_868aa
MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSC
STVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLP
SGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKD
KVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLF
EDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLK
AYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHP
DLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTM
FTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPS
SDSSGGRSSAPYFSAECPDPPKTDLVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPSHGAKVLTMAPGLITLEIVPFRVAAYNK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TBCK_ENST00000273980_chr4_107092252_-_PAPSS1_ENST00000265174_chr4_108553016_-_2604nt
ATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCT
CTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCT
AGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGT
TCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCAT
AATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATTTCCCA
ATAGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCT
TCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCT
GAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAG
GAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGAC
AAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACT
CTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGT
TTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTT
GAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAAT
AGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTG
TCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAG
GCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTG
GGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCT
CGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCT
GATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATG
TCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATG
ATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATG
TTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTA
GCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATT
GAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCT
TCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGGTCCAGTGGCATTGC
AGAGCACGGATGGTTGCAGGAGCCAACTTTTACATTGTTGGACGAGACCCTGCTGGCATGCCTCATCCAGAAACAGGGAAGGATCTTTAT
GAGCCAAGTCATGGTGCCAAAGTGCTGACGATGGCCCCTGGTTTAATCACTTTGGAAATAGTTCCCTTTCGAGTTGCAGCTTACAACAAG
AAAAAGAAGCGTATGGACTACTATGACTCTGAACACCATGAAGACTTTGAATTTATTTCAGGAACACGAATGCGCAAACTTGCTCGAGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TBCK_ENST00000273980_chr4_107092252_-_PAPSS1_ENST00000265174_chr4_108553016_-_3635nt
TCCTCACTTCTCAGACCGGGCAGCCGGTCAGAGACGCTCCTCACCTCCCAGACGGGGTGGCGGCGGGGCAGAGACACTCCTCAGTTCCCA
GACAGGGTCGCGGCCGGGCAGAGGCGCTCTTCACATCTCAGACGGGGCGACGGGGCAGAGATGCTCCCCACATCCCAGATGATGGGCGGC
TGGGCAGAGACGCTCCTCACTTCCTAGACAGGATGACGGCCGGGAAGAGGCCAGGGCTGGTCCTGCTGCGAACGGACTACCCATTAGCAG
CGCAGGCCAGGTCCTCTCTCCTGGAGGCAAGTTAGAGAAGGAAGACCCCTACGATCGCAATCGGCGATCCCCGAGTGAGTGACCCGCCAC
GACGTCACTCACATGAAGCGGAGGACCACGGGTTCCGAGACAGCCACAGCAGGAAGCATATTATCTTAGAAGACCTAGGACTCCAAAAAT
GTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCT
CACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAG
GGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTC
AACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCATAA
TATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATTTCCCAAT
AGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTC
TGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGA
AAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGA
GCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAA
AGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCT
GCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTT
GGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGA
GGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAG
ATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTC
TGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGC
TTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGG
AGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCG
CTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGA
TCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTC
TGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGAT
TGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTT
TACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGC
AATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGA
ACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTC
TGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGGTCCAGTGGCATTGCAG
AGCACGGATGGTTGCAGGAGCCAACTTTTACATTGTTGGACGAGACCCTGCTGGCATGCCTCATCCAGAAACAGGGAAGGATCTTTATGA
GCCAAGTCATGGTGCCAAAGTGCTGACGATGGCCCCTGGTTTAATCACTTTGGAAATAGTTCCCTTTCGAGTTGCAGCTTACAACAAGAA
AAAGAAGCGTATGGACTACTATGACTCTGAACACCATGAAGACTTTGAATTTATTTCAGGAACACGAATGCGCAAACTTGCTCGAGAAGG
CCAGAAACCACCTGAAGGTTTCATGGCTCCCAAGGCTTGGACCGTGCTGACAGAATACTACAAATCCTTGGAGAAAGCTTAGGCTGTTAA
CCCAGTCACTCCACCTTTGACACATTACTAGTAACAAGAGGGGACCACATAGTCTCTGTTGGCATTTCTTTGTGGTGTCTGTCTGGACAT
GCTTCCTAAAAACAGACCATTTTCCTTAACTTGCATCAGTTTTGGTCTGCCTTATGAGTTCTGTTTTGAACAAGTGTAACACACTGATGG
TTTTAATGTATCTTTTCCACTTATTATAGTTATATTCCTACAATACAATTTTAAAATTGTCTTTTTATATTATATTTATGCTTCTGTGTC
ATGATTTTTTCAAGCTGTTATATTAGTTGTAACCAGTAGTATTCACATTAAATCTTGCTTTTTTTCCCCTTAAAAAAAGAAAAAAATTAC
CAAACAATAAACTTGGCTAGACCTTGTTTTGAGGATTTTACAAGACCTTTGTAGCGATTAGATTTTTTTTCTACATTGAAAATAGAAACT
GCTTCCTTTCTTCTTTCCAGTCAGCTATTGGTCTTTCCAGCTGTTATAATCTAAAGTATTCTTATGATCTGTGTAAGCTCTGAATGAACT


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FusionGenePPI for TBCK_PAPSS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBCKAPP, STAM, PCDHB15, PPP1R21, IL6R, TCP10LPAPSS1PPP1R16A, EEF1A1, UNC119, ATIC, HMGB3, MTRR, PAFAH1B1, ACAT2, AHCY, ASNS, CAPN2, CAPZB, CTPS1, DHX15, FH, MSN, NAE1, NSFL1C, PPP5C, TATDN1, TUBB3, UBA3, XPOT, PTMA, NTRK1, NCK1, RNASEH2A, TMEM132A, FANCI, ERRFI1, PAPSS2, DYNC1I2, CCDC116, C2orf44, FANCG, C4orf26, SNRNP27, GPX7, FGB, TFCP2, GNL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBCK_PAPSS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePAPSS1O43252DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1small moleculeapproved|investigational

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RelatedDiseases for TBCK_PAPSS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBCKC4225161HYPOTONIA, INFANTILE, WITH PSYCHOMOTOR RETARDATION AND CHARACTERISTIC FACIES 32UNIPROT