|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37462 |
FusionGeneSummary for TBCK_PAPSS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBCK_PAPSS1 | Fusion gene ID: 37462 | Hgene | Tgene | Gene symbol | TBCK | PAPSS1 | Gene ID | 93627 | 9061 |
| Gene name | TBC1 domain containing kinase | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | |
| Synonyms | HSPC302|IHPRF3|TBCKL | ATPSK1|PAPSS|SK1 | |
| Cytomap | 4q24 | 4q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC domain-containing protein kinase-like protein | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TEA7 | O43252 | |
| Ensembl transtripts involved in fusion gene | ENST00000273980, ENST00000432496, ENST00000361687, ENST00000394706, ENST00000394708, ENST00000514689, | ENST00000265174, ENST00000511304, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 4 X 3=48 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TBCK [Title/Abstract] AND PAPSS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PAPSS1 | GO:0000103 | sulfate assimilation | 14747722 |
| Tgene | PAPSS1 | GO:0050428 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process | 14747722|23207770 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-21-5783-01A | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000273980 | ENST00000265174 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5CDS-intron | ENST00000273980 | ENST00000511304 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| Frame-shift | ENST00000432496 | ENST00000265174 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5CDS-intron | ENST00000432496 | ENST00000511304 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| Frame-shift | ENST00000361687 | ENST00000265174 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5CDS-intron | ENST00000361687 | ENST00000511304 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| Frame-shift | ENST00000394706 | ENST00000265174 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5CDS-intron | ENST00000394706 | ENST00000511304 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| Frame-shift | ENST00000394708 | ENST00000265174 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5CDS-intron | ENST00000394708 | ENST00000511304 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5UTR-3CDS | ENST00000514689 | ENST00000265174 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
| 5UTR-intron | ENST00000514689 | ENST00000511304 | TBCK | chr4 | 107092252 | - | PAPSS1 | chr4 | 108553016 | - |
Top |
FusionProtFeatures for TBCK_PAPSS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBCK | PAPSS1 |
| Bifunctional enzyme with both ATP sulfurylase and APSkinase activity, which mediates two steps in the sulfateactivation pathway. The first step is the transfer of a sulfategroup to ATP to yield adenosine 5'-phosphosulfate (APS), and thesecond step is the transfer of a phosphate group from ATP to APSyielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donorused by sulfotransferase). In mammals, PAPS is the sole source ofsulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121,PubMed:9648242, PubMed:14747722). Required for normal biosynthesisof sulfated L-selectin ligands in endothelial cells(PubMed:9576487). {ECO:0000269|PubMed:14747722,ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242,ECO:0000269|PubMed:9668121}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000273980 | - | 24 | 27 | 1_273 | 745 | 894 | Domain | Protein kinase |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000273980 | - | 24 | 27 | 466_651 | 745 | 894 | Domain | Rab-GAP TBC |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000361687 | - | 21 | 24 | 1_273 | 682 | 831 | Domain | Protein kinase |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000361687 | - | 21 | 24 | 466_651 | 682 | 831 | Domain | Rab-GAP TBC |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000394706 | - | 23 | 26 | 1_273 | 706 | 855 | Domain | Protein kinase |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000394706 | - | 23 | 26 | 466_651 | 706 | 855 | Domain | Rab-GAP TBC |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000394708 | - | 23 | 26 | 1_273 | 745 | 894 | Domain | Protein kinase |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000394708 | - | 23 | 26 | 466_651 | 745 | 894 | Domain | Rab-GAP TBC |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000432496 | - | 23 | 26 | 1_273 | 745 | 894 | Domain | Protein kinase |
| Hgene | TBCK | chr4:107092252 | chr4:108553016 | ENST00000432496 | - | 23 | 26 | 466_651 | 745 | 894 | Domain | Rab-GAP TBC |
| Tgene | >PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 521_525 | 502 | 625 | Nucleotide binding | ATP 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBCK | chr4:107092252 | chr4:108553016 | ENST00000273980 | - | 24 | 27 | 790_889 | 745 | 894 | Domain | Rhodanese |
| Hgene | >TBCK | chr4:107092252 | chr4:108553016 | ENST00000361687 | - | 21 | 24 | 790_889 | 682 | 831 | Domain | Rhodanese |
| Hgene | >TBCK | chr4:107092252 | chr4:108553016 | ENST00000394706 | - | 23 | 26 | 790_889 | 706 | 855 | Domain | Rhodanese |
| Hgene | >TBCK | chr4:107092252 | chr4:108553016 | ENST00000394708 | - | 23 | 26 | 790_889 | 745 | 894 | Domain | Rhodanese |
| Hgene | >TBCK | chr4:107092252 | chr4:108553016 | ENST00000432496 | - | 23 | 26 | 790_889 | 745 | 894 | Domain | Rhodanese |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 419_422 | 502 | 625 | Nucleotide binding | ATP 2 |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 62_67 | 502 | 625 | Nucleotide binding | ATP 1 |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 106_109 | 502 | 625 | Region | Adenylyl sulfate binding |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 132_133 | 502 | 625 | Region | Adenylyl sulfate binding |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 184_185 | 502 | 625 | Region | Adenylyl sulfate binding |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 1_225 | 502 | 625 | Region | Adenylyl-sulfate kinase |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 234_624 | 502 | 625 | Region | Sulfate adenylyltransferase |
| Tgene | PAPSS1 | chr4:107092252 | chr4:108553016 | ENST00000265174 | - | 9 | 12 | 89_92 | 502 | 625 | Region | Adenylyl sulfate binding |
Top |
FusionGeneSequence for TBCK_PAPSS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBCK_ENST00000273980_chr4_107092252_-_PAPSS1_ENST00000265174_chr4_108553016_-_868aa MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSC STVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLP SGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKD KVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLF EDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLK AYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHP DLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTM FTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPS SDSSGGRSSAPYFSAECPDPPKTDLVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPSHGAKVLTMAPGLITLEIVPFRVAAYNK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBCK_ENST00000273980_chr4_107092252_-_PAPSS1_ENST00000265174_chr4_108553016_-_2604nt ATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCT CTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCT AGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGT TCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCAT AATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATTTCCCA ATAGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCT TCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCT GAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAG GAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGAC AAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACT CTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGT TTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTT GAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAAT AGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTG TCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAG GCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTG GGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCT CGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCT GATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATG TCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATG ATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATG TTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTA GCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATT GAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCT TCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGGTCCAGTGGCATTGC AGAGCACGGATGGTTGCAGGAGCCAACTTTTACATTGTTGGACGAGACCCTGCTGGCATGCCTCATCCAGAAACAGGGAAGGATCTTTAT GAGCCAAGTCATGGTGCCAAAGTGCTGACGATGGCCCCTGGTTTAATCACTTTGGAAATAGTTCCCTTTCGAGTTGCAGCTTACAACAAG AAAAAGAAGCGTATGGACTACTATGACTCTGAACACCATGAAGACTTTGAATTTATTTCAGGAACACGAATGCGCAAACTTGCTCGAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBCK_ENST00000273980_chr4_107092252_-_PAPSS1_ENST00000265174_chr4_108553016_-_3635nt TCCTCACTTCTCAGACCGGGCAGCCGGTCAGAGACGCTCCTCACCTCCCAGACGGGGTGGCGGCGGGGCAGAGACACTCCTCAGTTCCCA GACAGGGTCGCGGCCGGGCAGAGGCGCTCTTCACATCTCAGACGGGGCGACGGGGCAGAGATGCTCCCCACATCCCAGATGATGGGCGGC TGGGCAGAGACGCTCCTCACTTCCTAGACAGGATGACGGCCGGGAAGAGGCCAGGGCTGGTCCTGCTGCGAACGGACTACCCATTAGCAG CGCAGGCCAGGTCCTCTCTCCTGGAGGCAAGTTAGAGAAGGAAGACCCCTACGATCGCAATCGGCGATCCCCGAGTGAGTGACCCGCCAC GACGTCACTCACATGAAGCGGAGGACCACGGGTTCCGAGACAGCCACAGCAGGAAGCATATTATCTTAGAAGACCTAGGACTCCAAAAAT GTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCT CACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAG GGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTC AACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCATAA TATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATTTCCCAAT AGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTC TGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGA AAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGA GCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAA AGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCT GCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTT GGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGA GGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAG ATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTC TGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGC TTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGG AGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCG CTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGA TCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTC TGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGAT TGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTT TACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGC AATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGA ACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTC TGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGGTCCAGTGGCATTGCAG AGCACGGATGGTTGCAGGAGCCAACTTTTACATTGTTGGACGAGACCCTGCTGGCATGCCTCATCCAGAAACAGGGAAGGATCTTTATGA GCCAAGTCATGGTGCCAAAGTGCTGACGATGGCCCCTGGTTTAATCACTTTGGAAATAGTTCCCTTTCGAGTTGCAGCTTACAACAAGAA AAAGAAGCGTATGGACTACTATGACTCTGAACACCATGAAGACTTTGAATTTATTTCAGGAACACGAATGCGCAAACTTGCTCGAGAAGG CCAGAAACCACCTGAAGGTTTCATGGCTCCCAAGGCTTGGACCGTGCTGACAGAATACTACAAATCCTTGGAGAAAGCTTAGGCTGTTAA CCCAGTCACTCCACCTTTGACACATTACTAGTAACAAGAGGGGACCACATAGTCTCTGTTGGCATTTCTTTGTGGTGTCTGTCTGGACAT GCTTCCTAAAAACAGACCATTTTCCTTAACTTGCATCAGTTTTGGTCTGCCTTATGAGTTCTGTTTTGAACAAGTGTAACACACTGATGG TTTTAATGTATCTTTTCCACTTATTATAGTTATATTCCTACAATACAATTTTAAAATTGTCTTTTTATATTATATTTATGCTTCTGTGTC ATGATTTTTTCAAGCTGTTATATTAGTTGTAACCAGTAGTATTCACATTAAATCTTGCTTTTTTTCCCCTTAAAAAAAGAAAAAAATTAC CAAACAATAAACTTGGCTAGACCTTGTTTTGAGGATTTTACAAGACCTTTGTAGCGATTAGATTTTTTTTCTACATTGAAAATAGAAACT GCTTCCTTTCTTCTTTCCAGTCAGCTATTGGTCTTTCCAGCTGTTATAATCTAAAGTATTCTTATGATCTGTGTAAGCTCTGAATGAACT |
Top |
FusionGenePPI for TBCK_PAPSS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBCK | APP, STAM, PCDHB15, PPP1R21, IL6R, TCP10L | PAPSS1 | PPP1R16A, EEF1A1, UNC119, ATIC, HMGB3, MTRR, PAFAH1B1, ACAT2, AHCY, ASNS, CAPN2, CAPZB, CTPS1, DHX15, FH, MSN, NAE1, NSFL1C, PPP5C, TATDN1, TUBB3, UBA3, XPOT, PTMA, NTRK1, NCK1, RNASEH2A, TMEM132A, FANCI, ERRFI1, PAPSS2, DYNC1I2, CCDC116, C2orf44, FANCG, C4orf26, SNRNP27, GPX7, FGB, TFCP2, GNL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TBCK_PAPSS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PAPSS1 | O43252 | DB09462 | Glycerin | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | small molecule | approved|investigational |
Top |
RelatedDiseases for TBCK_PAPSS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TBCK | C4225161 | HYPOTONIA, INFANTILE, WITH PSYCHOMOTOR RETARDATION AND CHARACTERISTIC FACIES 3 | 2 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|