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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37433

FusionGeneSummary for TBCB_B3GALNT1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBCB_B3GALNT1
Fusion gene ID: 37433
HgeneTgene
Gene symbol

TBCB

B3GALNT1

Gene ID

1155

8706

Gene nametubulin folding cofactor Bbeta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
SynonymsCG22|CKAP1|CKAPIB3GALT3|GLCT3|GLOB|Gb4Cer|P|P1|beta3Gal-T3|galT3
Cytomap

19q13.12

3q26.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin-folding cofactor Bcytoskeleton associated protein 1cytoskeleton-associated protein CKAPItubulin-specific chaperone BUDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1P antigen synthaseP blood group globosideUDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 (Globoside blood group)UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypepti
Modification date2018051920180523
UniProtAcc

Q99426

O75752

Ensembl transtripts involved in fusion geneENST00000221855, ENST00000392178, 
ENST00000589996, ENST00000585746, 
ENST00000586868, 		ENST00000320474, 
ENST00000392779, ENST00000392780, 
ENST00000392781, ENST00000473285, 
ENST00000417187, ENST00000488170, 
ENST00000494818, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TBCB [Title/Abstract] AND B3GALNT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA235308TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000221855ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000221855ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000221855ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
5CDS-intronENST00000221855ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-intronENST00000392178ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000589996ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000589996ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
5CDS-intronENST00000589996ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000585746ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000585746ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
5CDS-intronENST00000585746ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-intronENST00000586868ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-

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FusionProtFeatures for TBCB_B3GALNT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBCB

Q99426

B3GALNT1

O75752

Binds to alpha-tubulin folding intermediates after theirinteraction with cytosolic chaperonin in the pathway leading fromnewly synthesized tubulin to properly folded heterodimer(PubMed:9265649). Involved in regulation of tubulin heterodimerdissociation. May function as a negative regulator of axonalgrowth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6,ECO:0000269|PubMed:9265649}. Transfers N-acetylgalactosamine ontoglobotriaosylceramide. {ECO:0000269|PubMed:10993897}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBCB_B3GALNT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TBCB_ENST00000221855_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0aa

>In-frame_TBCB_ENST00000221855_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0aa

>In-frame_TBCB_ENST00000589996_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0aa

>In-frame_TBCB_ENST00000589996_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0aa

>In-frame_TBCB_ENST00000585746_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0aa

>In-frame_TBCB_ENST00000585746_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TBCB_ENST00000221855_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000221855_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000589996_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000589996_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000585746_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000585746_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_TBCB_ENST00000221855_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000221855_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000589996_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000589996_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000585746_chr19_36611637_+_B3GALNT1_ENST00000473285_chr3_160804539_-_0nt

>In-frame_TBCB_ENST00000585746_chr19_36611637_+_B3GALNT1_ENST00000488170_chr3_160804539_-_0nt


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FusionGenePPI for TBCB_B3GALNT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBCB_B3GALNT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBCB_B3GALNT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBCBC0027627Neoplasm Metastasis1CTD_human