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Fusion gene ID: 37429 |
FusionGeneSummary for TBC1D9_SMARCA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D9_SMARCA5 | Fusion gene ID: 37429 | Hgene | Tgene | Gene symbol | TBC1D9 | SMARCA5 | Gene ID | 23158 | 8467 |
| Gene name | TBC1 domain family member 9 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | |
| Synonyms | GRAMD9|MDR1 | ISWI|SNF2H|WCRF135|hISWI|hSNF2H | |
| Cytomap | 4q31.21 | 4q31.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 9TBC1 domain family member 9ATBC1 domain family, member 9 (with GRAM domain) | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5sucrose nonfermenting protein 2 homologsucrose nonfermenting-like 5 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6ZT07 | O60264 | |
| Ensembl transtripts involved in fusion gene | ENST00000442267, | ENST00000283131, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TBC1D9 [Title/Abstract] AND SMARCA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SMARCA5 | GO:0006334 | nucleosome assembly | 12972596 |
| Tgene | SMARCA5 | GO:0006338 | chromatin remodeling | 9836642 |
| Tgene | SMARCA5 | GO:0006352 | DNA-templated transcription, initiation | 9836642 |
| Tgene | SMARCA5 | GO:0016584 | nucleosome positioning | 9836642 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0BR-01A | TBC1D9 | chr4 | 141560240 | - | SMARCA5 | chr4 | 144438508 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000442267 | ENST00000283131 | TBC1D9 | chr4 | 141560240 | - | SMARCA5 | chr4 | 144438508 | + |
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FusionProtFeatures for TBC1D9_SMARCA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBC1D9 | SMARCA5 |
| May act as a GTPase-activating protein for Rab familyprotein(s). | Helicase that possesses intrinsic ATP-dependentnucleosome-remodeling activity. Complexes containing SMARCA5 arecapable of forming ordered nucleosome arrays on chromatin; thismay require intact histone H4 tails. Also required for replicationof pericentric heterochromatin in S-phase specifically inconjunction with BAZ1A. Probably plays a role in repression ofpolI dependent transcription of the rDNA locus, through therecruitment of the SIN3/HDAC1 corepressor complex to the rDNApromoter. Essential component of the WICH complex, a chromatinremodeling complex that mobilizes nucleosomes and reconfiguresirregular chromatin to a regular nucleosomal array structure. TheWICH complex regulates the transcription of various genes, has arole in RNA polymerase I and RNA polymerase III transcription,mediates the histone H2AX phosphorylation at 'Tyr-142', and isinvolved in the maintenance of chromatin structures during DNAreplication processes. Essential component of the NoRC (nucleolarremodeling complex) complex, a complex that mediates silencing ofa fraction of rDNA by recruiting histone-modifying enzymes and DNAmethyltransferases, leading to heterochromatin formation andtranscriptional silencing. {ECO:0000269|PubMed:10880450,ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550,ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596,ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TBC1D9 | chr4:141560240 | chr4:144438508 | ENST00000442267 | - | 15 | 21 | 146_213 | 835 | 1267 | Domain | Note=GRAM 1 |
| Hgene | TBC1D9 | chr4:141560240 | chr4:144438508 | ENST00000442267 | - | 15 | 21 | 293_361 | 835 | 1267 | Domain | Note=GRAM 2 |
| Hgene | TBC1D9 | chr4:141560240 | chr4:144438508 | ENST00000442267 | - | 15 | 21 | 515_702 | 835 | 1267 | Domain | Rab-GAP TBC |
| Tgene | >SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 192_357 | 59 | 1053 | Domain | Helicase ATP-binding |
| Tgene | >SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 487_638 | 59 | 1053 | Domain | Helicase C-terminal |
| Tgene | >SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 840_892 | 59 | 1053 | Domain | SANT 1 |
| Tgene | >SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 943_1007 | 59 | 1053 | Domain | SANT 2 |
| Tgene | >SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 308_311 | 59 | 1053 | Motif | Note=DEAH box |
| Tgene | >SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 205_212 | 59 | 1053 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBC1D9 | chr4:141560240 | chr4:144438508 | ENST00000442267 | - | 15 | 21 | 886_921 | 835 | 1267 | Domain | EF-hand |
| Tgene | SMARCA5 | chr4:141560240 | chr4:144438508 | ENST00000283131 | + | 0 | 24 | 7_13 | 59 | 1053 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for TBC1D9_SMARCA5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBC1D9_ENST00000442267_chr4_141560240_-_SMARCA5_ENST00000283131_chr4_144438508_+_1829aa MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTPDSLVYWTIACGGSRKEITEH WEWLEQNLLQTLSIFENENDITTFVRGKIQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQLLDNEGFEQDRSLPK LKRKSPKKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFN LNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPG YYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERM LPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDK LLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKR NVVRTIVTETSFTIDELEELYALFKEIFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGR PRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQ TISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRY LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLR RIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGK MVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVV ILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFAS KESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVDAYFREALRV SEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRNPELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTN WNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYKAPFHQ LRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBC1D9_ENST00000442267_chr4_141560240_-_SMARCA5_ENST00000283131_chr4_144438508_+_5487nt ATGTGGGTGAACCCGGAGGAGGTGTTGCTGGCCAACGCGCTGTGGATCACCGAGAGGGCCAACCCATACTTCATCCTGCAGCGGAGGAAG GGCCACGCCGGCGATGGAGGCGGCGGCGGCGGACTGGCGGGCCTGCTGGTGGGTACCCTTGATGTTGTGTTGGACTCCAGCGCCCGGGTC GCTCCTTACCGAATCTTGTACCAGACTCCAGACTCCCTGGTCTACTGGACCATCGCCTGTGGTGGTTCCAGGAAAGAAATCACTGAACAC TGGGAATGGCTTGAGCAAAATCTCTTGCAGACACTCTCCATCTTTGAAAATGAGAATGATATCACCACATTTGTGAGAGGAAAAATACAG GGCATCATTGCAGAATACAACAAAATCAATGATGTAAAGGAAGATGATGACACGGAGAAGTTTAAAGAAGCCATTGTGAAATTTCATAGG CTGTTTGGGATGCCAGAGGAAGAGAAACTCGTCAACTATTACTCTTGCAGCTATTGGAAGGGGAAGGTCCCCCGTCAGGGTTGGATGTAC CTCAGCATTAACCACCTTTGCTTTTATTCTTTTCTTATGGGAAGGGAAGCGAAACTGGTCATCCGGTGGGTAGACATCACTCAGCTTGAG AAGAATGCCACCCTGCTTCTGCCTGATGTGATCAAAGTGAGCACACGGTCCAGTGAGCATTTCTTCTCTGTATTCCTCAACATCAACGAG ACCTTCAAGTTAATGGAGCAGCTTGCCAACATAGCCATGAGGCAACTCTTAGACAATGAGGGATTTGAACAAGATCGATCCCTGCCCAAA CTCAAAAGGAAATCTCCTAAAAAAGTGTCTGCTCTAAAACGTGATCTTGATGCCAGGGCAAAGAGTGAGAGATACCGTGCACTTTTCCGG CTGCCCAAAGATGAAAAATTAGATGGCCACACAGACTGCACTCTCTGGACTCCATTTAACAAAATGCACATTTTGGGGCAGATGTTTGTG TCCACAAATTACATCTGTTTTACCAGCAAGGAGGAGAACTTATGTAGCCTCATTATCCCGCTCCGTGAGGTGACAATTGTGGAAAAGGCA GACAGCTCCAGTGTGCTCCCCAGTCCCTTATCCATCAGCACCCGAAACAGGATGACCTTCCTATTTGCCAACTTGAAAGATAGAGACTTT CTAGTGCAGAGGATCTCAGATTTCCTGCAACAGACTACTTCCAAAATATATTCTGACAAGGAGTTTGCAGGAAGTTACAACAGTTCAGAT GATGAGGTGTACTCTCGACCCAGCAGCCTCGTCTCCTCCAGCCCCCAGAGAAGCACGAGCTCTGATGCTGATGGAGAGCGCCAGTTTAAC CTAAATGGCAACAGCGTCCCCACAGCCACACAGACCCTGATGACCATGTATCGGCGGCGGTCTCCCGAGGAGTTCAACCCGAAATTGGCC AAAGAGTTTCTGAAAGAGCAAGCCTGGAAGATTCACTTTGCTGAGTATGGGCAAGGGATCTGCATGTACCGCACAGAGAAAACGCGGGAG CTGGTGTTGAAGGGCATCCCGGAGAGCATGCGTGGGGAGCTCTGGCTGCTGCTGTCAGGTGCCATCAATGAGAAGGCCACACATCCTGGG TACTATGAAGACCTAGTGGAGAAGTCCATGGGGAAGTATAATCTCGCCACGGAGGAGATTGAGAGGGATTTACACCGCTCCCTTCCAGAA CACCCAGCTTTTCAGAATGAAATGGGCATTGCTGCACTAAGGAGAGTCTTAACAGCTTATGCTTTTCGAAATCCCAACATAGGGTATTGC CAGGCCATGAATATTGTCACTTCAGTGCTGCTGCTTTATGCCAAAGAGGAGGAAGCTTTCTGGCTGCTTGTGGCTTTGTGTGAGCGCATG CTCCCAGATTACTACAACACCAGAGTTGTGGGTGCACTGGTGGACCAAGGTGTCTTTGAGGAGCTAGCACGAGACTACGTCCCACAGCTG TACGACTGCATGCAAGACCTGGGCGTGATTTCCACCATCTCCCTGTCTTGGTTCCTCACACTATTTCTCAGTGTGATGCCTTTTGAGAGT GCAGTTGTGGTTGTTGACTGTTTCTTCTATGAAGGAATTAAAGTGATATTCCAGTTGGCCCTAGCTGTGCTGGATGCAAATGTGGACAAA CTGTTGAACTGCAAGGATGATGGGGAGGCCATGACCGTTTTGGGAAGGTATTTAGACAGTGTGACCAATAAAGACAGCACACTGCCTCCC ATTCCTCACCTCCACTCCTTGCTCAGCGATGATGTGGAACCTTACCCTGAGGTAGACATCTTTAGACTCATCAGAACTTCCTACGAGAAA TTCGGAACTATCCGGGCAGATTTGATTGAACAGATGAGATTCAAACAGAGACTGAAAGTGATCCAGACGCTGGAGGATACTACGAAACGC AACGTGGTACGAACCATTGTGACAGAAACTTCCTTTACCATTGATGAGCTGGAAGAACTTTATGCTCTTTTCAAGGAAATATTTGATGAT GCGTCACCTGGAAAGCAAAAGGAAATCCAAGAACCAGATCCTACCTATGAAGAAAAAATGCAAACTGACCGGGCAAATAGATTCGAGTAT TTATTAAAGCAGACAGAACTTTTTGCACATTTCATTCAACCTGCTGCTCAGAAGACTCCAACTTCACCTTTGAAGATGAAACCAGGGCGC CCACGAATAAAAAAAGATGAGAAGCAGAACTTACTATCCGTTGGCGATTACCGACACCGTAGAACAGAGCAAGAGGAGGATGAAGAGCTA TTAACAGAAAGCTCCAAAGCAACCAATGTTTGCACTCGATTTGAAGACTCTCCATCGTATGTAAAATGGGGTAAACTGAGAGATTATCAG GTCCGAGGATTAAACTGGCTCATTTCTTTGTATGAGAATGGCATCAATGGTATCCTTGCAGATGAAATGGGCCTAGGAAAGACTCTTCAA ACAATTTCTCTTCTTGGGTACATGAAACATTATAGAAACATTCCTGGGCCTCATATGGTTTTGGTTCCTAAGTCTACATTACACAACTGG ATGAGTGAATTCAAGAGATGGGTACCAACACTTAGATCTGTTTGTTTGATAGGAGATAAAGAACAAAGAGCTGCTTTTGTCAGAGACGTT TTATTACCGGGAGAATGGGATGTATGTGTAACATCTTATGAAATGCTTATTAAAGAGAAGTCTGTGTTCAAAAAATTTAATTGGAGATAC TTAGTAATAGATGAAGCTCACAGGATCAAAAATGAAAAATCTAAGTTGTCAGAAATAGTGAGGGAATTCAAGACTACAAATAGACTATTA TTAACTGGAACACCTCTTCAGAACAACTTGCATGAGCTGTGGTCACTTCTTAACTTTCTGTTGCCAGATGTGTTTAATTCAGCAGATGAC TTTGATTCCTGGTTTGATACAAACAACTGCCTTGGGGATCAAAAACTAGTTGAGAGGCTTCATATGGTTTTGCGTCCATTCCTCCTTCGT CGAATTAAGGCTGATGTTGAAAAGAGTTTGCCTCCAAAGAAGGAAGTAAAAATCTATGTGGGCCTCAGCAAAATGCAAAGGGAATGGTAT ACTCGGATATTAATGAAGGATATAGATATACTCAACTCAGCAGGCAAGATGGACAAAATGAGGTTATTGAACATCCTAATGCAGTTGAGA AAATGTTGTAATCATCCATATCTCTTTGATGGAGCAGAACCTGGTCCACCTTATACAACAGATATGCATCTAGTAACCAACAGTGGCAAA ATGGTGGTTTTAGACAAGCTGCTCCCTAAGTTAAAAGAACAAGGTTCACGAGTACTAATCTTCAGTCAAATGACAAGGGTATTGGACATT TTGGAAGATTATTGCATGTGGAGAAATTATGAGTACTGCAGGTTGGATGGTCAGACACCCCATGATGAGAGACAAGACTCCATCAATGCA TACAATGAACCAAACAGCACAAAGTTTGTTTTCATGTTAAGCACGCGTGCTGGTGGTCTTGGCATCAATCTTGCGACTGCTGATGTAGTA ATTTTGTATGATTCTGATTGGAATCCCCAAGTAGATCTTCAGGCTATGGACCGAGCACATAGAATTGGGCAGACTAAGACAGTCAGAGTG TTCCGCTTTATAACTGATAACACTGTAGAAGAAAGAATAGTAGAACGTGCTGAGATGAAACTCAGACTGGATTCAATAGTCATTCAACAA GGGAGGCTTGTGGATCAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACATGTGTTTGCTTCA AAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAG ATGGGCGAAAGTTCACTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGAGAAAAACAAAAG ATTGCATTCACAGAGTGGATTGAACCACCTAAACGAGAAAGAAAAGCCAACTATGCCGTTGATGCATATTTCAGGGAAGCTCTTCGTGTT AGTGAACCTAAAGCACCCAAGGCTCCTCGACCTCCAAAACAACCCAATGTTCAGGATTTCCAGTTCTTTCCTCCACGTTTATTTGAATTA CTGGAAAAAGAAATTCTGTTTTACAGAAAAACTATTGGGTACAAGGTACCTCGAAATCCTGAGCTGCCTAATGCAGCACAGGCACAAAAA GAAGAACAGCTTAAAATTGATGAAGCTGAATCCCTTAATGATGAAGAGTTAGAGGAAAAAGAGAAGCTTCTAACACAGGGATTTACCAAT TGGAATAAGAGAGATTTTAACCAGTTTATCAAAGCTAATGAGAAGTGGGGTCGTGATGATATTGAAAATATAGCAAGAGAAGTAGAAGGC AAAACTCCAGAAGAAGTCATTGAATATTCAGCTGTGTTTTGGGAAAGGTGCAACGAGCTCCAGGACATAGAGAAGATTATGGCTCAGATT GAAAGGGGAGAGGCGAGAATTCAAAGAAGAATAAGCATCAAGAAAGCACTTGACACAAAGATTGGACGGTACAAAGCACCTTTTCATCAG CTGAGAATATCATATGGTACTAACAAAGGAAAAAACTATACTGAAGAAGAAGATCGTTTTCTGATTTGTATGCTTCACAAACTTGGATTT GACAAAGAAAATGTTTATGATGAATTGCGACAGTGTATTCGCAACTCTCCTCAGTTCAGATTTGACTGGTTTCTTAAGTCCAGAACTGCA ATGGAGCTCCAGAGGAGATGTAATACCTTAATTACTTTGATTGAAAGAGAAAACATGGAACTAGAAGAAAAGGAGAAGGCAGAGAAAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBC1D9_ENST00000442267_chr4_141560240_-_SMARCA5_ENST00000283131_chr4_144438508_+_9864nt GCGCGCCTGTCGCGGTGGTGGGTGCAGGACTGGACCCACGGGCCCATTGTGCGCCCGCCCGCGGCAGCCAGGACCATGTGGGTGAACCCG GAGGAGGTGTTGCTGGCCAACGCGCTGTGGATCACCGAGAGGGCCAACCCATACTTCATCCTGCAGCGGAGGAAGGGCCACGCCGGCGAT GGAGGCGGCGGCGGCGGACTGGCGGGCCTGCTGGTGGGTACCCTTGATGTTGTGTTGGACTCCAGCGCCCGGGTCGCTCCTTACCGAATC TTGTACCAGACTCCAGACTCCCTGGTCTACTGGACCATCGCCTGTGGTGGTTCCAGGAAAGAAATCACTGAACACTGGGAATGGCTTGAG CAAAATCTCTTGCAGACACTCTCCATCTTTGAAAATGAGAATGATATCACCACATTTGTGAGAGGAAAAATACAGGGCATCATTGCAGAA TACAACAAAATCAATGATGTAAAGGAAGATGATGACACGGAGAAGTTTAAAGAAGCCATTGTGAAATTTCATAGGCTGTTTGGGATGCCA GAGGAAGAGAAACTCGTCAACTATTACTCTTGCAGCTATTGGAAGGGGAAGGTCCCCCGTCAGGGTTGGATGTACCTCAGCATTAACCAC CTTTGCTTTTATTCTTTTCTTATGGGAAGGGAAGCGAAACTGGTCATCCGGTGGGTAGACATCACTCAGCTTGAGAAGAATGCCACCCTG CTTCTGCCTGATGTGATCAAAGTGAGCACACGGTCCAGTGAGCATTTCTTCTCTGTATTCCTCAACATCAACGAGACCTTCAAGTTAATG GAGCAGCTTGCCAACATAGCCATGAGGCAACTCTTAGACAATGAGGGATTTGAACAAGATCGATCCCTGCCCAAACTCAAAAGGAAATCT CCTAAAAAAGTGTCTGCTCTAAAACGTGATCTTGATGCCAGGGCAAAGAGTGAGAGATACCGTGCACTTTTCCGGCTGCCCAAAGATGAA AAATTAGATGGCCACACAGACTGCACTCTCTGGACTCCATTTAACAAAATGCACATTTTGGGGCAGATGTTTGTGTCCACAAATTACATC TGTTTTACCAGCAAGGAGGAGAACTTATGTAGCCTCATTATCCCGCTCCGTGAGGTGACAATTGTGGAAAAGGCAGACAGCTCCAGTGTG CTCCCCAGTCCCTTATCCATCAGCACCCGAAACAGGATGACCTTCCTATTTGCCAACTTGAAAGATAGAGACTTTCTAGTGCAGAGGATC TCAGATTTCCTGCAACAGACTACTTCCAAAATATATTCTGACAAGGAGTTTGCAGGAAGTTACAACAGTTCAGATGATGAGGTGTACTCT CGACCCAGCAGCCTCGTCTCCTCCAGCCCCCAGAGAAGCACGAGCTCTGATGCTGATGGAGAGCGCCAGTTTAACCTAAATGGCAACAGC GTCCCCACAGCCACACAGACCCTGATGACCATGTATCGGCGGCGGTCTCCCGAGGAGTTCAACCCGAAATTGGCCAAAGAGTTTCTGAAA GAGCAAGCCTGGAAGATTCACTTTGCTGAGTATGGGCAAGGGATCTGCATGTACCGCACAGAGAAAACGCGGGAGCTGGTGTTGAAGGGC ATCCCGGAGAGCATGCGTGGGGAGCTCTGGCTGCTGCTGTCAGGTGCCATCAATGAGAAGGCCACACATCCTGGGTACTATGAAGACCTA GTGGAGAAGTCCATGGGGAAGTATAATCTCGCCACGGAGGAGATTGAGAGGGATTTACACCGCTCCCTTCCAGAACACCCAGCTTTTCAG AATGAAATGGGCATTGCTGCACTAAGGAGAGTCTTAACAGCTTATGCTTTTCGAAATCCCAACATAGGGTATTGCCAGGCCATGAATATT GTCACTTCAGTGCTGCTGCTTTATGCCAAAGAGGAGGAAGCTTTCTGGCTGCTTGTGGCTTTGTGTGAGCGCATGCTCCCAGATTACTAC AACACCAGAGTTGTGGGTGCACTGGTGGACCAAGGTGTCTTTGAGGAGCTAGCACGAGACTACGTCCCACAGCTGTACGACTGCATGCAA GACCTGGGCGTGATTTCCACCATCTCCCTGTCTTGGTTCCTCACACTATTTCTCAGTGTGATGCCTTTTGAGAGTGCAGTTGTGGTTGTT GACTGTTTCTTCTATGAAGGAATTAAAGTGATATTCCAGTTGGCCCTAGCTGTGCTGGATGCAAATGTGGACAAACTGTTGAACTGCAAG GATGATGGGGAGGCCATGACCGTTTTGGGAAGGTATTTAGACAGTGTGACCAATAAAGACAGCACACTGCCTCCCATTCCTCACCTCCAC TCCTTGCTCAGCGATGATGTGGAACCTTACCCTGAGGTAGACATCTTTAGACTCATCAGAACTTCCTACGAGAAATTCGGAACTATCCGG GCAGATTTGATTGAACAGATGAGATTCAAACAGAGACTGAAAGTGATCCAGACGCTGGAGGATACTACGAAACGCAACGTGGTACGAACC ATTGTGACAGAAACTTCCTTTACCATTGATGAGCTGGAAGAACTTTATGCTCTTTTCAAGGAAATATTTGATGATGCGTCACCTGGAAAG CAAAAGGAAATCCAAGAACCAGATCCTACCTATGAAGAAAAAATGCAAACTGACCGGGCAAATAGATTCGAGTATTTATTAAAGCAGACA GAACTTTTTGCACATTTCATTCAACCTGCTGCTCAGAAGACTCCAACTTCACCTTTGAAGATGAAACCAGGGCGCCCACGAATAAAAAAA GATGAGAAGCAGAACTTACTATCCGTTGGCGATTACCGACACCGTAGAACAGAGCAAGAGGAGGATGAAGAGCTATTAACAGAAAGCTCC AAAGCAACCAATGTTTGCACTCGATTTGAAGACTCTCCATCGTATGTAAAATGGGGTAAACTGAGAGATTATCAGGTCCGAGGATTAAAC TGGCTCATTTCTTTGTATGAGAATGGCATCAATGGTATCCTTGCAGATGAAATGGGCCTAGGAAAGACTCTTCAAACAATTTCTCTTCTT GGGTACATGAAACATTATAGAAACATTCCTGGGCCTCATATGGTTTTGGTTCCTAAGTCTACATTACACAACTGGATGAGTGAATTCAAG AGATGGGTACCAACACTTAGATCTGTTTGTTTGATAGGAGATAAAGAACAAAGAGCTGCTTTTGTCAGAGACGTTTTATTACCGGGAGAA TGGGATGTATGTGTAACATCTTATGAAATGCTTATTAAAGAGAAGTCTGTGTTCAAAAAATTTAATTGGAGATACTTAGTAATAGATGAA GCTCACAGGATCAAAAATGAAAAATCTAAGTTGTCAGAAATAGTGAGGGAATTCAAGACTACAAATAGACTATTATTAACTGGAACACCT CTTCAGAACAACTTGCATGAGCTGTGGTCACTTCTTAACTTTCTGTTGCCAGATGTGTTTAATTCAGCAGATGACTTTGATTCCTGGTTT GATACAAACAACTGCCTTGGGGATCAAAAACTAGTTGAGAGGCTTCATATGGTTTTGCGTCCATTCCTCCTTCGTCGAATTAAGGCTGAT GTTGAAAAGAGTTTGCCTCCAAAGAAGGAAGTAAAAATCTATGTGGGCCTCAGCAAAATGCAAAGGGAATGGTATACTCGGATATTAATG AAGGATATAGATATACTCAACTCAGCAGGCAAGATGGACAAAATGAGGTTATTGAACATCCTAATGCAGTTGAGAAAATGTTGTAATCAT CCATATCTCTTTGATGGAGCAGAACCTGGTCCACCTTATACAACAGATATGCATCTAGTAACCAACAGTGGCAAAATGGTGGTTTTAGAC AAGCTGCTCCCTAAGTTAAAAGAACAAGGTTCACGAGTACTAATCTTCAGTCAAATGACAAGGGTATTGGACATTTTGGAAGATTATTGC ATGTGGAGAAATTATGAGTACTGCAGGTTGGATGGTCAGACACCCCATGATGAGAGACAAGACTCCATCAATGCATACAATGAACCAAAC AGCACAAAGTTTGTTTTCATGTTAAGCACGCGTGCTGGTGGTCTTGGCATCAATCTTGCGACTGCTGATGTAGTAATTTTGTATGATTCT GATTGGAATCCCCAAGTAGATCTTCAGGCTATGGACCGAGCACATAGAATTGGGCAGACTAAGACAGTCAGAGTGTTCCGCTTTATAACT GATAACACTGTAGAAGAAAGAATAGTAGAACGTGCTGAGATGAAACTCAGACTGGATTCAATAGTCATTCAACAAGGGAGGCTTGTGGAT CAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACATGTGTTTGCTTCAAAGGAAAGTGAGATC ACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCA CTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGAGAAAAACAAAAGATTGCATTCACAGAG TGGATTGAACCACCTAAACGAGAAAGAAAAGCCAACTATGCCGTTGATGCATATTTCAGGGAAGCTCTTCGTGTTAGTGAACCTAAAGCA CCCAAGGCTCCTCGACCTCCAAAACAACCCAATGTTCAGGATTTCCAGTTCTTTCCTCCACGTTTATTTGAATTACTGGAAAAAGAAATT CTGTTTTACAGAAAAACTATTGGGTACAAGGTACCTCGAAATCCTGAGCTGCCTAATGCAGCACAGGCACAAAAAGAAGAACAGCTTAAA ATTGATGAAGCTGAATCCCTTAATGATGAAGAGTTAGAGGAAAAAGAGAAGCTTCTAACACAGGGATTTACCAATTGGAATAAGAGAGAT TTTAACCAGTTTATCAAAGCTAATGAGAAGTGGGGTCGTGATGATATTGAAAATATAGCAAGAGAAGTAGAAGGCAAAACTCCAGAAGAA GTCATTGAATATTCAGCTGTGTTTTGGGAAAGGTGCAACGAGCTCCAGGACATAGAGAAGATTATGGCTCAGATTGAAAGGGGAGAGGCG AGAATTCAAAGAAGAATAAGCATCAAGAAAGCACTTGACACAAAGATTGGACGGTACAAAGCACCTTTTCATCAGCTGAGAATATCATAT GGTACTAACAAAGGAAAAAACTATACTGAAGAAGAAGATCGTTTTCTGATTTGTATGCTTCACAAACTTGGATTTGACAAAGAAAATGTT TATGATGAATTGCGACAGTGTATTCGCAACTCTCCTCAGTTCAGATTTGACTGGTTTCTTAAGTCCAGAACTGCAATGGAGCTCCAGAGG AGATGTAATACCTTAATTACTTTGATTGAAAGAGAAAACATGGAACTAGAAGAAAAGGAGAAGGCAGAGAAAAAGAAACGAGGACCAAAG CCTTCAACACAGAAACGTAAAATGGATGGCGCACCTGATGGTCGAGGAAGAAAAAAGAAGCTGAAACTATGAATATGTTTTTGTTTCATA ATCACTAACTTTAAACCAGTAGTTCTTTAATTTACGGGTCTTCATAAGATGTACTGTACAATGCTCAATTGTTATGTCATTTAAAGACAT CAGGTTCATCTGTTTACTGAGCTAGAAACATAGTATGTAGTTTCACTTTTTTAAATGCAACAGCTGTGCTGAAATTTTTTTATCATTAAC ACTTGAAGTAATAAAATAGGCTTCATTTATTACTAAGTGTTTCATTTGATTTATTTTTCTATTGTAGTTCCATTTGTGAAGATTGTGACT TTTTGTTTATTAGCTATAATTTCTACACTTGTAAGGCTTAAAAACAAGTTAAAAAGAAAATTGCAAATAACATTTGTCCCTTTCAGTCTT CACCTAGTTGTGTAATTATTTTAATTCACTTTGCCTTTGCAGAAATTTGGGTATTTTCTTTGTAGTGCTATTGAGTCTCATCTGGAAAGA TTATATAAATTGCATTCTCCTTGCTTATGTGGGTAGAATGGGAAAAGAAGGCAAGACAAAGTATACTTAAATTCTATGCATATTTCTGTT ATGCTTTCTGTTTTTTTTAGTTGATTCTGAAATGAATATGCCCTATTCTTTTGAAAGAATGGCCTTTTAGTTGTATAGCCAAAGACATTT AGTATTTTCCGGTTCCTTAAGGTATTACTGTACCATTTTGTAAAAGGAATATTATTATTATTATTTTTAATTATTTGGTAAATATTTTGT CATATGACCTTCTGAAGCAGCCACAACTTAGATAATGTCAGAACTAAGGTGATTTTTTTTTTTTAATTTTGAAAGCCCAGCCAAAATGAG GTGTGAATTTGTCATACTGTTACATTGAAATTGGTAACAAAATATATCCCCTCCCATTTGGACTTTTAGGGTAAATGAAAATTTTATTGT ATTTTAAAGTAGTTTCTAAGTGTTAGCAAGACTGACTATAATTCCAGTTTCTGTTTTCTATGGACAGACCTGATAAACTGGAGACCCTAA AGCAGGAATACCCAAATTATAGTGTCAGGATTTTAGCTGTACCAGAGGCCTTTATGTGCTACACATAATTTGTATAAAATTTTATATGTG CAGATTGGGTACATAAACAGTTCTCCATTTTTCTAAGGGAATGCAATAAATGTAGCATCGTGAATAAATATAACTTTTATAATCCGTAAA GTGGTCTTTTCTTTCCATTTCTTTAATTGTTTTCTCAATTTTTATTCACTTTTTCCTTTAGGACACATTTCCCTTAATTGGATATCTTTC CCTTAAATTTCTATTAGTAGTTGTTTTCATCTGCCCACATGTAATTGAAGATTTAAAAAAAAAATTTTGATACCTGCAGTATTACTAATA CTGCTTAATTTCTTGAAATGTGGAATTGCTGCTGTTAATGTCAAGCAAAACGCAGTATTTATGGCAAATTGTAAAGTAATTTGAATTTAG TGCTACCTCAAAATTAACTTTTTAAATACTATGTTAGATTCTTAACAGTTAAAGGTCTAATACATGCATGAGGAATGGTTACTTATGAAA GGAAAAAGAATTTGTAAGAGTTATCACCTCAGTTTGGAAGAAATTGAAAAAATGTAAGGCTGAAGAAAACTTACGGAGGTCACAAAAGTG ATGTTTTCAAGAGGAGGAGAAACTGGGAGGGAGATACACAGTGGAAATGCAAAATGAATCAAGTATAGTGGTAGCCCTGAGAGCTTAGGG ACTCAAATGGAAACTGTGTGAAGGGAAACTCACTTGAAAAAAAAGCATGAACCAGCTAGGCCCTGCCACCACTGTGTTTGGCCAAGTTCA CAAATCTGTTTTAACCTGTCACTTCCCTGTCACTTCTCTGGCTTTCCTCTCCCGCTAAGCTTTTGTTTCCTGGCAGTAATTAAAATCTTC TGTCAGTGCCACAGCTACTACTGCTACTGGAACTGCCTTAACCACTACTGCTACTGGAACTGCCTTAGCCACCTTGGTATCGTGGTTTGG CAAAGTATTGGCCTCTACCACCATAGGGCCCAGAGCTTCTGCCTCCAAAGTTTCCTCCCTTCATGGGTCCAAAATTTGAAGACTGATTGT TGTCATTGCCAAAATCATTGTAGCTTTTACCACCTCCAAAATTGCTTCAATCATTACCAAATCTATTATAGCAATCCCCACTGCCACCAT ATCCATCACCACCACCATGGCTGCCACCAAAGCCACCACGATCACAGAACTTGATGACTGTATTTGTGACTAATTGTATAATAGTTTCTG TTCTGTGGAAAGTAAAGCATTCCAACACAGGGTTTCAGTGTAGATTGTTTTGTTTTGTACCCATGCTGTTGATTGCTAAATGTTTTAATA ATCTGATCATGATACTGAATAAATGTCTTTTTTTTTTTTTAACAACAAAGCATGAAAGATTGCTTAATTGTACATCTGACAAAGTGCTGG AGGCTATTATAAAGTGTAATTATTACTACTTTTAAGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCACAGCT CACTGCAACCTCAAACTTCAGGGCTCAAGTGATCCTCCCACCTCAGCTTCCCAAGTAGCTAGGACTACAGATACCACGCCCAGCTAAGTT TTTTTAGTTTTTGTAGAGATAGGGCCTTGCTATGTTGCCCAGTCCGGTCTCAAACGCCGACTTCAGGCAATCCTCTTGCGTCAACCTCTC AAAGTGCTGGGATTACATGTGTAAGCCTACATTCCAAAGTGCTGGGATCATAGTTGTGAGCCTACACCACACCTGGCCTACATTTTGTTT TTCATAAAGTTGAGAGAAGCAAATCCTAAGCATAGAGTACAAGTTGAGCATCCCTAATCAAAAAATCTAAAATCAGAAATGCTCCATAAT TTGAATGCTCATTAGGGCATTTCTGATTTTTGGATTAGGGATGCTGAACTGATAAGTATAATGCAAGTATTCTAAAGTCTGGAAAATGCT AAAAACACTTCTGGTTCCAGGCATTTCAGATAAGGATTGCTCCATCTGCCCTTTGAGTATTTAATATATGCCGATTGTTTGAACTAATCT GGATTTAATTATATAAATGATTATATAAATGATCTTTGGCTTAGTACCTTTCTTAATCTCGATCTTAAAAAGCATTGTAAAACACCCCTG TGGTTTTTCAGAAAAATTCTGAGTAAAAAATAAATTTCATCTTGTTCTATCCCTTTGAATCTAAAAAACAAATCTTTTTGAAAGGATGTG CTACTATATTTCAAACCAGTAGTTTTGGAGTAGAACATTGCTAAAAAAATGGGTACTAAGGAGGGTAATTTAAACAAAGTAGATTAATGA CACAAGGTGGATTGATGAACTCATAAATCCAAATGAATGGAATGCTAGAAGACATGTATTAACGGAGTAGCTGTTACCAAAATATATACA TATTTTGTATATGTACATAGCTGTTACCAAAATGTATCTTTGCCTGTTGGAATCTGATGTCAAGATCAAAGGTGAGGGCATCCCTCAGAT GACAGATAATGGGCAAAATACATTCTTGGTGTGGAGCAGTGCTGCAGAATTAACTTCGCTGTGTACATCCCAGAATCGTTTTGGATCTGT TAAGGTTTTTATTAGAATGATTAAATAGGCTTTTGCAGCATTAACTTTACAGTAGTTACCAGAAAAGACTATGCTACAAGAACCAAAATT GAAGTAAGAAGAAAAAGACTGAAATGATATGATTCTAAATGAAAAAAATGAAGAAGTGGAATAGTTTCTCCACAGGCATAAGAGGCAAAG CATTGTTTCAGAAGTGGACTGGCACCTCACCTGAGATACTCAAGACTGGCAACATGGGTCTACATTCTTTGTTACCACAGATTCCCTTGT GTCCGGAGAGATTCCCTAGCTCTAATGACAGCTTTTTTGGGGGGTAATGAGGCTATGAGAAGATTGAGGATCTAGGTACTTGCCTTTAAC TCTACAGCATACAAGGTGTGTGGCTCTTATCTCTAGGACACCAATATTTAATGTTGCATATCATGTATCTCCAGTACAAGAAGAAAGTTT ATCAGAATTTAGTTAATGTTGGAAACTTTGTAATATAAACAATGTAAACACTACATTGACAAAAATATTTTATTAATACAAAGAATATGC ATATAGTTTGCTTACTACAGAAATTCTTGTTTTTGATGTAGACAACCCAAAGGAGTTTTTATGTATATAGATTGTGAATAAATTGGGAAA |
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FusionGenePPI for TBC1D9_SMARCA5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBC1D9 | MAP1LC3B, GABARAPL2, MAP1LC3A, GABARAPL1, LANCL1, PRICKLE3, SRSF2, SNRPE, SSB, YME1L1, DDX41, PRPF38B, ABHD16A, TBC1D9B, TMEM55A, MRS2, CPT1A, EPHA1, MUL1 | SMARCA5 | DNMT3B, BAZ2A, BAZ1A, POLE3, CHRAC1, BAZ1B, SATB1, RAD21, HDAC2, RBBP4, CHD3, SMC1A, SMC3, CDT1, CTNNB1, HIST1H4A, MAF, CREB1, MYO1C, SIN3A, RSF1, MCM3, HIST2H2AB, HIST1H3A, DNMT1, CENPA, USF1, XRCC5, MYC, SMARCAD1, SOX2, CECR2, UBTF, POLR1A, MYBBP1A, HDGF, CEBPB, CUL5, CDK2, SAP18, SMARCC2, HDAC1, SMARCC1, MBD3, SMARCA1, RUVBL1, RUVBL2, POLR3A, MSH2, S100A9, IK, SEPT2, EIF4A3, PHGDH, SEPT7, NCSTN, PRKDC, RBM14, HNRNPM, SFPQ, HNRNPR, PPP1CA, NOTCH1, RNF168, VCP, SS18, SSX2, SMARCA5, LMNA, RPA3, RPA2, RPA1, BRCA1, C17orf49, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, ABCE1, RBBP7, NTRK1, COPS3, INO80, IPO9, POLR1C, POLR3B, SCARNA22, IFI16, DAXX, HNRNPU, NPM1, RPL10, NLRP3, MAX, NFATC1, RBPJ, TEAD2, TP53, FOXB1, FOXC1, FOXC2, FOXE1, FOXG1, FOXJ2, FOXJ3, FOXK2, FOXL1, BEND3, FOXM1, FOXQ1, FOXR1, FOXS1, SNW1, CDC5L, NFATC2, RPL30, NCL, COX15, DLST, PDHA1, MTF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D9_SMARCA5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D9_SMARCA5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TBC1D9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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