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Fusion gene ID: 37428 |
FusionGeneSummary for TBC1D9_PAPSS1 |
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Fusion gene information | Fusion gene name: TBC1D9_PAPSS1 | Fusion gene ID: 37428 | Hgene | Tgene | Gene symbol | TBC1D9 | PAPSS1 | Gene ID | 23158 | 9061 |
Gene name | TBC1 domain family member 9 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | |
Synonyms | GRAMD9|MDR1 | ATPSK1|PAPSS|SK1 | |
Cytomap | 4q31.21 | 4q25 | |
Type of gene | protein-coding | protein-coding | |
Description | TBC1 domain family member 9TBC1 domain family member 9ATBC1 domain family, member 9 (with GRAM domain) | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6ZT07 | O43252 | |
Ensembl transtripts involved in fusion gene | ENST00000442267, | ENST00000265174, ENST00000511304, | |
Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 4 X 4 X 3=48 |
# samples | 5 | 4 | |
** MAII score | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TBC1D9 [Title/Abstract] AND PAPSS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PAPSS1 | GO:0000103 | sulfate assimilation | 14747722 |
Tgene | PAPSS1 | GO:0050428 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process | 14747722|23207770 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-2261-01A | TBC1D9 | chr4 | 141677070 | - | PAPSS1 | chr4 | 108535543 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000442267 | ENST00000265174 | TBC1D9 | chr4 | 141677070 | - | PAPSS1 | chr4 | 108535543 | - |
5CDS-intron | ENST00000442267 | ENST00000511304 | TBC1D9 | chr4 | 141677070 | - | PAPSS1 | chr4 | 108535543 | - |
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FusionProtFeatures for TBC1D9_PAPSS1 |
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Hgene | Tgene |
TBC1D9 | PAPSS1 |
May act as a GTPase-activating protein for Rab familyprotein(s). | Bifunctional enzyme with both ATP sulfurylase and APSkinase activity, which mediates two steps in the sulfateactivation pathway. The first step is the transfer of a sulfategroup to ATP to yield adenosine 5'-phosphosulfate (APS), and thesecond step is the transfer of a phosphate group from ATP to APSyielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donorused by sulfotransferase). In mammals, PAPS is the sole source ofsulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121,PubMed:9648242, PubMed:14747722). Required for normal biosynthesisof sulfated L-selectin ligands in endothelial cells(PubMed:9576487). {ECO:0000269|PubMed:14747722,ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242,ECO:0000269|PubMed:9668121}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TBC1D9_PAPSS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TBC1D9_PAPSS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TBC1D9 | MAP1LC3B, GABARAPL2, MAP1LC3A, GABARAPL1, LANCL1, PRICKLE3, SRSF2, SNRPE, SSB, YME1L1, DDX41, PRPF38B, ABHD16A, TBC1D9B, TMEM55A, MRS2, CPT1A, EPHA1, MUL1 | PAPSS1 | PPP1R16A, EEF1A1, UNC119, ATIC, HMGB3, MTRR, PAFAH1B1, ACAT2, AHCY, ASNS, CAPN2, CAPZB, CTPS1, DHX15, FH, MSN, NAE1, NSFL1C, PPP5C, TATDN1, TUBB3, UBA3, XPOT, PTMA, NTRK1, NCK1, RNASEH2A, TMEM132A, FANCI, ERRFI1, PAPSS2, DYNC1I2, CCDC116, C2orf44, FANCG, C4orf26, SNRNP27, GPX7, FGB, TFCP2, GNL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D9_PAPSS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PAPSS1 | O43252 | DB09462 | Glycerin | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | small molecule | approved|investigational |
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RelatedDiseases for TBC1D9_PAPSS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TBC1D9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |