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Fusion gene ID: 37426 |
FusionGeneSummary for TBC1D9_CORO1C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D9_CORO1C | Fusion gene ID: 37426 | Hgene | Tgene | Gene symbol | TBC1D9 | CORO1C | Gene ID | 23158 | 23603 |
| Gene name | TBC1 domain family member 9 | coronin 1C | |
| Synonyms | GRAMD9|MDR1 | HCRNN4 | |
| Cytomap | 4q31.21 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 9TBC1 domain family member 9ATBC1 domain family, member 9 (with GRAM domain) | coronin-1Ccoronin, actin binding protein, 1Ccoronin-3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6ZT07 | Q9ULV4 | |
| Ensembl transtripts involved in fusion gene | ENST00000442267, | ENST00000261401, ENST00000541050, ENST00000549384, ENST00000421578, ENST00000420959, ENST00000549772, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 8 X 6 X 5=240 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TBC1D9 [Title/Abstract] AND CORO1C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0BR-01A | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000442267 | ENST00000261401 | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
| In-frame | ENST00000442267 | ENST00000541050 | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
| 5CDS-intron | ENST00000442267 | ENST00000549384 | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
| 5CDS-5UTR | ENST00000442267 | ENST00000421578 | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
| 5CDS-5UTR | ENST00000442267 | ENST00000420959 | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
| 5CDS-5UTR | ENST00000442267 | ENST00000549772 | TBC1D9 | chr4 | 141591874 | - | CORO1C | chr12 | 109072170 | - |
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FusionProtFeatures for TBC1D9_CORO1C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBC1D9 | CORO1C |
| May act as a GTPase-activating protein for Rab familyprotein(s). | May be involved in cytokinesis, motility, and signaltransduction. {ECO:0000250}. Isoform 3: Involved in myogenic differentiation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TBC1D9 | chr4:141591874 | chr12:109072170 | ENST00000442267 | - | 7 | 21 | 146_213 | 422 | 1267 | Domain | Note=GRAM 1 |
| Hgene | TBC1D9 | chr4:141591874 | chr12:109072170 | ENST00000442267 | - | 7 | 21 | 293_361 | 422 | 1267 | Domain | Note=GRAM 2 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 436_474 | 65 | 475 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 436_474 | 118 | 528 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 436_474 | 65 | 475 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 436_474 | 71 | 481 | Coiled coil | Ontology_term=ECO:0000269 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 128_168 | 65 | 475 | Repeat | WD 3 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 172_202 | 65 | 475 | Repeat | WD 4 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 215_249 | 65 | 475 | Repeat | WD 5 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 263_303 | 65 | 475 | Repeat | WD 6 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 78_118 | 65 | 475 | Repeat | WD 2 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 128_168 | 118 | 528 | Repeat | WD 3 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 172_202 | 118 | 528 | Repeat | WD 4 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 215_249 | 118 | 528 | Repeat | WD 5 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 263_303 | 118 | 528 | Repeat | WD 6 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 128_168 | 65 | 475 | Repeat | WD 3 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 172_202 | 65 | 475 | Repeat | WD 4 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 215_249 | 65 | 475 | Repeat | WD 5 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 263_303 | 65 | 475 | Repeat | WD 6 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 78_118 | 65 | 475 | Repeat | WD 2 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 128_168 | 71 | 481 | Repeat | WD 3 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 172_202 | 71 | 481 | Repeat | WD 4 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 215_249 | 71 | 481 | Repeat | WD 5 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 263_303 | 71 | 481 | Repeat | WD 6 |
| Tgene | >CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 78_118 | 71 | 481 | Repeat | WD 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBC1D9 | chr4:141591874 | chr12:109072170 | ENST00000442267 | - | 7 | 21 | 515_702 | 422 | 1267 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D9 | chr4:141591874 | chr12:109072170 | ENST00000442267 | - | 7 | 21 | 886_921 | 422 | 1267 | Domain | EF-hand |
| Tgene | CORO1C | chr4:141591874 | chr12:109072170 | ENST00000261401 | - | 1 | 11 | 25_70 | 65 | 475 | Repeat | WD 1 |
| Tgene | CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 25_70 | 118 | 528 | Repeat | WD 1 |
| Tgene | CORO1C | chr4:141591874 | chr12:109072170 | ENST00000420959 | - | 1 | 11 | 78_118 | 118 | 528 | Repeat | WD 2 |
| Tgene | CORO1C | chr4:141591874 | chr12:109072170 | ENST00000541050 | - | 1 | 11 | 25_70 | 65 | 475 | Repeat | WD 1 |
| Tgene | CORO1C | chr4:141591874 | chr12:109072170 | ENST00000549772 | - | 1 | 11 | 25_70 | 71 | 481 | Repeat | WD 1 |
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FusionGeneSequence for TBC1D9_CORO1C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBC1D9_ENST00000442267_chr4_141591874_-_CORO1C_ENST00000261401_chr12_109072170_-_832aa MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTPDSLVYWTIACGGSRKEITEH WEWLEQNLLQTLSIFENENDITTFVRGKIQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQLLDNEGFEQDRSLPK LKRKSPKKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSDDETGRIDKSYPTVCGHTGPVLDIDWCPHND QVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWN RNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFY DPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYP DTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKD >In-frame_TBC1D9_ENST00000442267_chr4_141591874_-_CORO1C_ENST00000541050_chr12_109072170_-_832aa MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTPDSLVYWTIACGGSRKEITEH WEWLEQNLLQTLSIFENENDITTFVRGKIQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQLLDNEGFEQDRSLPK LKRKSPKKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSDDETGRIDKSYPTVCGHTGPVLDIDWCPHND QVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWN RNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFY DPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYP DTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBC1D9_ENST00000442267_chr4_141591874_-_CORO1C_ENST00000261401_chr12_109072170_-_2496nt ATGTGGGTGAACCCGGAGGAGGTGTTGCTGGCCAACGCGCTGTGGATCACCGAGAGGGCCAACCCATACTTCATCCTGCAGCGGAGGAAG GGCCACGCCGGCGATGGAGGCGGCGGCGGCGGACTGGCGGGCCTGCTGGTGGGTACCCTTGATGTTGTGTTGGACTCCAGCGCCCGGGTC GCTCCTTACCGAATCTTGTACCAGACTCCAGACTCCCTGGTCTACTGGACCATCGCCTGTGGTGGTTCCAGGAAAGAAATCACTGAACAC TGGGAATGGCTTGAGCAAAATCTCTTGCAGACACTCTCCATCTTTGAAAATGAGAATGATATCACCACATTTGTGAGAGGAAAAATACAG GGCATCATTGCAGAATACAACAAAATCAATGATGTAAAGGAAGATGATGACACGGAGAAGTTTAAAGAAGCCATTGTGAAATTTCATAGG CTGTTTGGGATGCCAGAGGAAGAGAAACTCGTCAACTATTACTCTTGCAGCTATTGGAAGGGGAAGGTCCCCCGTCAGGGTTGGATGTAC CTCAGCATTAACCACCTTTGCTTTTATTCTTTTCTTATGGGAAGGGAAGCGAAACTGGTCATCCGGTGGGTAGACATCACTCAGCTTGAG AAGAATGCCACCCTGCTTCTGCCTGATGTGATCAAAGTGAGCACACGGTCCAGTGAGCATTTCTTCTCTGTATTCCTCAACATCAACGAG ACCTTCAAGTTAATGGAGCAGCTTGCCAACATAGCCATGAGGCAACTCTTAGACAATGAGGGATTTGAACAAGATCGATCCCTGCCCAAA CTCAAAAGGAAATCTCCTAAAAAAGTGTCTGCTCTAAAACGTGATCTTGATGCCAGGGCAAAGAGTGAGAGATACCGTGCACTTTTCCGG CTGCCCAAAGATGAAAAATTAGATGGCCACACAGACTGCACTCTCTGGACTCCATTTAACAAAATGCACATTTTGGGGCAGATGTTTGTG TCCACAAATTACATCTGTTTTACCAGCAAGGAGGAGAACTTATGTAGCCTCATTATCCCGCTCCGTGAGGTGACAATTGTGGAAAAGGCA GACAGCTCCAGTGTGCTCCCCAGTCCCTTATCCATCAGCACCCGAAACAGGATGACCTTCCTATTTGCCAACTTGAAAGATAGAGACTTT CTAGTGCAGAGGATCTCAGATTTCCTGCAACAGACTACTTCCAAAATATATTCTGACAAGGAGTTTGCAGGAAGTTACAACAGTTCAGAT GATGAGACTGGTCGAATTGACAAATCTTACCCTACAGTATGTGGCCACACAGGACCAGTGCTGGACATAGACTGGTGCCCACATAACGAT CAGGTCATTGCCAGCGGTTCAGAGGACTGCACGGTCATGGTATGGCAGATCCCAGAAAATGGACTCACCCTTTCCCTGACTGAACCTGTG GTGATTTTGGAAGGCCACTCAAAGAGAGTCGGCATCGTGGCTTGGCATCCAACGGCCCGCAATGTGCTTCTTAGTGCAGGCTGTGATAAT GCCATTATCATCTGGAATGTGGGAACAGGGGAAGCCCTTATAAACTTGGACGATATGCATTCAGACATGATTTACAATGTGAGCTGGAAC CGGAATGGCAGTCTGATCTGCACAGCTTCCAAAGACAAGAAAGTGAGAGTCATTGATCCCAGGAAACAAGAGATTGTTGCTGAGAAGGAG AAAGCACATGAAGGAGCAAGACCCATGAGAGCCATCTTCCTGGCCGATGGCAATGTCTTCACCACTGGGTTCAGCCGCATGAGCGAGCGG CAGCTGGCTCTCTGGAATCCGAAAAATATGCAGGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTAT GACCCTGACACCAGCATCATTTACTTATGTGGAAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCAC TACCTCAACACATTCAGCAGCAAGGAGCCTCAGAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCC AGATTCTTCAAACTTCATGAGAGAAAGTGTGAACCTATTATTATGACTGTTCCCAGGAAGTCTGACCTTTTCCAAGATGACCTGTATCCT GACACAGCGGGGCCAGAGGCCGCGCTGGAGGCAGAAGAGTGGTTCGAAGGCAAGAATGCAGACCCAATCCTCATCTCCTTGAAGCACGGG TACATTCCAGGCAAAAACAGGGATCTCAAGGTGGTCAAGAAGAACATTCTGGATAGCAAGCCCACTGCAAACAAGAAGTGCGACCTGATC AGCATCCCCAAGAAAACCACAGACACGGCCAGTGTGCAAAATGAAGCCAAGTTGGATGAGATTTTAAAAGAGATCAAATCTATAAAAGAC >In-frame_TBC1D9_ENST00000442267_chr4_141591874_-_CORO1C_ENST00000541050_chr12_109072170_-_2496nt ATGTGGGTGAACCCGGAGGAGGTGTTGCTGGCCAACGCGCTGTGGATCACCGAGAGGGCCAACCCATACTTCATCCTGCAGCGGAGGAAG GGCCACGCCGGCGATGGAGGCGGCGGCGGCGGACTGGCGGGCCTGCTGGTGGGTACCCTTGATGTTGTGTTGGACTCCAGCGCCCGGGTC GCTCCTTACCGAATCTTGTACCAGACTCCAGACTCCCTGGTCTACTGGACCATCGCCTGTGGTGGTTCCAGGAAAGAAATCACTGAACAC TGGGAATGGCTTGAGCAAAATCTCTTGCAGACACTCTCCATCTTTGAAAATGAGAATGATATCACCACATTTGTGAGAGGAAAAATACAG GGCATCATTGCAGAATACAACAAAATCAATGATGTAAAGGAAGATGATGACACGGAGAAGTTTAAAGAAGCCATTGTGAAATTTCATAGG CTGTTTGGGATGCCAGAGGAAGAGAAACTCGTCAACTATTACTCTTGCAGCTATTGGAAGGGGAAGGTCCCCCGTCAGGGTTGGATGTAC CTCAGCATTAACCACCTTTGCTTTTATTCTTTTCTTATGGGAAGGGAAGCGAAACTGGTCATCCGGTGGGTAGACATCACTCAGCTTGAG AAGAATGCCACCCTGCTTCTGCCTGATGTGATCAAAGTGAGCACACGGTCCAGTGAGCATTTCTTCTCTGTATTCCTCAACATCAACGAG ACCTTCAAGTTAATGGAGCAGCTTGCCAACATAGCCATGAGGCAACTCTTAGACAATGAGGGATTTGAACAAGATCGATCCCTGCCCAAA CTCAAAAGGAAATCTCCTAAAAAAGTGTCTGCTCTAAAACGTGATCTTGATGCCAGGGCAAAGAGTGAGAGATACCGTGCACTTTTCCGG CTGCCCAAAGATGAAAAATTAGATGGCCACACAGACTGCACTCTCTGGACTCCATTTAACAAAATGCACATTTTGGGGCAGATGTTTGTG TCCACAAATTACATCTGTTTTACCAGCAAGGAGGAGAACTTATGTAGCCTCATTATCCCGCTCCGTGAGGTGACAATTGTGGAAAAGGCA GACAGCTCCAGTGTGCTCCCCAGTCCCTTATCCATCAGCACCCGAAACAGGATGACCTTCCTATTTGCCAACTTGAAAGATAGAGACTTT CTAGTGCAGAGGATCTCAGATTTCCTGCAACAGACTACTTCCAAAATATATTCTGACAAGGAGTTTGCAGGAAGTTACAACAGTTCAGAT GATGAGACTGGTCGAATTGACAAATCTTACCCTACAGTATGTGGCCACACAGGACCAGTGCTGGACATAGACTGGTGCCCACATAACGAT CAGGTCATTGCCAGCGGTTCAGAGGACTGCACGGTCATGGTATGGCAGATCCCAGAAAATGGACTCACCCTTTCCCTGACTGAACCTGTG GTGATTTTGGAAGGCCACTCAAAGAGAGTCGGCATCGTGGCTTGGCATCCAACGGCCCGCAATGTGCTTCTTAGTGCAGGCTGTGATAAT GCCATTATCATCTGGAATGTGGGAACAGGGGAAGCCCTTATAAACTTGGACGATATGCATTCAGACATGATTTACAATGTGAGCTGGAAC CGGAATGGCAGTCTGATCTGCACAGCTTCCAAAGACAAGAAAGTGAGAGTCATTGATCCCAGGAAACAAGAGATTGTTGCTGAGAAGGAG AAAGCACATGAAGGAGCAAGACCCATGAGAGCCATCTTCCTGGCCGATGGCAATGTCTTCACCACTGGGTTCAGCCGCATGAGCGAGCGG CAGCTGGCTCTCTGGAATCCGAAAAATATGCAGGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTAT GACCCTGACACCAGCATCATTTACTTATGTGGAAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCAC TACCTCAACACATTCAGCAGCAAGGAGCCTCAGAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCC AGATTCTTCAAACTTCATGAGAGAAAGTGTGAACCTATTATTATGACTGTTCCCAGGAAGTCTGACCTTTTCCAAGATGACCTGTATCCT GACACAGCGGGGCCAGAGGCCGCGCTGGAGGCAGAAGAGTGGTTCGAAGGCAAGAATGCAGACCCAATCCTCATCTCCTTGAAGCACGGG TACATTCCAGGCAAAAACAGGGATCTCAAGGTGGTCAAGAAGAACATTCTGGATAGCAAGCCCACTGCAAACAAGAAGTGCGACCTGATC AGCATCCCCAAGAAAACCACAGACACGGCCAGTGTGCAAAATGAAGCCAAGTTGGATGAGATTTTAAAAGAGATCAAATCTATAAAAGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBC1D9_ENST00000442267_chr4_141591874_-_CORO1C_ENST00000261401_chr12_109072170_-_4865nt GCGCGCCTGTCGCGGTGGTGGGTGCAGGACTGGACCCACGGGCCCATTGTGCGCCCGCCCGCGGCAGCCAGGACCATGTGGGTGAACCCG GAGGAGGTGTTGCTGGCCAACGCGCTGTGGATCACCGAGAGGGCCAACCCATACTTCATCCTGCAGCGGAGGAAGGGCCACGCCGGCGAT GGAGGCGGCGGCGGCGGACTGGCGGGCCTGCTGGTGGGTACCCTTGATGTTGTGTTGGACTCCAGCGCCCGGGTCGCTCCTTACCGAATC TTGTACCAGACTCCAGACTCCCTGGTCTACTGGACCATCGCCTGTGGTGGTTCCAGGAAAGAAATCACTGAACACTGGGAATGGCTTGAG CAAAATCTCTTGCAGACACTCTCCATCTTTGAAAATGAGAATGATATCACCACATTTGTGAGAGGAAAAATACAGGGCATCATTGCAGAA TACAACAAAATCAATGATGTAAAGGAAGATGATGACACGGAGAAGTTTAAAGAAGCCATTGTGAAATTTCATAGGCTGTTTGGGATGCCA GAGGAAGAGAAACTCGTCAACTATTACTCTTGCAGCTATTGGAAGGGGAAGGTCCCCCGTCAGGGTTGGATGTACCTCAGCATTAACCAC CTTTGCTTTTATTCTTTTCTTATGGGAAGGGAAGCGAAACTGGTCATCCGGTGGGTAGACATCACTCAGCTTGAGAAGAATGCCACCCTG CTTCTGCCTGATGTGATCAAAGTGAGCACACGGTCCAGTGAGCATTTCTTCTCTGTATTCCTCAACATCAACGAGACCTTCAAGTTAATG GAGCAGCTTGCCAACATAGCCATGAGGCAACTCTTAGACAATGAGGGATTTGAACAAGATCGATCCCTGCCCAAACTCAAAAGGAAATCT CCTAAAAAAGTGTCTGCTCTAAAACGTGATCTTGATGCCAGGGCAAAGAGTGAGAGATACCGTGCACTTTTCCGGCTGCCCAAAGATGAA AAATTAGATGGCCACACAGACTGCACTCTCTGGACTCCATTTAACAAAATGCACATTTTGGGGCAGATGTTTGTGTCCACAAATTACATC TGTTTTACCAGCAAGGAGGAGAACTTATGTAGCCTCATTATCCCGCTCCGTGAGGTGACAATTGTGGAAAAGGCAGACAGCTCCAGTGTG CTCCCCAGTCCCTTATCCATCAGCACCCGAAACAGGATGACCTTCCTATTTGCCAACTTGAAAGATAGAGACTTTCTAGTGCAGAGGATC TCAGATTTCCTGCAACAGACTACTTCCAAAATATATTCTGACAAGGAGTTTGCAGGAAGTTACAACAGTTCAGATGATGAGACTGGTCGA ATTGACAAATCTTACCCTACAGTATGTGGCCACACAGGACCAGTGCTGGACATAGACTGGTGCCCACATAACGATCAGGTCATTGCCAGC GGTTCAGAGGACTGCACGGTCATGGTATGGCAGATCCCAGAAAATGGACTCACCCTTTCCCTGACTGAACCTGTGGTGATTTTGGAAGGC CACTCAAAGAGAGTCGGCATCGTGGCTTGGCATCCAACGGCCCGCAATGTGCTTCTTAGTGCAGGCTGTGATAATGCCATTATCATCTGG AATGTGGGAACAGGGGAAGCCCTTATAAACTTGGACGATATGCATTCAGACATGATTTACAATGTGAGCTGGAACCGGAATGGCAGTCTG ATCTGCACAGCTTCCAAAGACAAGAAAGTGAGAGTCATTGATCCCAGGAAACAAGAGATTGTTGCTGAGAAGGAGAAAGCACATGAAGGA GCAAGACCCATGAGAGCCATCTTCCTGGCCGATGGCAATGTCTTCACCACTGGGTTCAGCCGCATGAGCGAGCGGCAGCTGGCTCTCTGG AATCCGAAAAATATGCAGGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTATGACCCTGACACCAGC ATCATTTACTTATGTGGAAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCACTACCTCAACACATTC AGCAGCAAGGAGCCTCAGAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCCAGATTCTTCAAACTT CATGAGAGAAAGTGTGAACCTATTATTATGACTGTTCCCAGGAAGTCTGACCTTTTCCAAGATGACCTGTATCCTGACACAGCGGGGCCA GAGGCCGCGCTGGAGGCAGAAGAGTGGTTCGAAGGCAAGAATGCAGACCCAATCCTCATCTCCTTGAAGCACGGGTACATTCCAGGCAAA AACAGGGATCTCAAGGTGGTCAAGAAGAACATTCTGGATAGCAAGCCCACTGCAAACAAGAAGTGCGACCTGATCAGCATCCCCAAGAAA ACCACAGACACGGCCAGTGTGCAAAATGAAGCCAAGTTGGATGAGATTTTAAAAGAGATCAAATCTATAAAAGACACAATCTGCAATCAA GATGAGCGTATTTCCAAGTTAGAACAGCAGATGGCAAAGATAGCAGCCTGAAGGTCCCACCCCCACCCCTACAGAAAAAATGGGAGCAAG AACTTGTGCTTGGGAGCTGGTTATTGGTGTGGTCCTAGGGAGGGCGGAAAGGGAGGCACTGCCATTTGGAGACATTCCATTTCAGATTTG TCAACCAGCGATAGGCCACATTCCAGTAAGAACTCAATTTGTCTCCCAAATTTGCAGAAACAAAACGTGATTTAAAAGCTGAGCTTTTTA TCAGAAAGCTTTTTTGATGTTTTAAGTGTTATGTGACTTGTTGAACTTTTTAAAAAGTGCTACTTTTAAAATCCCAGATACTCTGAATTT TAGAAAACAAACTAATTCTGATTGTGTCGTGCCCAAGTACCCTTTTTTTTTTAATGAATAGGGACCAATGCCACATTGCTTTTTATATTT CTTTCTTTTTTAATGTTGCCAAAACCAAAAGTAGCTTTGTTTTCCTTTGTATTTTGCTACTTTGCAGTATTTGTGTGTGTGGTTTTTTTT CCTTAATTTGAAAGGGACAGCACTGTGTATGTTTATAAACTAAATGAAGATAAGATATTATTTTGTATAAACATTCATCTGAGAACAATC AAAGCAGTAGCCACATGGTGCTGGCTCCTTTGCAGCACAAACCTGGTCATTTTGATGACTGTACAACAGGAAGACTTGAAAAATCACGTG GATTCATATTACCACCGCTCTCATTTCATGGAGTCTTCTGATCAAAAAAGCTCACGTCGTATTTCTTCTTTTCCTTTCTCTTTTCTAGAA ATTGGGTGTTTGTACCAGAATGGAATTTTGCTTCTCGGTTATCCTGTGCTTCAGATGATTATAATCTAACCCAAACTAGCATGTGTTTCT GCAGTTTGTTACACACCTAGGATCATATTGCATTCATCACTTTAAACATCATGTTTCAGGTTTTGGTCAATACTTGACAAGGGTGCCCAG GACAGGAAGACGTGTACTGCTGAGTGTTCCTTCTTGCCCTTTTCAGCAGCTTGCCCAGCTCTTGAGTACAGTGGTGGGGACTAAAAATGT GGGCATGTGGAGAGGGGTATTTGCCCTGGGTGATCCTGTTTCCCTGTGCTGTCCCCATGCTGTGTTGGAGGAGGAAGTGGCTCTCCTTCC ACCAACAAAGCTCCTGCTCTACCCTCTTCCTCACATGTGCTGCGACCTCTCTCAGGGCTCCCCCAGCCATTCCTTCTTTCCTTCCTGCCT TTTAGCTCTAACCACATTAAGCTAAGACAAGGCCAGAGGGTGCGATTGAATGAGTATTGAGACTGAGGAGAATGATAGAGAGTGAAGCAG AAACAGGAGCACAGACCTCTGCTGTAGCTTTAATGCATACAAACATGTCCCTCCGCACAACTAACCTGCCCTGCCTCTCCATCTCTCACC AAGGCTGCGTCAAAGCACAGAGGCTCCCCGGACTCGGAGGGGGCCAGAGACTGAGCTCTGGTCACCTGTTCATTCCTCGGTTAGCTGGAA CTTTGCCCCGTTTCCAGTTTCTTATAGTGCATGCTTGGGAAACAAGATTTAAGGAGCCTCTGTTTTGGAAGGGCTGTCTGTGATTGAACG TGAAATGTGTAGTGCCATTGGGACCACGAAGGGAATTCTTGCACATGCTCGTGCTGGTGTGGGCATGGGACTGGCTGGAAACGTCTGTAT GCAGGGAGCCAGGGTGAGGGCAGAGTGTGGTGACAGCCGAACTTGGAGTAATGTCCGTGTAGAAAAAGGACCATGTTCTTATCCAGCCAA TACTGGGAGTGCTGTCTCCACAATTTCAGGGCATCTGAATGTTTGATGTGGTTTTGTGTGTGTGTATGTATGTGTTTAATATTGAAGTGG ATCATGAGATGTAAAGAAAACAATAATGGCAATGACTTATATTCAAATCTGTATTTGTTTCTTTATCAATGTAATCTGCTGAGGACCTTT TGTCTAAGATTCAGTAGTGTTTTAAGGTTCTGATATCGAATTAATGAAGTAAAGTTGTTGATGGTGGTGAAACACCGTAGGGCATGTGGT TCAAAGAGAAGCAGGAGGGCAAGGGAAAGTTACCCTGATCTTAGTTTGTAGCTTATGACTTATTTAATGAATGGATGCCCAGCCAAGCTC AGAGTAGGCGCCCAAAGCATTGTGGATTATTTTCCTGTTTTGTCTTTTTTTTTTTTTTTTTTTAAGCCATGACATCCCAGAAGAGGACAG TGAATTACTCCTAGGTCGGCTCTTATAGAGTGGCCATAGTGTTCTGTCAAAACACTTGCTTCCATTTTCAGAGATAAAAATCATTGATTA >In-frame_TBC1D9_ENST00000442267_chr4_141591874_-_CORO1C_ENST00000541050_chr12_109072170_-_3407nt GCGCGCCTGTCGCGGTGGTGGGTGCAGGACTGGACCCACGGGCCCATTGTGCGCCCGCCCGCGGCAGCCAGGACCATGTGGGTGAACCCG GAGGAGGTGTTGCTGGCCAACGCGCTGTGGATCACCGAGAGGGCCAACCCATACTTCATCCTGCAGCGGAGGAAGGGCCACGCCGGCGAT GGAGGCGGCGGCGGCGGACTGGCGGGCCTGCTGGTGGGTACCCTTGATGTTGTGTTGGACTCCAGCGCCCGGGTCGCTCCTTACCGAATC TTGTACCAGACTCCAGACTCCCTGGTCTACTGGACCATCGCCTGTGGTGGTTCCAGGAAAGAAATCACTGAACACTGGGAATGGCTTGAG CAAAATCTCTTGCAGACACTCTCCATCTTTGAAAATGAGAATGATATCACCACATTTGTGAGAGGAAAAATACAGGGCATCATTGCAGAA TACAACAAAATCAATGATGTAAAGGAAGATGATGACACGGAGAAGTTTAAAGAAGCCATTGTGAAATTTCATAGGCTGTTTGGGATGCCA GAGGAAGAGAAACTCGTCAACTATTACTCTTGCAGCTATTGGAAGGGGAAGGTCCCCCGTCAGGGTTGGATGTACCTCAGCATTAACCAC CTTTGCTTTTATTCTTTTCTTATGGGAAGGGAAGCGAAACTGGTCATCCGGTGGGTAGACATCACTCAGCTTGAGAAGAATGCCACCCTG CTTCTGCCTGATGTGATCAAAGTGAGCACACGGTCCAGTGAGCATTTCTTCTCTGTATTCCTCAACATCAACGAGACCTTCAAGTTAATG GAGCAGCTTGCCAACATAGCCATGAGGCAACTCTTAGACAATGAGGGATTTGAACAAGATCGATCCCTGCCCAAACTCAAAAGGAAATCT CCTAAAAAAGTGTCTGCTCTAAAACGTGATCTTGATGCCAGGGCAAAGAGTGAGAGATACCGTGCACTTTTCCGGCTGCCCAAAGATGAA AAATTAGATGGCCACACAGACTGCACTCTCTGGACTCCATTTAACAAAATGCACATTTTGGGGCAGATGTTTGTGTCCACAAATTACATC TGTTTTACCAGCAAGGAGGAGAACTTATGTAGCCTCATTATCCCGCTCCGTGAGGTGACAATTGTGGAAAAGGCAGACAGCTCCAGTGTG CTCCCCAGTCCCTTATCCATCAGCACCCGAAACAGGATGACCTTCCTATTTGCCAACTTGAAAGATAGAGACTTTCTAGTGCAGAGGATC TCAGATTTCCTGCAACAGACTACTTCCAAAATATATTCTGACAAGGAGTTTGCAGGAAGTTACAACAGTTCAGATGATGAGACTGGTCGA ATTGACAAATCTTACCCTACAGTATGTGGCCACACAGGACCAGTGCTGGACATAGACTGGTGCCCACATAACGATCAGGTCATTGCCAGC GGTTCAGAGGACTGCACGGTCATGGTATGGCAGATCCCAGAAAATGGACTCACCCTTTCCCTGACTGAACCTGTGGTGATTTTGGAAGGC CACTCAAAGAGAGTCGGCATCGTGGCTTGGCATCCAACGGCCCGCAATGTGCTTCTTAGTGCAGGCTGTGATAATGCCATTATCATCTGG AATGTGGGAACAGGGGAAGCCCTTATAAACTTGGACGATATGCATTCAGACATGATTTACAATGTGAGCTGGAACCGGAATGGCAGTCTG ATCTGCACAGCTTCCAAAGACAAGAAAGTGAGAGTCATTGATCCCAGGAAACAAGAGATTGTTGCTGAGAAGGAGAAAGCACATGAAGGA GCAAGACCCATGAGAGCCATCTTCCTGGCCGATGGCAATGTCTTCACCACTGGGTTCAGCCGCATGAGCGAGCGGCAGCTGGCTCTCTGG AATCCGAAAAATATGCAGGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTATGACCCTGACACCAGC ATCATTTACTTATGTGGAAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCACTACCTCAACACATTC AGCAGCAAGGAGCCTCAGAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCCAGATTCTTCAAACTT CATGAGAGAAAGTGTGAACCTATTATTATGACTGTTCCCAGGAAGTCTGACCTTTTCCAAGATGACCTGTATCCTGACACAGCGGGGCCA GAGGCCGCGCTGGAGGCAGAAGAGTGGTTCGAAGGCAAGAATGCAGACCCAATCCTCATCTCCTTGAAGCACGGGTACATTCCAGGCAAA AACAGGGATCTCAAGGTGGTCAAGAAGAACATTCTGGATAGCAAGCCCACTGCAAACAAGAAGTGCGACCTGATCAGCATCCCCAAGAAA ACCACAGACACGGCCAGTGTGCAAAATGAAGCCAAGTTGGATGAGATTTTAAAAGAGATCAAATCTATAAAAGACACAATCTGCAATCAA GATGAGCGTATTTCCAAGTTAGAACAGCAGATGGCAAAGATAGCAGCCTGAAGGTCCCACCCCCACCCCTACAGAAAAAATGGGAGCAAG AACTTGTGCTTGGGAGCTGGTTATTGGTGTGGTCCTAGGGAGGGCGGAAAGGGAGGCACTGCCATTTGGAGACATTCCATTTCAGATTTG TCAACCAGCGATAGGCCACATTCCAGTAAGAACTCAATTTGTCTCCCAAATTTGCAGAAACAAAACGTGATTTAAAAGCTGAGCTTTTTA TCAGAAAGCTTTTTTGATGTTTTAAGTGTTATGTGACTTGTTGAACTTTTTAAAAAGTGCTACTTTTAAAATCCCAGATACTCTGAATTT TAGAAAACAAACTAATTCTGATTGTGTCGTGCCCAAGTACCCTTTTTTTTTTAATGAATAGGGACCAATGCCACATTGCTTTTTATATTT CTTTCTTTTTTAATGTTGCCAAAACCAAAAGTAGCTTTGTTTTCCTTTGTATTTTGCTACTTTGCAGTATTTGTGTGTGTGGTTTTTTTT CCTTAATTTGAAAGGGACAGCACTGTGTATGTTTATAAACTAAATGAAGATAAGATATTATTTTGTATAAACATTCATCTGAGAACAATC AAAGCAGTAGCCACATGGTGCTGGCTCCTTTGCAGCACAAACCTGGTCATTTTGATGACTGTACAACAGGAAGACTTGAAAAATCACGTG GATTCATATTACCACCGCTCTCATTTCATGGAGTCTTCTGATCAAAAAAGCTCACGTCGTATTTCTTCTTTTCCTTTCTCTTTTCTAGAA |
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FusionGenePPI for TBC1D9_CORO1C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBC1D9 | MAP1LC3B, GABARAPL2, MAP1LC3A, GABARAPL1, LANCL1, PRICKLE3, SRSF2, SNRPE, SSB, YME1L1, DDX41, PRPF38B, ABHD16A, TBC1D9B, TMEM55A, MRS2, CPT1A, EPHA1, MUL1 | CORO1C | USP45, ELAVL1, CBL, UBASH3B, PIK3R2, SHC1, CRK, AP2M1, MRPS5, ACTB, STT3B, GNAI2, RAB7A, CYB5B, MMGT1, ACTR2, RHOB, TPM4, PREB, FMNL1, BTK, FN1, VCAM1, UBL4A, PAN2, LMO2, LRCH3, CORO1B, DNAJB11, VPS26A, VPS35, ETF1, FAM129B, GARS, H3F3A, NUDC, PAPOLA, SMOC1, TARS, TP53, ALK, CUL7, OBSL1, DAPK1, ABCE1, ACTG1, ACTR3, AIMP1, ATP6V1F, ALG9, FAP, MCTS1, MDH2, NFYC, NHP2L1, PHKB, RAD23B, SEPT10, SFTPA2, MRPL1, MYCBP, PDIA3, RPA1, SKP1, TIPRL, MED4, MED20, MED23, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, SYNPO, LIMA1, ANLN, MYO19, MYO18A, RCC2, RAC1, ESR1, PDP1, CORO6, CORO1A, GTPBP1, SSH1, DLST, PDHA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D9_CORO1C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D9_CORO1C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TBC1D9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CORO1C | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | CORO1C | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
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