![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 37415 |
FusionGeneSummary for TBC1D8B_RNF128 |
![]() |
Fusion gene information | Fusion gene name: TBC1D8B_RNF128 | Fusion gene ID: 37415 | Hgene | Tgene | Gene symbol | TBC1D8B | RNF128 | Gene ID | 54885 | 79589 |
Gene name | TBC1 domain family member 8B | ring finger protein 128, E3 ubiquitin protein ligase | |
Synonyms | GRAMD8B | GRAIL | |
Cytomap | Xq22.3 | Xq22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | TBC1 domain family member 8BRP11-321G1.1TBC1 domain family, member 8B (with GRAM domain) | E3 ubiquitin-protein ligase RNF128RING-type E3 ubiquitin transferase RNF128gene related to anergy in lymphocytes protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q0IIM8 | Q8TEB7 | |
Ensembl transtripts involved in fusion gene | ENST00000357242, ENST00000310452, ENST00000481617, ENST00000276175, | ENST00000324342, ENST00000255499, | |
Fusion gene scores | * DoF score | 1 X 2 X 3=6 | 2 X 4 X 4=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/6*10)=2.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TBC1D8B [Title/Abstract] AND RNF128 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-C4-A0F6-01A | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
TCGA | LD | OV | TCGA-20-1682-01A | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
TCGA | RV | UCS | TCGA-N6-A4V9-01A | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000357242 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000357242 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000310452 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000310452 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000481617 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000481617 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000276175 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
In-frame | ENST00000276175 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106038810 | + |
5UTR-3CDS | ENST00000357242 | ENST00000324342 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
5UTR-3CDS | ENST00000357242 | ENST00000255499 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
5UTR-3CDS | ENST00000310452 | ENST00000324342 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
5UTR-3CDS | ENST00000310452 | ENST00000255499 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
5UTR-3CDS | ENST00000481617 | ENST00000324342 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
5UTR-3CDS | ENST00000481617 | ENST00000255499 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
intron-3CDS | ENST00000276175 | ENST00000324342 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
intron-3CDS | ENST00000276175 | ENST00000255499 | TBC1D8B | chrX | 106046035 | + | RNF128 | chrX | 106034296 | + |
Frame-shift | ENST00000357242 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000357242 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000310452 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000310452 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000481617 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000481617 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000276175 | ENST00000324342 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Frame-shift | ENST00000276175 | ENST00000255499 | TBC1D8B | chrX | 106046213 | + | RNF128 | chrX | 106028295 | + |
Top |
FusionProtFeatures for TBC1D8B_RNF128 |
![]() |
Hgene | Tgene |
TBC1D8B | RNF128 |
May act as a GTPase-activating protein for Rab familyprotein(s). | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and'Lys-63'-linked polyubiquitin chains formation. Functions as aninhibitor of cytokine gene transcription. Inhibits IL2 and IL4transcription, thereby playing an important role in the inductionof the anergic phenotype, a long-term stable state of T-lymphocyteunresponsiveness to antigenic stimulation associated with theblockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to theirdegradation, down-regulation of these cytosleletal componentsresults in impaired lamellipodium formation and reducedaccumulation of F-actin at the immunological synapse. Functions inthe patterning of the dorsal ectoderm; sensitizes ectoderm torespond to neural-inducing signals. {ECO:0000269|PubMed:12705856,ECO:0000269|PubMed:22016387}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000310452 | + | 1 | 12 | 145_212 | 43 | 633 | Domain | Note=GRAM 1 |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000310452 | + | 1 | 12 | 285_353 | 43 | 633 | Domain | Note=GRAM 2 |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000310452 | + | 1 | 12 | 487_674 | 43 | 633 | Domain | Rab-GAP TBC |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000310452 | + | 1 | 12 | 858_893 | 43 | 633 | Domain | EF-hand |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000357242 | + | 1 | 21 | 145_212 | 43 | 1121 | Domain | Note=GRAM 1 |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000357242 | + | 1 | 21 | 285_353 | 43 | 1121 | Domain | Note=GRAM 2 |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000357242 | + | 1 | 21 | 487_674 | 43 | 1121 | Domain | Rab-GAP TBC |
Hgene | >TBC1D8B | chrX:106046213 | chrX:106038810 | ENST00000357242 | + | 1 | 21 | 858_893 | 43 | 1121 | Domain | EF-hand |
Tgene | RNF128 | chrX:106046213 | chrX:106038810 | ENST00000255499 | + | 5 | 7 | 75_183 | 384 | 429 | Domain | Note=PA |
Tgene | RNF128 | chrX:106046213 | chrX:106038810 | ENST00000324342 | + | 5 | 7 | 75_183 | 358 | 403 | Domain | Note=PA |
Tgene | RNF128 | chrX:106046213 | chrX:106038810 | ENST00000255499 | + | 5 | 7 | 208_228 | 384 | 429 | Transmembrane | Helical |
Tgene | RNF128 | chrX:106046213 | chrX:106038810 | ENST00000324342 | + | 5 | 7 | 208_228 | 358 | 403 | Transmembrane | Helical |
Tgene | RNF128 | chrX:106046213 | chrX:106038810 | ENST00000255499 | + | 5 | 7 | 277_318 | 384 | 429 | Zinc finger | RING-type%3B atypical |
Tgene | RNF128 | chrX:106046213 | chrX:106038810 | ENST00000324342 | + | 5 | 7 | 277_318 | 358 | 403 | Zinc finger | RING-type%3B atypical |
Top |
FusionGeneSequence for TBC1D8B_RNF128 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TBC1D8B_RNF128 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TBC1D8B | RNF128 | OTUB1, USP8, UBE2N, CD40LG, UBE2I, UBE2T, RNF128, UBE2E1, UBE2H, UBE2D1, TP53, APPBP2, CEP76, TBK1, CD83 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TBC1D8B_RNF128 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TBC1D8B_RNF128 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |