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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37415

FusionGeneSummary for TBC1D8B_RNF128

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D8B_RNF128
Fusion gene ID: 37415
HgeneTgene
Gene symbol

TBC1D8B

RNF128

Gene ID

54885

79589

Gene nameTBC1 domain family member 8Bring finger protein 128, E3 ubiquitin protein ligase
SynonymsGRAMD8BGRAIL
Cytomap

Xq22.3

Xq22.3

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 8BRP11-321G1.1TBC1 domain family, member 8B (with GRAM domain)E3 ubiquitin-protein ligase RNF128RING-type E3 ubiquitin transferase RNF128gene related to anergy in lymphocytes protein
Modification date2018052320180523
UniProtAcc

Q0IIM8

Q8TEB7

Ensembl transtripts involved in fusion geneENST00000357242, ENST00000310452, 
ENST00000481617, ENST00000276175, 
ENST00000324342, ENST00000255499, 
Fusion gene scores* DoF score1 X 2 X 3=62 X 4 X 4=32
# samples 34
** MAII scorelog2(3/6*10)=2.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TBC1D8B [Title/Abstract] AND RNF128 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-C4-A0F6-01ATBC1D8BchrX

106046213

+RNF128chrX

106038810

+
TCGALDOVTCGA-20-1682-01ATBC1D8BchrX

106046035

+RNF128chrX

106034296

+
TCGARVUCSTCGA-N6-A4V9-01ATBC1D8BchrX

106046213

+RNF128chrX

106028295

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000357242ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000357242ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000310452ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000310452ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000481617ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000481617ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000276175ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
In-frameENST00000276175ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106038810

+
5UTR-3CDSENST00000357242ENST00000324342TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
5UTR-3CDSENST00000357242ENST00000255499TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
5UTR-3CDSENST00000310452ENST00000324342TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
5UTR-3CDSENST00000310452ENST00000255499TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
5UTR-3CDSENST00000481617ENST00000324342TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
5UTR-3CDSENST00000481617ENST00000255499TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
intron-3CDSENST00000276175ENST00000324342TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
intron-3CDSENST00000276175ENST00000255499TBC1D8BchrX

106046035

+RNF128chrX

106034296

+
Frame-shiftENST00000357242ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000357242ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000310452ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000310452ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000481617ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000481617ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000276175ENST00000324342TBC1D8BchrX

106046213

+RNF128chrX

106028295

+
Frame-shiftENST00000276175ENST00000255499TBC1D8BchrX

106046213

+RNF128chrX

106028295

+

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FusionProtFeatures for TBC1D8B_RNF128


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D8B

Q0IIM8

RNF128

Q8TEB7

May act as a GTPase-activating protein for Rab familyprotein(s). E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and'Lys-63'-linked polyubiquitin chains formation. Functions as aninhibitor of cytokine gene transcription. Inhibits IL2 and IL4transcription, thereby playing an important role in the inductionof the anergic phenotype, a long-term stable state of T-lymphocyteunresponsiveness to antigenic stimulation associated with theblockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to theirdegradation, down-regulation of these cytosleletal componentsresults in impaired lamellipodium formation and reducedaccumulation of F-actin at the immunological synapse. Functions inthe patterning of the dorsal ectoderm; sensitizes ectoderm torespond to neural-inducing signals. {ECO:0000269|PubMed:12705856,ECO:0000269|PubMed:22016387}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000310452+112145_21243633DomainNote=GRAM 1
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000310452+112285_35343633DomainNote=GRAM 2
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000310452+112487_67443633DomainRab-GAP TBC
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000310452+112858_89343633DomainEF-hand
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000357242+121145_212431121DomainNote=GRAM 1
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000357242+121285_353431121DomainNote=GRAM 2
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000357242+121487_674431121DomainRab-GAP TBC
HgeneTBC1D8BchrX:106046213chrX:106038810ENST00000357242+121858_893431121DomainEF-hand
TgeneRNF128chrX:106046213chrX:106038810ENST00000255499+5775_183384429DomainNote=PA
TgeneRNF128chrX:106046213chrX:106038810ENST00000324342+5775_183358403DomainNote=PA
TgeneRNF128chrX:106046213chrX:106038810ENST00000255499+57208_228384429TransmembraneHelical
TgeneRNF128chrX:106046213chrX:106038810ENST00000324342+57208_228358403TransmembraneHelical
TgeneRNF128chrX:106046213chrX:106038810ENST00000255499+57277_318384429Zinc fingerRING-type%3B atypical
TgeneRNF128chrX:106046213chrX:106038810ENST00000324342+57277_318358403Zinc fingerRING-type%3B atypical


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FusionGeneSequence for TBC1D8B_RNF128


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D8B_RNF128


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBC1D8BRNF128OTUB1, USP8, UBE2N, CD40LG, UBE2I, UBE2T, RNF128, UBE2E1, UBE2H, UBE2D1, TP53, APPBP2, CEP76, TBK1, CD83


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D8B_RNF128


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D8B_RNF128


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource