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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3741

FusionGeneSummary for B4GALT4_CBLB

check button Fusion gene summary
Fusion gene informationFusion gene name: B4GALT4_CBLB
Fusion gene ID: 3741
HgeneTgene
Gene symbol

B4GALT4

CBLB

Gene ID

8702

868

Gene namebeta-1,4-galactosyltransferase 4Cbl proto-oncogene B
SynonymsB4Gal-T4|beta4Gal-T4Cbl-b|Nbla00127|RNF56
Cytomap

3q13.32

3q13.11

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-galactosyltransferase 4UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4UDP-galactose:beta-N-acetylglucosamine beta-1,4-gaE3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase
Modification date2018051920180523
UniProtAcc

O60513

Q13191

Ensembl transtripts involved in fusion geneENST00000483209, ENST00000467604, 
ENST00000471675, ENST00000359213, 
ENST00000393765, ENST00000460321, 
ENST00000264122, ENST00000407712, 
ENST00000394027, ENST00000403724, 
ENST00000405772, ENST00000545639, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 8 X 4=192
# samples 38
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B4GALT4 [Title/Abstract] AND CBLB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-WY-A85C-01AB4GALT4chr3

118955700

-CBLBchr3

105572508

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000483209ENST00000264122B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000483209ENST00000407712B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000483209ENST00000394027B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000483209ENST00000403724B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000483209ENST00000405772B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000483209ENST00000545639B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-3CDSENST00000467604ENST00000264122B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000467604ENST00000407712B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000467604ENST00000394027B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000467604ENST00000403724B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000467604ENST00000405772B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000467604ENST00000545639B4GALT4chr3

118955700

-CBLBchr3

105572508

-
intron-3CDSENST00000471675ENST00000264122B4GALT4chr3

118955700

-CBLBchr3

105572508

-
intron-intronENST00000471675ENST00000407712B4GALT4chr3

118955700

-CBLBchr3

105572508

-
intron-intronENST00000471675ENST00000394027B4GALT4chr3

118955700

-CBLBchr3

105572508

-
intron-intronENST00000471675ENST00000403724B4GALT4chr3

118955700

-CBLBchr3

105572508

-
intron-intronENST00000471675ENST00000405772B4GALT4chr3

118955700

-CBLBchr3

105572508

-
intron-intronENST00000471675ENST00000545639B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-3CDSENST00000359213ENST00000264122B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000359213ENST00000407712B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000359213ENST00000394027B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000359213ENST00000403724B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000359213ENST00000405772B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000359213ENST00000545639B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-3CDSENST00000393765ENST00000264122B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000393765ENST00000407712B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000393765ENST00000394027B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000393765ENST00000403724B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000393765ENST00000405772B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000393765ENST00000545639B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-3CDSENST00000460321ENST00000264122B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000460321ENST00000407712B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000460321ENST00000394027B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000460321ENST00000403724B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000460321ENST00000405772B4GALT4chr3

118955700

-CBLBchr3

105572508

-
5UTR-intronENST00000460321ENST00000545639B4GALT4chr3

118955700

-CBLBchr3

105572508

-

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FusionProtFeatures for B4GALT4_CBLB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B4GALT4

O60513

CBLB

Q13191

Responsible for the synthesis of complex-type N-linkedoligosaccharides in many glycoproteins as well as the carbohydratemoieties of glycolipids. {ECO:0000269|PubMed:9792633}. E3 ubiquitin-protein ligase which accepts ubiquitin fromspecific E2 ubiquitin-conjugating enzymes, and transfers it tosubstrates, generally promoting their degradation by theproteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilonreceptor) signal transduction pathways. In naive T-cells, inhibitsVAV1 activation upon TCR engagement and imposes a requirement forCD28 costimulation for proliferation and IL-2 production. Alsoacts by promoting PIK3R1/p85 ubiquitination, which impairs itsrecruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization uponrestimulation and promotes anergy. In B-cells, acts byubiquitinating SYK and promoting its proteasomal degradation.Slightly promotes SRC ubiquitination. May be involved in EGFRubiquitination and internalization. May be functionally coupledwith the E2 ubiquitin-protein ligase UB2D3.{ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340,ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404,ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for B4GALT4_CBLB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for B4GALT4_CBLB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B4GALT4MOV10, NXF1, CLDND1, HLA-DPA1, NGLY1, ITGA6, SP3, CBWD3, STRN3, HSPA5, SDF2L1CBLBGORASP2, CRY1, NCK2, SORBS3, EGFR, NEDD4, ZAP70, GRB2, SHC1, PIK3R1, VAV1, BTK, PLCG2, SH3KBP1, KIT, SYK, CRKL, IRS1, UBC, CARD11, ASAP1, CD2AP, ARHGEF7, ITSN1, MS4A2, MYD88, TICAM1, PTPN11, TANK, TRAF3, TRAF6, LCK, PIK3R2, CFLAR, ABL1, CBL, CRK, UBE2D2, CBLB, SPRY1, VAV2, HNRNPK, TGFB1I1, RNF11, WAS, DDR2, PTK2B, SIRT2, GLRX3, UBASH3B, NTRK1, APPL1, FYN, GRAP2, IPO8, SP7, USP12, PDGFRB, TNFRSF10B, TRAF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B4GALT4_CBLB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for B4GALT4_CBLB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneB4GALT4C0033578Prostatic Neoplasms1CTD_human
TgeneCBLBC0014072Experimental Autoimmune Encephalomyelitis1CTD_human
TgeneCBLBC0026769Multiple Sclerosis1CTD_human