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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37404

FusionGeneSummary for TBC1D4_COMMD6

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D4_COMMD6
Fusion gene ID: 37404
HgeneTgene
Gene symbol

TBC1D4

COMMD6

Gene ID

9882

170622

Gene nameTBC1 domain family member 4COMM domain containing 6
SynonymsAS160|NIDDM5Acrg
Cytomap

13q22.2

13q22.2

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 4TBC (Tre-2, BUB2, CDC16) domain-containing proteinakt substrate of 160 kDaCOMM domain-containing protein 6Acrg embryonic lethality minimal region ortholog
Modification date2018052320180519
UniProtAcc

O60343

Q7Z4G1

Ensembl transtripts involved in fusion geneENST00000377636, ENST00000431480, 
ENST00000425511, ENST00000377625, 
ENST00000478591, 
ENST00000406936, 
ENST00000377615, ENST00000377619, 
ENST00000355801, ENST00000460675, 
Fusion gene scores* DoF score4 X 3 X 4=483 X 4 X 3=36
# samples 54
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TBC1D4 [Title/Abstract] AND COMMD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOMMD6

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16573520


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A14N-01ATBC1D4chr13

76055406

-COMMD6chr13

76111811

-
TCGARVBRCATCGA-OL-A5S0-01ATBC1D4chr13

76055406

-COMMD6chr13

76104402

-
TCGALDBRCATCGA-E2-A14N-01ATBC1D4chr13

76055406

-COMMD6chr13

76100775

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377636ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377636ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377636ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377636ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377636ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000431480ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000431480ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000431480ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000431480ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000431480ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-intronENST00000425511ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-intronENST00000425511ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-intronENST00000425511ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377625ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377625ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377625ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377625ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377625ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-intronENST00000478591ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-intronENST00000478591ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-intronENST00000478591ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377636ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377636ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377636ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377636ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5CDS-5UTRENST00000377636ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5CDS-5UTRENST00000431480ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-5UTRENST00000425511ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5CDS-5UTRENST00000377625ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-5UTRENST00000478591ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
Frame-shitENST00000377636ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000377636ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000377636ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000377636ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5CDS-5UTRENST00000377636ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000431480ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000431480ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000431480ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000431480ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5CDS-5UTRENST00000431480ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-5UTRENST00000425511ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000377625ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000377625ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shitENST00000377625ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000377625ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5CDS-5UTRENST00000377625ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-5UTRENST00000478591ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-

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FusionProtFeatures for TBC1D4_COMMD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D4

O60343

COMMD6

Q7Z4G1

May act as a GTPase-activating protein for RAB2A, RAB8A,RAB10 and RAB14. Isoform 2 promotes insulin-induced glucosetransporter SLC2A4/GLUT4 translocation at the plasma membrane,thus increasing glucose uptake. {ECO:0000269|PubMed:15971998,ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). Down-regulates activation ofNF-kappa-B. Inhibits TNF-induced NFKB1 activation.{ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520,ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMMD6chr13:76055406chr13:76104402ENST00000355801-1518_851899DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76104402ENST00000377615-2518_851886DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76104402ENST00000406936-1418_851886DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76111811ENST00000355801-0518_851499DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76111811ENST00000377615-1518_851486DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76111811ENST00000406936-0418_851486DomainCOMM

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-119672_7591661236Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-121672_7591661299Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-120672_759-617463Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-120672_7591661291Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-119672_7591661236Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-121672_7591661299Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-120672_759-617463Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-120672_7591661291Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-119312_4681661236DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-11953_2091661236DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-119918_11121661236DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-121312_4681661299DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-12153_2091661299DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-121918_11121661299DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-120312_468-617463DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-12053_209-617463DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-120918_1112-617463DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-120312_4681661291DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-12053_2091661291DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-120918_11121661291DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-119312_4681661236DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-11953_2091661236DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-119918_11121661236DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-121312_4681661299DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-12153_2091661299DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-121918_11121661299DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-120312_468-617463DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-12053_209-617463DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-120918_1112-617463DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-120312_4681661291DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-12053_2091661291DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-120918_11121661291DomainRab-GAP TBC


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FusionGeneSequence for TBC1D4_COMMD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D4_COMMD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBC1D4DNPEP, U2SURP, RBM12, EP400, TET2, CUL2, ROR1, YWHAE, YWHAQ, AKT1, YWHAB, PIN1, TBC1D2, POLD1, RPL3, SMC4, TSEN2, TLE3, WDR77, AURKB, CDKN1A, CEP57, CEP72, TP53, FBXW11, BTRC, CTDSP2, APBB2, TMOD1, EIF4E3, CCNA2, NTRK1, MPHOSPH8, MBOAT1, CHAMP1, FOXK1, YWHAZ, CTDSPL, PPP2CA, PPP2CB, TMOD3, TP53INP1, MYF6, IQCF1, LRRC8E, COMMD1, RAB2B, NCF2, TKT, CALM1COMMD6COMMD1, RELA, NFKB1, COMMD6, COMMD4, VCP, CCDC22, COMMD10, ZFP36, CCDC93, E2F6, COMMD3, UNK, COMMD9, SCLT1, COMMD7, FAM45A, COMMD2, COMMD8, C16orf62, COMMD5, DSCR3, VPS29, TFDP1, VPS33B, MFAP3, KIF2B, EMB, TM2D3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D4_COMMD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D4_COMMD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource