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Fusion gene ID: 37391 |
FusionGeneSummary for TBC1D2B_ACSBG1 |
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Fusion gene information | Fusion gene name: TBC1D2B_ACSBG1 | Fusion gene ID: 37391 | Hgene | Tgene | Gene symbol | TBC1D2B | ACSBG1 | Gene ID | 23102 | 23205 |
Gene name | TBC1 domain family member 2B | acyl-CoA synthetase bubblegum family member 1 | |
Synonyms | - | BG|BG1|BGM|GR-LACS|LPD | |
Cytomap | 15q24.3-q25.1 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | TBC1 domain family member 2B | long-chain-fatty-acid--CoA ligase ACSBG1bubblegumlipidosinvery long-chain acyl-CoA synthetase | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9UPU7 | Q96GR2 | |
Ensembl transtripts involved in fusion gene | ENST00000300584, ENST00000409931, ENST00000492078, | ENST00000258873, ENST00000541759, ENST00000560817, ENST00000558828, | |
Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 3 X 3 X 3=27 |
# samples | 12 | 3 | |
** MAII score | log2(12/280*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TBC1D2B [Title/Abstract] AND ACSBG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACSBG1 | GO:0000038 | very long-chain fatty acid metabolic process | 10954726 |
Tgene | ACSBG1 | GO:0001676 | long-chain fatty acid metabolic process | 10954726 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-D1-A3DG-01A | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000300584 | ENST00000258873 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
Frame-shift | ENST00000300584 | ENST00000541759 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
Frame-shift | ENST00000300584 | ENST00000560817 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
5CDS-intron | ENST00000300584 | ENST00000558828 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
Frame-shift | ENST00000409931 | ENST00000258873 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
Frame-shift | ENST00000409931 | ENST00000541759 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
Frame-shift | ENST00000409931 | ENST00000560817 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
5CDS-intron | ENST00000409931 | ENST00000558828 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
intron-3CDS | ENST00000492078 | ENST00000258873 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
intron-3CDS | ENST00000492078 | ENST00000541759 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
intron-3CDS | ENST00000492078 | ENST00000560817 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
intron-intron | ENST00000492078 | ENST00000558828 | TBC1D2B | chr15 | 78295647 | - | ACSBG1 | chr15 | 78472122 | - |
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FusionProtFeatures for TBC1D2B_ACSBG1 |
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Hgene | Tgene |
TBC1D2B | ACSBG1 |
May act as a GTPase-activating protein. {ECO:0000250}. | Mediates activation of long-chain fatty acids for bothsynthesis of cellular lipids, and degradation via beta-oxidation.Able to activate long-chain fatty acids. Also able to activatevery long-chain fatty acids; however, the relevance of suchactivity is unclear in vivo. Can activate diverse saturated,monosaturated and polyunsaturated fatty acids.{ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TBC1D2B_ACSBG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TBC1D2B_ACSBG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TBC1D2B | GABARAPL1, MAP1LC3A, ECT2, TRDMT1, APBB2, PSMC3, THBS3, OFD1, MKS1, CEP89, XPO1, PTCD3, PAK7, ALOX5, CCDC53, KLHL40, CAV3, COG6, S100A6, C6orf141, TRIM25 | ACSBG1 | GSK3B, APP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D2B_ACSBG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D2B_ACSBG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |