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Fusion gene ID: 37366 |
FusionGeneSummary for TBC1D22A_GKN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D22A_GKN1 | Fusion gene ID: 37366 | Hgene | Tgene | Gene symbol | TBC1D22A | GKN1 | Gene ID | 25771 | 56287 |
| Gene name | TBC1 domain family member 22A | gastrokine 1 | |
| Synonyms | C22orf4|HSC79E021 | AMP18|BRICD1|CA11|FOV|foveolin | |
| Cytomap | 22q13.31 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 22Aputative GTPase activator | gastrokine-118 kDa antrum mucosa proteinAMP-18BRICHOS domain containing 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8WUA7 | Q9NS71 | |
| Ensembl transtripts involved in fusion gene | ENST00000337137, ENST00000380995, ENST00000407381, ENST00000355704, ENST00000472791, ENST00000406733, | ENST00000377938, | |
| Fusion gene scores | * DoF score | 18 X 10 X 12=2160 | 2 X 1 X 2=4 |
| # samples | 19 | 2 | |
| ** MAII score | log2(19/2160*10)=-3.50695998871988 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: TBC1D22A [Title/Abstract] AND GKN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-49-4514-01A | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000337137 | ENST00000377938 | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
| In-frame | ENST00000380995 | ENST00000377938 | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
| In-frame | ENST00000407381 | ENST00000377938 | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
| In-frame | ENST00000355704 | ENST00000377938 | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
| intron-3CDS | ENST00000472791 | ENST00000377938 | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
| In-frame | ENST00000406733 | ENST00000377938 | TBC1D22A | chr22 | 47274619 | + | GKN1 | chr2 | 69204627 | + |
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FusionProtFeatures for TBC1D22A_GKN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBC1D22A | GKN1 |
| Has mitogenic activity and may be involved inmaintaining the integrity of the gastric mucosal epithelium.{ECO:0000269|PubMed:12851218}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GKN1 | chr22:47274619 | chr2:69204627 | ENST00000377938 | + | 0 | 6 | 68_164 | 18 | 200 | Domain | BRICHOS |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBC1D22A | chr22:47274619 | chr2:69204627 | ENST00000337137 | + | 5 | 13 | 222_446 | 236 | 518 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D22A | chr22:47274619 | chr2:69204627 | ENST00000355704 | + | 3 | 11 | 222_446 | 158 | 440 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D22A | chr22:47274619 | chr2:69204627 | ENST00000380995 | + | 5 | 9 | 222_446 | 189 | 325 | Domain | Rab-GAP TBC |
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FusionGeneSequence for TBC1D22A_GKN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBC1D22A_ENST00000337137_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_418aa MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQ SVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVMPSIQSLDALVKEKKLQGKGPGGPPPKGLMYSVNPNKV >In-frame_TBC1D22A_ENST00000380995_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_371aa MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPV RPMTWKLLSIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHK MNKEVMPSIQSLDALVKEKKLQGKGPGGPPPKGLMYSVNPNKVDDLSKFGKNIANMCRGIPTYMAEEMQEASLFFYSGTCYTTSVLWIVD >In-frame_TBC1D22A_ENST00000407381_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_359aa MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSIVF AGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVMPSIQSL >In-frame_TBC1D22A_ENST00000355704_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_340aa MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSIVFAGLLGVFLAPALANYNINV NDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVMPSIQSLDALVKEKKLQGKGPGGPPP >In-frame_TBC1D22A_ENST00000406733_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_371aa MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPV RPMTWKLLSIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHK MNKEVMPSIQSLDALVKEKKLQGKGPGGPPPKGLMYSVNPNKVDDLSKFGKNIANMCRGIPTYMAEEMQEASLFFYSGTCYTTSVLWIVD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBC1D22A_ENST00000337137_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1254nt ATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCAC CCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACC TTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAAC TCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTT CAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCC TGTCCTGCAGAAAGTGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCT GACCCCAGCACTCTCAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACG GACCTTGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCT GGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAG TCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAAT GGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGAT GCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTC GATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTG >In-frame_TBC1D22A_ENST00000380995_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1113nt ATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGAC GACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAG CGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGAC CTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCT CTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGG CTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTG CGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAAC GTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAAC GGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAA ATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCT CCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATT CCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGAC >In-frame_TBC1D22A_ENST00000407381_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1077nt ATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCAC CCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACC TTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAAC TCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTT CAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCC TGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTT GCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAG CAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGA AATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTT GATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAA GTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGC >In-frame_TBC1D22A_ENST00000355704_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1020nt ATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTCCACGGCCAAGATGCCG ACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGAT GAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAG GGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGG CTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGT CCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTC AATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGA TGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATG AACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCC AAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCA ACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGACATT >In-frame_TBC1D22A_ENST00000406733_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1113nt ATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGAC GACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAG CGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGAC CTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCT CTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGG CTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTG CGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAAC GTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAAC GGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAA ATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCT CCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATT CCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBC1D22A_ENST00000337137_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1571nt GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGT CTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAA CAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAAC CAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGA AAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAA GTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGG AACGTGCTACACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGACACGGTGGAGAACTAAACAATTTTTTAAAGCCACTA TGGATTTAGTCATCTGAATATGCTGTGCAGAAAAAATATGGGCTCCAGTGGTTTTTACCATGTCATTCTGAAATTTTTCTCTACTAGTTA >In-frame_TBC1D22A_ENST00000380995_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1560nt CAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGC CGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGC AATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATG GCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCA GCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCA ACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAG AGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGATG CCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTCAG CGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTTGA GCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTC CTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACA ATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTC AAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTC AGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAA ACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACA CGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGACACGGTGGAGAACTAAACAATTTTTTAAAGCCACTATGGATTTAGTC ATCTGAATATGCTGTGCAGAAAAAATATGGGCTCCAGTGGTTTTTACCATGTCATTCTGAAATTTTTCTCTACTAGTTATGTTTGATTTC >In-frame_TBC1D22A_ENST00000407381_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1343nt CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC GTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGA CAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGTTGACAATAACAACGGATGGGACTC CTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGA AGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCT GATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACATGTGTCGTGGGATTCCAACATACAT GGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTG TGGAGACACGGTGGAGAACTAAACAATTTTTTAAAGCCACTATGGATTTAGTCATCTGAATATGCTGTGCAGAAAAAATATGGGCTCCAG >In-frame_TBC1D22A_ENST00000355704_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1277nt CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGCTCCTGCCCTAGCTAA CTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACACAATGTGGCCAATGT TGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTTTCAAAAGAAGACATG CATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCTTCAGGGTAAGGGACC AGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAAAAACATTGCAAACAT GTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTACACGACCAGTGTACT ATGGATTGTGGACATTTCCTTCTGTGGAGACACGGTGGAGAACTAAACAATTTTTTAAAGCCACTATGGATTTAGTCATCTGAATATGCT GTGCAGAAAAAATATGGGCTCCAGTGGTTTTTACCATGTCATTCTGAAATTTTTCTCTACTAGTTATGTTTGATTTCTTTAAGTTTCAAT >In-frame_TBC1D22A_ENST00000406733_chr22_47274619_+_GKN1_ENST00000377938_chr2_69204627_+_1652nt AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAATTGTCTTTGCTGGACTTCTTGGAGTCTTTCTAGC TCCTGCCCTAGCTAACTATAATATCAACGTCAATGATGACAACAACAATGCTGGAAGTGGGCAGCAGTCAGTGAGTGTCAACAATGAACA CAATGTGGCCAATGTTGACAATAACAACGGATGGGACTCCTGGAATTCCATCTGGGATTATGGAAATGGCTTTGCTGCAACCAGACTCTT TCAAAAGAAGACATGCATTGTGCACAAAATGAACAAGGAAGTCATGCCCTCCATTCAATCCCTTGATGCACTGGTCAAGGAAAAGAAGCT TCAGGGTAAGGGACCAGGAGGACCACCTCCCAAGGGCCTGATGTACTCAGTCAACCCAAACAAAGTCGATGACCTGAGCAAGTTCGGAAA AAACATTGCAAACATGTGTCGTGGGATTCCAACATACATGGCTGAGGAGATGCAAGAGGCAAGCCTGTTTTTTTACTCAGGAACGTGCTA CACGACCAGTGTACTATGGATTGTGGACATTTCCTTCTGTGGAGACACGGTGGAGAACTAAACAATTTTTTAAAGCCACTATGGATTTAG TCATCTGAATATGCTGTGCAGAAAAAATATGGGCTCCAGTGGTTTTTACCATGTCATTCTGAAATTTTTCTCTACTAGTTATGTTTGATT |
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FusionGenePPI for TBC1D22A_GKN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBC1D22A | YWHAB, HSPA1L, ACBD3, FDXR, ACSL4, FLYWCH2, BIRC6, ARFGEF1, QSOX2, MICU1, KIRREL, MICU2, DNAJB4, SUPT6H, EFNB3, EPHA4, EXOG, METTL13, PVRL2, DNAJB5, AMBRA1, CERK, TBC1D22B | GKN1 | CDC27, UBR5, C6orf58, LYZL1, CST1, AMY1C, PIGR, CST4, ZG16B, MUC7, IGHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D22A_GKN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D22A_GKN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GKN1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | GKN1 | C0029927 | Ovarian Cysts | 1 | CTD_human |
| Tgene | GKN1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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