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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37353

FusionGeneSummary for TBC1D1_CRMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D1_CRMP1
Fusion gene ID: 37353
HgeneTgene
Gene symbol

TBC1D1

CRMP1

Gene ID

23216

1400

Gene nameTBC1 domain family member 1collapsin response mediator protein 1
SynonymsTBC|TBC1CRMP-1|DPYSL1|DRP-1|DRP1|ULIP-3
Cytomap

4p14

4p16.2

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1dihydropyrimidinase-related protein 1dihydropyrimidinase-like 1unc-33-like phosphoprotein 3
Modification date2018052320180519
UniProtAcc

Q86TI0

Q14194

Ensembl transtripts involved in fusion geneENST00000508802, ENST00000261439, 
ENST00000402522, ENST00000407365, 
ENST00000324989, ENST00000397890, 
ENST00000511535, ENST00000512574, 
Fusion gene scores* DoF score7 X 6 X 5=2106 X 6 X 4=144
# samples 76
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D1 [Title/Abstract] AND CRMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRMP1

GO:1904530

negative regulation of actin filament binding

25358863


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW014054TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000508802ENST00000324989TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000508802ENST00000397890TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000508802ENST00000511535TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000508802ENST00000512574TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000261439ENST00000324989TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000261439ENST00000397890TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000261439ENST00000511535TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000261439ENST00000512574TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000402522ENST00000324989TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000402522ENST00000397890TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000402522ENST00000511535TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000402522ENST00000512574TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000407365ENST00000324989TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000407365ENST00000397890TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000407365ENST00000511535TBC1D1chr4

38016127

-CRMP1chr4

5836506

+
intron-intronENST00000407365ENST00000512574TBC1D1chr4

38016127

-CRMP1chr4

5836506

+

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FusionProtFeatures for TBC1D1_CRMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D1

Q86TI0

CRMP1

Q14194

May act as a GTPase-activating protein for Rab familyprotein(s). May play a role in the cell cycle and differentiationof various tissues. Involved in the trafficking and translocationof GLUT4-containing vesicles and insulin-stimulated glucose uptakeinto cells (By similarity). {ECO:0000250}. Necessary for signaling by class 3 semaphorins andsubsequent remodeling of the cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration. May participate incytokinesis. {ECO:0000269|PubMed:11562390,ECO:0000269|PubMed:19799413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBC1D1_CRMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D1_CRMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D1_CRMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D1_CRMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBC1D1C0028754Obesity3CTD_human
TgeneCRMP1C0036341Schizophrenia1PSYGENET
TgeneCRMP1C3178803Social Anhedonia1PSYGENET