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Fusion gene ID: 37352 |
FusionGeneSummary for TBC1D1_CD47 |
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Fusion gene information | Fusion gene name: TBC1D1_CD47 | Fusion gene ID: 37352 | Hgene | Tgene | Gene symbol | TBC1D1 | CD47 | Gene ID | 23216 | 961 |
Gene name | TBC1 domain family member 1 | CD47 molecule | |
Synonyms | TBC|TBC1 | IAP|MER6|OA3 | |
Cytomap | 4p14 | 3q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | TBC1 domain family member 1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | leukocyte surface antigen CD47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)CD47 glycoproteinRh-related antigenantigen identified by monoclonal antibody 1D8antigenic surface determinant protein OA3integrin associated protei | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86TI0 | Q08722 | |
Ensembl transtripts involved in fusion gene | ENST00000508802, ENST00000261439, ENST00000402522, ENST00000407365, | ENST00000471694, ENST00000355354, ENST00000361309, | |
Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 8 X 6 X 4=192 |
# samples | 7 | 8 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TBC1D1 [Title/Abstract] AND CD47 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CD47 | GO:0008284 | positive regulation of cell proliferation | 15383453 |
Tgene | CD47 | GO:0022409 | positive regulation of cell-cell adhesion | 15383453 |
Tgene | CD47 | GO:0050870 | positive regulation of T cell activation | 15383453 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF996478 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000508802 | ENST00000471694 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-3UTR | ENST00000508802 | ENST00000355354 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-intron | ENST00000508802 | ENST00000361309 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-5UTR | ENST00000261439 | ENST00000471694 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-3UTR | ENST00000261439 | ENST00000355354 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-intron | ENST00000261439 | ENST00000361309 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-5UTR | ENST00000402522 | ENST00000471694 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-3UTR | ENST00000402522 | ENST00000355354 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-intron | ENST00000402522 | ENST00000361309 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-5UTR | ENST00000407365 | ENST00000471694 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-3UTR | ENST00000407365 | ENST00000355354 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
intron-intron | ENST00000407365 | ENST00000361309 | TBC1D1 | chr4 | 38084601 | + | CD47 | chr3 | 107763727 | - |
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FusionProtFeatures for TBC1D1_CD47 |
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Hgene | Tgene |
TBC1D1 | CD47 |
May act as a GTPase-activating protein for Rab familyprotein(s). May play a role in the cell cycle and differentiationof various tissues. Involved in the trafficking and translocationof GLUT4-containing vesicles and insulin-stimulated glucose uptakeinto cells (By similarity). {ECO:0000250}. | Has a role in both cell adhesion by acting as anadhesion receptor for THBS1 on platelets, and in the modulation ofintegrins. Plays an important role in memory formation andsynaptic plasticity in the hippocampus (By similarity). Receptorfor SIRPA, binding to which prevents maturation of immaturedendritic cells and inhibits cytokine production by maturedendritic cells. Interaction with SIRPG mediates cell-celladhesion, enhances superantigen-dependent T-cell-mediatedproliferation and costimulates T-cell activation. May play a rolein membrane transport and/or integrin dependent signaltransduction. May prevent premature elimination of red bloodcells. May be involved in membrane permeability changes inducedfollowing virus infection. {ECO:0000250,ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453,ECO:0000269|PubMed:7691831}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TBC1D1_CD47 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TBC1D1_CD47 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D1_CD47 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D1_CD47 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TBC1D1 | C0028754 | Obesity | 3 | CTD_human |