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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3735

FusionGeneSummary for B4GALT1_STRA8

check button Fusion gene summary
Fusion gene informationFusion gene name: B4GALT1_STRA8
Fusion gene ID: 3735
HgeneTgene
Gene symbol

B4GALT1

STRA8

Gene ID

2683

346673

Gene namebeta-1,4-galactosyltransferase 1stimulated by retinoic acid 8
SynonymsB4GAL-T1|CDG2D|GGTB2|GT1|GTB|beta4Gal-T1-
Cytomap

9p21.1

7q33

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-galactosyltransferase 1UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1beta-1,4-GalTase 1glycoproteinstimulated by retinoic acid gene 8 protein homologstimulated by retinoic acid 8 homologstimulated by retinoic acid gene 8 homolog
Modification date2018051920180329
UniProtAcc

P15291

Q7Z7C7

Ensembl transtripts involved in fusion geneENST00000535206, ENST00000379731, 
ENST00000541851, 
ENST00000275764, 
Fusion gene scores* DoF score9 X 6 X 9=4862 X 1 X 2=4
# samples 132
** MAII scorelog2(13/486*10)=-1.90244469057733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: B4GALT1 [Title/Abstract] AND STRA8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneB4GALT1

GO:0006487

protein N-linked glycosylation

16157350

HgeneB4GALT1

GO:0009312

oligosaccharide biosynthetic process

2120039

HgeneB4GALT1

GO:0051260

protein homooligomerization

7744867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-23-1026-01BB4GALT1chr9

33166756

-STRA8chr7

134925271

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000535206ENST00000275764B4GALT1chr9

33166756

-STRA8chr7

134925271

+
In-frameENST00000379731ENST00000275764B4GALT1chr9

33166756

-STRA8chr7

134925271

+
intron-3CDSENST00000541851ENST00000275764B4GALT1chr9

33166756

-STRA8chr7

134925271

+

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FusionProtFeatures for B4GALT1_STRA8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B4GALT1

P15291

STRA8

Q7Z7C7

Meiosis-inducer required for the transition into meiosisfor both female and male germ cells. In female germ cells,required for premeiotic DNA replication and subsequent events inmeiotic prophase. During spermatogenesis, next to its role inmeiotic initiation, promotes (but is not required for)spermatogonial differentiation. Can associate with DNA (possiblyin an indirect manner), and in vitro can activate DNAtranscription (By similarity). {ECO:0000250|UniProtKB:P70278}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-161_24137399Topological domainCytoplasmic
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-1625_44137399TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSTRA8chr9:33166756chr7:134925271ENST00000275764+0988_11220331Coiled coilOntology_term=ECO:0000255
TgeneSTRA8chr9:33166756chr7:134925271ENST00000275764+0950_5520331MotifNuclear localization signal (NLS)

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-16183_187137399RegionNote=UDP-alpha-D-galactose binding
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-16222_224137399RegionUDP-alpha-D-galactose binding
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-16249_250137399RegionNote=UDP-alpha-D-galactose binding
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-16312_315137399RegionNote=N-acetyl-D-glucosamine binding
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-16343_346137399RegionNote=UDP-alpha-D-galactose binding
HgeneB4GALT1chr9:33166756chr7:134925271ENST00000379731-1645_398137399Topological domainLumenal


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FusionGeneSequence for B4GALT1_STRA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_B4GALT1_ENST00000535206_chr9_33166756_-_STRA8_ENST00000275764_chr7_134925271_+_448aa
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGA
SSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLAYNGNPXRKQQSPXQSNTPAASTAAGAXASGGPETAVPGPPPS
HPGSALQQPQEDSVLSVXSHSLKVAGSEXGKESYSRTGANPGXFAEAESILQPGRWACKQLRGGQERICQHVFWKXQFSSEWFLPLVSQL
LQTDDGPSDWQRDHYPAGGGAAHRLRGHLPPVAEPLGGEEGQPPAGLGAEAPRPCDPGGGLPRAGLCRGQREGQRRGQPGGQLLAGLHAR

>In-frame_B4GALT1_ENST00000379731_chr9_33166756_-_STRA8_ENST00000275764_chr7_134925271_+_448aa
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGA
SSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLAYNGNPXRKQQSPXQSNTPAASTAAGAXASGGPETAVPGPPPS
HPGSALQQPQEDSVLSVXSHSLKVAGSEXGKESYSRTGANPGXFAEAESILQPGRWACKQLRGGQERICQHVFWKXQFSSEWFLPLVSQL
LQTDDGPSDWQRDHYPAGGGAAHRLRGHLPPVAEPLGGEEGQPPAGLGAEAPRPCDPGGGLPRAGLCRGQREGQRRGQPGGQLLAGLHAR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_B4GALT1_ENST00000535206_chr9_33166756_-_STRA8_ENST00000275764_chr7_134925271_+_1345nt
ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCTGCCGCCTGCTCGTGGCCGTCTGC
GCTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTG
CAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGGGCCCGGCCGCCGCCTCCTCTAGGCGCC
TCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCC
CACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGCTTATAATGGCAACCCCTGAAGAAAACAGCAATCCCCA
TGACAGAGCAACACCCCAGCTGCCAGCACAGCTGCAGGAGCTTGAGCATCGGGTGGCCCGGAGACGGCTGTCCCAGGCCCGCCACCGAGC
CACCCTGGCAGCGCTCTTCAACAACCTCAGGAAGACAGTGTACTCTCAGTCTGATCTCATAGCCTCAAAGTGGCAGGTTCTGAATAAGGC
AAAGAGTCATATTCCAGAACTGGAGCAAACCCTGGATAATTTGCTGAAGCTGAAAGCATCCTTCAACCTGGAAGATGGGCATGCAAGCAG
CTTAGAGGAGGTCAAGAAAGAATATGCCAGCATGTATTCTGGAAATGACAGTTTTCCTCAGAATGGTTCCTCCCCTTGGTATCTCAACTT
TTACAAACAGACGATGGACCTTCTGACTGGCAGCGGGATCATTACCCCGCAGGAGGCGGCGCTGCCCATCGTCTCCGCGGCCATCTCCCA
CCTGTGGCAGAACCTCTCGGAGGAGAGGAAGGCCAGCCTCCGGCAGGCCTGGGCGCAGAAGCACCGCGGCCCTGCGACCCTGGCGGAGGC
CTGCCGAGAGCCGGCCTGTGCCGAGGGCAGCGTGAAGGACAGCGGCGTGGACAGCCAGGGGGCCAGCTGCTCGCTGGTCTCCACGCCCGA
GGAGATCCTTTTTGAGGATGCCTTTGATGTGGCAAGCTTCCTGGACAAAAGTGAGGTTCCGAGTACATCTAGCTCCAGTTCAGTGCTTGC
CAGCTGCAACCCAGAAAACCCAGAGGAGAAGTTTCAGCTCTATATGCAGATCATCAACTTTTTTAAAGGCCTTAGCTGTGCAAACACTCA

>In-frame_B4GALT1_ENST00000379731_chr9_33166756_-_STRA8_ENST00000275764_chr7_134925271_+_1345nt
ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCTGCCGCCTGCTCGTGGCCGTCTGC
GCTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTG
CAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGGGCCCGGCCGCCGCCTCCTCTAGGCGCC
TCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCC
CACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGCTTATAATGGCAACCCCTGAAGAAAACAGCAATCCCCA
TGACAGAGCAACACCCCAGCTGCCAGCACAGCTGCAGGAGCTTGAGCATCGGGTGGCCCGGAGACGGCTGTCCCAGGCCCGCCACCGAGC
CACCCTGGCAGCGCTCTTCAACAACCTCAGGAAGACAGTGTACTCTCAGTCTGATCTCATAGCCTCAAAGTGGCAGGTTCTGAATAAGGC
AAAGAGTCATATTCCAGAACTGGAGCAAACCCTGGATAATTTGCTGAAGCTGAAAGCATCCTTCAACCTGGAAGATGGGCATGCAAGCAG
CTTAGAGGAGGTCAAGAAAGAATATGCCAGCATGTATTCTGGAAATGACAGTTTTCCTCAGAATGGTTCCTCCCCTTGGTATCTCAACTT
TTACAAACAGACGATGGACCTTCTGACTGGCAGCGGGATCATTACCCCGCAGGAGGCGGCGCTGCCCATCGTCTCCGCGGCCATCTCCCA
CCTGTGGCAGAACCTCTCGGAGGAGAGGAAGGCCAGCCTCCGGCAGGCCTGGGCGCAGAAGCACCGCGGCCCTGCGACCCTGGCGGAGGC
CTGCCGAGAGCCGGCCTGTGCCGAGGGCAGCGTGAAGGACAGCGGCGTGGACAGCCAGGGGGCCAGCTGCTCGCTGGTCTCCACGCCCGA
GGAGATCCTTTTTGAGGATGCCTTTGATGTGGCAAGCTTCCTGGACAAAAGTGAGGTTCCGAGTACATCTAGCTCCAGTTCAGTGCTTGC
CAGCTGCAACCCAGAAAACCCAGAGGAGAAGTTTCAGCTCTATATGCAGATCATCAACTTTTTTAAAGGCCTTAGCTGTGCAAACACTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_B4GALT1_ENST00000535206_chr9_33166756_-_STRA8_ENST00000275764_chr7_134925271_+_1532nt
GCCTCGGGCGGCTTCTCGCCGCTCCCAGGTCTGGCTGGCTGGAGGAGTCTCAGCTCTCAGCCGCTCGCCCGCCCCCGCTCCGGGCCCTCC
CCTAGTCGCCGCTGTGGGGCAGCGCCTGGCGGGCGGCCCGCGGGCGGGTCGCCTCCCCTCCTGTAGCCCACACCCTTCTTAAAGCGGCGG
CGGGAAGATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCTGCCGCCTGCTCGTGGC
CGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCAC
ACCGCTGCAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGGGCCCGGCCGCCGCCTCCTCT
AGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCC
AGTGCCCCACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGCTTATAATGGCAACCCCTGAAGAAAACAGCA
ATCCCCATGACAGAGCAACACCCCAGCTGCCAGCACAGCTGCAGGAGCTTGAGCATCGGGTGGCCCGGAGACGGCTGTCCCAGGCCCGCC
ACCGAGCCACCCTGGCAGCGCTCTTCAACAACCTCAGGAAGACAGTGTACTCTCAGTCTGATCTCATAGCCTCAAAGTGGCAGGTTCTGA
ATAAGGCAAAGAGTCATATTCCAGAACTGGAGCAAACCCTGGATAATTTGCTGAAGCTGAAAGCATCCTTCAACCTGGAAGATGGGCATG
CAAGCAGCTTAGAGGAGGTCAAGAAAGAATATGCCAGCATGTATTCTGGAAATGACAGTTTTCCTCAGAATGGTTCCTCCCCTTGGTATC
TCAACTTTTACAAACAGACGATGGACCTTCTGACTGGCAGCGGGATCATTACCCCGCAGGAGGCGGCGCTGCCCATCGTCTCCGCGGCCA
TCTCCCACCTGTGGCAGAACCTCTCGGAGGAGAGGAAGGCCAGCCTCCGGCAGGCCTGGGCGCAGAAGCACCGCGGCCCTGCGACCCTGG
CGGAGGCCTGCCGAGAGCCGGCCTGTGCCGAGGGCAGCGTGAAGGACAGCGGCGTGGACAGCCAGGGGGCCAGCTGCTCGCTGGTCTCCA
CGCCCGAGGAGATCCTTTTTGAGGATGCCTTTGATGTGGCAAGCTTCCTGGACAAAAGTGAGGTTCCGAGTACATCTAGCTCCAGTTCAG
TGCTTGCCAGCTGCAACCCAGAAAACCCAGAGGAGAAGTTTCAGCTCTATATGCAGATCATCAACTTTTTTAAAGGCCTTAGCTGTGCAA
ACACTCAAGTAAAGCAGGAAGCATCCTTTCCCGTTGATGAAGAGATGATCATGTTGCAGTGCACAGAGACCTTTGACGATGAAGATTTGT

>In-frame_B4GALT1_ENST00000379731_chr9_33166756_-_STRA8_ENST00000275764_chr7_134925271_+_1532nt
GCCTCGGGCGGCTTCTCGCCGCTCCCAGGTCTGGCTGGCTGGAGGAGTCTCAGCTCTCAGCCGCTCGCCCGCCCCCGCTCCGGGCCCTCC
CCTAGTCGCCGCTGTGGGGCAGCGCCTGGCGGGCGGCCCGCGGGCGGGTCGCCTCCCCTCCTGTAGCCCACACCCTTCTTAAAGCGGCGG
CGGGAAGATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCTGCCGCCTGCTCGTGGC
CGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCAC
ACCGCTGCAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGGGCCCGGCCGCCGCCTCCTCT
AGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCC
AGTGCCCCACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGCTTATAATGGCAACCCCTGAAGAAAACAGCA
ATCCCCATGACAGAGCAACACCCCAGCTGCCAGCACAGCTGCAGGAGCTTGAGCATCGGGTGGCCCGGAGACGGCTGTCCCAGGCCCGCC
ACCGAGCCACCCTGGCAGCGCTCTTCAACAACCTCAGGAAGACAGTGTACTCTCAGTCTGATCTCATAGCCTCAAAGTGGCAGGTTCTGA
ATAAGGCAAAGAGTCATATTCCAGAACTGGAGCAAACCCTGGATAATTTGCTGAAGCTGAAAGCATCCTTCAACCTGGAAGATGGGCATG
CAAGCAGCTTAGAGGAGGTCAAGAAAGAATATGCCAGCATGTATTCTGGAAATGACAGTTTTCCTCAGAATGGTTCCTCCCCTTGGTATC
TCAACTTTTACAAACAGACGATGGACCTTCTGACTGGCAGCGGGATCATTACCCCGCAGGAGGCGGCGCTGCCCATCGTCTCCGCGGCCA
TCTCCCACCTGTGGCAGAACCTCTCGGAGGAGAGGAAGGCCAGCCTCCGGCAGGCCTGGGCGCAGAAGCACCGCGGCCCTGCGACCCTGG
CGGAGGCCTGCCGAGAGCCGGCCTGTGCCGAGGGCAGCGTGAAGGACAGCGGCGTGGACAGCCAGGGGGCCAGCTGCTCGCTGGTCTCCA
CGCCCGAGGAGATCCTTTTTGAGGATGCCTTTGATGTGGCAAGCTTCCTGGACAAAAGTGAGGTTCCGAGTACATCTAGCTCCAGTTCAG
TGCTTGCCAGCTGCAACCCAGAAAACCCAGAGGAGAAGTTTCAGCTCTATATGCAGATCATCAACTTTTTTAAAGGCCTTAGCTGTGCAA
ACACTCAAGTAAAGCAGGAAGCATCCTTTCCCGTTGATGAAGAGATGATCATGTTGCAGTGCACAGAGACCTTTGACGATGAAGATTTGT


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FusionGenePPI for B4GALT1_STRA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
B4GALT1LALBA, CDK11A, ELAVL1, JUP, B4GALT1, TFRC, TUBA1A, TUBB, TSPAN5, POMK, PTCH1, TNF, HTR3C, PON2, IFI30, TMEM30B, TMPRSS11B, MME, MMP10, TCTN2, IL13RA2, IL27RA, KIAA1467, GAA, TRIM25STRA8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for B4GALT1_STRA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for B4GALT1_STRA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource