FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 37323

FusionGeneSummary for TBC1D15_ANTXR2

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D15_ANTXR2
Fusion gene ID: 37323
HgeneTgene
Gene symbol

TBC1D15

ANTXR2

Gene ID

64786

118429

Gene nameTBC1 domain family member 15ANTXR cell adhesion molecule 2
SynonymsRAB7-GAPCMG-2|CMG2|HFS|ISH|JHF
Cytomap

12q21.1

4q21.21

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 15GAP for RAB7GTPase-activating protein RAB7Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15Tre2/Bub2/Cdc16 domain family member 15anthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2
Modification date2018052320180523
UniProtAcc

Q8TC07

P58335

Ensembl transtripts involved in fusion geneENST00000550746, ENST00000319106, 
ENST00000485960, ENST00000393309, 
ENST00000548679, 		ENST00000403729, 
ENST00000482406, ENST00000404191, 
ENST00000346652, ENST00000307333, 
ENST00000295465, 
Fusion gene scores* DoF score15 X 10 X 9=13506 X 7 X 3=126
# samples 177
** MAII scorelog2(17/1350*10)=-2.98935275580049
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D15 [Title/Abstract] AND ANTXR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-3C-AAAU-01ATBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000550746ENST00000403729TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000550746ENST00000482406TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000550746ENST00000404191TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000550746ENST00000346652TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000550746ENST00000307333TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000550746ENST00000295465TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000319106ENST00000403729TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000319106ENST00000482406TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000319106ENST00000404191TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000319106ENST00000346652TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000319106ENST00000307333TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000319106ENST00000295465TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000485960ENST00000403729TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000485960ENST00000482406TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000485960ENST00000404191TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000485960ENST00000346652TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000485960ENST00000307333TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5CDS-intronENST00000485960ENST00000295465TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5UTR-intronENST00000393309ENST00000403729TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5UTR-intronENST00000393309ENST00000482406TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5UTR-intronENST00000393309ENST00000404191TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5UTR-intronENST00000393309ENST00000346652TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5UTR-intronENST00000393309ENST00000307333TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
5UTR-intronENST00000393309ENST00000295465TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
intron-intronENST00000548679ENST00000403729TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
intron-intronENST00000548679ENST00000482406TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
intron-intronENST00000548679ENST00000404191TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
intron-intronENST00000548679ENST00000346652TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
intron-intronENST00000548679ENST00000307333TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-
intron-intronENST00000548679ENST00000295465TBC1D15chr12

72266783

+ANTXR2chr4

81042431

-

Top

FusionProtFeatures for TBC1D15_ANTXR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D15

Q8TC07

ANTXR2

P58335

Acts as a GTPase activating protein for RAB7A. Does notact on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TBC1D15_ANTXR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TBC1D15_ANTXR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBC1D15MEPCE, GABARAP, TERF2, UBC, CUL2, NEDD8, RAB5A, RAB5B, RAB5C, FIS1, PARK2, ARFIP1, ATP6V1C1, DNM1L, IDE, PSMG3, SHMT2, SNX2, STAT3, VPS26A, OPTN, CALCOCO1, CEP63, CCDC8, UBAC2, SPINT2, STX12, CCDC121, CCNH, ST3GAL4, PNKD, DLK1, FLOT2, FAM189A2, PTGER3, ALDH3A2, NTRK1, XPO1, UBXN8, GRAMD4, KIF22, TBC1D17, CAMLG, ATF6B, MRS2, DNM1, UTP15, SLC30A9, HTR2C, VTI1B, TMEM206, DNM2, TNFRSF1A, UXS1, PTPN1, PTPRNANTXR2SMAD2, COL4A5, LAMB1, LAMC1, LGR4, TCEB3, HS1BP3, IKBIP, ANKRD13D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TBC1D15_ANTXR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TBC1D15_ANTXR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneANTXR2C0009917Contracture2CTD_human
TgeneANTXR2C0016045fibroma2CTD_human
TgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
TgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
TgeneANTXR2C2745948Hyalinosis, Systemic2CTD_human;ORPHANET;UNIPROT
TgeneANTXR2C0029456Osteoporosis1CTD_human
TgeneANTXR2C0221204Lytic lesion1CTD_human