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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37321

FusionGeneSummary for TBC1D14_MRFAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D14_MRFAP1
Fusion gene ID: 37321
HgeneTgene
Gene symbol

TBC1D14

MRFAP1

Gene ID

57533

93621

Gene nameTBC1 domain family member 14Morf4 family associated protein 1
Synonyms-PAM14|PGR1
Cytomap

4p16.1

4p16.1

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 14MORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDa
Modification date2018052320180522
UniProtAcc

Q9P2M4

Q9Y605

Ensembl transtripts involved in fusion geneENST00000448507, ENST00000409757, 
ENST00000410031, ENST00000451522, 
ENST00000446947, 
ENST00000320912, 
ENST00000507420, ENST00000382581, 
Fusion gene scores* DoF score7 X 4 X 8=2246 X 5 X 4=120
# samples 96
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D14 [Title/Abstract] AND MRFAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A8NI-01ATBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000448507ENST00000320912TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
5CDS-5UTRENST00000448507ENST00000507420TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
5CDS-5UTRENST00000448507ENST00000382581TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
5CDS-5UTRENST00000409757ENST00000320912TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
5CDS-5UTRENST00000409757ENST00000507420TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
5CDS-5UTRENST00000409757ENST00000382581TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000410031ENST00000320912TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000410031ENST00000507420TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000410031ENST00000382581TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000451522ENST00000320912TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000451522ENST00000507420TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000451522ENST00000382581TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000446947ENST00000320912TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000446947ENST00000507420TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+
intron-5UTRENST00000446947ENST00000382581TBC1D14chr4

6925838

+MRFAP1chr4

6642555

+

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FusionProtFeatures for TBC1D14_MRFAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TBC1D14

Q9P2M4

MRFAP1

Q9Y605

Negative regulator of starvation-induced autophagosomeformation. {ECO:0000269|PubMed:22613832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TBC1D14_MRFAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TBC1D14_MRFAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TBC1D14UBE3A, XPO1, CENPA, PML, TFEB, TRAPPC11, TRAPPC12, TRAPPC13, ADRBK1, TRAPPC8, TRAPPC4, TRAPPC3, TRAPPC6B, SELENBP1, HEPHL1, TRAPPC2, TRAPPC9, TRAPPC5, LRRC15, TRAPPC2L, TRAPPC10, TRAPPC1, TCHHMRFAP1MORF4L2, MORF4L1, RB1, MRGBP, PAM16, TK1, MAP1LC3B, C8orf33, HTT, SUV39H2, DCDC2, C14orf93, MRFAP1L1, GOLGA8G, C3orf62, GOLGA8F, ZDHHC17, MED4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TBC1D14_MRFAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TBC1D14_MRFAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource