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Fusion gene ID: 37318 |
FusionGeneSummary for TBC1D14_GRPEL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D14_GRPEL1 | Fusion gene ID: 37318 | Hgene | Tgene | Gene symbol | TBC1D14 | GRPEL1 | Gene ID | 57533 | 80273 |
| Gene name | TBC1 domain family member 14 | GrpE like 1, mitochondrial | |
| Synonyms | - | GrpE|HMGE|mt-GrpE#1 | |
| Cytomap | 4p16.1 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 14 | grpE protein homolog 1, mitochondrialGrpE-like protein cochaperone | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9P2M4 | Q9HAV7 | |
| Ensembl transtripts involved in fusion gene | ENST00000448507, ENST00000409757, ENST00000410031, ENST00000451522, ENST00000446947, | ENST00000264954, ENST00000514056, | |
| Fusion gene scores | * DoF score | 7 X 4 X 8=224 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TBC1D14 [Title/Abstract] AND GRPEL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-A9T0-01A | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000448507 | ENST00000264954 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| 5CDS-5UTR | ENST00000448507 | ENST00000514056 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| In-frame | ENST00000409757 | ENST00000264954 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| 5CDS-5UTR | ENST00000409757 | ENST00000514056 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| intron-3CDS | ENST00000410031 | ENST00000264954 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| intron-5UTR | ENST00000410031 | ENST00000514056 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| intron-3CDS | ENST00000451522 | ENST00000264954 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| intron-5UTR | ENST00000451522 | ENST00000514056 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| intron-3CDS | ENST00000446947 | ENST00000264954 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
| intron-5UTR | ENST00000446947 | ENST00000514056 | TBC1D14 | chr4 | 6925838 | + | GRPEL1 | chr4 | 7065950 | - |
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FusionProtFeatures for TBC1D14_GRPEL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBC1D14 | GRPEL1 |
| Negative regulator of starvation-induced autophagosomeformation. {ECO:0000269|PubMed:22613832}. | Essential component of the PAM complex, a complexrequired for the translocation of transit peptide-containingproteins from the inner membrane into the mitochondrial matrix inan ATP-dependent manner (By similarity). Seems to control thenucleotide-dependent binding of mitochondrial HSP70 to substrateproteins (PubMed:11311562). {ECO:0000250|UniProtKB:P38523,ECO:0000269|PubMed:11311562}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TBC1D14 | chr4:6925838 | chr4:7065950 | ENST00000409757 | + | 2 | 14 | 401_611 | 240 | 694 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D14 | chr4:6925838 | chr4:7065950 | ENST00000448507 | + | 2 | 14 | 401_611 | 240 | 694 | Domain | Rab-GAP TBC |
| Hgene | >TBC1D14 | chr4:6925838 | chr4:7065950 | ENST00000451522 | + | 1 | 12 | 401_611 | -62 | 414 | Domain | Rab-GAP TBC |
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FusionGeneSequence for TBC1D14_GRPEL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TBC1D14_ENST00000448507_chr4_6925838_+_GRPEL1_ENST00000264954_chr4_7065950_-_438aa MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARPSPRLLCTATKQKNSGQNLEEDMGQSEQK ADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNL >In-frame_TBC1D14_ENST00000409757_chr4_6925838_+_GRPEL1_ENST00000264954_chr4_7065950_-_438aa MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARPSPRLLCTATKQKNSGQNLEEDMGQSEQK ADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TBC1D14_ENST00000448507_chr4_6925838_+_GRPEL1_ENST00000264954_chr4_7065950_-_1314nt ATGACTGATGGAAAACTCTCCACCTCTACAAATGGCGTAGCCTTCATGGGTATTCTGGATGGTCGACCAGGAAACCCCCTTCAGAACCTG CAACACGTCAATCTCAAGGCGCCCCGACTCCTCTCCGCGCCTGAGTACGGGCCCAAGCTGAAACTCAGGGCTTTAGAAGACCGGCACAGC CTCCAGTCCGTGGACTCGGGGATTCCTACCCTGGAGATCGGGAACCCGGAGCCTGTACCCTGCAGCGCGGTCCACGTGAGGAGGAAGCAG TCCGACTCCGACCTCATCCCCGAGCGGGCCTTCCAGAGCGCCTGCGCGCTGCCATCCTGTGCGCCACCAGCTCCTAGCAGCACCGAGCGG GAACAGAGCGTGCGCAAATCCTCCACGTTTCCCAGGACAGGCTATGACTCGGTAAAGCTCTATAGCCCGACCTCCAAAGCCCTGACCCGC AGCGATGATGTCTCCGTCTGCAGCGTGTCCAGTCTTGGGACAGAGCTGTCCACCACGCTGTCCGTCAGCAATGAGGACATCTTGGACCTT GTGGTCACGAGCAGCTCCAGTGCCATTGTGACCCTGGAGAATGACGATGACCCACAGTTTACCAACGTCACCTTGAGCTCTATCAAGGAA ACCCGTGGCTTACACCAGCAGGACTGTGTTCATGAAGCTGAGGAGGGGAGTAAATTGAAAATATTGGGGCCATTTAGTAACTTCTTTGCA AGGCCATCTCCCCGGTTGTTGTGCACAGCCACGAAACAAAAGAACAGTGGCCAGAACCTGGAAGAGGACATGGGTCAGAGTGAACAGAAG GCAGATCCTCCTGCTACAGAGAAGACCCTCCTGGAAGAGAAGGTCAAGTTGGAGGAACAGCTGAAGGAGACTGTGGAAAAATATAAACGA GCTTTGGCAGACACTGAGAACTTACGGCAGAGGAGCCAGAAATTGGTGGAGGAGGCAAAATTATACGGCATTCAAGCCTTCTGCAAGGAC TTGTTGGAGGTGGCAGACGTTCTGGAGAAGGCAACACAGTGTGTTCCAAAAGAAGAAATTAAAGACGATAACCCTCACCTGAAGAACCTC TATGAGGGGCTGGTCATGACTGAAGTCCAGATCCAGAAGGTGTTCACAAAGCATGGCTTGCTCAAGTTGAACCCTGTCGGAGCCAAGTTC GACCCTTATGAACATGAGGCCTTGTTCCACACACCGGTTGAGGGGAAGGAGCCAGGCACAGTGGCCCTAGTTAGCAAAGTGGGGTACAAG >In-frame_TBC1D14_ENST00000409757_chr4_6925838_+_GRPEL1_ENST00000264954_chr4_7065950_-_1314nt ATGACTGATGGAAAACTCTCCACCTCTACAAATGGCGTAGCCTTCATGGGTATTCTGGATGGTCGACCAGGAAACCCCCTTCAGAACCTG CAACACGTCAATCTCAAGGCGCCCCGACTCCTCTCCGCGCCTGAGTACGGGCCCAAGCTGAAACTCAGGGCTTTAGAAGACCGGCACAGC CTCCAGTCCGTGGACTCGGGGATTCCTACCCTGGAGATCGGGAACCCGGAGCCTGTACCCTGCAGCGCGGTCCACGTGAGGAGGAAGCAG TCCGACTCCGACCTCATCCCCGAGCGGGCCTTCCAGAGCGCCTGCGCGCTGCCATCCTGTGCGCCACCAGCTCCTAGCAGCACCGAGCGG GAACAGAGCGTGCGCAAATCCTCCACGTTTCCCAGGACAGGCTATGACTCGGTAAAGCTCTATAGCCCGACCTCCAAAGCCCTGACCCGC AGCGATGATGTCTCCGTCTGCAGCGTGTCCAGTCTTGGGACAGAGCTGTCCACCACGCTGTCCGTCAGCAATGAGGACATCTTGGACCTT GTGGTCACGAGCAGCTCCAGTGCCATTGTGACCCTGGAGAATGACGATGACCCACAGTTTACCAACGTCACCTTGAGCTCTATCAAGGAA ACCCGTGGCTTACACCAGCAGGACTGTGTTCATGAAGCTGAGGAGGGGAGTAAATTGAAAATATTGGGGCCATTTAGTAACTTCTTTGCA AGGCCATCTCCCCGGTTGTTGTGCACAGCCACGAAACAAAAGAACAGTGGCCAGAACCTGGAAGAGGACATGGGTCAGAGTGAACAGAAG GCAGATCCTCCTGCTACAGAGAAGACCCTCCTGGAAGAGAAGGTCAAGTTGGAGGAACAGCTGAAGGAGACTGTGGAAAAATATAAACGA GCTTTGGCAGACACTGAGAACTTACGGCAGAGGAGCCAGAAATTGGTGGAGGAGGCAAAATTATACGGCATTCAAGCCTTCTGCAAGGAC TTGTTGGAGGTGGCAGACGTTCTGGAGAAGGCAACACAGTGTGTTCCAAAAGAAGAAATTAAAGACGATAACCCTCACCTGAAGAACCTC TATGAGGGGCTGGTCATGACTGAAGTCCAGATCCAGAAGGTGTTCACAAAGCATGGCTTGCTCAAGTTGAACCCTGTCGGAGCCAAGTTC GACCCTTATGAACATGAGGCCTTGTTCCACACACCGGTTGAGGGGAAGGAGCCAGGCACAGTGGCCCTAGTTAGCAAAGTGGGGTACAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TBC1D14_ENST00000448507_chr4_6925838_+_GRPEL1_ENST00000264954_chr4_7065950_-_3349nt GAGCCCCTTCCCCCTCCCGGCCGCTTCCCACTTCCAAGATGGCTGCGGGTGGAGCCGACCAGTTTCTCCTTGGACCAAGATGACTGATGG AAAACTCTCCACCTCTACAAATGGCGTAGCCTTCATGGGTATTCTGGATGGTCGACCAGGAAACCCCCTTCAGAACCTGCAACACGTCAA TCTCAAGGCGCCCCGACTCCTCTCCGCGCCTGAGTACGGGCCCAAGCTGAAACTCAGGGCTTTAGAAGACCGGCACAGCCTCCAGTCCGT GGACTCGGGGATTCCTACCCTGGAGATCGGGAACCCGGAGCCTGTACCCTGCAGCGCGGTCCACGTGAGGAGGAAGCAGTCCGACTCCGA CCTCATCCCCGAGCGGGCCTTCCAGAGCGCCTGCGCGCTGCCATCCTGTGCGCCACCAGCTCCTAGCAGCACCGAGCGGGAACAGAGCGT GCGCAAATCCTCCACGTTTCCCAGGACAGGCTATGACTCGGTAAAGCTCTATAGCCCGACCTCCAAAGCCCTGACCCGCAGCGATGATGT CTCCGTCTGCAGCGTGTCCAGTCTTGGGACAGAGCTGTCCACCACGCTGTCCGTCAGCAATGAGGACATCTTGGACCTTGTGGTCACGAG CAGCTCCAGTGCCATTGTGACCCTGGAGAATGACGATGACCCACAGTTTACCAACGTCACCTTGAGCTCTATCAAGGAAACCCGTGGCTT ACACCAGCAGGACTGTGTTCATGAAGCTGAGGAGGGGAGTAAATTGAAAATATTGGGGCCATTTAGTAACTTCTTTGCAAGGCCATCTCC CCGGTTGTTGTGCACAGCCACGAAACAAAAGAACAGTGGCCAGAACCTGGAAGAGGACATGGGTCAGAGTGAACAGAAGGCAGATCCTCC TGCTACAGAGAAGACCCTCCTGGAAGAGAAGGTCAAGTTGGAGGAACAGCTGAAGGAGACTGTGGAAAAATATAAACGAGCTTTGGCAGA CACTGAGAACTTACGGCAGAGGAGCCAGAAATTGGTGGAGGAGGCAAAATTATACGGCATTCAAGCCTTCTGCAAGGACTTGTTGGAGGT GGCAGACGTTCTGGAGAAGGCAACACAGTGTGTTCCAAAAGAAGAAATTAAAGACGATAACCCTCACCTGAAGAACCTCTATGAGGGGCT GGTCATGACTGAAGTCCAGATCCAGAAGGTGTTCACAAAGCATGGCTTGCTCAAGTTGAACCCTGTCGGAGCCAAGTTCGACCCTTATGA ACATGAGGCCTTGTTCCACACACCGGTTGAGGGGAAGGAGCCAGGCACAGTGGCCCTAGTTAGCAAAGTGGGGTACAAGCTGCATGGGCG CACTCTGAGACCCGCCCTGGTGGGGGTGGTGAAGGAAGCTTAGCTGCTGTTGATGGGGTGGGTGTTTTTAAACTCACTTGATGTAACTCT CAAGGCTGGTTCATTGTTTCTCATCTATGAGTACGTGTGACCTTTTCCCAAACCTTATTGGAAACCTTAAGTAACCAGTGGCTAAACAGA AAAGCCGGTTGCCCAACTGCATTAATGAACTCTAATTCGGGAGTCTGTTCCCTTTTAGTGCCACGCGTTGAATAGTTCCACATACTTTCA GAAGAGCTCAGCAGGGCCCTGCCTGGTCTCCCGAGCATCATGAGTAACGTGTCTGCTCAGACTCTGCTGACACCAAAGTATTTTAAACAA ATAAAAGGTCTTGGGGAATTCTGTTTGGCTACCTGGGCACGCCAGTCTGCACCATGTGTCCCTGCGGCGCATGAGTGACTGGCGTATTTA GCCCGTCACATTTCATTCGCTGAAGGAAAGGCAAGAGAGTTGAAACATTTTTCTTACTTAAAAAAAATGATCTTTGTGAAGAACATAGTG AGTTCGTTTGTCTTCAGTCAACAGCGGCTGAAACTGACCACTGAGAAATGGGTGTGGGCACTGACAGTTCTCCCCCATTATTTGGCCAGG AATTGAGCTTGGCTTGGCAAAGTTCCTTTTACCCTGTTCTGTTCATCTAAATGCAGACATATTTAAATCATATTCAACTAGTTACTAATG ACCTCAAGTTGTATTCCCTGGCAAAATGGACTTTCTCAAAATAGGACTGCACGCTTGGTGTACTTTAAATGTTAATGTTTAATTTAAAAT TTTTATTTAAGAGGATTAAAGCCCTAATGTTTATTTTCCTACTTTCTGAAAACAATTTTGTGTCCTCTCATGGAGATCCTTGCCGCTGAG GCAAGCATGGCTTAGCCTTCCCATTCTCTACTCCAGCCCAGAAGCTGTCAGCTTGACACGTGCGTGCGTGCACATTCACGTACACACATA TACAGGCTTCTACACAGAAAGGGAGAGCCACACTCCCCCAGTGCAGCTGCAGCCCGTCCGGTAAGAATACGAAACACCCAGGAGCCACAG CAAGGGCACAGGATTTGCAAAATCATCTTGCCAAAGGGCTGTTCCTCATTTACACGGTCATCCAGGGCTTAGAAAAAGGCTGAATGATTG GCGTCTGTTACAAAAAAGAGAAAAGAACCTTTCGCTGCCTTTGCTTCTAGAATGGAAGATACTTGTGAAAGCCATTTGCTGCACAGGAAA GATGGGGCAGTTTATTTCACTTCTAATTTTAAAAGACGCAAGTAATGGTCCCATAATACTTCATCTTGGGATACCATTCCCAAACATGTT CCACCTTTAAGATGCCTTAAGTTAATTTGGTCAGAAACAACTAAAGGCAGCATCGTGTATTGAAGAAAACATGACTGGGAGCTCCAGCGC TGCCTGTTTTCACGCTGTGGGGTTGTGAGTGCATCATCACCCCTGGAGCTCCCGAGTTAAATGGAGGCTAAGAAAAGTAATTTATCAACT CATTTCTGTGAATGTTTGCAGTCTCCTACCGTCTCAACTACAGCTGCAGTTGCTAAAAAGCACTTAACTCGTAACCTAGAGGCAATATAG CTTAAGTAGCAAAATATTTTTTTACAGTAAGCTTCAGTCATCCATAGTCACTATAAGTTGGTTATCATCTGAAATGCTTAGAACCAGAAT TGTTTCAAACTTGGGGGGTTTTCGGATTTTGGAATATAGTCAAGCATGGCTTAACCACAGGGATGTGTTCTGAGAAATGCGCTGTCAGGC AGTTTTTCCTGTGAACACCATGTGTACCTACATGGACCTAAAAAACAGGTGGTGGAGCCTCCTCCACACCTAGGCTATATGGTGTATGTA GCCTGTTGCTCTAGACTGGAGGGCACGTTACTGTACTGATACTGTAGGCAACTGTTAACACAATGGTATCTGTGTATCTGAACATAACAT >In-frame_TBC1D14_ENST00000409757_chr4_6925838_+_GRPEL1_ENST00000264954_chr4_7065950_-_3394nt TGCCTACCGCGTGCCCGGCGTCCTCGTCGCGCGAGTTGCCGGTCCCGCGGGGCCTGGGCTGCGGGCCCACGGGTCCCGGGGATGGCGTCG GAGCCGCGCTAACTCCGTTTCTCCTTGGACCAAGATGACTGATGGAAAACTCTCCACCTCTACAAATGGCGTAGCCTTCATGGGTATTCT GGATGGTCGACCAGGAAACCCCCTTCAGAACCTGCAACACGTCAATCTCAAGGCGCCCCGACTCCTCTCCGCGCCTGAGTACGGGCCCAA GCTGAAACTCAGGGCTTTAGAAGACCGGCACAGCCTCCAGTCCGTGGACTCGGGGATTCCTACCCTGGAGATCGGGAACCCGGAGCCTGT ACCCTGCAGCGCGGTCCACGTGAGGAGGAAGCAGTCCGACTCCGACCTCATCCCCGAGCGGGCCTTCCAGAGCGCCTGCGCGCTGCCATC CTGTGCGCCACCAGCTCCTAGCAGCACCGAGCGGGAACAGAGCGTGCGCAAATCCTCCACGTTTCCCAGGACAGGCTATGACTCGGTAAA GCTCTATAGCCCGACCTCCAAAGCCCTGACCCGCAGCGATGATGTCTCCGTCTGCAGCGTGTCCAGTCTTGGGACAGAGCTGTCCACCAC GCTGTCCGTCAGCAATGAGGACATCTTGGACCTTGTGGTCACGAGCAGCTCCAGTGCCATTGTGACCCTGGAGAATGACGATGACCCACA GTTTACCAACGTCACCTTGAGCTCTATCAAGGAAACCCGTGGCTTACACCAGCAGGACTGTGTTCATGAAGCTGAGGAGGGGAGTAAATT GAAAATATTGGGGCCATTTAGTAACTTCTTTGCAAGGCCATCTCCCCGGTTGTTGTGCACAGCCACGAAACAAAAGAACAGTGGCCAGAA CCTGGAAGAGGACATGGGTCAGAGTGAACAGAAGGCAGATCCTCCTGCTACAGAGAAGACCCTCCTGGAAGAGAAGGTCAAGTTGGAGGA ACAGCTGAAGGAGACTGTGGAAAAATATAAACGAGCTTTGGCAGACACTGAGAACTTACGGCAGAGGAGCCAGAAATTGGTGGAGGAGGC AAAATTATACGGCATTCAAGCCTTCTGCAAGGACTTGTTGGAGGTGGCAGACGTTCTGGAGAAGGCAACACAGTGTGTTCCAAAAGAAGA AATTAAAGACGATAACCCTCACCTGAAGAACCTCTATGAGGGGCTGGTCATGACTGAAGTCCAGATCCAGAAGGTGTTCACAAAGCATGG CTTGCTCAAGTTGAACCCTGTCGGAGCCAAGTTCGACCCTTATGAACATGAGGCCTTGTTCCACACACCGGTTGAGGGGAAGGAGCCAGG CACAGTGGCCCTAGTTAGCAAAGTGGGGTACAAGCTGCATGGGCGCACTCTGAGACCCGCCCTGGTGGGGGTGGTGAAGGAAGCTTAGCT GCTGTTGATGGGGTGGGTGTTTTTAAACTCACTTGATGTAACTCTCAAGGCTGGTTCATTGTTTCTCATCTATGAGTACGTGTGACCTTT TCCCAAACCTTATTGGAAACCTTAAGTAACCAGTGGCTAAACAGAAAAGCCGGTTGCCCAACTGCATTAATGAACTCTAATTCGGGAGTC TGTTCCCTTTTAGTGCCACGCGTTGAATAGTTCCACATACTTTCAGAAGAGCTCAGCAGGGCCCTGCCTGGTCTCCCGAGCATCATGAGT AACGTGTCTGCTCAGACTCTGCTGACACCAAAGTATTTTAAACAAATAAAAGGTCTTGGGGAATTCTGTTTGGCTACCTGGGCACGCCAG TCTGCACCATGTGTCCCTGCGGCGCATGAGTGACTGGCGTATTTAGCCCGTCACATTTCATTCGCTGAAGGAAAGGCAAGAGAGTTGAAA CATTTTTCTTACTTAAAAAAAATGATCTTTGTGAAGAACATAGTGAGTTCGTTTGTCTTCAGTCAACAGCGGCTGAAACTGACCACTGAG AAATGGGTGTGGGCACTGACAGTTCTCCCCCATTATTTGGCCAGGAATTGAGCTTGGCTTGGCAAAGTTCCTTTTACCCTGTTCTGTTCA TCTAAATGCAGACATATTTAAATCATATTCAACTAGTTACTAATGACCTCAAGTTGTATTCCCTGGCAAAATGGACTTTCTCAAAATAGG ACTGCACGCTTGGTGTACTTTAAATGTTAATGTTTAATTTAAAATTTTTATTTAAGAGGATTAAAGCCCTAATGTTTATTTTCCTACTTT CTGAAAACAATTTTGTGTCCTCTCATGGAGATCCTTGCCGCTGAGGCAAGCATGGCTTAGCCTTCCCATTCTCTACTCCAGCCCAGAAGC TGTCAGCTTGACACGTGCGTGCGTGCACATTCACGTACACACATATACAGGCTTCTACACAGAAAGGGAGAGCCACACTCCCCCAGTGCA GCTGCAGCCCGTCCGGTAAGAATACGAAACACCCAGGAGCCACAGCAAGGGCACAGGATTTGCAAAATCATCTTGCCAAAGGGCTGTTCC TCATTTACACGGTCATCCAGGGCTTAGAAAAAGGCTGAATGATTGGCGTCTGTTACAAAAAAGAGAAAAGAACCTTTCGCTGCCTTTGCT TCTAGAATGGAAGATACTTGTGAAAGCCATTTGCTGCACAGGAAAGATGGGGCAGTTTATTTCACTTCTAATTTTAAAAGACGCAAGTAA TGGTCCCATAATACTTCATCTTGGGATACCATTCCCAAACATGTTCCACCTTTAAGATGCCTTAAGTTAATTTGGTCAGAAACAACTAAA GGCAGCATCGTGTATTGAAGAAAACATGACTGGGAGCTCCAGCGCTGCCTGTTTTCACGCTGTGGGGTTGTGAGTGCATCATCACCCCTG GAGCTCCCGAGTTAAATGGAGGCTAAGAAAAGTAATTTATCAACTCATTTCTGTGAATGTTTGCAGTCTCCTACCGTCTCAACTACAGCT GCAGTTGCTAAAAAGCACTTAACTCGTAACCTAGAGGCAATATAGCTTAAGTAGCAAAATATTTTTTTACAGTAAGCTTCAGTCATCCAT AGTCACTATAAGTTGGTTATCATCTGAAATGCTTAGAACCAGAATTGTTTCAAACTTGGGGGGTTTTCGGATTTTGGAATATAGTCAAGC ATGGCTTAACCACAGGGATGTGTTCTGAGAAATGCGCTGTCAGGCAGTTTTTCCTGTGAACACCATGTGTACCTACATGGACCTAAAAAA CAGGTGGTGGAGCCTCCTCCACACCTAGGCTATATGGTGTATGTAGCCTGTTGCTCTAGACTGGAGGGCACGTTACTGTACTGATACTGT |
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FusionGenePPI for TBC1D14_GRPEL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TBC1D14 | UBE3A, XPO1, CENPA, PML, TFEB, TRAPPC11, TRAPPC12, TRAPPC13, ADRBK1, TRAPPC8, TRAPPC4, TRAPPC3, TRAPPC6B, SELENBP1, HEPHL1, TRAPPC2, TRAPPC9, TRAPPC5, LRRC15, TRAPPC2L, TRAPPC10, TRAPPC1, TCHH | GRPEL1 | TERF1, ICT1, GRPEL1, IFIT1, ATF2, ACTR2, ANP32B, ARPC4, BAG1, FUBP1, NIF3L1, RPA1, RPA3, RPRD1B, SHMT2, MOV10, CCAR1, PALLD, GRPEL2, DENND2D, AHNAK, DNAJA4, DNAJB1, DNAJB4, DNAJC3, DUT, DNAJC21, HSPA9, HSPB1, HSPA2, HSPA4, HSPA4L, HSPA8, HSPH1, ITPA, MDH2, STIP1, STMN1, TIMM44, NTRK1, SCLT1, NF2, EYA1, CDC25C, EYA3, SPATA24, PROSER2, TPPP, WBP2, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TBC1D14_GRPEL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TBC1D14_GRPEL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GRPEL1 | C0019693 | HIV Infections | 1 | CTD_human |
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